Nfatc4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Nfatc4
Entrez Gene ID	305897
Full Name	nuclear factor of activated T-cells 4
General protein information	Preferred Names nuclear factor of activated T-cells 4 Names nuclear factor of activated T-cells, cytoplasmic 4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 15 Map Location: 15p13

mRNA and Protein(s)

mRNA	Protein	Name
NM_001107264.1	NP_001100734.1	nuclear factor of activated T-cells, cytoplasmic 4

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Nfatc4	NP_076188.3
Xenopus tropicalis (tropical clawed frog)	nfatc4	XP_002934369.1
Pan troglodytes (chimpanzee)	NFATC4	XP_001170041.2
Danio rerio (zebrafish)	nfatc4	XP_690183.5
Homo sapiens (human)	NFATC4	NP_004545.2
Rattus norvegicus (Norway rat)	Nfatc4	NP_001100734.1
Canis lupus familiaris (dog)	NFATC4	XP_537395.2
	LOC714785	XP_002808504.1

Gene Ontology
Bibliography

Related articles in PubMed

NFATc4 and myocardin synergistically up-regulate the expression of LTCC ?1C in ET-1-induced cardiomyocyte hypertrophy.
Li M, He HP, Gong HQ, Zhang J, Ma WJ, Zhou H, Cao DS, Wang N, Zhang TC
Life sciences15511-20(2016 Jun)

Tropisetron inhibits high glucose-induced calcineurin/NFAT hypertrophic pathway in H9c2 myocardial cells.
Asadi F, Razmi A, Dehpour AR, Shafiei M
The Journal of pharmacy and pharmacology68(4)485-93(2016 Apr)

Peroxisome proliferator-activated receptor gamma coactivator 1 alpha protects cardiomyocytes from hypertrophy by suppressing calcineurin-nuclear factor of activated T cells c4 signaling pathway.
Liu XP, Gao H, Huang XY, Chen YF, Feng XJ, He YH, Li ZM, Liu PQ
Translational research : the journal of laboratory and clinical medicine166(5)459-473.e3(2015 Nov)

Anabolic steroids activate calcineurin-NFAT signaling and thereby increase myotube size and reduce denervation atrophy.
Qin W, Pan J, Wu Y, Bauman WA, Cardozo C
Molecular and cellular endocrinology399336-45(2015 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

results suggest a novel mechanism of the transcriptional regulation of LTCC alpha1C by synergistic activities of NFATc4 and myocardin in ET-1-induced cardiomyocyte hypertrophy
Title: NFATc4 and myocardin synergistically up-regulate the expression of LTCC ?1C in ET-1-induced cardiomyocyte hypertrophy.

Tropisetron may have protective effects against high glucose-induced cardiomyocyte hypertrophy. The mechanism responsible for this beneficial effect seems to be, at least in part, blockade of calcineurin/NFATc4 signalling pathway.
Title: Tropisetron inhibits high glucose-induced calcineurin/NFAT hypertrophic pathway in H9c2 myocardial cells.

binding activity and transcription activity of NFATc4 to DNA promoter of brain natriuretic peptide were abrogated by PGC-1alpha overexpression but were enhanced by PGC-1alpha knockdown
Title: Peroxisome proliferator-activated receptor gamma coactivator 1 alpha protects cardiomyocytes from hypertrophy by suppressing calcineurin-nuclear factor of activated T cells c4 signaling pathway.

nandrolone increased calcineurin activity and nuclear NFATc4 levels in cultured L6 myotubes.
Title: Anabolic steroids activate calcineurin-NFAT signaling and thereby increase myotube size and reduce denervation atrophy.

After TBI insult, in the hippocampus ipsilateral to the injury, NFATc4 expression levels were increased in the cytoplasmic fraction but decreased in the nuclear fraction.
Title: Differential effect of traumatic brain injury on the nuclear factor of activated T Cells C3 and C4 isoforms in the rat hippocampus.

