Pkp2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pkp2
Entrez Gene ID	287925
Full Name	plakophilin 2
General protein information	Preferred Names plakophilin 2 Names plakophilin-2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 11 Map Location: 11q23

mRNA and Protein(s)

mRNA	Protein	Name
NM_001100499.1	NP_001093969.1	plakophilin-2

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	PKP2	XP_416362.4
Homo sapiens (human)	PKP2	NP_001005242.2
Canis lupus familiaris (dog)	PKP2	XP_543739.2
Danio rerio (zebrafish)	pkp2	NP_001106904.1
Rattus norvegicus (Norway rat)	Pkp2	NP_001093969.1
Pan troglodytes (chimpanzee)	PKP2	XP_003954415.1
Bos taurus (cattle)	PKP2	NP_001077198.1
Mus musculus (house mouse)	Pkp2	NP_080439.1
Xenopus tropicalis (tropical clawed frog)	pkp2	NP_001096312.1

Gene Ontology
Bibliography

Related articles in PubMed

Plakophilin-2 loss promotes TGF-?1/p38 MAPK-dependent fibrotic gene expression in cardiomyocytes.
Dubash AD, Kam CY, Aguado BA, Patel DM, Delmar M, Shea LD, Green KJ
The Journal of cell biology212(4)425-38(2016 Feb)

Plakophilins 1 and 3 bind to FXR1 and thereby influence the mRNA stability of desmosomal proteins.
Fischer-Ke?o R, Breuninger S, Hofmann S, Henn M, R?hrig T, Str?bel P, Stoecklin G, Hofmann I
Molecular and cellular biology34(23)4244-56(2014 Dec)

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Guo Z, Neilson LJ, Zhong H, Murray PS, Zanivan S, Zaidel-Bar R
Science signaling7(354)rs7(2014 Dec)

Homozygous founder mutation in desmocollin-2 (DSC2) causes arrhythmogenic cardiomyopathy in the Hutterite population.
Gerull B, Kirchner F, Chong JX, Tagoe J, Chandrasekharan K, Strohm O, Waggoner D, Ober C, Duff HJ
Circulation. Cardiovascular genetics6(4)327-36(2013 Aug)

Mutations in the area composita protein ?T-catenin are associated with arrhythmogenic right ventricular cardiomyopathy.
van Hengel J, Calore M, Bauce B, Dazzo E, Mazzotti E, De Bortoli M, Lorenzon A, Li Mura IE, Beffagna G, Rigato I, Vleeschouwers M, Tyberghein K, Hulpiau P, van Hamme E, Zaglia T, Corrado D, Basso C, Thiene G, Daliento L, Nava A, van Roy F, Rampazzo A
European heart journal34(3)201-10(2013 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Plakophilin-2 loss promotes TGF-beta1/p38 MAPK-dependent fibrotic gene expression in cardiomyocytes.
Title: Plakophilin-2 loss promotes TGF-?1/p38 MAPK-dependent fibrotic gene expression in cardiomyocytes.

Plakophilin-2 silencing in epicardial cultures showed increased velocity of migration, increased proliferative rate, and increased adiposis.
Title: Plakophilin-2 and the migration, differentiation and transformation of cells derived from the epicardium of neonatal rat hearts.

demonstrated that loss of AnkG expression caused significant changes in subcellular distribution and/or abundance of PKP2 and Connexin43 as well as a decrease in intercellular adhesion strength and electric coupling
Title: Interactions between ankyrin-G, Plakophilin-2, and Connexin43 at the cardiac intercalated disc.

PKP2 associates with Na(V)1.5, and that knockdown of PKP2 expression alters the properties of the sodium current, and the velocity of action potential propagation in cultured cardiomyocytes.
Title: Loss of plakophilin-2 expression leads to decreased sodium current and slower conduction velocity in cultured cardiac myocytes.

Cx43 and PKP2 form a protein complex within the desmosome-like junction to regulate cell adhesion at the blood-testis barrier, partly through its effects on the occludin/ZO-1 complex, so as to facilitate the transit of primary preleptotene spermatocytes.
Title: Connexin 43 and plakophilin-2 as a protein complex that regulates blood-testis barrier dynamics.

