Abcd4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Abcd4
Entrez Gene ID	299196
Full Name	ATP binding cassette subfamily D member 4
Synonyms	Pxmp1l
General protein information	Preferred Names ATP binding cassette subfamily D member 4 Names ATP-binding cassette sub-family D member 4 ATP-binding cassette, sub-family D (ALD), member 4 ATP-binding cassette, sub-family D, member 4 ATP-binding cassette, subfamily D (ALD), member 4
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 6 Map Location: 6q31

mRNA and Protein(s)

mRNA	Protein	Name
NM_001013100.3	NP_001013118.2	ATP-binding cassette sub-family D member 4

Pathways from BioSystems

Homologies

Homo sapiens (human)	ABCD4	NP_005041.1
Pan troglodytes (chimpanzee)	ABCD4	XP_001156286.1
Canis lupus familiaris (dog)	ABCD4	XP_547903.2
Xenopus tropicalis (tropical clawed frog)	abcd4	XP_004917106.1
	ABCD4	XP_001093730.1
Caenorhabditis elegans (roundworm)	pmp-3	NP_001256607.1
Mus musculus (house mouse)	Abcd4	NP_033018.2
Rattus norvegicus (Norway rat)	Abcd4	NP_001013118.2
Gallus gallus (chicken)	ABCD4	XP_421264.4
Danio rerio (zebrafish)	abcd4	NP_001070185.2

Gene Ontology
Bibliography

Related articles in PubMed

Mutations in ABCD4 cause a new inborn error of vitamin B12 metabolism.
Coelho D, Kim JC, Miousse IR, Fung S, du Moulin M, Buers I, Suormala T, Burda P, Frapolli M, Stucki M, N?rnberg P, Thiele H, Robenek H, H?hne W, Longo N, Pasquali M, Mengel E, Watkins D, Shoubridge EA, Majewski J, Rosenblatt DS, Fowler B, Rutsch F, Baumgartner MR
Nature genetics44(10)1152-5(2012 Oct)

miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells.
Tarantino C, Paolella G, Cozzuto L, Minopoli G, Pastore L, Parisi S, Russo T
FASEB journal : official publication of the Federation of American Societies for Experimental Biology24(9)3255-63(2010 Sep)

70-kDa peroxisomal membrane protein related protein (P70R/ABCD4) localizes to endoplasmic reticulum not peroxisomes, and NH2-terminal hydrophobic property determines the subcellular localization of ABC subfamily D proteins.
Kashiwayama Y, Seki M, Yasui A, Murasaki Y, Morita M, Yamashita Y, Sakaguchi M, Tanaka Y, Imanaka T
Experimental cell research315(2)190-205(2009 Jan)

Targeting of the human adrenoleukodystrophy protein to the peroxisomal membrane by an internal region containing a highly conserved motif.
Landgraf P, Mayerhofer PU, Polanetz R, Roscher AA, Holzinger A
European journal of cell biology82(8)401-10(2003 Aug)

Identification of a fourth half ABC transporter in the human peroxisomal membrane.
Shani N, Jimenez-Sanchez G, Steel G, Dean M, Valle D
Human molecular genetics6(11)1925-31(1997 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

P70R resides in the ER but not the peroxisomal membranes, and the hydrophobic property of NH(2)-terminal region determines the subcellular localization of ABC subfamily D proteins.
Title: 70-kDa peroxisomal membrane protein related protein (P70R/ABCD4) localizes to endoplasmic reticulum not peroxisomes, and NH2-terminal hydrophobic property determines the subcellular localization of ABC subfamily D proteins.

The following Abcd4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Abcd4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa03369	NM_001013100.3 Latest version!	Rattus norvegicus ATP binding cassette subfamily D member 4 (Abcd4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Abcd4 ( NM_001013100.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001013118.2 Rattus norvegicus ATP binding cassette subfamily D member 4 (Abcd4), mRNA.

