Il18r1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Il18r1
Entrez Gene ID	301365
Full Name	interleukin 18 receptor 1
General protein information	Preferred Names interleukin 18 receptor 1 Names interleukin-18 receptor 1 IL18Ralpha2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 9 Map Location: 9q22

mRNA and Protein(s)

mRNA	Protein	Name
XM_008767018.2	XP_008765240.1	interleukin-18 receptor 1 isoform X1
XM_006244786.3	XP_006244848.1	interleukin-18 receptor 1 isoform X2
NM_001106905.2	NP_001100375.1	interleukin-18 receptor 1 precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Il18r1	NP_032391.1
Pan troglodytes (chimpanzee)	IL18R1	XP_515669.2
Homo sapiens (human)	IL18R1	NP_003846.1
Rattus norvegicus (Norway rat)	Il18r1	NP_001100375.1
Gallus gallus (chicken)	IL18R1	NP_001138697.2
Xenopus tropicalis (tropical clawed frog)	LOC100491382	XP_002934550.2
Canis lupus familiaris (dog)	IL18R1	XP_005626050.1
Xenopus tropicalis (tropical clawed frog)	LOC101732855	XP_004912408.1
	IL18R1	XP_002799400.1
Bos taurus (cattle)	IL18R1	XP_005212517.1

Gene Ontology
Bibliography

Related articles in PubMed

Inflammation-Dependent IL18 Signaling Restricts Hepatocellular Carcinoma Growth by Enhancing the Accumulation and Activity of Tumor-Infiltrating Lymphocytes.
Markowitz GJ, Yang P, Fu J, Michelotti GA, Chen R, Sui J, Yang B, Qin WH, Zhang Z, Wang FS, Diehl AM, Li QJ, Wang H, Wang XF
Cancer research76(8)2394-405(2016 04)

Divergent responses to thermogenic stimuli in BAT and subcutaneous adipose tissue from interleukin 18 and interleukin 18 receptor 1-deficient mice.
Pazos P, Lima L, Tovar S, Gonz?lez-Touceda D, Di?guez C, Garc?a MC
Scientific reports517977(2015 Dec)

The structural basis for receptor recognition of human interleukin-18.
Tsutsumi N, Kimura T, Arita K, Ariyoshi M, Ohnishi H, Yamamoto T, Zuo X, Maenaka K, Park EY, Kondo N, Shirakawa M, Tochio H, Kato Z
Nature communications55340(2014 Dec)

Structural basis for the specific recognition of IL-18 by its alpha receptor.
Wei H, Wang D, Qian Y, Liu X, Fan S, Yin HS, Wang X
FEBS letters588(21)3838-43(2014 Nov)

Identification of a truncated splice variant of IL-18 receptor alpha in the human and rat, with evidence of wider evolutionary conservation.
Booker CS, Grattan DR
PeerJ2e560(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The aim of this study was to evaluate the constitutive expression of IL-18 and its receptors (IL-18Ralpha and IL-18Rbeta) in intestinal epithelial cells (IEC) stimulated by tumor necrosis factor-alpha and interferon-gamma.
Title: Constitutive expression of IL-18 and IL-18R in differentiated IEC-6 cells: effect of TNF-alpha and IFN-gamma treatment.

The following Il18r1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Il18r1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa32140	NM_001106905.2 Latest version!	Rattus norvegicus interleukin 18 receptor 1 (Il18r1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
ORa32140	XM_006244786.3 Latest version!	Rattus norvegicus interleukin 18 receptor 1 (Il18r1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
ORa45854	XM_008767018.2 Latest version!	Rattus norvegicus interleukin 18 receptor 1 (Il18r1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Il18r1 ( NM_001106905.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001100375.1 Rattus norvegicus interleukin 18 receptor 1 (Il18r1), mRNA.