The following Nfatc4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nfatc4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12706	NM_001107264.1 Latest version!	Rattus norvegicus nuclear factor of activated T-cells 4 (Nfatc4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$531.30 $759.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Nfatc4 ( NM_001107264.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001100734.1 Rattus norvegicus nuclear factor of activated T-cells 4 (Nfatc4), mRNA.

Price & Availability↑

CloneID	ORa12706
Clone ID Related Accession (Same CDS sequence)	NM_001107264.1
Accession Version	NM_001107264.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2706bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Rattus norvegicus(Norway rat)
Product	nuclear factor of activated T-cells, cytoplasmic 4
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH474049.1. On or before Oct 4, 2007 this sequence version replaced XM_240184.4, XM_001061815.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN00632250, SAMN00632252 [ECO:0000348] ##Evidence-Data-END##

ATGGGGGCGG CAAGCTGCGA GGATGAGGAG CTGGAATTTA AGCTGGTGTT CGGGGAGGAA 
AAGGAGGCCC CCCCGCTGGG CCCTGGGGGC CCTGGGGAAG AGCTGGACTC GGAGGATGCC 
CCTCCGTGCT GTCGTTTGGC CCTGGGGGAA CCCCTTCCTT ATGGTGCTGC CCCTATTGGT 
ATTCCCCGAC CCCCACCCCC TCGGCCAGGG ATGCACTCAC CACCACCCCG TCCTGCCCCT 
TCACCTGGCA CCTGGGAGAG CCAGCCACCT CGGTCGGTGA GGCTGGGGGG CCCAGGAGGC 
ACTGCGGGGG GTACTGGGGG CGGTCGTGTT CTTGAGTGTC CCAGCATCCG GATCACCTCT 
ATCTCTCCCA CGCCTGACCC ACCGACCTCA CTAGAGGATG CTCCTGAAAC TTGGGGGGAC 
GGCTCTCCTA GAGATTACCC TCCACCAGAA GGCTTTGGGG GCTACCGAGA GGCTGGAGGT 
CAGGGCGGAG GAGCCTTCTT CAGCCCGAGC CCTGGCAGCA GCAGCCTGTC TTCGTGGAGC 
TTCTTCTCTG ATGCCTCAGA CGAGGCAGCC CTGTATGCAG CATGCGACGA AGTGGAGTCT 
GAACTTAATG AAGCAGCCTC TCGTTTCGGC TTGAGCTCTC CACTGCCCTC GCCCCGGGCT 
TCTCCTAGGC CATGGACCCC GGAGGATCCG TGGAGCCTAT ATGGTCCAAG CTCCGGAGGC 
CGAGCGCCAG AGGATAGCTG GCTACTTCTC AGCGCTCCTG GGCCCATCCC AGCCTCCCCT 
CGGCCTGCTT CTCCCTGCGG CAAGCGGCGC TATTCCAGTT CCGGAACCCC ATCTTCGGCC 
TCCCCAGCTT TGTCCCGCCG GGGTAGCCTT GGGGAAGAGG GTCCAGAGCC ACCTCCACCA 
CCCCCATTGC CTCTGGTCCG GGACCCTAGT TCCTCTGGCC CTTTTGACTA TGTGGGTGCT 
CCACCAACCG AGAGCGTCCC TCAGAAAACC AGGAGGACTT CTAGCGAGCA AGCAGTGGCC 
TTGCCTCGGT CTGAGGAGCC TGCCTCGTGC AATGGGAAGC TGCCCTCTGG TACAGAGGAC 
TCCGTGGCTG CTCCCGGGGC TCTGCGGAAA GAGATGGCTG GCATGGATTA CTTAGCAGTT 
CCTTCTCCCC TCGCTTGGTC CAAGGCCCGG ATTGGGGGAC ACAGCCCCAT CTTCAGGACC 
TCTGCCCTAC CTCCCCTGGA CTGGCCTTTA CCCAGCCAGT ACGAGCAGCT GGAGCTGAGG 
ATTGAGGTGC AGCCCAGAGC TCACCACCGA GCTCATTATG AGACTGAGGG CAGCCGGGGA 