The following Pkp2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pkp2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa11554	NM_001100499.1 Latest version!	Rattus norvegicus plakophilin 2 (Pkp2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pkp2 ( NM_001100499.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001093969.1 Rattus norvegicus plakophilin 2 (Pkp2), mRNA.

Price & Availability↑

CloneID	ORa11554
Clone ID Related Accession (Same CDS sequence)	NM_001100499.1
Accession Version	NM_001100499.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2388bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Rattus norvegicus(Norway rat)
Product	plakophilin-2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473999.2. On or before Nov 30, 2008 this sequence version replaced XM_001065241.1, XM_213560.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGCGATCC CAGGCTCACT GGGCGAGTGT GGTTACATCC GGACCGTGCT GGGCCAGCAG 
ATCCTGGGTC ACCTGGACAG CTCCAGCCTG GCCTTGCCCT CCGAGGCCAG GCTGAGGCTA 
GCGGGCAGCA GCGGCCGCGG CGACCCGGTG GCCCGGAGCC AGCGGATCCA GGAGCAGGTG 
CAGCAAACCC TGGCTCGCCG GGGCCGGAGC TCTGTAGTCG GCGGGAACCT TCACCGAACC 
AGCAGTGTTC CTGAGTATGT CTACAAGCTG CACTTGGTTG AGAATGACTT TGTTGGAAGG 
CAGTCACCTG CCGCTAGGGA CTATGACATG CTTAAGGCTG GAGTGACTGC CACTTACGGA 
AGTCGTTGGG GGAGAGGAAC AGCACAGTAT AGTTCGCAGA AGTCAGTAGA GGAGAGATCC 
TGGAGGCAGC CCCTGAGGAG ACTTGAGATT TCCCCAGATA GCAGCCCGGA GAGAGCCCAC 
TATGGGCACA GCGAATACCA ATATGCCTGG CGGAGCCATG TGGTGCCTGG TGGGCGCCTT 
ACCCTTCCAC GCTATGCTCG CTCAGAGATC CTGGGCCTGC GCCAGACTGG CACAGCCCGA 
AGGGCACCTG GGTGCGGGTC AGTCAGCGAT GCTGTCTTTG ACAATGGCCC GCTTAACCCC 
ACCATACCCA CCCACCCTCC TGGCACCAGC CACAGCGCAG GCAGCCTGCT GGAGGAGACC 
ACTGTGCGTG TGAGCCAGGC TCGATTTCAG GGCCTGCAGA GCAGAGCCGG CCGCTCCTCC 
TGGCCCCGGA GCTCAGTCCA CAGTACCTTG CGGGAGTCAG GAAGAATGCT GCCCACCGCA 
GGCCAGGCTG CGGTGGGCAG CGGGGATGCG CATCGGGACA GGAGCGCCTT CGCTGACTCC 
CAGCTCGGGA ATGCAGACTT AGAGATGACC TTGGAGCGAG CTGTGAATAT GCTGGATGCA 
GACCATGTAC CACTGTCCAA GATCTCTGCT GCGGCTACCT TCATACAGCA TGAGAGCTTC 
CAAAAATCTG AAGCACGGAA AAGGGTCAAT CAACTTCAAG GCATCCCTAA ACTTCTGCAG 
CTGCTCAAAG TTCAGAATGA AGACGTTCAG CGGGCTGTGT GTGGGGCCCT GAGAAATTTG 
GTATTTGAAG ACAATGATAA CAAGTTGGAG GTCGCTGAAC TGAATGGAGT GCCTCGGCTG 