Price & Availability↑

CloneID	ORa32140
Clone ID Related Accession (Same CDS sequence)	XM_006244786.3 , NM_001106905.2
Accession Version	NM_001106905.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1614bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-15
Organism	Rattus norvegicus(Norway rat)
Product	interleukin-18 receptor 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07067462.1. On Jun 19, 2009 this sequence version replaced NM_001106905.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

ATGCATCATG AAGAATTAAT CTTGATACTT TGTGTTCTCG TTGTTAAAAG TGCCCCGAAA 
AGTTGCATTC GCCGGTCGCA AATTCACGTA GTAGAGGGAG AGCCTTTTTA TCTGAAGCCC 
TGTGATATGT CTGCACCCAT GCATAACAAT GAGACAGCCA CCATGAGATG GTTCAAAGGC 
AATGCTTCAC ATGGCTACAG AGAGCTGAAC ATGAGAAGCT CGCCCAGAAT CGCTTTTCAT 
GGTCACGCTT TGGAATTCTG GCCAGTTGAG CTGGAGGACA AGGGAACGTA CTTTTCTCAA 
GTGGGAAATG ATCGTCAAAA TTGGACCTTA AATGTCACCA AAAGAAACAA ACACAGCTGC 
TTCTCTGAGA AGCTTGTGAC GAACAGAGAT GTGGAGGTTA AGAAATCTCT GTGGATTACC 
TGTGAAAATC CTAGCTATGG AGAGCTGATC AACCACACGT TGCTGTATAA GAACTGTAAG 
GAAATATCCA AAACCCCAAT GATCCTGAAG GATGCCGAGT TTGGAGATGA AGGTTATTAC 
TCCTGCGTGT TTTCTGTCCA CCATAACGGG CAACAGTACA ACATCACCAA GACTGTCAAT 
ATAACGGTTA TTGAAGGGAA CAGTAAAATA ACTCCGGCTA TTTTTGGATC AAAGTCTGCG 
AAGGTTGGTG TAGAACTAGG AGAAGATGTG GAGCTGAACT GCAGTGCTGT GCTGAATAGA 
AATGATCTGT TTTATTGGAG CATCAGGAAA GAGGACAGCT TAGACCCTAA CGTGCATGAA 
GACAGGAACG AGACAACATG GACTTTTGAA GGCAAATTGC ATGCTTCAAA AATCCTGAGA 
ATTCAGAAAG TTACAGAAAA ATATCTCAAT GTTTTATATA ATTGTACCGT GGCCAACGAA 
GAAGCCACAG ACACCAAAAG CTTCATCTTG GTGAGAAAAG AAACACCTGA CATCCAAGGC 
CATGTCTTTA TGAGAGGAAT AACCATGGTT GTTCTCACCT CTGTGGCAGC AGTGTGCGTG 
GTGATTTTGT GCATCATTTA TAAAGTTGAT TTGGTTTTAT TCTATAGACG TGTAGCAGAA 
AGAGACGAGA CACTAACAGA TGGTAAAACA TATGATGCCT TTGTGTCTTA CCTGAGAGAG 
TGTCATCCTG AGAATGGAGA AGAGTACACT TTTGCTGTGG AGACGTTACC CAGGGTCCTG 
GAGAAACAGT TTGGCTATAA GTTGTGCATA TTTGAAAGAG ATGTGGTGCC TGGTGGAGCT 
GTCGTTGATG AGATCCATTC ACTGATAGAG AAAAGCCGGA GGCTAATCAT CGTCCTCAGC 
AAGAGTTACA TGACTAATGG ATCCAGGCTC GAGCTGGAGA GCGGACTCCA CCAAGCACTG 
GTGGAGAGGA AGATTAAAAT AATCTTAATC GAGTTTACTC CAGCCAGCAA CATCACCTTT 
CTCCCGCCGT CGCTGAAACT CCTCAAGTCC TACAGAGTTC TGAGGTGGAA GGCTGACAAG 
CCACTCTCTT CGAAATCACG ATTCTGGAAG AATCTTCTTT ACCTGATGCC TGCCAAAGCC 
GTCAAGCCAT GGAGAGAAGA ATCAGAGGCC CGGCCTGTTC TCTCAGCACC TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001100375.1
CDS	377..1990
Translation	MHHEELILILCVLVVKSAPKSCIRRSQIHVVEGEPFYLKPCDMSAPMHNNETATMRWFKGNASHGYRELNMRSSPRIAFHGHALEFWPVELEDKGTYFSQVGNDRQNWTLNVTKRNKHSCFSEKLVTNRDVEVKKSLWITCENPSYGELINHTLLYKNCKEISKTPMILKDAEFGDEGYYSCVFSVHHNGQQYNITKTVNITVIEGNSKITPAIFGSKSAKVGVELGEDVELNCSAVLNRNDLFYWSIRKEDSLDPNVHEDRNETTWTFEGKLHASKILRIQKVTEKYLNVLYNCTVANEEATDTKSFILVRKETPDIQGHVFMRGITMVVLTSVAAVCVVILCIIYKVDLVLFYRRVAERDETLTDGKTYDAFVSYLRECHPENGEEYTFAVETLPRVLEKQFGYKLCIFERDVVPGGAVVDEIHSLIEKSRRLIIVLSKSYMTNGSRLELESGLHQALVERKIKIILIEFTPASNITFLPPSLKLLKSYRVLRWKADKPLSSKSRFWKNLLYLMPAKAVKPWREESEARPVLSAP