GCTGTCAAAG CTGCTCCTGG AGGTCACCCT GTGGTCAAGC TCCTAGGCTA CAATGAGAAG 
CCATTGACTC TTCAGATGTT CATTGGCACT GCAGACGAGA GGAGCCTGCG GCCCCATGCC 
TTCTACCAGG TGCACCGGAT CACTGGCAAG ATGGTGGCTA CAGCCAGCTA TGAAGCTGTA 
GTCAGTGGTA CTAAAGTGTT GGAGATGACT TTGCTCCCAG AGAACAACAT GGCTGCCAAC 
ATTGACTGTG CTGGAATCCT GAAGCTTCGG AATTCAGACA TTGAGCTACG GAAGGGCGAG 
ACAGACATCG GGCGCAAAAA CACACGTGTG CGACTGGTGT TCCGTGTGCA TGTGCCTCAG 
GGCGGCGGGA AGGTCGTCTC TGTGCAGGCA GCATCGGTGC CCATCGAGTG CTCCCAGCGC 
TCAGCCCAGG AGCTGCCCCA AGTGGAGGCC TACAGCCCCA GTGCCTGCTC CGTGAGAGGA 
GGGGAGGAGC TAGTGTTGAC TGGATCCAAC TTCCTGCCAG ACTCTAAAGT GGTGTTCATT 
GAGAGGGGCC CTGATGGAAA ACTGCAGTGG GAGGAAGAGG CCGCAGTGAA CCGGCTGCAG 
AGCAGTGAGG TGACACTGAC TCTGACCATC CCTGAGTACA GCAACAAGCG GGTGTCCCGG 
CCAGTCCAGG TCTACTTTTA TGTCTCCAAT GGGCGGAGGA AGCGCAGTCC CACCCAAAGT 
TTCAAGTTCC TGCCTGTGAT CTTCAAGGAG GAGCCCCTAC CAGACTCATC TCTCCGGGGC 
TTCCCTTCCA CATCGGGTCC CCCCTTTGGC CCCGACATGG ACTTCTCACC GCCCAGGCCC 
CCTTATCCCT CCTATCCCCA TGAAGACCCT GCTTATGAGA CTCCTTATCT GTCAGAAGGC 
TTTGGTTATA GCACACCCGC TCTGTACCCC CAGACAGGGC CCCCACCGTC TTATAGATCT 
GGCCTACGGA TGTTCCCTGA GACTGGGGGT ACCACAGGTT GTGCCCGCCT ACCTTCAGTC 
TCCTTTCTTC CGCGCCCCTT TCCTGGTGAT CAGTATGGAG GACAGGGCTC CTCTTTTCCC 
CTGGGGCTTC CATTCTCCCC TCCGGCCCCC TTTAGGCCTC CATTACCTTC CTCCCCACCA 
CTCGAAGACC CCTTTAACCC CCAGAGTGCT GTCCACCCCT TACCTGCTGA GGGCTACAAT 
GAGGTGGGGC CAGGCTATAC CCCTGGGGAG GGGGCTTCGG AGCAGGAGAA ATCCAGGGGT 
GGCTACGGCA GCGGCTTCAG AGACAATGTG CCTATCCAGG GTATCACCCT GGAGGAAGTG 
AGTGAGATCA TTGGCCGAGA CCTGAGTGGC TTCCCTGCAC GTCCTGGAGA AGAGCCTCCT 
GCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001100734.1
CDS	138..2843
Translation	MGAASCEDEELEFKLVFGEEKEAPPLGPGGPGEELDSEDAPPCCRLALGEPLPYGAAPIGIPRPPPPRPGMHSPPPRPAPSPGTWESQPPRSVRLGGPGGTAGGTGGGRVLECPSIRITSISPTPDPPTSLEDAPETWGDGSPRDYPPPEGFGGYREAGGQGGGAFFSPSPGSSSLSSWSFFSDASDEAALYAACDEVESELNEAASRFGLSSPLPSPRASPRPWTPEDPWSLYGPSSGGRAPEDSWLLLSAPGPIPASPRPASPCGKRRYSSSGTPSSASPALSRRGSLGEEGPEPPPPPPLPLVRDPSSSGPFDYVGAPPTESVPQKTRRTSSEQAVALPRSEEPASCNGKLPSGTEDSVAAPGALRKEMAGMDYLAVPSPLAWSKARIGGHSPIFRTSALPPLDWPLPSQYEQLELRIEVQPRAHHRAHYETEGSRGAVKAAPGGHPVVKLLGYNEKPLTLQMFIGTADERSLRPHAFYQVHRITGKMVATASYEAVVSGTKVLEMTLLPENNMAANIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHVPQGGGKVVSVQAASVPIECSQRSAQELPQVEAYSPSACSVRGGEELVLTGSNFLPDSKVVFIERGPDGKLQWEEEAAVNRLQSSEVTLTLTIPEYSNKRVSRPVQVYFYVSNGRRKRSPTQSFKFLPVIFKEEPLPDSSLRGFPSTSGPPFGPDMDFSPPRPPYPSYPHEDPAYETPYLSEGFGYSTPALYPQTGPPPSYRSGLRMFPETGGTTGCARLPSVSFLPRPFPGDQYGGQGSSFPLGLPFSPPAPFRPPLPSSPPLEDPFNPQSAVHPLPAEGYNEVGPGYTPGEGASEQEKSRGGYGSGFRDNVPIQGITLEEVSEIIGRDLSGFPARPGEEPPA

