Cops3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cops3
Entrez Gene ID	287367
Full Name	COP9 signalosome subunit 3
General protein information	Preferred Names COP9 signalosome subunit 3 Names COP9 signalosome complex subunit 3 COP9 (constitutive photomorphogenic) homolog, subunit 3 SGN3 signalosome subunit 3
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q22
Summary	subunit of the COP9 signalosome complex; mouse homolog plays a role in early embryonic development [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017597079.1	XP_017452568.1	COP9 signalosome complex subunit 3 isoform X1
NM_001004200.1	NP_001004200.1	COP9 signalosome complex subunit 3

Pathways from BioSystems

Homologies

Drosophila melanogaster (fruit fly)	CSN3	NP_524190.2
Pan troglodytes (chimpanzee)	COPS3	XP_001160602.1
Bos taurus (cattle)	COPS3	NP_001092374.1
Mus musculus (house mouse)	Cops3	NP_036121.1
Homo sapiens (human)	COPS3	NP_003644.2
Canis lupus familiaris (dog)	COPS3	XP_864801.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006445	XP_316484.4
Arabidopsis thaliana (thale cress)	COP13	NP_568296.1
Danio rerio (zebrafish)	cops3	NP_955979.1
Oryza sativa (rice)	Os08g0119000	NP_001060870.1
	COPS3	XP_001089733.2
Rattus norvegicus (Norway rat)	Cops3	NP_001004200.1
Gallus gallus (chicken)	COPS3	NP_001006163.1
Xenopus tropicalis (tropical clawed frog)	cops3	NP_001017238.1

Gene Ontology
Bibliography

Related articles in PubMed

Symmetrical modularity of the COP9 signalosome complex suggests its multifunctionality.
Sharon M, Mao H, Boeri Erba E, Stephens E, Zheng N, Robinson CV
Structure (London, England : 1993)17(1)31-40(2009 Jan)

Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry.
Fang L, Wang X, Yamoah K, Chen PL, Pan ZQ, Huang L
Journal of proteome research7(11)4914-25(2008 Nov)

COP9 signalosome subunit 3 is essential for maintenance of cell proliferation in the mouse embryonic epiblast.
Yan J, Walz K, Nakamura H, Carattini-Rivera S, Zhao Q, Vogel H, Wei N, Justice MJ, Bradley A, Lupski JR
Molecular and cellular biology23(19)6798-808(2003 Oct)

The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex.
Wei N, Tsuge T, Serino G, Dohmae N, Takio K, Matsui M, Deng XW
Current biology : CB8(16)919-22(1998 Jul 30-Aug 13)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Cops3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cops3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa10053	NM_001004200.1 Latest version!	Rattus norvegicus COP9 signalosome subunit 3 (Cops3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
ORa57214	XM_017597079.1 Latest version!	Rattus norvegicus COP9 signalosome subunit 3 (Cops3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cops3 ( NM_001004200.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001004200.1 Rattus norvegicus COP9 signalosome subunit 3 (Cops3), mRNA.