Target ORF information:

RefSeq Version	NM_001106905.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus interleukin 18 receptor 1 (Il18r1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001106905.2

ORF Insert Sequence:

ATGCATCATG AAGAATTAAT CTTGATACTT TGTGTTCTCG TTGTTAAAAG TGCCCCGAAA 
AGTTGCATTC GCCGGTCGCA AATTCACGTA GTAGAGGGAG AGCCTTTTTA TCTGAAGCCC 
TGTGATATGT CTGCACCCAT GCATAACAAT GAGACAGCCA CCATGAGATG GTTCAAAGGC 
AATGCTTCAC ATGGCTACAG AGAGCTGAAC ATGAGAAGCT CGCCCAGAAT CGCTTTTCAT 
GGTCACGCTT TGGAATTCTG GCCAGTTGAG CTGGAGGACA AGGGAACGTA CTTTTCTCAA 
GTGGGAAATG ATCGTCAAAA TTGGACCTTA AATGTCACCA AAAGAAACAA ACACAGCTGC 
TTCTCTGAGA AGCTTGTGAC GAACAGAGAT GTGGAGGTTA AGAAATCTCT GTGGATTACC 
TGTGAAAATC CTAGCTATGG AGAGCTGATC AACCACACGT TGCTGTATAA GAACTGTAAG 
GAAATATCCA AAACCCCAAT GATCCTGAAG GATGCCGAGT TTGGAGATGA AGGTTATTAC 
TCCTGCGTGT TTTCTGTCCA CCATAACGGG CAACAGTACA ACATCACCAA GACTGTCAAT 
ATAACGGTTA TTGAAGGGAA CAGTAAAATA ACTCCGGCTA TTTTTGGATC AAAGTCTGCG 
AAGGTTGGTG TAGAACTAGG AGAAGATGTG GAGCTGAACT GCAGTGCTGT GCTGAATAGA 
AATGATCTGT TTTATTGGAG CATCAGGAAA GAGGACAGCT TAGACCCTAA CGTGCATGAA 
GACAGGAACG AGACAACATG GACTTTTGAA GGCAAATTGC ATGCTTCAAA AATCCTGAGA 
ATTCAGAAAG TTACAGAAAA ATATCTCAAT GTTTTATATA ATTGTACCGT GGCCAACGAA 
GAAGCCACAG ACACCAAAAG CTTCATCTTG GTGAGAAAAG AAACACCTGA CATCCAAGGC 
CATGTCTTTA TGAGAGGAAT AACCATGGTT GTTCTCACCT CTGTGGCAGC AGTGTGCGTG 
GTGATTTTGT GCATCATTTA TAAAGTTGAT TTGGTTTTAT TCTATAGACG TGTAGCAGAA 
AGAGACGAGA CACTAACAGA TGGTAAAACA TATGATGCCT TTGTGTCTTA CCTGAGAGAG 
TGTCATCCTG AGAATGGAGA AGAGTACACT TTTGCTGTGG AGACGTTACC CAGGGTCCTG 
GAGAAACAGT TTGGCTATAA GTTGTGCATA TTTGAAAGAG ATGTGGTGCC TGGTGGAGCT 
GTCGTTGATG AGATCCATTC ACTGATAGAG AAAAGCCGGA GGCTAATCAT CGTCCTCAGC 
AAGAGTTACA TGACTAATGG ATCCAGGCTC GAGCTGGAGA GCGGACTCCA CCAAGCACTG 
GTGGAGAGGA AGATTAAAAT AATCTTAATC GAGTTTACTC CAGCCAGCAA CATCACCTTT 
CTCCCGCCGT CGCTGAAACT CCTCAAGTCC TACAGAGTTC TGAGGTGGAA GGCTGACAAG 
CCACTCTCTT CGAAATCACG ATTCTGGAAG AATCTTCTTT ACCTGATGCC TGCCAAAGCC 
GTCAAGCCAT GGAGAGAAGA ATCAGAGGCC CGGCCTGTTC TCTCAGCACC TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Il18r1 ( XM_006244786.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006244848.1 Rattus norvegicus interleukin 18 receptor 1 (Il18r1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa32140
Clone ID Related Accession (Same CDS sequence)	XM_006244786.3 , NM_001106905.2
Accession Version	XM_006244786.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1614bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	interleukin-18 receptor 1 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005108.4) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006244786.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCATCATG AAGAATTAAT CTTGATACTT TGTGTTCTCG TTGTTAAAAG TGCCCCGAAA 