Target ORF information:

RefSeq Version	NM_001107264.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus nuclear factor of activated T-cells 4 (Nfatc4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001107264.1

ORF Insert Sequence:

ATGGGGGCGG CAAGCTGCGA GGATGAGGAG CTGGAATTTA AGCTGGTGTT CGGGGAGGAA 
AAGGAGGCCC CCCCGCTGGG CCCTGGGGGC CCTGGGGAAG AGCTGGACTC GGAGGATGCC 
CCTCCGTGCT GTCGTTTGGC CCTGGGGGAA CCCCTTCCTT ATGGTGCTGC CCCTATTGGT 
ATTCCCCGAC CCCCACCCCC TCGGCCAGGG ATGCACTCAC CACCACCCCG TCCTGCCCCT 
TCACCTGGCA CCTGGGAGAG CCAGCCACCT CGGTCGGTGA GGCTGGGGGG CCCAGGAGGC 
ACTGCGGGGG GTACTGGGGG CGGTCGTGTT CTTGAGTGTC CCAGCATCCG GATCACCTCT 
ATCTCTCCCA CGCCTGACCC ACCGACCTCA CTAGAGGATG CTCCTGAAAC TTGGGGGGAC 
GGCTCTCCTA GAGATTACCC TCCACCAGAA GGCTTTGGGG GCTACCGAGA GGCTGGAGGT 
CAGGGCGGAG GAGCCTTCTT CAGCCCGAGC CCTGGCAGCA GCAGCCTGTC TTCGTGGAGC 
TTCTTCTCTG ATGCCTCAGA CGAGGCAGCC CTGTATGCAG CATGCGACGA AGTGGAGTCT 
GAACTTAATG AAGCAGCCTC TCGTTTCGGC TTGAGCTCTC CACTGCCCTC GCCCCGGGCT 
TCTCCTAGGC CATGGACCCC GGAGGATCCG TGGAGCCTAT ATGGTCCAAG CTCCGGAGGC 
CGAGCGCCAG AGGATAGCTG GCTACTTCTC AGCGCTCCTG GGCCCATCCC AGCCTCCCCT 
CGGCCTGCTT CTCCCTGCGG CAAGCGGCGC TATTCCAGTT CCGGAACCCC ATCTTCGGCC 
TCCCCAGCTT TGTCCCGCCG GGGTAGCCTT GGGGAAGAGG GTCCAGAGCC ACCTCCACCA 
CCCCCATTGC CTCTGGTCCG GGACCCTAGT TCCTCTGGCC CTTTTGACTA TGTGGGTGCT 
CCACCAACCG AGAGCGTCCC TCAGAAAACC AGGAGGACTT CTAGCGAGCA AGCAGTGGCC 
TTGCCTCGGT CTGAGGAGCC TGCCTCGTGC AATGGGAAGC TGCCCTCTGG TACAGAGGAC 
TCCGTGGCTG CTCCCGGGGC TCTGCGGAAA GAGATGGCTG GCATGGATTA CTTAGCAGTT 
CCTTCTCCCC TCGCTTGGTC CAAGGCCCGG ATTGGGGGAC ACAGCCCCAT CTTCAGGACC 
TCTGCCCTAC CTCCCCTGGA CTGGCCTTTA CCCAGCCAGT ACGAGCAGCT GGAGCTGAGG 
