Pou3f2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pou3f2
Entrez Gene ID	29588
Full Name	POU class 3 homeobox 2
Synonyms	Brn-2,OTF-7,oct-7
General protein information	Preferred Names POU class 3 homeobox 2 Names POU domain, class 3, transcription factor 2 brain-2 brain-specific homeobox/POU domain protein 2 nervous system-specific octamer-binding transcription factor N-Oct-3 octamer-binding protein 7 octamer-binding transcription factor 7 protein Brn-2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q21
Summary	binds DNA; may act as a transcription factor during neurogenesis [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_172085.2	NP_742082.2	POU domain, class 3, transcription factor 2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	POU3F2	XP_003950948.1
	LOC694524	XP_001083202.1
Bos taurus (cattle)	POU3F2	NP_001073817.1
Xenopus tropicalis (tropical clawed frog)	LOC100486226	NP_001263306.1
Rattus norvegicus (Norway rat)	Pou3f2	NP_742082.1
Danio rerio (zebrafish)	pou3f2b	NP_571235.1
Homo sapiens (human)	POU3F2	NP_005595.2
Canis lupus familiaris (dog)	LOC481931	XP_539052.3
Mus musculus (house mouse)	Pou3f2	NP_032925.1

Gene Ontology
Bibliography

Related articles in PubMed

Hierarchical mechanisms for direct reprogramming of fibroblasts to neurons.
Wapinski OL, Vierbuchen T, Qu K, Lee QY, Chanda S, Fuentes DR, Giresi PG, Ng YH, Marro S, Neff NF, Drechsel D, Martynoga B, Castro DS, Webb AE, S?dhof TC, Brunet A, Guillemot F, Chang HY, Wernig M
Cell155(3)621-35(2013 Oct)

BRN2 is a transcriptional repressor of CDH13 (T-cadherin) in melanoma cells.
Ellmann L, Joshi MB, Resink TJ, Bosserhoff AK, Kuphal S
Laboratory investigation; a journal of technical methods and pathology92(12)1788-800(2012 Dec)

The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in the cortical subventricular zone.
Arnold SJ, Huang GJ, Cheung AF, Era T, Nishikawa S, Bikoff EK, Moln?r Z, Robertson EJ, Groszer M
Genes & development22(18)2479-84(2008 Sep)

Sox12 deletion in the mouse reveals nonreciprocal redundancy with the related Sox4 and Sox11 transcription factors.
Hoser M, Potzner MR, Koch JM, B?sl MR, Wegner M, Sock E
Molecular and cellular biology28(15)4675-87(2008 Aug)

Proneural bHLH and Brn proteins coregulate a neurogenic program through cooperative binding to a conserved DNA motif.
Castro DS, Skowronska-Krawczyk D, Armant O, Donaldson IJ, Parras C, Hunt C, Critchley JA, Nguyen L, Gossler A, G?ttgens B, Matter JM, Guillemot F
Developmental cell11(6)831-44(2006 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Pou3f2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pou3f2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa43310	NM_172085.2 Latest version!	Rattus norvegicus POU class 3 homeobox 2 (Pou3f2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$265.30 $379.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pou3f2 ( NM_172085.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_742082.2 Rattus norvegicus POU class 3 homeobox 2 (Pou3f2), mRNA.

Price & Availability↑

CloneID	ORa43310
Clone ID Related Accession (Same CDS sequence)	NM_172085.2
Accession Version	NM_172085.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1338bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Rattus norvegicus(Norway rat)
Product	POU domain, class 3, transcription factor 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07047531.1. On Apr 28, 2015 this sequence version replaced NM_172085.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end.

