Gpr119 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gpr119
Entrez Gene ID	302813
Full Name	G protein-coupled receptor 119
General protein information	Preferred Names G protein-coupled receptor 119 Names glucose-dependent insulinotropic receptor
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: X Map Location: Xq36
Summary	a member of the rhodopsin subgroup of the G protein-coupled receptor superfamily [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_181770.1	NP_861435.1	glucose-dependent insulinotropic receptor

Pathways from BioSystems

Homologies

	GPR119	XP_001093395.1
Bos taurus (cattle)	GPR119	XP_002699578.1
Rattus norvegicus (Norway rat)	Gpr119	NP_861435.1
Homo sapiens (human)	GPR119	NP_848566.1
Danio rerio (zebrafish)	LOC100001479	XP_001337269.1
Pan troglodytes (chimpanzee)	GPR119	XP_521262.2
Canis lupus familiaris (dog)	GPR119	XP_549255.1
Mus musculus (house mouse)	Gpr119	NP_861416.1
Gallus gallus (chicken)	GPR119	XP_004940626.1

Gene Ontology
Bibliography

Related articles in PubMed

A role of CB1R in inducing ?-rhythm coordination between the gustatory and gastrointestinal insula.
Kang Y, Sato H, Saito M, Yin DX, Park SK, Oh SB, Bae YC, Toyoda H
Scientific reports632529(2016 Sep)

Angelica dahurica Extracts Improve Glucose Tolerance through the Activation of GPR119.
Park EY, Kim EH, Kim CY, Kim MH, Choung JS, Oh YS, Moon HS, Jun HS
PloS one11(7)e0158796(2016)

Direct activation of the proposed anti-diabetic receptor, GPR119 in cardiomyoblasts decreases markers of muscle metabolic activity.
Cornall LM, Hryciw DH, Mathai ML, McAinch AJ
Molecular and cellular endocrinology40272-85(2015 Feb)

Gastrointestinal hormonal responses on GPR119 activation in lean and diseased rodent models of type 2 diabetes.
Patel S, Mace OJ, Tough IR, White J, Cock TA, Warpman Berglund U, Schindler M, Cox HM
International journal of obesity (2005)38(10)1365-73(2014 Oct)

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.
Ghai R, Bugarcic A, Liu H, Norwood SJ, Skeldal S, Coulson EJ, Li SS, Teasdale RD, Collins BM
Proceedings of the National Academy of Sciences of the United States of America110(8)E643-52(2013 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Angelica dahurica extract-treated cells showed significant increases in GPR119 activation, intracellular cAMP levels, GLP-1 levels and glucose-stimulated insulin secretion as compared with controls
Title: Angelica dahurica Extracts Improve Glucose Tolerance through the Activation of GPR119.

Pathways activated in response to GPR119 modulation in cardiac muscle cells differ between healthy and metabolically dysregulated states.
Title: Direct activation of the proposed anti-diabetic receptor, GPR119 in cardiomyoblasts decreases markers of muscle metabolic activity.

Results show that functional GPR119 responses are similar in lean and diabetic rodent, and human colon; that GPR119 stimulation can result in glucose lowering through release of intestinal peptide hormones.
Title: Gastrointestinal hormonal responses on GPR119 activation in lean and diseased rodent models of type 2 diabetes.

Data suggest that GPR119 activation/up-regulation in skeletal muscle impairs fatty acid and glucose oxidation; diet-induced obesity appears to up-regulate skeletal muscle GPR119.
Title: GPR119 regulates genetic markers of fatty acid oxidation in cultured skeletal muscle myotubes.

The following Gpr119 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gpr119 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa42378	NM_181770.1 Latest version!	Rattus norvegicus G protein-coupled receptor 119 (Gpr119), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$272.30 $389.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gpr119 ( NM_181770.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_861435.1 Rattus norvegicus G protein-coupled receptor 119 (Gpr119), mRNA.

