Pde12 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pde12
Entrez Gene ID	306231
Full Name	phosphodiesterase 12
Synonyms	LRRGT00074,RGD1310975
General protein information	Preferred Names phosphodiesterase 12 Names 2',5'-phosphodiesterase 12 2'-PDE 2-PDE mitochondrial deadenylase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 16 Map Location: 16p16

mRNA and Protein(s)

mRNA	Protein	Name
NM_001013998.2	NP_001014020.2	2',5'-phosphodiesterase 12

Pathways from BioSystems

Homologies

	PDE12	XP_001099328.1
Canis lupus familiaris (dog)	PDE12	XP_541830.2
Rattus norvegicus (Norway rat)	Pde12	NP_001014020.2
Homo sapiens (human)	PDE12	NP_808881.3
Bos taurus (cattle)	PDE12	NP_001069601.1
Mus musculus (house mouse)	Pde12	NP_848783.3
Danio rerio (zebrafish)	pde12	NP_001038753.2
Drosophila melanogaster (fruit fly)	CG31759	NP_723735.2
Pan troglodytes (chimpanzee)	PDE12	XP_517033.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009079	XP_319828.3

Gene Ontology
Bibliography

Related articles in PubMed

Characterization of human phosphodiesterase 12 and identification of a novel 2'-5' oligoadenylate nuclease - The ectonucleotide pyrophosphatase/phosphodiesterase 1.
Poulsen JB, Andersen KR, Kj?r KH, Vestergaard AL, Justesen J, Martensen PM
Biochimie94(5)1098-107(2012 May)

PDE12 removes mitochondrial RNA poly(A) tails and controls translation in human mitochondria.
Rorbach J, Nicholls TJ, Minczuk M
Nucleic acids research39(17)7750-63(2011 Sep)

Human 2'-phosphodiesterase localizes to the mitochondrial matrix with a putative function in mitochondrial RNA turnover.
Poulsen JB, Andersen KR, Kj?r KH, Durand F, Faou P, Vestergaard AL, Talbo GH, Hoogenraad N, Brodersen DE, Justesen J, Martensen PM
Nucleic acids research39(9)3754-70(2011 May)

Identification of 2'-phosphodiesterase, which plays a role in the 2-5A system regulated by interferon.
Kubota K, Nakahara K, Ohtsuka T, Yoshida S, Kawaguchi J, Fujita Y, Ozeki Y, Hara A, Yoshimura C, Furukawa H, Haruyama H, Ichikawa K, Yamashita M, Matsuoka T, Iijima Y
The Journal of biological chemistry279(36)37832-41(2004 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Pde12 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pde12 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa42650	NM_001013998.2 Latest version!	Rattus norvegicus phosphodiesterase 12 (Pde12), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$412.30 $589.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pde12 ( NM_001013998.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001014020.2 Rattus norvegicus phosphodiesterase 12 (Pde12), mRNA.

Price & Availability↑

CloneID	ORa42650
Clone ID Related Accession (Same CDS sequence)	NM_001013998.2
Accession Version	NM_001013998.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2118bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-09-15
Organism	Rattus norvegicus(Norway rat)
Product	2',5'-phosphodiesterase 12
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY387060.1. On Jun 3, 2007 this sequence version replaced NM_001013998.1. ##Evidence-Data-START## Transcript exon combination :: AY387060.1 [ECO:0000332] ##Evidence-Data-END##