Price & Availability↑

CloneID	ORa03369
Clone ID Related Accession (Same CDS sequence)	NM_001013100.3
Accession Version	NM_001013100.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1821bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Rattus norvegicus(Norway rat)
Product	ATP-binding cassette sub-family D member 4
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC128402.3 and AC114437.5. On Nov 29, 2008 this sequence version replaced NM_001013100.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGTCC CGGGACCCAC GGCCCGAGCT AGTGCCAGGC CCAGATTAGA TCTGCAACTT 
GTCCAGAAGT TCATAAGGAT ACAGAAGGTT TTCTTTCCTT CTTGGTCATC ACAGAATGTC 
TTAATGTTCA TGACACTCTT GTGTGTGGCC CTCCTGGAGC AACTGGTGAT CTACCAAGTT 
GGCTTGATCC CCAGTCAGTA TTATGGTGTC TTGGGAAACA AAGACCTGGA TGGATTTAAG 
GCACTGACCT TCCTGGCCGT GGCACTCATT GTTCTCAACT CCACCCTGAA GAGTTTTGAC 
CAGTTCACCT GCAACCTGCT GTATGTGAGC TGGAGGAAAG ACCTCACAGA GCACCTGCAC 
CAGCTCTACT TCCGGGCCCG CGTGTACTAC ACCCTCAACG TGCTGCGGGA CGACATCGAT 
AATCCGGACC AGCGGATCAG CCAGGACGTG GAGCGGTTCT GCCGGCAGCT CAGCAGCGTG 
ACCAGCAAGC TCATCATCTC CCCCTTCACT CTCGCCTACT ATACCTACCA GTGCTTCCAA 
AGCACAGGCT GGCTTGGGCC TGTGAGCATC TTTGGATATT TCATCCTGGG TACCATGGTG 
AACAAAACTT TGATGGGGCC CATCGTGACG AAGCTGGTGC AGCAGGAGAA GCTGGAGGGG 
GATTTTAGGT TCAAGCATAT GCAGATTCGA GTGAACGCTG AGCCTGCAGC TTTCTACAGA 
GCTGGGCTCG TAGAGCACAT GAGGACGGAC CGCAGGCTGC AGAGACTCCT TCAGACCCAG 
AGAGAGCTGA TGTCCAGGGA GCTCTGGCTC TACATTGGCA TCAACACCTT TGACTACCTG 
GGCAGCATTC TGAGTTACGT CGTCATCGCC ATCCCCATTT TCAGGGGGGT CTACGGAGAC 
TTGAGCCCCA CAGAGCTCAG CACCCTGGTC AGCAAGAATG CCTTTGTGTG CATCTACCTC 
ATCAGCTGCT TCACCCAGCT CATTGACCTG TCCACCACGC TCTCGGATGT CGCCGGTTAC 