Price & Availability↑

CloneID	ORa10053
Clone ID Related Accession (Same CDS sequence)	NM_001004200.1
Accession Version	NM_001004200.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1272bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-19
Organism	Rattus norvegicus(Norway rat)
Product	COP9 signalosome complex subunit 3
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC079143.1. On Sep 10, 2004 this sequence version replaced XM_213326.2. ##Evidence-Data-START## Transcript exon combination :: BC079143.1, FQ228882.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGCGTCTG CTCTGGAGCA GTTCGTGAAC AGTGTCCGAC AGCTCTCAGC TCAAGGGCAG 
ATGACTCAGC TTTGTGAACT CATCAACAAG AGTGGAGAAC TCCTTGCGAA GAACTTGTCC 
CACTTGGACA CTGTGCTTGG GGCTTTAGAT GTTCAAGAAC ACTCATTGGG TGTCCTTGCC 
GTTCTGTTTG TGAAGTTTTC CATGCCCAGT GTTCCTGACT TCGAGACACT GTTCTCACAG 
GTGCAGCTTT TCATTAGTAC TTGTAACGGC GAGCACATTC GATACGCAAC AGATACGTTC 
GCTGGGCTTT GCCATCAGCT AACAAACGCA CTCGTGGAGA GAAAACAGCC CCTTCGAGGA 
ATTGGCATCC TTAAGCAAGC CATAGACAAG ATGCAGATGA ATACAAACCA GCTGACCTCA 
GTACACGCCG ATCTCTGCCA GCTCTGTTTA CTAGCGAAGT GCTTTAAACC TGCCCTGCCA 
TATCTTGATG TGGATATGAT GGATATCTGT AAAGAGAATG GAGCCTATGA TGCAAAACAC 
TTTCTGTGCT ACTACTATTA TGGAGGGATG ATCTATACGG GGCTGAAGAA CTTTGAAAGA 
GCACTGTATT TTTATGAGCA GGCCATAACT ACCCCAGCCA TGGCCGTCAG CCATATCATG 
TTGGAGTCAT ATAAAAAGTA TATTTTAGTG TCTTTGATAT TACTTGGGAA AGTACAACAG 
CTGCCTAAAT ACACCTCTCA AATTGTGGGC AGATTTATTA AGCCTCTCAG CAACGCTTAC 
CACGAGTTAG CACAAGTTTA TTCAACCAAC AACCCGTCCG AGCTCCGGAA CCTGGTGAAC 
AAGCACAGTG AGACCTTCAC TCGAGATAAC AACATGGGCC TGGTGAAGCA GTGCCTGTCG 
TCTCTTTATA AGAAGAACAT TCAGAGGCTG ACAAAGACCT TTTTAACACT TTCATTACAA 
GATATGGCAA GTCGCGTGCA GTTATCTGGA CCTCAGGAGG CAGAAAAGTA TGTTCTACAC 
ATGATAGAAG ATGGAGAAAT TTTTGCAAGT ATTAACCAGA AGGATGGTAT GGTCAGTTTC 
CATGATAATC CTGAAAAGTA TAACAACCCA GCCATGCTTC ATAACATTGA TCAAGAGATG 
CTAAAATGCA TAGAGCTGGA TGAGCGACTG AAGGCCATGG ACCAGGAGAT CACAGTGAAC 
CCCCAGTTTG TTCAAAAGAG CATGGGCTCA CAAGAAGATG ACTCAGGAAA CAAGCCCTCC 
AGCTACTCTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001004200.1
CDS	45..1316
Translation	MASALEQFVNSVRQLSAQGQMTQLCELINKSGELLAKNLSHLDTVLGALDVQEHSLGVLAVLFVKFSMPSVPDFETLFSQVQLFISTCNGEHIRYATDTFAGLCHQLTNALVERKQPLRGIGILKQAIDKMQMNTNQLTSVHADLCQLCLLAKCFKPALPYLDVDMMDICKENGAYDAKHFLCYYYYGGMIYTGLKNFERALYFYEQAITTPAMAVSHIMLESYKKYILVSLILLGKVQQLPKYTSQIVGRFIKPLSNAYHELAQVYSTNNPSELRNLVNKHSETFTRDNNMGLVKQCLSSLYKKNIQRLTKTFLTLSLQDMASRVQLSGPQEAEKYVLHMIEDGEIFASINQKDGMVSFHDNPEKYNNPAMLHNIDQEMLKCIELDERLKAMDQEITVNPQFVQKSMGSQEDDSGNKPSSYS

Target ORF information:

RefSeq Version	NM_001004200.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus COP9 signalosome subunit 3 (Cops3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001004200.1

ORF Insert Sequence:

ATGGCGTCTG CTCTGGAGCA GTTCGTGAAC AGTGTCCGAC AGCTCTCAGC TCAAGGGCAG 
ATGACTCAGC TTTGTGAACT CATCAACAAG AGTGGAGAAC TCCTTGCGAA GAACTTGTCC 
CACTTGGACA CTGTGCTTGG GGCTTTAGAT GTTCAAGAAC ACTCATTGGG TGTCCTTGCC 
GTTCTGTTTG TGAAGTTTTC CATGCCCAGT GTTCCTGACT TCGAGACACT GTTCTCACAG 
GTGCAGCTTT TCATTAGTAC TTGTAACGGC GAGCACATTC GATACGCAAC AGATACGTTC 
GCTGGGCTTT GCCATCAGCT AACAAACGCA CTCGTGGAGA GAAAACAGCC CCTTCGAGGA 
ATTGGCATCC TTAAGCAAGC CATAGACAAG ATGCAGATGA ATACAAACCA GCTGACCTCA 
GTACACGCCG ATCTCTGCCA GCTCTGTTTA CTAGCGAAGT GCTTTAAACC TGCCCTGCCA 
TATCTTGATG TGGATATGAT GGATATCTGT AAAGAGAATG GAGCCTATGA TGCAAAACAC 
TTTCTGTGCT ACTACTATTA TGGAGGGATG ATCTATACGG GGCTGAAGAA CTTTGAAAGA 
GCACTGTATT TTTATGAGCA GGCCATAACT ACCCCAGCCA TGGCCGTCAG CCATATCATG 
TTGGAGTCAT ATAAAAAGTA TATTTTAGTG TCTTTGATAT TACTTGGGAA AGTACAACAG 
CTGCCTAAAT ACACCTCTCA AATTGTGGGC AGATTTATTA AGCCTCTCAG CAACGCTTAC 
CACGAGTTAG CACAAGTTTA TTCAACCAAC AACCCGTCCG AGCTCCGGAA CCTGGTGAAC 
AAGCACAGTG AGACCTTCAC TCGAGATAAC AACATGGGCC TGGTGAAGCA GTGCCTGTCG 
TCTCTTTATA AGAAGAACAT TCAGAGGCTG ACAAAGACCT TTTTAACACT TTCATTACAA 
GATATGGCAA GTCGCGTGCA GTTATCTGGA CCTCAGGAGG CAGAAAAGTA TGTTCTACAC 
ATGATAGAAG ATGGAGAAAT TTTTGCAAGT ATTAACCAGA AGGATGGTAT GGTCAGTTTC 
CATGATAATC CTGAAAAGTA TAACAACCCA GCCATGCTTC ATAACATTGA TCAAGAGATG 
CTAAAATGCA TAGAGCTGGA TGAGCGACTG AAGGCCATGG ACCAGGAGAT CACAGTGAAC 
CCCCAGTTTG TTCAAAAGAG CATGGGCTCA CAAGAAGATG ACTCAGGAAA CAAGCCCTCC 
AGCTACTCTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cops3 ( XM_017597079.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017452568.1 Rattus norvegicus COP9 signalosome subunit 3 (Cops3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa57214
Clone ID Related Accession (Same CDS sequence)	XM_017597079.1
Accession Version	XM_017597079.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 882bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	COP9 signalosome complex subunit 3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005109.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCAGATGA ATACAAACCA GCTGACCTCA GTACACGCCG ATCTCTGCCA GCTCTGTTTA 
CTAGCGAAGT GCTTTAAACC TGCCCTGCCA TATCTTGATG TGGATATGAT GGATATCTGT 
AAAGAGAATG GAGCCTATGA TGCAAAACAC TTTCTGTGCT ACTACTATTA TGGAGGGATG 
ATCTATACGG GGCTGAAGAA CTTTGAAAGA GCACTGTATT TTTATGAGCA GGCCATAACT 
ACCCCAGCCA TGGCCGTCAG CCATATCATG TTGGAGTCAT ATAAAAAGTA TATTTTAGTG 
TCTTTGATAT TACTTGGGAA AGTACAACAG CTGCCTAAAT ACACCTCTCA AATTGTGGGC 
AGATTTATTA AGCCTCTCAG CAACGCTTAC CACGAGTTAG CACAAGTTTA TTCAACCAAC 
AACCCGTCCG AGCTCCGGAA CCTGGTGAAC AAGCACAGTG AGACCTTCAC TCGAGATAAC 
AACATGGGCC TGGTGAAGCA GTGCCTGTCG TCTCTTTATA AGAAGAACAT TCAGAGGCTG 
ACAAAGACCT TTTTAACACT TTCATTACAA GATATGGCAA GTCGCGTGCA GTTATCTGGA 
CCTCAGGAGG CAGAAAAGTA TGTTCTACAC ATGATAGAAG ATGGAGAAAT TTTTGCAAGT 
ATTAACCAGA AGGATGGTAT GGTCAGTTTC CATGATAATC CTGAAAAGTA TAACAACCCA 
GCCATGCTTC ATAACATTGA TCAAGAGATG CTAAAATGCA TAGAGCTGGA TGAGCGACTG 
AAGGCCATGG ACCAGGAGAT CACAGTGAAC CCCCAGTTTG TTCAAAAGAG CATGGGCTCA 
CAAGAAGATG ACTCAGGAAA CAAGCCCTCC AGCTACTCTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017452568.1
CDS	378..1259
Translation	MQMNTNQLTSVHADLCQLCLLAKCFKPALPYLDVDMMDICKENGAYDAKHFLCYYYYGGMIYTGLKNFERALYFYEQAITTPAMAVSHIMLESYKKYILVSLILLGKVQQLPKYTSQIVGRFIKPLSNAYHELAQVYSTNNPSELRNLVNKHSETFTRDNNMGLVKQCLSSLYKKNIQRLTKTFLTLSLQDMASRVQLSGPQEAEKYVLHMIEDGEIFASINQKDGMVSFHDNPEKYNNPAMLHNIDQEMLKCIELDERLKAMDQEITVNPQFVQKSMGSQEDDSGNKPSSYS

