ID3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ID3
Entrez Gene ID	3399
Full Name	inhibitor of DNA binding 3, HLH protein
Synonyms	HEIR-1,bHLHb25
General protein information	Preferred Names inhibitor of DNA binding 3, HLH protein Names DNA-binding protein inhibitor ID-3 ID-like protein inhibitor HLH 1R21 class B basic helix-loop-helix protein 25 helix-loop-helix protein HEIR-1 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein inhibitor of differentiation 3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p36.12
Summary	The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with other HLH proteins. However, the encoded protein lacks a basic DNA-binding domain and therefore inhibits the DNA binding of any HLH protein with which it interacts. [provided by RefSeq, Aug 2011].
Disorder MIM:	600277

mRNA and Protein(s)

mRNA	Protein	Name
NM_002167.4	NP_002158.3	DNA-binding protein inhibitor ID-3
NM_002167.5	NP_002158.3	DNA-binding protein inhibitor ID-3

Pathways from BioSystems

Homologies

Homo sapiens (human)	ID3	NP_002158.3
Xenopus tropicalis (tropical clawed frog)	id3	NP_001016271.1
Bos taurus (cattle)	ID3	NP_001014950.1
Mus musculus (house mouse)	Id3	NP_032347.1
Gallus gallus (chicken)	ID3	NP_989920.1
Danio rerio (zebrafish)	id3	NP_694499.1
Rattus norvegicus (Norway rat)	Id3	NP_037190.1
Pan troglodytes (chimpanzee)	ID3	XP_003949371.1
Canis lupus familiaris (dog)	ID3	NP_001003025.1

Gene Ontology
Bibliography

Related articles in PubMed

ID3 regulates the MDC1-mediated DNA damage response in order to maintain genome stability.
Lee JH, Park SJ, Hariharasudhan G, Kim MJ, Jung SM, Jeong SY, Chang IY, Kim C, Kim E, Yu J, Bae S, You HJ
Nature communications8(1)903(2017 Oct)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The results of the present study revealed that overexpression of Id3 may serve as a novel strategy for inhibiting cisplatinsensitive lung cancer.
Title: Upregulation of Id3 inhibits cell proliferation and induces apoptosis in A549/DDP human lung cancer cells in?vitro.

Results show that ID1, ID3 and IGJ genes are highly expressed in adult B-ALL and correlate with poor prognosis in Hispanic patients.
Title: High expression of ID family and IGJ genes signature as predictor of low induction treatment response and worst survival in adult Hispanic patients with B-acute lymphoblastic leukemia.

Upon Id3 transfection, A549 cells displayed decreased migratory and invasive capabilities, however, co-transfection of miRId3 and Id3 into A549 cells reversed the Id3-induced inhibitions of migratory and invasive capabilities.
Title: Effects of upregulation of Id3 in human lung adenocarcinoma cells on proliferation, apoptosis, mobility and tumorigenicity.

Inhibitor of differentiation 4 (ID4) acts as an inhibitor of ID-1, -2 and -3 and promotes basic helix loop helix (bHLH) E47 DNA binding and transcriptional activity.
Title: Inhibitor of differentiation 4 (ID4) acts as an inhibitor of ID-1, -2 and -3 and promotes basic helix loop helix (bHLH) E47 DNA binding and transcriptional activity.

ID3 has a role in the acquisition of molecular stem cell-like signature in microvascular endothelial cells
Title: ID3 contributes to the acquisition of molecular stem cell-like signature in microvascular endothelial cells: its implication for understanding microvascular diseases.

The following ID3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ID3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu11441	NM_002167.5 Latest version!	Homo sapiens inhibitor of DNA binding 3, HLH protein (ID3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu11441	NM_002167.4	Homo sapiens inhibitor of DNA binding 3, HLH protein (ID3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ID3 ( NM_002167.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002158.3 Homo sapiens inhibitor of DNA binding 3, HLH protein (ID3), mRNA.

Price & Availability↑

CloneID	OHu11441
Clone ID Related Accession (Same CDS sequence)	NM_002167.4 , NM_002167.5
Accession Version	NM_002167.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 360bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	DNA-binding protein inhibitor ID-3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X69111.1, AL021154.1 and BC003107.1. On Sep 1, 2011 this sequence version replaced NM_002167.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X69111.1, SRR1163657.256647.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGGCGC TGAGCCCGGT GCGCGGCTGC TACGAGGCGG TGTGCTGCCT GTCGGAACGC 
AGTCTGGCCA TCGCCCGGGG CCGAGGGAAG GGCCCGGCAG CTGAGGAGCC GCTGAGCTTG 
CTGGACGACA TGAACCACTG CTACTCCCGC CTGCGGGAAC TGGTACCCGG AGTCCCGAGA 
GGCACTCAGC TTAGCCAGGT GGAAATCCTA CAGCGCGTCA TCGACTACAT TCTCGACCTG 
CAGGTAGTCC TGGCCGAGCC AGCCCCTGGA CCCCCTGATG GCCCCCACCT TCCCATCCAG 
ACAGCCGAGC TCACTCCGGA ACTTGTCATC TCCAACGACA AAAGGAGCTT TTGCCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002158.3
CDS	369..728
Translation	MKALSPVRGCYEAVCCLSERSLAIARGRGKGPAAEEPLSLLDDMNHCYSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQVVLAEPAPGPPDGPHLPIQTAELTPELVISNDKRSFCH