CTGCAGGTGC TGAAGCAAAC CAGAGACTTG GAGACAAAGA AGCAAATAAC AGGTTTGCTC 
TGGAACTTGT CCTCTAGTGA TAAACTCAAG CATCTCATGA TAACAGAAGC CTTGCTCACC 
TTGACAGAGA GTGTCATCAT CCCCTTCTCA GGGTGGCCTG AAGGAGACTA CCCCAAAGCC 
AATGGCTTGC TTGATTTTGA TATATTCTAC AATGTCACTG GATGCCTAAG AAACATGAGC 
TCCGCTGGCC CTGATGGGAG GAAGGTGATG AGGAGGTGTG ATGGTCTCAT TGATTCATTG 
GTCCATTACG TCAGAGGAAC CATTGCAGAC TACCAGCCAG ATGATAAGGC CACAGAGAAC 
TGCGTATGCA TTCTTCATAA CCTCTCCTAC CAGCTGGAGG CTGAGCTCCC AGAGAAATAT 
TCCCAGAGTA TCTACATGCA AAACCGGAAT ATCCAGACCA ACAGTAACAA AAGCATCGGG 
TGTTTTGGCA GCCGGAGTAG AAAAGTAAAG GAGCAATACC AAGACACGCC GATGCCAGAG 
GAAAGGAGCA GTCCCCGTGG CATTGAGTGG CTGTGGCATT CCATTGTGAT AAGGATGTAT 
TTGTCCTTAA TTGCCAAGAG TTCCCGAAAC TATACCCAAG AGGCATCATT GGGAGCTCTC 
CAGAACCTCA CAGCAGGAAG CGGCCCGATA CCCACATCGG TAGCTCGCAT GGTTGTCCAG 
AAGGAAAATG GTCTTCAGCA CACCCGGAAG ATGCTGCACG TGGGTGATCC CAGTGTGAAA 
AAGACTGCAG TCTCCCTGCT GAGGAATTTG TCACGGAATC TTTCTCTGCA GAATGAAATT 
GCTAAAGAAA CTCTACCAGA TTTGGTTTCT ATAATTCCTG ACACAGTCCC AAGTACTGAC 
CTCCTCATTG AAACTACAGC TTCTGCTTGC TATACGTTGA ACAATTTAAT GCAAAATAGT 
TACCAGAATG CACGAGACCT TCTGAACACT GGAGGGCTGC AGAAAATTAT GACCATCAGC 
ATAGGAGAAG GCTATGCCCC CAACAAGGCC AGCAAAGCTG CCTCTGTCCT CCTGTACTCT 
CTGTGGGCAC ACACCGAGCT CCATAATGCC TACAAGAAGG CTCAGTTTAA GAAGACGGAC 
TTCGTCAACA GCCGGACTGC CAAGGCCTCC CACTCCCTTA AAGACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001093969.1
CDS	38..2425
Translation	MAIPGSLGECGYIRTVLGQQILGHLDSSSLALPSEARLRLAGSSGRGDPVARSQRIQEQVQQTLARRGRSSVVGGNLHRTSSVPEYVYKLHLVENDFVGRQSPAARDYDMLKAGVTATYGSRWGRGTAQYSSQKSVEERSWRQPLRRLEISPDSSPERAHYGHSEYQYAWRSHVVPGGRLTLPRYARSEILGLRQTGTARRAPGCGSVSDAVFDNGPLNPTIPTHPPGTSHSAGSLLEETTVRVSQARFQGLQSRAGRSSWPRSSVHSTLRESGRMLPTAGQAAVGSGDAHRDRSAFADSQLGNADLEMTLERAVNMLDADHVPLSKISAAATFIQHESFQKSEARKRVNQLQGIPKLLQLLKVQNEDVQRAVCGALRNLVFEDNDNKLEVAELNGVPRLLQVLKQTRDLETKKQITGLLWNLSSSDKLKHLMITEALLTLTESVIIPFSGWPEGDYPKANGLLDFDIFYNVTGCLRNMSSAGPDGRKVMRRCDGLIDSLVHYVRGTIADYQPDDKATENCVCILHNLSYQLEAELPEKYSQSIYMQNRNIQTNSNKSIGCFGSRSRKVKEQYQDTPMPEERSSPRGIEWLWHSIVIRMYLSLIAKSSRNYTQEASLGALQNLTAGSGPIPTSVARMVVQKENGLQHTRKMLHVGDPSVKKTAVSLLRNLSRNLSLQNEIAKETLPDLVSIIPDTVPSTDLLIETTASACYTLNNLMQNSYQNARDLLNTGGLQKIMTISIGEGYAPNKASKAASVLLYSLWAHTELHNAYKKAQFKKTDFVNSRTAKASHSLKD