Target ORF information:

RefSeq Version	XM_017597079.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus COP9 signalosome subunit 3 (Cops3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017597079.1

ORF Insert Sequence:

ATGCAGATGA ATACAAACCA GCTGACCTCA GTACACGCCG ATCTCTGCCA GCTCTGTTTA 
CTAGCGAAGT GCTTTAAACC TGCCCTGCCA TATCTTGATG TGGATATGAT GGATATCTGT 
AAAGAGAATG GAGCCTATGA TGCAAAACAC TTTCTGTGCT ACTACTATTA TGGAGGGATG 
ATCTATACGG GGCTGAAGAA CTTTGAAAGA GCACTGTATT TTTATGAGCA GGCCATAACT 
ACCCCAGCCA TGGCCGTCAG CCATATCATG TTGGAGTCAT ATAAAAAGTA TATTTTAGTG 
TCTTTGATAT TACTTGGGAA AGTACAACAG CTGCCTAAAT ACACCTCTCA AATTGTGGGC 
AGATTTATTA AGCCTCTCAG CAACGCTTAC CACGAGTTAG CACAAGTTTA TTCAACCAAC 
AACCCGTCCG AGCTCCGGAA CCTGGTGAAC AAGCACAGTG AGACCTTCAC TCGAGATAAC 
AACATGGGCC TGGTGAAGCA GTGCCTGTCG TCTCTTTATA AGAAGAACAT TCAGAGGCTG 
ACAAAGACCT TTTTAACACT TTCATTACAA GATATGGCAA GTCGCGTGCA GTTATCTGGA 
CCTCAGGAGG CAGAAAAGTA TGTTCTACAC ATGATAGAAG ATGGAGAAAT TTTTGCAAGT 
ATTAACCAGA AGGATGGTAT GGTCAGTTTC CATGATAATC CTGAAAAGTA TAACAACCCA 
GCCATGCTTC ATAACATTGA TCAAGAGATG CTAAAATGCA TAGAGCTGGA TGAGCGACTG 
AAGGCCATGG ACCAGGAGAT CACAGTGAAC CCCCAGTTTG TTCAAAAGAG CATGGGCTCA 
CAAGAAGATG ACTCAGGAAA CAAGCCCTCC AGCTACTCTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Symmetrical modularity of the COP9 signalosome complex suggests its multifunctionality.
Structure (London, England : 1993)17(1)31-40(2009 Jan)
Sharon M,Mao H,Boeri Erba E,Stephens E,Zheng N,Robinson CV

Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry.
Journal of proteome research7(11)4914-25(2008 Nov)
Fang L,Wang X,Yamoah K,Chen PL,Pan ZQ,Huang L

COP9 signalosome subunit 3 is essential for maintenance of cell proliferation in the mouse embryonic epiblast.
Molecular and cellular biology23(19)6798-808(2003 Oct)
Yan J,Walz K,Nakamura H,Carattini-Rivera S,Zhao Q,Vogel H,Wei N,Justice MJ,Bradley A,Lupski JR

The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex.
Current biology : CB8(16)919-22(1998 Jul 30-Aug 13)
Wei N,Tsuge T,Serino G,Dohmae N,Takio K,Matsui M,Deng XW