Price & Availability↑

CloneID	ORa42378
Clone ID Related Accession (Same CDS sequence)	NM_181770.1
Accession Version	NM_181770.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1407bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-03
Organism	Rattus norvegicus(Norway rat)
Product	glucose-dependent insulinotropic receptor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY288429.1. ##Evidence-Data-START## Transcript exon combination :: AY288429.1 [ECO:0000332] ##Evidence-Data-END##

ATGGAGTCAT CTTTCTCATT TGGAGTGATC CTTGCTGTCC TGACCATCCT TATCATTGCT 
GTTAATGCGC TGGTGGTTGT GGCTATGCTG CTATCAATCT ACAAGAATGA TGGTGTTGGC 
CTTTGCTTCA CCTTAAATCT GGCCGTGGCT GATACCTTGA TTGGCGTGGC TATTTCTGGG 
CTAGTTACAG ACCAGCTCTC CAGCTCTGCT CAGCACACAC AGAAGACCTT GTGTAGCCTT 
CGGATGGCAT TCGTCACTTC TTCTGCAGCC GCCTCTGTCC TCACGGTCAT GCTGATTGCC 
TTTGACAGGT ACCTGGCCAT TAAGCAGCCC CTCCGTTACT TCCAGATCAT GAATGGGCTT 
GTAGCCGGAG GATGCATTGC AGGGCTGTGG TTGATATCTT ACCTTATCGG CTTCCTCCCA 
CTTGGAGTCT CCATATTCCA GCAGACCACC TACCATGGGC CCTGCACCTT CTTTGCTGTG 
TTTCACCCAA GGTTTGTGCT GACCCTCTCC TGTGCTGGCT TCTTCCCAGC TGTGCTCCTC 
TTTGTCTTCT TCTACTGTGA CATGCTCAAG ATTGCCTCTG TGCACAGCCA GCACATCCGG 
AAGATGGAAC ATGCAGGAGC CATGGTTGGA GCTTGCCGGC CCCCACGGCC TGTCAATGAC 
TTCAAGGCTG TCCGGACTGT ATCTGTCCTT ATTGGGAGCT TCACCCTGTC CTGGTCTCCG 
TTTCTCATCA CTAGCATTGT GCAGGTGGCC TGCCACAAAT GCTGCCTCTA CCAAGTGCTG 
GAAAAATACC TCTGGCTCCT TGGAGTTGGC AACTCCCTGC TCAACCCACT CATCTATGCC 
TATTGGCAGA GGGAGGTTCG GCAGCAGCTC TGCCACATGG CCCTGGGGCT ACTTGCTGAT 
GGCAGTACAC AACCCCAAAT TGAGACACTG AAAGGGAAGG AAGAGAGAAA GAAGGTAGGA 
AGAAAGACGC TGTACACATG TGATGCACAG ACGCTGTACA CATGTGATGC ACAGACGCTG 
TACACATGTG ATGCACAGAC GCTGTACACA TGTGATGCAT GTGATACACA GACACTGTAC 
ACATGTGATG CACAGACGCT GTACACATGT GATGCACAGA CGCTGTACAC ATGTGATGCA 
CAGACGCTGT ACACATGTGA TGCACAGACG CTGTACACAT GTGATGCACA GACACTGTAC 
ACATGTGATA CACAGACGCT GTACACATGT GATGCACAGA CGCTGTACAC ATGTGATGCA 
CAGACGCTGT ACACATGTGA TGCACAGACG CTGTACACAT GTGATGCACA GACGCTGTAC 
ACATCAAGTT TGGTAACTGG CCAAACTGAG CAGACACCAC TGAAACGAGC AAACATGAGT 
GATCCTCTGA GGACATGCAG GGGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_861435.1
CDS	1..1407
Translation	MESSFSFGVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLGVSIFQQTTYHGPCTFFAVFHPRFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQHIRKMEHAGAMVGACRPPRPVNDFKAVRTVSVLIGSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQLCHMALGLLADGSTQPQIETLKGKEERKKVGRKTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDACDTQTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDTQTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDAQTLYTSSLVTGQTEQTPLKRANMSDPLRTCRG

Target ORF information:

RefSeq Version	NM_181770.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus G protein-coupled receptor 119 (Gpr119), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_181770.1

ORF Insert Sequence:

ATGGAGTCAT CTTTCTCATT TGGAGTGATC CTTGCTGTCC TGACCATCCT TATCATTGCT 
GTTAATGCGC TGGTGGTTGT GGCTATGCTG CTATCAATCT ACAAGAATGA TGGTGTTGGC 
CTTTGCTTCA CCTTAAATCT GGCCGTGGCT GATACCTTGA TTGGCGTGGC TATTTCTGGG 
CTAGTTACAG ACCAGCTCTC CAGCTCTGCT CAGCACACAC AGAAGACCTT GTGTAGCCTT 
CGGATGGCAT TCGTCACTTC TTCTGCAGCC GCCTCTGTCC TCACGGTCAT GCTGATTGCC 
TTTGACAGGT ACCTGGCCAT TAAGCAGCCC CTCCGTTACT TCCAGATCAT GAATGGGCTT 
GTAGCCGGAG GATGCATTGC AGGGCTGTGG TTGATATCTT ACCTTATCGG CTTCCTCCCA 
CTTGGAGTCT CCATATTCCA GCAGACCACC TACCATGGGC CCTGCACCTT CTTTGCTGTG 
TTTCACCCAA GGTTTGTGCT GACCCTCTCC TGTGCTGGCT TCTTCCCAGC TGTGCTCCTC 
TTTGTCTTCT TCTACTGTGA CATGCTCAAG ATTGCCTCTG TGCACAGCCA GCACATCCGG 
AAGATGGAAC ATGCAGGAGC CATGGTTGGA GCTTGCCGGC CCCCACGGCC TGTCAATGAC 
TTCAAGGCTG TCCGGACTGT ATCTGTCCTT ATTGGGAGCT TCACCCTGTC CTGGTCTCCG 
TTTCTCATCA CTAGCATTGT GCAGGTGGCC TGCCACAAAT GCTGCCTCTA CCAAGTGCTG 
GAAAAATACC TCTGGCTCCT TGGAGTTGGC AACTCCCTGC TCAACCCACT CATCTATGCC 
TATTGGCAGA GGGAGGTTCG GCAGCAGCTC TGCCACATGG CCCTGGGGCT ACTTGCTGAT 
GGCAGTACAC AACCCCAAAT TGAGACACTG AAAGGGAAGG AAGAGAGAAA GAAGGTAGGA 
AGAAAGACGC TGTACACATG TGATGCACAG ACGCTGTACA CATGTGATGC ACAGACGCTG 
TACACATGTG ATGCACAGAC GCTGTACACA TGTGATGCAT GTGATACACA GACACTGTAC 
ACATGTGATG CACAGACGCT GTACACATGT GATGCACAGA CGCTGTACAC ATGTGATGCA 
CAGACGCTGT ACACATGTGA TGCACAGACG CTGTACACAT GTGATGCACA GACACTGTAC 
ACATGTGATA CACAGACGCT GTACACATGT GATGCACAGA CGCTGTACAC ATGTGATGCA 
CAGACGCTGT ACACATGTGA TGCACAGACG CTGTACACAT GTGATGCACA GACGCTGTAC 
ACATCAAGTT TGGTAACTGG CCAAACTGAG CAGACACCAC TGAAACGAGC AAACATGAGT 
GATCCTCTGA GGACATGCAG GGGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A role of CB1R in inducing ?-rhythm coordination between the gustatory and gastrointestinal insula.
Scientific reports632529(2016 Sep)
Kang Y,Sato H,Saito M,Yin DX,Park SK,Oh SB,Bae YC,Toyoda H

Angelica dahurica Extracts Improve Glucose Tolerance through the Activation of GPR119.
PloS one11(7)e0158796(2016)
Park EY,Kim EH,Kim CY,Kim MH,Choung JS,Oh YS,Moon HS,Jun HS

Direct activation of the proposed anti-diabetic receptor, GPR119 in cardiomyoblasts decreases markers of muscle metabolic activity.
Molecular and cellular endocrinology40272-85(2015 Feb)
Cornall LM,Hryciw DH,Mathai ML,McAinch AJ

Gastrointestinal hormonal responses on GPR119 activation in lean and diseased rodent models of type 2 diabetes.
International journal of obesity (2005)38(10)1365-73(2014 Oct)
Patel S,Mace OJ,Tough IR,White J,Cock TA,Warpman Berglund U,Schindler M,Cox HM

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.
Proceedings of the National Academy of Sciences of the United States of America110(8)E643-52(2013 Feb)
Ghai R,Bugarcic A,Liu H,Norwood SJ,Skeldal S,Coulson EJ,Li SS,Teasdale RD,Collins BM

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Gpr119 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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