Csrp2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Csrp2
Entrez Gene ID	29317
Full Name	cysteine and glycine-rich protein 2
Synonyms	SmLIM
General protein information	Preferred Names cysteine and glycine-rich protein 2 Names cysteine and glycine-rich protein 2 CRP2 LIM/double zinc-finger protein cysteine-rich protein 2 smooth muscle cell LIM protein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 7 Map Location: 7q22
Summary	may act as an adaptor molecule in the JAK/STAT signalling pathway [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_177425.3	NP_803174.2	cysteine and glycine-rich protein 2

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	csrp2	NP_957191.1
	CSRP2	XP_001082599.1
Canis lupus familiaris (dog)	LOC475409	XP_005629483.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012305	XP_551886.3
Bos taurus (cattle)	CSRP2	NP_001033272.1
Mus musculus (house mouse)	Csrp2	NP_031818.3
Gallus gallus (chicken)	CSRP2	NP_990539.1
Drosophila melanogaster (fruit fly)	Mlp84B	NP_477122.1
Xenopus tropicalis (tropical clawed frog)	csrp2	NP_001016615.1
Rattus norvegicus (Norway rat)	Csrp2	NP_803174.2
Caenorhabditis elegans (roundworm)	mlp-1	NP_498301.2
Homo sapiens (human)	CSRP2	NP_001312.1
Pan troglodytes (chimpanzee)	CSRP2	XP_003313876.1

Gene Ontology
Bibliography

Related articles in PubMed

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for ?-Pix in negative regulation of focal adhesion maturation.
Kuo JC, Han X, Hsiao CT, Yates JR 3rd, Waterman CM
Nature cell biology13(4)383-93(2011 Apr)

Polyclonal antibodies to LIM proteins CRP2 and CRIP2 reveal their subcellular localizations in olfactory precursor cells.
Gao X, Sun JY, Cao ZY, Lin Y, Zha DJ, Wang F, Xue T, Qiao L, Lu LJ, Qiu JH
Biochemistry. Biokhimiia74(3)336-41(2009 Mar)

Transforming growth factor beta up-regulates cysteine-rich protein 2 in vascular smooth muscle cells via activating transcription factor 2.
Lin DW, Chang IC, Tseng A, Wu ML, Chen CH, Patenaude CA, Layne MD, Yet SF
The Journal of biological chemistry283(22)15003-14(2008 May)

LIM-only protein, CRP2, switched on smooth muscle gene activity in adult cardiac myocytes.
Chang DF, Belaguli NS, Chang J, Schwartz RJ
Proceedings of the National Academy of Sciences of the United States of America104(1)157-62(2007 Jan)

Caveolin-1, Id3a and two LIM protein genes are upregulated by estrogen in vascular smooth muscle cells.
Watanabe T, Akishita M, Nakaoka T, He H, Miyahara Y, Yamashita N, Wada Y, Aburatani H, Yoshizumi M, Kozaki K, Ouchi Y
Life sciences75(10)1219-29(2004 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results demonstrated that in undifferentiated olfactory precursor cells Csrp2 was distributed both in the nucleus and the cytoplasm, whereas CRIP2 was predominantly localized in the cytoplasm.
Title: Polyclonal antibodies to LIM proteins CRP2 and CRIP2 reveal their subcellular localizations in olfactory precursor cells.

TGFbeta activates ATF2 phosphorylation and Csrp2 gene expression via a CRE promoter element.
Title: Transforming growth factor beta up-regulates cysteine-rich protein 2 in vascular smooth muscle cells via activating transcription factor 2.

CRP2 acted as a potent transcription coadaptor that remodeled silent cardiac myocyte chromatin and directed serum response factor-dependent smooth muscle gene activity.
Title: LIM-only protein, CRP2, switched on smooth muscle gene activity in adult cardiac myocytes.

In rats, estrogen was found to up-regulate SmLIM genes in smooth muscle vascular cells.
Title: Caveolin-1, Id3a and two LIM protein genes are upregulated by estrogen in vascular smooth muscle cells.

The following Csrp2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Csrp2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa04024	NM_177425.3 Latest version!	Rattus norvegicus cysteine and glycine-rich protein 2 (Csrp2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Csrp2 ( NM_177425.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_803174.2 Rattus norvegicus cysteine and glycine-rich protein 2 (Csrp2), mRNA.