ATGGAGCGCG CGGTGGTGCG CTGTGTGCCC TCGGAGCCCA AGCTCAGCCT GTCTTTTGCG 
TTGGCCGACG GCAGCCACAA AAACATGCAG CGGGACCAGA GCGAGCCTCT GGGCCGTGCT 
CTCAGCCGGA TCGCTACCAA CGCCCTCAAG GGGCACGCTA AGGTAGCGGC TGCCAAAAAG 
AGCAGGAAGA ACCGAGCCCA CTCGAGCGGT GGCGCGGCCT GCGCGGCGAC AGGGTCTGAA 
CCGGCTGCGA CCTGCGAGCC GGTGGTGAAG CTGTACTACC GGGAGGAGGC GGTAGCTGAG 
GATGTGCTCA ATGTGGACGC CTGGCAGGAC GGAGCGGTGC TGCAGATCGG CGATGTCAAG 
TACAAGGTGG AGCGCAACCC GCCTGCCTTC ACGGAGCTAC AATTGCCGCG CTACATCATG 
GCTGGCTTCC CGGTGTGTCC CAAACTCGGT CTGGAATTTG GGGATCCCGC CAGCTCCGTG 
TTCCGCTGGT ACAAGGAAGT CAAACCCGGG GCGGCAGAAC CTGGAGACAG CGGTCTCGCG 
TCATCGTCTC ACTCTTTGCA GTCTTCAGCT TGGATCGAGA CGGGTGTGGA CGAGCGCGTT 
TACACCCCGT GCAATGCTGA CATCGGGCTA CGGCTCAAGC TTCACTGCAC GCCGGGCAAT 
GGGCAGCGCT TCGGGCCAAG CCGCGAGCTA GAGAGCGTGT GCCCGGTGGA GGCCGGGCCT 
GGCACCTGCA CTTTTGACCA TCGACATCTA TACACCAAGA AGGTGACAGA GGACTCTTTC 
ATCCGCACTG TCTCCTACAA CATCCTGGCA GACACGTACG CCCAGACTGA GTTTTCTCGG 
ACAGTCCTGT ACCCGTACTG TGCCCCCTAC GCCCTGGAGC TTGACTACCG CCAGAACCTT 
ATTCAAAAGG AGCTCACAGG CTACAACGCA GACCTCATCT GTTTGCAGGA GGTGGACCGC 
GCAGTGTTCT CGGACAGCTT GGTACCGGCC CTAGAGGCCT TCGGGCTGGA GGGTGTGTTC 
CGAATCAAGC AGCACGAAGG CCTGGCCACT TTCTACCGGA AGTCGAAGTT CAGGCTCCTT 
AGCCAACATG ACATTTCTTT TCAAGAAGCC CTGAAGTCGG ACCCACTGCA CAAAGAATTA 
CTAGAGAAAC TGGCTTTGAA CCCGTTAGCA CAGGAGAAAG TACTCCAGAG ATCGTCTGTC 
CTTCAGATTT CAGTTCTTCA GTCTACCACG GACTCTTCTA AAAAGATCTG TGTTGCTAAT 
ACTCATCTCT ACTGGCACCC AAAAGGTGGA TACATTCGTC TCATTCAAAT GGCAGCAGCC 
TTGGTTCACA TTAGACATGT TTCCTGTGAT CTATATCCTG GCATACCAGT TATATTTTGT 
GGAGACTTTA ATAGCACACC ATCAACAGGA ATGTATCATT TTGTCATCAA TGGCAGCGTT 