ACGCACAGGA TTGGAGAGCT TCAGGAGGCC CTGCTGGACA TGTCCCGAAA ATCACACGAC 
TGTGAGACCC TAGGCGAGAG CGAGTGGGAT TTGGACAAGG CCCCAGGGTG GCCGACAACA 
GAGCCATCAG ACACTGCTTT TCTGCTTGAT CGGGTCTCCA TCTTGGCCCC TTCCTCCGAC 
AAGCCCCTGA TCAAGGACTT GAGCCTGAAG ATCTGTGAGG GGCAGAGTCT GCTCATTACG 
GGCAACACAG GCACTGGCAA GACCTCCCTG CTGCGGGTGC TGGGAGGCCT GTGGGAGAGC 
ATGAAAGGCT CAGTGCAGAT GCTGGCTGAT TTTGGGCCCC ACGGGGTGCT GTTCCTGCCT 
CAGAAGCCGT TCTTCACTGA TGGGACACTT CGGGAGCAGG TGATATATCC CCTGAAGGAG 
ATCTACCCTG ACTCAGGTTC TGCCGATGAT GAGAGGATCG TGAGGTTCTT GGAGTTGGCA 
GGCCTGTCCA GCTTGGTGGC AAGAACAGGA GGTCTGGACC AGCAGGTGGA TTGGAACTGG 
TATGATGTCC TGTCCCCAGG GGAGATGCAA AGACTGTCCT TCGCCCGCCT CTTCTACCTG 
CAGCCTAAGT ATGCAGTGCT TGATGAAGCC ACCAGTGCCC TGACAGAGGA AGCGGAGAGT 
GAGCTCTACC GAATTGGCCA GCAACTGGGG ATGACATTTA TCAGCGTGGG ACATCGGCCC 
AGCCTTGAGA AGTTTCACTC CTGGGTTCTG AGACTCCATG GAGGAGGAAG CTGGGAACTG 
ACTAGAATCA AAATGGGATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001013118.2
CDS	52..1872
Translation	MAVPGPTARASARPRLDLQLVQKFIRIQKVFFPSWSSQNVLMFMTLLCVALLEQLVIYQVGLIPSQYYGVLGNKDLDGFKALTFLAVALIVLNSTLKSFDQFTCNLLYVSWRKDLTEHLHQLYFRARVYYTLNVLRDDIDNPDQRISQDVERFCRQLSSVTSKLIISPFTLAYYTYQCFQSTGWLGPVSIFGYFILGTMVNKTLMGPIVTKLVQQEKLEGDFRFKHMQIRVNAEPAAFYRAGLVEHMRTDRRLQRLLQTQRELMSRELWLYIGINTFDYLGSILSYVVIAIPIFRGVYGDLSPTELSTLVSKNAFVCIYLISCFTQLIDLSTTLSDVAGYTHRIGELQEALLDMSRKSHDCETLGESEWDLDKAPGWPTTEPSDTAFLLDRVSILAPSSDKPLIKDLSLKICEGQSLLITGNTGTGKTSLLRVLGGLWESMKGSVQMLADFGPHGVLFLPQKPFFTDGTLREQVIYPLKEIYPDSGSADDERIVRFLELAGLSSLVARTGGLDQQVDWNWYDVLSPGEMQRLSFARLFYLQPKYAVLDEATSALTEEAESELYRIGQQLGMTFISVGHRPSLEKFHSWVLRLHGGGSWELTRIKMG

