Id3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Id3
Entrez Gene ID	25585
Full Name	inhibitor of DNA binding 3, HLH protein
General protein information	Preferred Names inhibitor of DNA binding 3, HLH protein Names DNA-binding protein inhibitor ID-3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein inhibitor of differentiation 3
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q36
Summary	helix-loop-helix transcription factor; involved in transcriptional regulation in smooth muscle cells [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_013058.2	NP_037190.1	DNA-binding protein inhibitor ID-3

Pathways from BioSystems

Homologies

Homo sapiens (human)	ID3	NP_002158.3
Xenopus tropicalis (tropical clawed frog)	id3	NP_001016271.1
Bos taurus (cattle)	ID3	NP_001014950.1
Mus musculus (house mouse)	Id3	NP_032347.1
Gallus gallus (chicken)	ID3	NP_989920.1
Danio rerio (zebrafish)	id3	NP_694499.1
Rattus norvegicus (Norway rat)	Id3	NP_037190.1
Pan troglodytes (chimpanzee)	ID3	XP_003949371.1
Canis lupus familiaris (dog)	ID3	NP_001003025.1

Gene Ontology
Bibliography

Related articles in PubMed

GLCE regulates PC12 cell neuritogenesis induced by nerve growth factor through activating SMAD/ID3 signalling.
Li J, Fang J, Qin Y, Liao W, Liu H, Zhou Y, Ding K
The Biochemical journal459(2)405-15(2014 Apr)

Ankyrin repeat domain protein 2 and inhibitor of DNA binding 3 cooperatively inhibit myoblast differentiation by physical interaction.
Mohamed JS, Lopez MA, Cox GA, Boriek AM
The Journal of biological chemistry288(34)24560-8(2013 Aug)

The metalloid arsenite induces nuclear export of Id3 possibly via binding to the N-terminal cysteine residues.
Kurooka H, Sugai M, Mori K, Yokota Y
Biochemical and biophysical research communications433(4)579-85(2013 Apr)

Interaction of Inhibitor of DNA binding 3 (Id3) with Gut-enriched Kr?ppel-like factor (GKLF) and p53 regulates proliferation of vascular smooth muscle cells.
Wassmann K, Mueller CF, Becher UM, Werner C, Jung A, Zimmer S, Steinmetz M, Nickenig G, Wassmann S
Molecular and cellular biochemistry333(1-2)33-9(2010 Jan)

A role for Id2 in regulating photic entrainment of the mammalian circadian system.
Duffield GE, Watson NP, Mantani A, Peirson SN, Robles-Murguia M, Loros JJ, Israel MA, Dunlap JC
Current biology : CB19(4)297-304(2009 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The function of GLCE in neuritogenesis via SMAD/ID3 signalling was studied via mutagenesis and gene silencing studies.
Title: GLCE regulates PC12 cell neuritogenesis induced by nerve growth factor through activating SMAD/ID3 signalling.

relevant interaction of GKLF, Id3, and p53 for VSMC proliferation
Title: Interaction of Inhibitor of DNA binding 3 (Id3) with Gut-enriched Kr?ppel-like factor (GKLF) and p53 regulates proliferation of vascular smooth muscle cells.

Id2, Id3, and Id4 proteins have roles in vibrissae follicle development
Title: Id2, Id3, and Id4 proteins show dynamic changes in expression during vibrissae follicle development.

Expression of all 4 members of the Id family of transcription factors is differentially regulated in response to orchidectomy along the epididymis.
Title: Expression, localization, and regulation of inhibitor of DNA binding (Id) proteins in the rat epididymis.

induced in the presence of Epstein-Barr virus LMP1 and confirmed by mRNA and protein in C33A and Rat-1 cells
Title: Induction of Id1 and Id3 by latent membrane protein 1 of Epstein-Barr virus and regulation of p27/Kip and cyclin-dependent kinase 2 in rodent fibroblast transformation.

The following Id3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Id3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa01810	NM_013058.2 Latest version!	Rattus norvegicus inhibitor of DNA binding 3, HLH protein (Id3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Id3 ( NM_013058.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037190.1 Rattus norvegicus inhibitor of DNA binding 3, HLH protein (Id3), mRNA.