Target ORF information:

RefSeq Version	NM_002167.4
Organism	Homo sapiens(human)
Definition	Homo sapiens inhibitor of DNA binding 3, HLH protein (ID3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002167.4

ORF Insert Sequence:

ATGAAGGCGC TGAGCCCGGT GCGCGGCTGC TACGAGGCGG TGTGCTGCCT GTCGGAACGC 
AGTCTGGCCA TCGCCCGGGG CCGAGGGAAG GGCCCGGCAG CTGAGGAGCC GCTGAGCTTG 
CTGGACGACA TGAACCACTG CTACTCCCGC CTGCGGGAAC TGGTACCCGG AGTCCCGAGA 
GGCACTCAGC TTAGCCAGGT GGAAATCCTA CAGCGCGTCA TCGACTACAT TCTCGACCTG 
CAGGTAGTCC TGGCCGAGCC AGCCCCTGGA CCCCCTGATG GCCCCCACCT TCCCATCCAG 
ACAGCCGAGC TCACTCCGGA ACTTGTCATC TCCAACGACA AAAGGAGCTT TTGCCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ID3 ( NM_002167.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_002158.3 Homo sapiens inhibitor of DNA binding 3, HLH protein (ID3), mRNA.

Price & Availability↑

CloneID	OHu11441
Clone ID Related Accession (Same CDS sequence)	NM_002167.4 , NM_002167.5
Accession Version	NM_002167.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 360bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-13
Organism	Homo sapiens(human)
Product	DNA-binding protein inhibitor ID-3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC003107.1 and AL021154.1. On Nov 23, 2018 this sequence version replaced NM_002167.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189655.174333.1, SRR5189655.132403.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000374561.6/ ENSP00000363689.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAGGCGC TGAGCCCGGT GCGCGGCTGC TACGAGGCGG TGTGCTGCCT GTCGGAACGC 
AGTCTGGCCA TCGCCCGGGG CCGAGGGAAG GGCCCGGCAG CTGAGGAGCC GCTGAGCTTG 
CTGGACGACA TGAACCACTG CTACTCCCGC CTGCGGGAAC TGGTACCCGG AGTCCCGAGA 
GGCACTCAGC TTAGCCAGGT GGAAATCCTA CAGCGCGTCA TCGACTACAT TCTCGACCTG 
CAGGTAGTCC TGGCCGAGCC AGCCCCTGGA CCCCCTGATG GCCCCCACCT TCCCATCCAG 
ACAGCCGAGC TCACTCCGGA ACTTGTCATC TCCAACGACA AAAGGAGCTT TTGCCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002158.3
CDS	76..435
Translation	MKALSPVRGCYEAVCCLSERSLAIARGRGKGPAAEEPLSLLDDMNHCYSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQVVLAEPAPGPPDGPHLPIQTAELTPELVISNDKRSFCH

Target ORF information:

RefSeq Version	NM_002167.5
Organism	Homo sapiens(human)
Definition	Homo sapiens inhibitor of DNA binding 3, HLH protein (ID3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002167.5

ORF Insert Sequence:

ATGAAGGCGC TGAGCCCGGT GCGCGGCTGC TACGAGGCGG TGTGCTGCCT GTCGGAACGC 
AGTCTGGCCA TCGCCCGGGG CCGAGGGAAG GGCCCGGCAG CTGAGGAGCC GCTGAGCTTG 
CTGGACGACA TGAACCACTG CTACTCCCGC CTGCGGGAAC TGGTACCCGG AGTCCCGAGA 
GGCACTCAGC TTAGCCAGGT GGAAATCCTA CAGCGCGTCA TCGACTACAT TCTCGACCTG 
CAGGTAGTCC TGGCCGAGCC AGCCCCTGGA CCCCCTGATG GCCCCCACCT TCCCATCCAG 
ACAGCCGAGC TCACTCCGGA ACTTGTCATC TCCAACGACA AAAGGAGCTT TTGCCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

ID3 regulates the MDC1-mediated DNA damage response in order to maintain genome stability.
Nature communications8(1)903(2017 Oct)
Lee JH,Park SJ,Hariharasudhan G,Kim MJ,Jung SM,Jeong SY,Chang IY,Kim C,Kim E,Yu J,Bae S,You HJ

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

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ID3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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