AGTTGCATTC GCCGGTCGCA AATTCACGTA GTAGAGGGAG AGCCTTTTTA TCTGAAGCCC 
TGTGATATGT CTGCACCCAT GCATAACAAT GAGACAGCCA CCATGAGATG GTTCAAAGGC 
AATGCTTCAC ATGGCTACAG AGAGCTGAAC ATGAGAAGCT CGCCCAGAAT CGCTTTTCAT 
GGTCACGCTT TGGAATTCTG GCCAGTTGAG CTGGAGGACA AGGGAACGTA CTTTTCTCAA 
GTGGGAAATG ATCGTCAAAA TTGGACCTTA AATGTCACCA AAAGAAACAA ACACAGCTGC 
TTCTCTGAGA AGCTTGTGAC GAACAGAGAT GTGGAGGTTA AGAAATCTCT GTGGATTACC 
TGTGAAAATC CTAGCTATGG AGAGCTGATC AACCACACGT TGCTGTATAA GAACTGTAAG 
GAAATATCCA AAACCCCAAT GATCCTGAAG GATGCCGAGT TTGGAGATGA AGGTTATTAC 
TCCTGCGTGT TTTCTGTCCA CCATAACGGG CAACAGTACA ACATCACCAA GACTGTCAAT 
ATAACGGTTA TTGAAGGGAA CAGTAAAATA ACTCCGGCTA TTTTTGGATC AAAGTCTGCG 
AAGGTTGGTG TAGAACTAGG AGAAGATGTG GAGCTGAACT GCAGTGCTGT GCTGAATAGA 
AATGATCTGT TTTATTGGAG CATCAGGAAA GAGGACAGCT TAGACCCTAA CGTGCATGAA 
GACAGGAACG AGACAACATG GACTTTTGAA GGCAAATTGC ATGCTTCAAA AATCCTGAGA 
ATTCAGAAAG TTACAGAAAA ATATCTCAAT GTTTTATATA ATTGTACCGT GGCCAACGAA 
GAAGCCACAG ACACCAAAAG CTTCATCTTG GTGAGAAAAG AAACACCTGA CATCCAAGGC 
CATGTCTTTA TGAGAGGAAT AACCATGGTT GTTCTCACCT CTGTGGCAGC AGTGTGCGTG 
GTGATTTTGT GCATCATTTA TAAAGTTGAT TTGGTTTTAT TCTATAGACG TGTAGCAGAA 
AGAGACGAGA CACTAACAGA TGGTAAAACA TATGATGCCT TTGTGTCTTA CCTGAGAGAG 
TGTCATCCTG AGAATGGAGA AGAGTACACT TTTGCTGTGG AGACGTTACC CAGGGTCCTG 
GAGAAACAGT TTGGCTATAA GTTGTGCATA TTTGAAAGAG ATGTGGTGCC TGGTGGAGCT 
GTCGTTGATG AGATCCATTC ACTGATAGAG AAAAGCCGGA GGCTAATCAT CGTCCTCAGC 
AAGAGTTACA TGACTAATGG ATCCAGGCTC GAGCTGGAGA GCGGACTCCA CCAAGCACTG 
GTGGAGAGGA AGATTAAAAT AATCTTAATC GAGTTTACTC CAGCCAGCAA CATCACCTTT 
CTCCCGCCGT CGCTGAAACT CCTCAAGTCC TACAGAGTTC TGAGGTGGAA GGCTGACAAG 
CCACTCTCTT CGAAATCACG ATTCTGGAAG AATCTTCTTT ACCTGATGCC TGCCAAAGCC 
GTCAAGCCAT GGAGAGAAGA ATCAGAGGCC CGGCCTGTTC TCTCAGCACC TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006244848.1
CDS	1168..2781
Translation	MHHEELILILCVLVVKSAPKSCIRRSQIHVVEGEPFYLKPCDMSAPMHNNETATMRWFKGNASHGYRELNMRSSPRIAFHGHALEFWPVELEDKGTYFSQVGNDRQNWTLNVTKRNKHSCFSEKLVTNRDVEVKKSLWITCENPSYGELINHTLLYKNCKEISKTPMILKDAEFGDEGYYSCVFSVHHNGQQYNITKTVNITVIEGNSKITPAIFGSKSAKVGVELGEDVELNCSAVLNRNDLFYWSIRKEDSLDPNVHEDRNETTWTFEGKLHASKILRIQKVTEKYLNVLYNCTVANEEATDTKSFILVRKETPDIQGHVFMRGITMVVLTSVAAVCVVILCIIYKVDLVLFYRRVAERDETLTDGKTYDAFVSYLRECHPENGEEYTFAVETLPRVLEKQFGYKLCIFERDVVPGGAVVDEIHSLIEKSRRLIIVLSKSYMTNGSRLELESGLHQALVERKIKIILIEFTPASNITFLPPSLKLLKSYRVLRWKADKPLSSKSRFWKNLLYLMPAKAVKPWREESEARPVLSAP