Target ORF information:

RefSeq Version	NM_001013100.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ATP binding cassette subfamily D member 4 (Abcd4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001013100.3

ORF Insert Sequence:

ATGGCGGTCC CGGGACCCAC GGCCCGAGCT AGTGCCAGGC CCAGATTAGA TCTGCAACTT 
GTCCAGAAGT TCATAAGGAT ACAGAAGGTT TTCTTTCCTT CTTGGTCATC ACAGAATGTC 
TTAATGTTCA TGACACTCTT GTGTGTGGCC CTCCTGGAGC AACTGGTGAT CTACCAAGTT 
GGCTTGATCC CCAGTCAGTA TTATGGTGTC TTGGGAAACA AAGACCTGGA TGGATTTAAG 
GCACTGACCT TCCTGGCCGT GGCACTCATT GTTCTCAACT CCACCCTGAA GAGTTTTGAC 
CAGTTCACCT GCAACCTGCT GTATGTGAGC TGGAGGAAAG ACCTCACAGA GCACCTGCAC 
CAGCTCTACT TCCGGGCCCG CGTGTACTAC ACCCTCAACG TGCTGCGGGA CGACATCGAT 
AATCCGGACC AGCGGATCAG CCAGGACGTG GAGCGGTTCT GCCGGCAGCT CAGCAGCGTG 
ACCAGCAAGC TCATCATCTC CCCCTTCACT CTCGCCTACT ATACCTACCA GTGCTTCCAA 
AGCACAGGCT GGCTTGGGCC TGTGAGCATC TTTGGATATT TCATCCTGGG TACCATGGTG 
AACAAAACTT TGATGGGGCC CATCGTGACG AAGCTGGTGC AGCAGGAGAA GCTGGAGGGG 
GATTTTAGGT TCAAGCATAT GCAGATTCGA GTGAACGCTG AGCCTGCAGC TTTCTACAGA 
GCTGGGCTCG TAGAGCACAT GAGGACGGAC CGCAGGCTGC AGAGACTCCT TCAGACCCAG 
AGAGAGCTGA TGTCCAGGGA GCTCTGGCTC TACATTGGCA TCAACACCTT TGACTACCTG 
GGCAGCATTC TGAGTTACGT CGTCATCGCC ATCCCCATTT TCAGGGGGGT CTACGGAGAC 
TTGAGCCCCA CAGAGCTCAG CACCCTGGTC AGCAAGAATG CCTTTGTGTG CATCTACCTC 
ATCAGCTGCT TCACCCAGCT CATTGACCTG TCCACCACGC TCTCGGATGT CGCCGGTTAC 
ACGCACAGGA TTGGAGAGCT TCAGGAGGCC CTGCTGGACA TGTCCCGAAA ATCACACGAC 
TGTGAGACCC TAGGCGAGAG CGAGTGGGAT TTGGACAAGG CCCCAGGGTG GCCGACAACA 
GAGCCATCAG ACACTGCTTT TCTGCTTGAT CGGGTCTCCA TCTTGGCCCC TTCCTCCGAC 
AAGCCCCTGA TCAAGGACTT GAGCCTGAAG ATCTGTGAGG GGCAGAGTCT GCTCATTACG 
GGCAACACAG GCACTGGCAA GACCTCCCTG CTGCGGGTGC TGGGAGGCCT GTGGGAGAGC 
ATGAAAGGCT CAGTGCAGAT GCTGGCTGAT TTTGGGCCCC ACGGGGTGCT GTTCCTGCCT 
CAGAAGCCGT TCTTCACTGA TGGGACACTT CGGGAGCAGG TGATATATCC CCTGAAGGAG 
ATCTACCCTG ACTCAGGTTC TGCCGATGAT GAGAGGATCG TGAGGTTCTT GGAGTTGGCA 
GGCCTGTCCA GCTTGGTGGC AAGAACAGGA GGTCTGGACC AGCAGGTGGA TTGGAACTGG 
TATGATGTCC TGTCCCCAGG GGAGATGCAA AGACTGTCCT TCGCCCGCCT CTTCTACCTG 
CAGCCTAAGT ATGCAGTGCT TGATGAAGCC ACCAGTGCCC TGACAGAGGA AGCGGAGAGT 
GAGCTCTACC GAATTGGCCA GCAACTGGGG ATGACATTTA TCAGCGTGGG ACATCGGCCC 
AGCCTTGAGA AGTTTCACTC CTGGGTTCTG AGACTCCATG GAGGAGGAAG CTGGGAACTG 
ACTAGAATCA AAATGGGATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mutations in ABCD4 cause a new inborn error of vitamin B12 metabolism.
Nature genetics44(10)1152-5(2012 Oct)
Coelho D,Kim JC,Miousse IR,Fung S,du Moulin M,Buers I,Suormala T,Burda P,Frapolli M,Stucki M,N?rnberg P,Thiele H,Robenek H,H?hne W,Longo N,Pasquali M,Mengel E,Watkins D,Shoubridge EA,Majewski J,Rosenblatt DS,Fowler B,Rutsch F,Baumgartner MR

miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology24(9)3255-63(2010 Sep)
Tarantino C,Paolella G,Cozzuto L,Minopoli G,Pastore L,Parisi S,Russo T

70-kDa peroxisomal membrane protein related protein (P70R/ABCD4) localizes to endoplasmic reticulum not peroxisomes, and NH2-terminal hydrophobic property determines the subcellular localization of ABC subfamily D proteins.
Experimental cell research315(2)190-205(2009 Jan)
Kashiwayama Y,Seki M,Yasui A,Murasaki Y,Morita M,Yamashita Y,Sakaguchi M,Tanaka Y,Imanaka T

Targeting of the human adrenoleukodystrophy protein to the peroxisomal membrane by an internal region containing a highly conserved motif.
European journal of cell biology82(8)401-10(2003 Aug)
Landgraf P,Mayerhofer PU,Polanetz R,Roscher AA,Holzinger A

Identification of a fourth half ABC transporter in the human peroxisomal membrane.
Human molecular genetics6(11)1925-31(1997 Oct)
Shani N,Jimenez-Sanchez G,Steel G,Dean M,Valle D

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Abcd4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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