CCGGAGGATC ATGAAGACTG GGCTTCCAAT GGGGAGGAGG AGAGATGTGG CATGTCTCTC 
ACACACTGTT TCAAACTGAA AAGCGCTTGT GGTGAACCTG CCTACACAAA TTATGTCGGT 
GGCTTTCATG GATGTCTCGA TTACATTTTC ATTGACTTAA ATGCTTTAGA GGTTGAACAG 
ACATTTCAGG ATATTCAGAT AACGAAGTGT AAAGATTTGA CTCCAGCATA CAGATATCAG 
GATGATTGGA TACAAAGCCC ACCTTCAGGA ATTGCTACTT TTATTTATGA GTTTGTGCCA 
AGTGGGAAAG GTTTTACTGC TTCCTTTAAA GAAAACTGTG AATATCAAAG ACTAATGGAC 
ATTCATACTG CTTACACTTA TAGACTAATG GACATTCATA CTGCTTATAC TTATGGATTA 
ATGGACATTC ATACTGCTTA TACTTATGGA TTAATGGACA TTCATACTGT TTATACTTAT 
GGATTAATGG ACATTCATAC TGCTTATACT TATGGATTAA TGGACATTCA TACTGCTTCC 
ACTAGTAATT TTGCTAACAT TTGTGTACAA GTTCTGTGTG GGTGTCTTAA TTTCTCTTGG 
GCAGTCCTTT GCCATGGGCA GAACTCTTGG GTCATGTGGA AACACTTACC TTTTGAGAAA 
TTGCTAGAGT ATTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001014020.2
CDS	1..2118
Translation	MERAVVRCVPSEPKLSLSFALADGSHKNMQRDQSEPLGRALSRIATNALKGHAKVAAAKKSRKNRAHSSGGAACAATGSEPAATCEPVVKLYYREEAVAEDVLNVDAWQDGAVLQIGDVKYKVERNPPAFTELQLPRYIMAGFPVCPKLGLEFGDPASSVFRWYKEVKPGAAEPGDSGLASSSHSLQSSAWIETGVDERVYTPCNADIGLRLKLHCTPGNGQRFGPSRELESVCPVEAGPGTCTFDHRHLYTKKVTEDSFIRTVSYNILADTYAQTEFSRTVLYPYCAPYALELDYRQNLIQKELTGYNADLICLQEVDRAVFSDSLVPALEAFGLEGVFRIKQHEGLATFYRKSKFRLLSQHDISFQEALKSDPLHKELLEKLALNPLAQEKVLQRSSVLQISVLQSTTDSSKKICVANTHLYWHPKGGYIRLIQMAAALVHIRHVSCDLYPGIPVIFCGDFNSTPSTGMYHFVINGSVPEDHEDWASNGEEERCGMSLTHCFKLKSACGEPAYTNYVGGFHGCLDYIFIDLNALEVEQTFQDIQITKCKDLTPAYRYQDDWIQSPPSGIATFIYEFVPSGKGFTASFKENCEYQRLMDIHTAYTYRLMDIHTAYTYGLMDIHTAYTYGLMDIHTVYTYGLMDIHTAYTYGLMDIHTASTSNFANICVQVLCGCLNFSWAVLCHGQNSWVMWKHLPFEKLLEYY