Target ORF information:

RefSeq Version	XM_006244786.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus interleukin 18 receptor 1 (Il18r1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006244786.3

ORF Insert Sequence:

ATGCATCATG AAGAATTAAT CTTGATACTT TGTGTTCTCG TTGTTAAAAG TGCCCCGAAA 
AGTTGCATTC GCCGGTCGCA AATTCACGTA GTAGAGGGAG AGCCTTTTTA TCTGAAGCCC 
TGTGATATGT CTGCACCCAT GCATAACAAT GAGACAGCCA CCATGAGATG GTTCAAAGGC 
AATGCTTCAC ATGGCTACAG AGAGCTGAAC ATGAGAAGCT CGCCCAGAAT CGCTTTTCAT 
GGTCACGCTT TGGAATTCTG GCCAGTTGAG CTGGAGGACA AGGGAACGTA CTTTTCTCAA 
GTGGGAAATG ATCGTCAAAA TTGGACCTTA AATGTCACCA AAAGAAACAA ACACAGCTGC 
TTCTCTGAGA AGCTTGTGAC GAACAGAGAT GTGGAGGTTA AGAAATCTCT GTGGATTACC 
TGTGAAAATC CTAGCTATGG AGAGCTGATC AACCACACGT TGCTGTATAA GAACTGTAAG 
GAAATATCCA AAACCCCAAT GATCCTGAAG GATGCCGAGT TTGGAGATGA AGGTTATTAC 
TCCTGCGTGT TTTCTGTCCA CCATAACGGG CAACAGTACA ACATCACCAA GACTGTCAAT 
ATAACGGTTA TTGAAGGGAA CAGTAAAATA ACTCCGGCTA TTTTTGGATC AAAGTCTGCG 
AAGGTTGGTG TAGAACTAGG AGAAGATGTG GAGCTGAACT GCAGTGCTGT GCTGAATAGA 
AATGATCTGT TTTATTGGAG CATCAGGAAA GAGGACAGCT TAGACCCTAA CGTGCATGAA 
GACAGGAACG AGACAACATG GACTTTTGAA GGCAAATTGC ATGCTTCAAA AATCCTGAGA 
ATTCAGAAAG TTACAGAAAA ATATCTCAAT GTTTTATATA ATTGTACCGT GGCCAACGAA 
GAAGCCACAG ACACCAAAAG CTTCATCTTG GTGAGAAAAG AAACACCTGA CATCCAAGGC 
CATGTCTTTA TGAGAGGAAT AACCATGGTT GTTCTCACCT CTGTGGCAGC AGTGTGCGTG 
GTGATTTTGT GCATCATTTA TAAAGTTGAT TTGGTTTTAT TCTATAGACG TGTAGCAGAA 
AGAGACGAGA CACTAACAGA TGGTAAAACA TATGATGCCT TTGTGTCTTA CCTGAGAGAG 
TGTCATCCTG AGAATGGAGA AGAGTACACT TTTGCTGTGG AGACGTTACC CAGGGTCCTG 
GAGAAACAGT TTGGCTATAA GTTGTGCATA TTTGAAAGAG ATGTGGTGCC TGGTGGAGCT 
GTCGTTGATG AGATCCATTC ACTGATAGAG AAAAGCCGGA GGCTAATCAT CGTCCTCAGC 
AAGAGTTACA TGACTAATGG ATCCAGGCTC GAGCTGGAGA GCGGACTCCA CCAAGCACTG 
GTGGAGAGGA AGATTAAAAT AATCTTAATC GAGTTTACTC CAGCCAGCAA CATCACCTTT 
CTCCCGCCGT CGCTGAAACT CCTCAAGTCC TACAGAGTTC TGAGGTGGAA GGCTGACAAG 
CCACTCTCTT CGAAATCACG ATTCTGGAAG AATCTTCTTT ACCTGATGCC TGCCAAAGCC 
GTCAAGCCAT GGAGAGAAGA ATCAGAGGCC CGGCCTGTTC TCTCAGCACC TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Il18r1 ( XM_008767018.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008765240.1 Rattus norvegicus interleukin 18 receptor 1 (Il18r1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa45854
Clone ID Related Accession (Same CDS sequence)	XM_008767018.2
Accession Version	XM_008767018.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1674bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	interleukin-18 receptor 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005108.4) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008767018.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGCTTAA CCTTACATTA CTCTTTCTCT ACAGAGACCA GTGCAAGCAG AAGCCTAAAC 
