Pkp2 cDNA ORF clone, Mus musculus(house mouse)

Loss of control over the ethanol consumption: differential transcriptional regulation in prefrontal cortex.
de Paiva Lima C, da Silva E Silva DA, Damasceno S, Ribeiro AF, Rocha CS, Berenguer de Matos AH, Correia D, Boerngen-Lacerda R, Brunialti Godard AL
Journal of neurogenetics31(3)170-177(2017 Sep)

Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm.
Cerrone M, Montnach J, Lin X, Zhao YT, Zhang M, Agullo-Pascual E, Leo-Macias A, Alvarado FJ, Dolgalev I, Karathanos TV, Malkani K, Van Opbergen CJM, van Bavel JJA, Yang HQ, Vasquez C, Tester D, Fowler S, Liang F, Rothenberg E, Heguy A, Morley GE, Coetzee WA, Trayanova NA, Ackerman MJ, van Veen TAB, Valdivia HH, Delmar M
Nature communications8(1)106(2017 07)

Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth.
Ragni CV, Diguet N, Le Garrec JF, Novotova M, Resende TP, Pop S, Charon N, Guillemot L, Kitasato L, Badouel C, Dufour A, Olivo-Marin JC, Trouv? A, McNeill H, Meilhac SM
Nature communications814582(2017 Feb)

Knockdown of Plakophilin 2 Downregulates miR-184 Through CpG Hypermethylation and Suppression of the E2F1 Pathway and Leads to Enhanced Adipogenesis In Vitro.
Gurha P, Chen X, Lombardi R, Willerson JT, Marian AJ
Circulation research119(6)731-50(2016 Sep)

Molecular disturbance underlies to arrhythmogenic cardiomyopathy induced by transgene content, age and exercise in a truncated PKP2 mouse model.
Moncayo-Arlandi J, Guasch E, Sanz-de la Garza M, Casado M, Garcia NA, Mont L, Sitges M, Kn?ll R, Buyandelger B, Campuzano O, Diez-Juan A, Brugada R
Human molecular genetics25(17)3676-3688(2016 09)

Data indicate that lack of plakophilin-2 (PKP2) can cause arrhythmia in a structurally normal heart.
Title: Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm.

PKP2 deficiency leads to suppression of the E2F1 pathway and hypermethylation of CPG sites at miR-184 promoter.
Title: Knockdown of Plakophilin 2 Downregulates miR-184 Through CpG Hypermethylation and Suppression of the E2F1 Pathway and Leads to Enhanced Adipogenesis In Vitro.

Results demonstrated that truncated PKP2 provokes arrhythmogenic cardiomyopathy in the absence of fibro-fatty replacement in the mouse.
Title: Molecular disturbance underlies to arrhythmogenic cardiomyopathy induced by transgene content, age and exercise in a truncated PKP2 mouse model.

Plakophilin-2 loss promotes TGF-beta1/p38 MAPK-dependent fibrotic gene expression in cardiomyocytes.
Title: Plakophilin-2 loss promotes TGF-?1/p38 MAPK-dependent fibrotic gene expression in cardiomyocytes.

Missense mutations in plakophilin-2 cause sodium current deficit and associate with a Brugada syndrome phenotype.
Title: Missense mutations in plakophilin-2 cause sodium current deficit and associate with a Brugada syndrome phenotype.