Target ORF information:

RefSeq Version	NM_001013998.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus phosphodiesterase 12 (Pde12), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001013998.2

ORF Insert Sequence:

ATGGAGCGCG CGGTGGTGCG CTGTGTGCCC TCGGAGCCCA AGCTCAGCCT GTCTTTTGCG 
TTGGCCGACG GCAGCCACAA AAACATGCAG CGGGACCAGA GCGAGCCTCT GGGCCGTGCT 
CTCAGCCGGA TCGCTACCAA CGCCCTCAAG GGGCACGCTA AGGTAGCGGC TGCCAAAAAG 
AGCAGGAAGA ACCGAGCCCA CTCGAGCGGT GGCGCGGCCT GCGCGGCGAC AGGGTCTGAA 
CCGGCTGCGA CCTGCGAGCC GGTGGTGAAG CTGTACTACC GGGAGGAGGC GGTAGCTGAG 
GATGTGCTCA ATGTGGACGC CTGGCAGGAC GGAGCGGTGC TGCAGATCGG CGATGTCAAG 
TACAAGGTGG AGCGCAACCC GCCTGCCTTC ACGGAGCTAC AATTGCCGCG CTACATCATG 
GCTGGCTTCC CGGTGTGTCC CAAACTCGGT CTGGAATTTG GGGATCCCGC CAGCTCCGTG 
TTCCGCTGGT ACAAGGAAGT CAAACCCGGG GCGGCAGAAC CTGGAGACAG CGGTCTCGCG 
TCATCGTCTC ACTCTTTGCA GTCTTCAGCT TGGATCGAGA CGGGTGTGGA CGAGCGCGTT 
TACACCCCGT GCAATGCTGA CATCGGGCTA CGGCTCAAGC TTCACTGCAC GCCGGGCAAT 
GGGCAGCGCT TCGGGCCAAG CCGCGAGCTA GAGAGCGTGT GCCCGGTGGA GGCCGGGCCT 
GGCACCTGCA CTTTTGACCA TCGACATCTA TACACCAAGA AGGTGACAGA GGACTCTTTC 
ATCCGCACTG TCTCCTACAA CATCCTGGCA GACACGTACG CCCAGACTGA GTTTTCTCGG 
ACAGTCCTGT ACCCGTACTG TGCCCCCTAC GCCCTGGAGC TTGACTACCG CCAGAACCTT 
ATTCAAAAGG AGCTCACAGG CTACAACGCA GACCTCATCT GTTTGCAGGA GGTGGACCGC 
GCAGTGTTCT CGGACAGCTT GGTACCGGCC CTAGAGGCCT TCGGGCTGGA GGGTGTGTTC 
CGAATCAAGC AGCACGAAGG CCTGGCCACT TTCTACCGGA AGTCGAAGTT CAGGCTCCTT 
AGCCAACATG ACATTTCTTT TCAAGAAGCC CTGAAGTCGG ACCCACTGCA CAAAGAATTA 
CTAGAGAAAC TGGCTTTGAA CCCGTTAGCA CAGGAGAAAG TACTCCAGAG ATCGTCTGTC 
CTTCAGATTT CAGTTCTTCA GTCTACCACG GACTCTTCTA AAAAGATCTG TGTTGCTAAT 
ACTCATCTCT ACTGGCACCC AAAAGGTGGA TACATTCGTC TCATTCAAAT GGCAGCAGCC 
TTGGTTCACA TTAGACATGT TTCCTGTGAT CTATATCCTG GCATACCAGT TATATTTTGT 
GGAGACTTTA ATAGCACACC ATCAACAGGA ATGTATCATT TTGTCATCAA TGGCAGCGTT 
CCGGAGGATC ATGAAGACTG GGCTTCCAAT GGGGAGGAGG AGAGATGTGG CATGTCTCTC 
ACACACTGTT TCAAACTGAA AAGCGCTTGT GGTGAACCTG CCTACACAAA TTATGTCGGT 
GGCTTTCATG GATGTCTCGA TTACATTTTC ATTGACTTAA ATGCTTTAGA GGTTGAACAG 
ACATTTCAGG ATATTCAGAT AACGAAGTGT AAAGATTTGA CTCCAGCATA CAGATATCAG 
GATGATTGGA TACAAAGCCC ACCTTCAGGA ATTGCTACTT TTATTTATGA GTTTGTGCCA 
AGTGGGAAAG GTTTTACTGC TTCCTTTAAA GAAAACTGTG AATATCAAAG ACTAATGGAC 
ATTCATACTG CTTACACTTA TAGACTAATG GACATTCATA CTGCTTATAC TTATGGATTA 
ATGGACATTC ATACTGCTTA TACTTATGGA TTAATGGACA TTCATACTGT TTATACTTAT 
GGATTAATGG ACATTCATAC TGCTTATACT TATGGATTAA TGGACATTCA TACTGCTTCC 
ACTAGTAATT TTGCTAACAT TTGTGTACAA GTTCTGTGTG GGTGTCTTAA TTTCTCTTGG 
GCAGTCCTTT GCCATGGGCA GAACTCTTGG GTCATGTGGA AACACTTACC TTTTGAGAAA 
TTGCTAGAGT ATTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Characterization of human phosphodiesterase 12 and identification of a novel 2'-5' oligoadenylate nuclease - The ectonucleotide pyrophosphatase/phosphodiesterase 1.
Biochimie94(5)1098-107(2012 May)
Poulsen JB,Andersen KR,Kj?r KH,Vestergaard AL,Justesen J,Martensen PM

PDE12 removes mitochondrial RNA poly(A) tails and controls translation in human mitochondria.
Nucleic acids research39(17)7750-63(2011 Sep)
Rorbach J,Nicholls TJ,Minczuk M

Human 2'-phosphodiesterase localizes to the mitochondrial matrix with a putative function in mitochondrial RNA turnover.
Nucleic acids research39(9)3754-70(2011 May)
Poulsen JB,Andersen KR,Kj?r KH,Durand F,Faou P,Vestergaard AL,Talbo GH,Hoogenraad N,Brodersen DE,Justesen J,Martensen PM

Identification of 2'-phosphodiesterase, which plays a role in the 2-5A system regulated by interferon.
The Journal of biological chemistry279(36)37832-41(2004 Sep)
Kubota K,Nakahara K,Ohtsuka T,Yoshida S,Kawaguchi J,Fujita Y,Ozeki Y,Hara A,Yoshimura C,Furukawa H,Haruyama H,Ichikawa K,Yamashita M,Matsuoka T,Iijima Y

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Pde12 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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