ATGCATCATG AAGAATTAAT CTTGATACTT TGTGTTCTCG TTGTTAAAAG TGCCCCGAAA 
AGTTGCATTC GCCGGTCGCA AATTCACGTA GTAGAGGGAG AGCCTTTTTA TCTGAAGCCC 
TGTGATATGT CTGCACCCAT GCATAACAAT GAGACAGCCA CCATGAGATG GTTCAAAGGC 
AATGCTTCAC ATGGCTACAG AGAGCTGAAC ATGAGAAGCT CGCCCAGAAT CGCTTTTCAT 
GGTCACGCTT TGGAATTCTG GCCAGTTGAG CTGGAGGACA AGGGAACGTA CTTTTCTCAA 
GTGGGAAATG ATCGTCAAAA TTGGACCTTA AATGTCACCA AAAGAAACAA ACACAGCTGC 
TTCTCTGAGA AGCTTGTGAC GAACAGAGAT GTGGAGGTTA AGAAATCTCT GTGGATTACC 
TGTGAAAATC CTAGCTATGG AGAGCTGATC AACCACACGT TGCTGTATAA GAACTGTAAG 
GAAATATCCA AAACCCCAAT GATCCTGAAG GATGCCGAGT TTGGAGATGA AGGTTATTAC 
TCCTGCGTGT TTTCTGTCCA CCATAACGGG CAACAGTACA ACATCACCAA GACTGTCAAT 
ATAACGGTTA TTGAAGGGAA CAGTAAAATA ACTCCGGCTA TTTTTGGATC AAAGTCTGCG 
AAGGTTGGTG TAGAACTAGG AGAAGATGTG GAGCTGAACT GCAGTGCTGT GCTGAATAGA 
AATGATCTGT TTTATTGGAG CATCAGGAAA GAGGACAGCT TAGACCCTAA CGTGCATGAA 
GACAGGAACG AGACAACATG GACTTTTGAA GGCAAATTGC ATGCTTCAAA AATCCTGAGA 
ATTCAGAAAG TTACAGAAAA ATATCTCAAT GTTTTATATA ATTGTACCGT GGCCAACGAA 
GAAGCCACAG ACACCAAAAG CTTCATCTTG GTGAGAAAAG AAACACCTGA CATCCAAGGC 
CATGTCTTTA TGAGAGGAAT AACCATGGTT GTTCTCACCT CTGTGGCAGC AGTGTGCGTG 
GTGATTTTGT GCATCATTTA TAAAGTTGAT TTGGTTTTAT TCTATAGACG TGTAGCAGAA 
AGAGACGAGA CACTAACAGA TGGTAAAACA TATGATGCCT TTGTGTCTTA CCTGAGAGAG 
TGTCATCCTG AGAATGGAGA AGAGTACACT TTTGCTGTGG AGACGTTACC CAGGGTCCTG 
GAGAAACAGT TTGGCTATAA GTTGTGCATA TTTGAAAGAG ATGTGGTGCC TGGTGGAGCT 
GTCGTTGATG AGATCCATTC ACTGATAGAG AAAAGCCGGA GGCTAATCAT CGTCCTCAGC 
AAGAGTTACA TGACTAATGG ATCCAGGCTC GAGCTGGAGA GCGGACTCCA CCAAGCACTG 
GTGGAGAGGA AGATTAAAAT AATCTTAATC GAGTTTACTC CAGCCAGCAA CATCACCTTT 
CTCCCGCCGT CGCTGAAACT CCTCAAGTCC TACAGAGTTC TGAGGTGGAA GGCTGACAAG 
CCACTCTCTT CGAAATCACG ATTCTGGAAG AATCTTCTTT ACCTGATGCC TGCCAAAGCC 
GTCAAGCCAT GGAGAGAAGA ATCAGAGGCC CGGCCTGTTC TCTCAGCACC TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008765240.1
CDS	375..2048
Translation	MSLTLHYSFSTETSASRSLNMHHEELILILCVLVVKSAPKSCIRRSQIHVVEGEPFYLKPCDMSAPMHNNETATMRWFKGNASHGYRELNMRSSPRIAFHGHALEFWPVELEDKGTYFSQVGNDRQNWTLNVTKRNKHSCFSEKLVTNRDVEVKKSLWITCENPSYGELINHTLLYKNCKEISKTPMILKDAEFGDEGYYSCVFSVHHNGQQYNITKTVNITVIEGNSKITPAIFGSKSAKVGVELGEDVELNCSAVLNRNDLFYWSIRKEDSLDPNVHEDRNETTWTFEGKLHASKILRIQKVTEKYLNVLYNCTVANEEATDTKSFILVRKETPDIQGHVFMRGITMVVLTSVAAVCVVILCIIYKVDLVLFYRRVAERDETLTDGKTYDAFVSYLRECHPENGEEYTFAVETLPRVLEKQFGYKLCIFERDVVPGGAVVDEIHSLIEKSRRLIIVLSKSYMTNGSRLELESGLHQALVERKIKIILIEFTPASNITFLPPSLKLLKSYRVLRWKADKPLSSKSRFWKNLLYLMPAKAVKPWREESEARPVLSAP