Price & Availability↑

CloneID	ORa04024
Clone ID Related Accession (Same CDS sequence)	NM_177425.3
Accession Version	NM_177425.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 582bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-19
Organism	Rattus norvegicus(Norway rat)
Product	cysteine and glycine-rich protein 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from U44948.1 and CD373038.1. On Oct 28, 2005 this sequence version replaced NM_177425.2. ##Evidence-Data-START## Transcript exon combination :: U44948.1, FM073056.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCCTGTCT GGGGCGGTGG AAATAAGTGC GGGGCCTGCG GGAGAACCGT GTACCACGCT 
GAAGAGGTGC AGTGTGATGG GCGGAGCTTC CACCGCTGCT GCTTTCTGTG CATGGTTTGC 
AGGAAAAATT TAGACAGCAC AACAGTGGCA ATTCATGATG AAGAGATCTA CTGCAAATCA 
TGCTACGGAA AGAAGTATGG ACCAAAAGGC TATGGTTATG GCCAGGGCGC TGGCACGCTC 
AACATGGACC GTGGTGAGAG GCTGGGCATC AAGCCAGAGA GTGCTCAACC TCACAGGCCT 
ACAACAAATC CAAACACTTC TAAATTTGCC CAGAAATATG GAGGTGCTGA GAAGTGCTCC 
AGATGTGGGG ATTCTGTGTA TGCTGCTGAG AAGATCATTG GAGCTGGAAA GCCCTGGCAC 
AAAAACTGTT TCCGATGTGC CAAGTGTGGG AAGAGTCTGG AGTCTACAAC TCTGACTGAG 
AAGGAAGGTG AAATCTACTG TAAAGGGTGC TACGCAAAGA ACTTTGGGCC CAAGGGATTC 
GGCTATGGTC AAGGAGCAGG GGCCCTTGTT CATGCTCAGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_803174.2
CDS	50..631
Translation	MPVWGGGNKCGACGRTVYHAEEVQCDGRSFHRCCFLCMVCRKNLDSTTVAIHDEEIYCKSCYGKKYGPKGYGYGQGAGTLNMDRGERLGIKPESAQPHRPTTNPNTSKFAQKYGGAEKCSRCGDSVYAAEKIIGAGKPWHKNCFRCAKCGKSLESTTLTEKEGEIYCKGCYAKNFGPKGFGYGQGAGALVHAQ

Target ORF information:

RefSeq Version	NM_177425.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cysteine and glycine-rich protein 2 (Csrp2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_177425.3

ORF Insert Sequence:

ATGCCTGTCT GGGGCGGTGG AAATAAGTGC GGGGCCTGCG GGAGAACCGT GTACCACGCT 
GAAGAGGTGC AGTGTGATGG GCGGAGCTTC CACCGCTGCT GCTTTCTGTG CATGGTTTGC 
AGGAAAAATT TAGACAGCAC AACAGTGGCA ATTCATGATG AAGAGATCTA CTGCAAATCA 
TGCTACGGAA AGAAGTATGG ACCAAAAGGC TATGGTTATG GCCAGGGCGC TGGCACGCTC 
AACATGGACC GTGGTGAGAG GCTGGGCATC AAGCCAGAGA GTGCTCAACC TCACAGGCCT 
ACAACAAATC CAAACACTTC TAAATTTGCC CAGAAATATG GAGGTGCTGA GAAGTGCTCC 
AGATGTGGGG ATTCTGTGTA TGCTGCTGAG AAGATCATTG GAGCTGGAAA GCCCTGGCAC 
AAAAACTGTT TCCGATGTGC CAAGTGTGGG AAGAGTCTGG AGTCTACAAC TCTGACTGAG 
AAGGAAGGTG AAATCTACTG TAAAGGGTGC TACGCAAAGA ACTTTGGGCC CAAGGGATTC 
GGCTATGGTC AAGGAGCAGG GGCCCTTGTT CATGCTCAGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for ?-Pix in negative regulation of focal adhesion maturation.
Nature cell biology13(4)383-93(2011 Apr)
Kuo JC,Han X,Hsiao CT,Yates JR 3rd,Waterman CM

Polyclonal antibodies to LIM proteins CRP2 and CRIP2 reveal their subcellular localizations in olfactory precursor cells.
Biochemistry. Biokhimiia74(3)336-41(2009 Mar)
Gao X,Sun JY,Cao ZY,Lin Y,Zha DJ,Wang F,Xue T,Qiao L,Lu LJ,Qiu JH

Transforming growth factor beta up-regulates cysteine-rich protein 2 in vascular smooth muscle cells via activating transcription factor 2.
The Journal of biological chemistry283(22)15003-14(2008 May)
Lin DW,Chang IC,Tseng A,Wu ML,Chen CH,Patenaude CA,Layne MD,Yet SF

LIM-only protein, CRP2, switched on smooth muscle gene activity in adult cardiac myocytes.
Proceedings of the National Academy of Sciences of the United States of America104(1)157-62(2007 Jan)
Chang DF,Belaguli NS,Chang J,Schwartz RJ

Caveolin-1, Id3a and two LIM protein genes are upregulated by estrogen in vascular smooth muscle cells.
Life sciences75(10)1219-29(2004 Jul)
Watanabe T,Akishita M,Nakaoka T,He H,Miyahara Y,Yamashita N,Wada Y,Aburatani H,Yoshizumi M,Kozaki K,Ouchi Y

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Csrp2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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