Target ORF information:

RefSeq Version	NM_001100499.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus plakophilin 2 (Pkp2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001100499.1

ORF Insert Sequence:

ATGGCGATCC CAGGCTCACT GGGCGAGTGT GGTTACATCC GGACCGTGCT GGGCCAGCAG 
ATCCTGGGTC ACCTGGACAG CTCCAGCCTG GCCTTGCCCT CCGAGGCCAG GCTGAGGCTA 
GCGGGCAGCA GCGGCCGCGG CGACCCGGTG GCCCGGAGCC AGCGGATCCA GGAGCAGGTG 
CAGCAAACCC TGGCTCGCCG GGGCCGGAGC TCTGTAGTCG GCGGGAACCT TCACCGAACC 
AGCAGTGTTC CTGAGTATGT CTACAAGCTG CACTTGGTTG AGAATGACTT TGTTGGAAGG 
CAGTCACCTG CCGCTAGGGA CTATGACATG CTTAAGGCTG GAGTGACTGC CACTTACGGA 
AGTCGTTGGG GGAGAGGAAC AGCACAGTAT AGTTCGCAGA AGTCAGTAGA GGAGAGATCC 
TGGAGGCAGC CCCTGAGGAG ACTTGAGATT TCCCCAGATA GCAGCCCGGA GAGAGCCCAC 
TATGGGCACA GCGAATACCA ATATGCCTGG CGGAGCCATG TGGTGCCTGG TGGGCGCCTT 
ACCCTTCCAC GCTATGCTCG CTCAGAGATC CTGGGCCTGC GCCAGACTGG CACAGCCCGA 
AGGGCACCTG GGTGCGGGTC AGTCAGCGAT GCTGTCTTTG ACAATGGCCC GCTTAACCCC 
ACCATACCCA CCCACCCTCC TGGCACCAGC CACAGCGCAG GCAGCCTGCT GGAGGAGACC 
ACTGTGCGTG TGAGCCAGGC TCGATTTCAG GGCCTGCAGA GCAGAGCCGG CCGCTCCTCC 
TGGCCCCGGA GCTCAGTCCA CAGTACCTTG CGGGAGTCAG GAAGAATGCT GCCCACCGCA 
GGCCAGGCTG CGGTGGGCAG CGGGGATGCG CATCGGGACA GGAGCGCCTT CGCTGACTCC 
CAGCTCGGGA ATGCAGACTT AGAGATGACC TTGGAGCGAG CTGTGAATAT GCTGGATGCA 
GACCATGTAC CACTGTCCAA GATCTCTGCT GCGGCTACCT TCATACAGCA TGAGAGCTTC 
CAAAAATCTG AAGCACGGAA AAGGGTCAAT CAACTTCAAG GCATCCCTAA ACTTCTGCAG 
CTGCTCAAAG TTCAGAATGA AGACGTTCAG CGGGCTGTGT GTGGGGCCCT GAGAAATTTG 
GTATTTGAAG ACAATGATAA CAAGTTGGAG GTCGCTGAAC TGAATGGAGT GCCTCGGCTG 
CTGCAGGTGC TGAAGCAAAC CAGAGACTTG GAGACAAAGA AGCAAATAAC AGGTTTGCTC 
TGGAACTTGT CCTCTAGTGA TAAACTCAAG CATCTCATGA TAACAGAAGC CTTGCTCACC 
TTGACAGAGA GTGTCATCAT CCCCTTCTCA GGGTGGCCTG AAGGAGACTA CCCCAAAGCC 
AATGGCTTGC TTGATTTTGA TATATTCTAC AATGTCACTG GATGCCTAAG AAACATGAGC 
TCCGCTGGCC CTGATGGGAG GAAGGTGATG AGGAGGTGTG ATGGTCTCAT TGATTCATTG 
GTCCATTACG TCAGAGGAAC CATTGCAGAC TACCAGCCAG ATGATAAGGC CACAGAGAAC 
TGCGTATGCA TTCTTCATAA CCTCTCCTAC CAGCTGGAGG CTGAGCTCCC AGAGAAATAT 
TCCCAGAGTA TCTACATGCA AAACCGGAAT ATCCAGACCA ACAGTAACAA AAGCATCGGG 
TGTTTTGGCA GCCGGAGTAG AAAAGTAAAG GAGCAATACC AAGACACGCC GATGCCAGAG 
GAAAGGAGCA GTCCCCGTGG CATTGAGTGG CTGTGGCATT CCATTGTGAT AAGGATGTAT 
TTGTCCTTAA TTGCCAAGAG TTCCCGAAAC TATACCCAAG AGGCATCATT GGGAGCTCTC 
CAGAACCTCA CAGCAGGAAG CGGCCCGATA CCCACATCGG TAGCTCGCAT GGTTGTCCAG 
AAGGAAAATG GTCTTCAGCA CACCCGGAAG ATGCTGCACG TGGGTGATCC CAGTGTGAAA 
AAGACTGCAG TCTCCCTGCT GAGGAATTTG TCACGGAATC TTTCTCTGCA GAATGAAATT 
GCTAAAGAAA CTCTACCAGA TTTGGTTTCT ATAATTCCTG ACACAGTCCC AAGTACTGAC 
CTCCTCATTG AAACTACAGC TTCTGCTTGC TATACGTTGA ACAATTTAAT GCAAAATAGT 
TACCAGAATG CACGAGACCT TCTGAACACT GGAGGGCTGC AGAAAATTAT GACCATCAGC 
ATAGGAGAAG GCTATGCCCC CAACAAGGCC AGCAAAGCTG CCTCTGTCCT CCTGTACTCT 
CTGTGGGCAC ACACCGAGCT CCATAATGCC TACAAGAAGG CTCAGTTTAA GAAGACGGAC 
TTCGTCAACA GCCGGACTGC CAAGGCCTCC CACTCCCTTA AAGACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Plakophilin-2 loss promotes TGF-?1/p38 MAPK-dependent fibrotic gene expression in cardiomyocytes.
The Journal of cell biology212(4)425-38(2016 Feb)
Dubash AD,Kam CY,Aguado BA,Patel DM,Delmar M,Shea LD,Green KJ