Price & Availability↑

CloneID	ORa01810
Clone ID Related Accession (Same CDS sequence)	NM_013058.2
Accession Version	NM_013058.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 360bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-21
Organism	Rattus norvegicus(Norway rat)
Product	DNA-binding protein inhibitor ID-3
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC064658.1. On Feb 22, 2004 this sequence version replaced NM_013058.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC064658.1, DV724169.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGAAGGCGC TGAGCCCGGT GCGCGGCTGC TACGAGGCGG TGTGCTGCCT GTCGGAACGT 
AGCCTAGCCA TTGCGCGAGG CCGGGGTAAG AGCCCGTCGG CGGAGGAGCC GCTTAGCCTC 
TTGGACGACA TGAACCACTG CTACTCGCGC CTGCGGGAAC TGGTGCCGGG AGTCCCGCGG 
GGCACTCAGC TTAGCCAGGT GGAAATCCTG CAGCGTGTCA TAGACTACAT CCTCGACCTT 
CAAGTGGTTC TGGCAGAGCC CGCGCCTGGA CCCCCGGATG GTCCGCATCT CCCGATCCAG 
ACAGCTGAGC TCACTCCGGA ACTTGTGATC TCCAAGGACA AGAGGAGTTT TTGCCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037190.1
CDS	38..397
Translation	MKALSPVRGCYEAVCCLSERSLAIARGRGKSPSAEEPLSLLDDMNHCYSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQVVLAEPAPGPPDGPHLPIQTAELTPELVISKDKRSFCH

Target ORF information:

RefSeq Version	NM_013058.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus inhibitor of DNA binding 3, HLH protein (Id3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013058.2

ORF Insert Sequence:

ATGAAGGCGC TGAGCCCGGT GCGCGGCTGC TACGAGGCGG TGTGCTGCCT GTCGGAACGT 
AGCCTAGCCA TTGCGCGAGG CCGGGGTAAG AGCCCGTCGG CGGAGGAGCC GCTTAGCCTC 
TTGGACGACA TGAACCACTG CTACTCGCGC CTGCGGGAAC TGGTGCCGGG AGTCCCGCGG 
GGCACTCAGC TTAGCCAGGT GGAAATCCTG CAGCGTGTCA TAGACTACAT CCTCGACCTT 
CAAGTGGTTC TGGCAGAGCC CGCGCCTGGA CCCCCGGATG GTCCGCATCT CCCGATCCAG 
ACAGCTGAGC TCACTCCGGA ACTTGTGATC TCCAAGGACA AGAGGAGTTT TTGCCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

GLCE regulates PC12 cell neuritogenesis induced by nerve growth factor through activating SMAD/ID3 signalling.
The Biochemical journal459(2)405-15(2014 Apr)
Li J,Fang J,Qin Y,Liao W,Liu H,Zhou Y,Ding K

Ankyrin repeat domain protein 2 and inhibitor of DNA binding 3 cooperatively inhibit myoblast differentiation by physical interaction.
The Journal of biological chemistry288(34)24560-8(2013 Aug)
Mohamed JS,Lopez MA,Cox GA,Boriek AM

The metalloid arsenite induces nuclear export of Id3 possibly via binding to the N-terminal cysteine residues.
Biochemical and biophysical research communications433(4)579-85(2013 Apr)
Kurooka H,Sugai M,Mori K,Yokota Y

Interaction of Inhibitor of DNA binding 3 (Id3) with Gut-enriched Kr?ppel-like factor (GKLF) and p53 regulates proliferation of vascular smooth muscle cells.
Molecular and cellular biochemistry333(1-2)33-9(2010 Jan)
Wassmann K,Mueller CF,Becher UM,Werner C,Jung A,Zimmer S,Steinmetz M,Nickenig G,Wassmann S

A role for Id2 in regulating photic entrainment of the mammalian circadian system.
Current biology : CB19(4)297-304(2009 Feb)
Duffield GE,Watson NP,Mantani A,Peirson SN,Robles-Murguia M,Loros JJ,Israel MA,Dunlap JC

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Id3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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