ATGGCGACCG CAGCGTCTAA CCACTACAGC CTGCTCACCT CCAGCGCCTC CATCGTGCAC 
GCCGAGCCGC CTGGCGGCAT GCAGCAGGGC GCGGGGGGCT ACCGCGAGGC ACAGAGCCTG 
GTGCAGGGCG ACTACGGTGC GCTGCAGAGC AACGGGCACC CGCTCAGCCA CGCTCACCAG 
TGGATCACCG CGCTGTCCCA CGGCGGCAGC GGCGGGGGCG GCGGCGGTGG TGGAGGAGGC 
GGGGGAGGCG GCGGGGGAGG CGGCGACGGC TCCCCGTGGT CCACCAGCCC CCTAGGCCAG 
CCGGACATCA AGCCCTCGGT GGTGGTACAG CAGGGTGGCC GAGGCGACGA GCTGCACGGG 
CCAGGAGCGC TGCAGCAGCA GCACCAACAG CAACAGCAGC AGCAGCAACA GCAACAGCAG 
CAACAACAGC AACAGCAGCA GCAGCAACAA CAGCGACCGC CACATCTGGT GCACCACGCT 
GCCAACCACC ATCCCGGGCC CGGGGCATGG CGGAGTGCGG CGGCTGCAGC TCACCTTCCT 
CCCTCCATGG GAGCTTCCAA CGGTGGTTTG CTCTATTCGC AGCCCAGCTT CACGGTGAAC 
GGCATGCTGG GCGCAGGAGG GCAGCCGGCT GGGCTGCACC ACCACGGCCT GAGGGACGCC 
CACGATGAGC CCCATCATGC AGACCACCAC CCGCATCCGC ACTCTCACCC GCACCAGCAA 
CCGCCCCCGC CACCTCCCCC ACAAGGCCCA CCGGGCCACC CAGGCGCGCA CCACGACCCG 
CACTCGGACG AGGACACGCC GACCTCAGAC GACCTGGAGC AGTTCGCCAA GCAATTCAAG 
CAGAGGCGGA TCAAACTAGG ATTTACTCAA GCAGACGTGG GGCTGGCGCT TGGCACCCTG 
TACGGCAACG TCTTCTCGCA GACCACCATC TGCAGGTTTG AGGCCCTGCA GCTGAGCTTC 
AAGAACATGT GCAAGCTGAA GCCTTTGTTG AACAAGTGGT TGGAAGAGGC AGACTCATCC 
TCGGGCAGCC CCACCAGCAT AGACAAGATC GCTGCGCAAG GGCGCAAACG GAAAAAGCGG 
ACCTCCATCG AGGTGAGCGT CAAGGGGGCT CTGGAGAGCC ATTTCCTCAA ATGCCCTAAG 
CCCTCGGCCC AGGAGATCAC CTCCCTCGCG GACAGCTTAC AGCTGGAGAA GGAGGTGGTG 
AGAGTTTGGT TTTGTAACAG GAGACAGAAA GAGAAAAGGA TGACCCCTCC CGGAGGGACT 
CTGCCGGGCG CCGAGGATGT GTATGGGGGG AGTAGGGACA CGCCACCACA CCACGGGGTG 
CAGACGCCCG TCCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_742082.2
CDS	71..1408
Translation	MATAASNHYSLLTSSASIVHAEPPGGMQQGAGGYREAQSLVQGDYGALQSNGHPLSHAHQWITALSHGGSGGGGGGGGGGGGGGGGGGDGSPWSTSPLGQPDIKPSVVVQQGGRGDELHGPGALQQQHQQQQQQQQQQQQQQQQQQQQQQQRPPHLVHHAANHHPGPGAWRSAAAAAHLPPSMGASNGGLLYSQPSFTVNGMLGAGGQPAGLHHHGLRDAHDEPHHADHHPHPHSHPHQQPPPPPPPQGPPGHPGAHHDPHSDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSSGSPTSIDKIAAQGRKRKKRTSIEVSVKGALESHFLKCPKPSAQEITSLADSLQLEKEVVRVWFCNRRQKEKRMTPPGGTLPGAEDVYGGSRDTPPHHGVQTPVQ

Target ORF information:

RefSeq Version	NM_172085.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus POU class 3 homeobox 2 (Pou3f2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172085.2

ORF Insert Sequence:

ATGGCGACCG CAGCGTCTAA CCACTACAGC CTGCTCACCT CCAGCGCCTC CATCGTGCAC 
GCCGAGCCGC CTGGCGGCAT GCAGCAGGGC GCGGGGGGCT ACCGCGAGGC ACAGAGCCTG 
GTGCAGGGCG ACTACGGTGC GCTGCAGAGC AACGGGCACC CGCTCAGCCA CGCTCACCAG 
TGGATCACCG CGCTGTCCCA CGGCGGCAGC GGCGGGGGCG GCGGCGGTGG TGGAGGAGGC 
GGGGGAGGCG GCGGGGGAGG CGGCGACGGC TCCCCGTGGT CCACCAGCCC CCTAGGCCAG 
CCGGACATCA AGCCCTCGGT GGTGGTACAG CAGGGTGGCC GAGGCGACGA GCTGCACGGG 
CCAGGAGCGC TGCAGCAGCA GCACCAACAG CAACAGCAGC AGCAGCAACA GCAACAGCAG 
CAACAACAGC AACAGCAGCA GCAGCAACAA CAGCGACCGC CACATCTGGT GCACCACGCT 
GCCAACCACC ATCCCGGGCC CGGGGCATGG CGGAGTGCGG CGGCTGCAGC TCACCTTCCT 
CCCTCCATGG GAGCTTCCAA CGGTGGTTTG CTCTATTCGC AGCCCAGCTT CACGGTGAAC 
GGCATGCTGG GCGCAGGAGG GCAGCCGGCT GGGCTGCACC ACCACGGCCT GAGGGACGCC 
CACGATGAGC CCCATCATGC AGACCACCAC CCGCATCCGC ACTCTCACCC GCACCAGCAA 
CCGCCCCCGC CACCTCCCCC ACAAGGCCCA CCGGGCCACC CAGGCGCGCA CCACGACCCG 
CACTCGGACG AGGACACGCC GACCTCAGAC GACCTGGAGC AGTTCGCCAA GCAATTCAAG 
CAGAGGCGGA TCAAACTAGG ATTTACTCAA GCAGACGTGG GGCTGGCGCT TGGCACCCTG 
TACGGCAACG TCTTCTCGCA GACCACCATC TGCAGGTTTG AGGCCCTGCA GCTGAGCTTC 
AAGAACATGT GCAAGCTGAA GCCTTTGTTG AACAAGTGGT TGGAAGAGGC AGACTCATCC 
TCGGGCAGCC CCACCAGCAT AGACAAGATC GCTGCGCAAG GGCGCAAACG GAAAAAGCGG 
ACCTCCATCG AGGTGAGCGT CAAGGGGGCT CTGGAGAGCC ATTTCCTCAA ATGCCCTAAG 
CCCTCGGCCC AGGAGATCAC CTCCCTCGCG GACAGCTTAC AGCTGGAGAA GGAGGTGGTG 
AGAGTTTGGT TTTGTAACAG GAGACAGAAA GAGAAAAGGA TGACCCCTCC CGGAGGGACT 
CTGCCGGGCG CCGAGGATGT GTATGGGGGG AGTAGGGACA CGCCACCACA CCACGGGGTG 
CAGACGCCCG TCCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Hierarchical mechanisms for direct reprogramming of fibroblasts to neurons.
Cell155(3)621-35(2013 Oct)
Wapinski OL,Vierbuchen T,Qu K,Lee QY,Chanda S,Fuentes DR,Giresi PG,Ng YH,Marro S,Neff NF,Drechsel D,Martynoga B,Castro DS,Webb AE,S?dhof TC,Brunet A,Guillemot F,Chang HY,Wernig M

BRN2 is a transcriptional repressor of CDH13 (T-cadherin) in melanoma cells.
Laboratory investigation; a journal of technical methods and pathology92(12)1788-800(2012 Dec)
Ellmann L,Joshi MB,Resink TJ,Bosserhoff AK,Kuphal S

The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in the cortical subventricular zone.
Genes & development22(18)2479-84(2008 Sep)
Arnold SJ,Huang GJ,Cheung AF,Era T,Nishikawa S,Bikoff EK,Moln?r Z,Robertson EJ,Groszer M

Sox12 deletion in the mouse reveals nonreciprocal redundancy with the related Sox4 and Sox11 transcription factors.
Molecular and cellular biology28(15)4675-87(2008 Aug)
Hoser M,Potzner MR,Koch JM,B?sl MR,Wegner M,Sock E

Proneural bHLH and Brn proteins coregulate a neurogenic program through cooperative binding to a conserved DNA motif.
Developmental cell11(6)831-44(2006 Dec)
Castro DS,Skowronska-Krawczyk D,Armant O,Donaldson IJ,Parras C,Hunt C,Critchley JA,Nguyen L,Gossler A,G?ttgens B,Matter JM,Guillemot F