Target ORF information:

RefSeq Version	XM_008767018.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus interleukin 18 receptor 1 (Il18r1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008767018.2

ORF Insert Sequence:

ATGAGCTTAA CCTTACATTA CTCTTTCTCT ACAGAGACCA GTGCAAGCAG AAGCCTAAAC 
ATGCATCATG AAGAATTAAT CTTGATACTT TGTGTTCTCG TTGTTAAAAG TGCCCCGAAA 
AGTTGCATTC GCCGGTCGCA AATTCACGTA GTAGAGGGAG AGCCTTTTTA TCTGAAGCCC 
TGTGATATGT CTGCACCCAT GCATAACAAT GAGACAGCCA CCATGAGATG GTTCAAAGGC 
AATGCTTCAC ATGGCTACAG AGAGCTGAAC ATGAGAAGCT CGCCCAGAAT CGCTTTTCAT 
GGTCACGCTT TGGAATTCTG GCCAGTTGAG CTGGAGGACA AGGGAACGTA CTTTTCTCAA 
GTGGGAAATG ATCGTCAAAA TTGGACCTTA AATGTCACCA AAAGAAACAA ACACAGCTGC 
TTCTCTGAGA AGCTTGTGAC GAACAGAGAT GTGGAGGTTA AGAAATCTCT GTGGATTACC 
TGTGAAAATC CTAGCTATGG AGAGCTGATC AACCACACGT TGCTGTATAA GAACTGTAAG 
GAAATATCCA AAACCCCAAT GATCCTGAAG GATGCCGAGT TTGGAGATGA AGGTTATTAC 
TCCTGCGTGT TTTCTGTCCA CCATAACGGG CAACAGTACA ACATCACCAA GACTGTCAAT 
ATAACGGTTA TTGAAGGGAA CAGTAAAATA ACTCCGGCTA TTTTTGGATC AAAGTCTGCG 
AAGGTTGGTG TAGAACTAGG AGAAGATGTG GAGCTGAACT GCAGTGCTGT GCTGAATAGA 
AATGATCTGT TTTATTGGAG CATCAGGAAA GAGGACAGCT TAGACCCTAA CGTGCATGAA 
GACAGGAACG AGACAACATG GACTTTTGAA GGCAAATTGC ATGCTTCAAA AATCCTGAGA 
ATTCAGAAAG TTACAGAAAA ATATCTCAAT GTTTTATATA ATTGTACCGT GGCCAACGAA 
GAAGCCACAG ACACCAAAAG CTTCATCTTG GTGAGAAAAG AAACACCTGA CATCCAAGGC 
CATGTCTTTA TGAGAGGAAT AACCATGGTT GTTCTCACCT CTGTGGCAGC AGTGTGCGTG 
GTGATTTTGT GCATCATTTA TAAAGTTGAT TTGGTTTTAT TCTATAGACG TGTAGCAGAA 
AGAGACGAGA CACTAACAGA TGGTAAAACA TATGATGCCT TTGTGTCTTA CCTGAGAGAG 
TGTCATCCTG AGAATGGAGA AGAGTACACT TTTGCTGTGG AGACGTTACC CAGGGTCCTG 
GAGAAACAGT TTGGCTATAA GTTGTGCATA TTTGAAAGAG ATGTGGTGCC TGGTGGAGCT 