Plakophilins 1 and 3 bind to FXR1 and thereby influence the mRNA stability of desmosomal proteins.
Molecular and cellular biology34(23)4244-56(2014 Dec)
Fischer-Ke?o R,Breuninger S,Hofmann S,Henn M,R?hrig T,Str?bel P,Stoecklin G,Hofmann I

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Science signaling7(354)rs7(2014 Dec)
Guo Z,Neilson LJ,Zhong H,Murray PS,Zanivan S,Zaidel-Bar R

Homozygous founder mutation in desmocollin-2 (DSC2) causes arrhythmogenic cardiomyopathy in the Hutterite population.
Circulation. Cardiovascular genetics6(4)327-36(2013 Aug)
Gerull B,Kirchner F,Chong JX,Tagoe J,Chandrasekharan K,Strohm O,Waggoner D,Ober C,Duff HJ

Mutations in the area composita protein ?T-catenin are associated with arrhythmogenic right ventricular cardiomyopathy.
European heart journal34(3)201-10(2013 Jan)
van Hengel J,Calore M,Bauce B,Dazzo E,Mazzotti E,De Bortoli M,Lorenzon A,Li Mura IE,Beffagna G,Rigato I,Vleeschouwers M,Tyberghein K,Hulpiau P,van Hamme E,Zaglia T,Corrado D,Basso C,Thiene G,Daliento L,Nava A,van Roy F,Rampazzo A

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Pkp2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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