ATTGAGGTGC AGCCCAGAGC TCACCACCGA GCTCATTATG AGACTGAGGG CAGCCGGGGA 
GCTGTCAAAG CTGCTCCTGG AGGTCACCCT GTGGTCAAGC TCCTAGGCTA CAATGAGAAG 
CCATTGACTC TTCAGATGTT CATTGGCACT GCAGACGAGA GGAGCCTGCG GCCCCATGCC 
TTCTACCAGG TGCACCGGAT CACTGGCAAG ATGGTGGCTA CAGCCAGCTA TGAAGCTGTA 
GTCAGTGGTA CTAAAGTGTT GGAGATGACT TTGCTCCCAG AGAACAACAT GGCTGCCAAC 
ATTGACTGTG CTGGAATCCT GAAGCTTCGG AATTCAGACA TTGAGCTACG GAAGGGCGAG 
ACAGACATCG GGCGCAAAAA CACACGTGTG CGACTGGTGT TCCGTGTGCA TGTGCCTCAG 
GGCGGCGGGA AGGTCGTCTC TGTGCAGGCA GCATCGGTGC CCATCGAGTG CTCCCAGCGC 
TCAGCCCAGG AGCTGCCCCA AGTGGAGGCC TACAGCCCCA GTGCCTGCTC CGTGAGAGGA 
GGGGAGGAGC TAGTGTTGAC TGGATCCAAC TTCCTGCCAG ACTCTAAAGT GGTGTTCATT 
GAGAGGGGCC CTGATGGAAA ACTGCAGTGG GAGGAAGAGG CCGCAGTGAA CCGGCTGCAG 
AGCAGTGAGG TGACACTGAC TCTGACCATC CCTGAGTACA GCAACAAGCG GGTGTCCCGG 
CCAGTCCAGG TCTACTTTTA TGTCTCCAAT GGGCGGAGGA AGCGCAGTCC CACCCAAAGT 
TTCAAGTTCC TGCCTGTGAT CTTCAAGGAG GAGCCCCTAC CAGACTCATC TCTCCGGGGC 
TTCCCTTCCA CATCGGGTCC CCCCTTTGGC CCCGACATGG ACTTCTCACC GCCCAGGCCC 
CCTTATCCCT CCTATCCCCA TGAAGACCCT GCTTATGAGA CTCCTTATCT GTCAGAAGGC 
TTTGGTTATA GCACACCCGC TCTGTACCCC CAGACAGGGC CCCCACCGTC TTATAGATCT 
GGCCTACGGA TGTTCCCTGA GACTGGGGGT ACCACAGGTT GTGCCCGCCT ACCTTCAGTC 
TCCTTTCTTC CGCGCCCCTT TCCTGGTGAT CAGTATGGAG GACAGGGCTC CTCTTTTCCC 
CTGGGGCTTC CATTCTCCCC TCCGGCCCCC TTTAGGCCTC CATTACCTTC CTCCCCACCA 
CTCGAAGACC CCTTTAACCC CCAGAGTGCT GTCCACCCCT TACCTGCTGA GGGCTACAAT 
GAGGTGGGGC CAGGCTATAC CCCTGGGGAG GGGGCTTCGG AGCAGGAGAA ATCCAGGGGT 
GGCTACGGCA GCGGCTTCAG AGACAATGTG CCTATCCAGG GTATCACCCT GGAGGAAGTG 
AGTGAGATCA TTGGCCGAGA CCTGAGTGGC TTCCCTGCAC GTCCTGGAGA AGAGCCTCCT 
GCCTGA