GTCGTTGATG AGATCCATTC ACTGATAGAG AAAAGCCGGA GGCTAATCAT CGTCCTCAGC 
AAGAGTTACA TGACTAATGG ATCCAGGCTC GAGCTGGAGA GCGGACTCCA CCAAGCACTG 
GTGGAGAGGA AGATTAAAAT AATCTTAATC GAGTTTACTC CAGCCAGCAA CATCACCTTT 
CTCCCGCCGT CGCTGAAACT CCTCAAGTCC TACAGAGTTC TGAGGTGGAA GGCTGACAAG 
CCACTCTCTT CGAAATCACG ATTCTGGAAG AATCTTCTTT ACCTGATGCC TGCCAAAGCC 
GTCAAGCCAT GGAGAGAAGA ATCAGAGGCC CGGCCTGTTC TCTCAGCACC TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Inflammation-Dependent IL18 Signaling Restricts Hepatocellular Carcinoma Growth by Enhancing the Accumulation and Activity of Tumor-Infiltrating Lymphocytes.
Cancer research76(8)2394-405(2016 04)
Markowitz GJ,Yang P,Fu J,Michelotti GA,Chen R,Sui J,Yang B,Qin WH,Zhang Z,Wang FS,Diehl AM,Li QJ,Wang H,Wang XF

Divergent responses to thermogenic stimuli in BAT and subcutaneous adipose tissue from interleukin 18 and interleukin 18 receptor 1-deficient mice.
Scientific reports517977(2015 Dec)
Pazos P,Lima L,Tovar S,Gonz?lez-Touceda D,Di?guez C,Garc?a MC

The structural basis for receptor recognition of human interleukin-18.
Nature communications55340(2014 Dec)
Tsutsumi N,Kimura T,Arita K,Ariyoshi M,Ohnishi H,Yamamoto T,Zuo X,Maenaka K,Park EY,Kondo N,Shirakawa M,Tochio H,Kato Z

Structural basis for the specific recognition of IL-18 by its alpha receptor.
FEBS letters588(21)3838-43(2014 Nov)
Wei H,Wang D,Qian Y,Liu X,Fan S,Yin HS,Wang X

Identification of a truncated splice variant of IL-18 receptor alpha in the human and rat, with evidence of wider evolutionary conservation.
PeerJ2e560(2014)
Booker CS,Grattan DR

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Il18r1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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