Sstr4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sstr4
Entrez Gene ID	25555
Full Name	somatostatin receptor 4
Synonyms	Smstr4
General protein information	Preferred Names somatostatin receptor 4 Names somatostatin receptor type 4 SS-4-R SS4-R SS4R Somatostatin receptor subtype 4 Rattus norvegicus Sprague-Dawley major hippocampal somatostatin receptor (SSTR4) mRNA
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3q41
Summary	transmembrane receptor for somatostatin; coupled to a G-protein which inhibits adenylyl cyclase; may also activate the mitogen-activated protein (MAP) kinase cascade [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_013036.2	NP_037168.1	somatostatin receptor type 4

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Sstr4	NP_037168.1
Gallus gallus (chicken)	SSTR4	NP_001026689.1
Mus musculus (house mouse)	Sstr4	NP_033245.2
Drosophila melanogaster (fruit fly)	AlCR2	NP_001262015.1
Anopheles gambiae (African malaria mosquito)	GPRSMS	XP_320274.2
Homo sapiens (human)	SSTR4	NP_001043.2
Pan troglodytes (chimpanzee)	SSTR4	XP_525282.1
Danio rerio (zebrafish)	LOC557645	XP_005172275.1
Xenopus tropicalis (tropical clawed frog)	LOC100496787	XP_004914786.1
	SSTR4	XP_001095303.1

Gene Ontology
Bibliography

Related articles in PubMed

Somatostatin receptor 1-5; expression profiles during rat development.
Ludvigsen E, Carlsson C, Tiensuu Janson E, Sandler S, Stridsberg M
Upsala journal of medical sciences120(3)157-68(2015)

Somatostatin 4 receptor activation modulates G-protein coupled inward rectifying potassium channels and voltage stimulated calcium signals in dorsal root ganglion neurons.
Gorham L, Just S, Doods H
European journal of pharmacology736101-6(2014 Aug)

Activity-regulated somatostatin expression reduces dendritic spine density and lowers excitatory synaptic transmission via postsynaptic somatostatin receptor 4.
Hou ZH, Yu X
The Journal of biological chemistry288(4)2501-9(2013 Jan)

Somatostatin stimulates the migration of hepatic oval cells in the injured rat liver.
Jung Y, Oh SH, Witek RP, Petersen BE
Liver international : official journal of the International Association for the Study of the Liver32(2)312-20(2012 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

All SSTR1-5 proteins were observed at embryonal day 10 and increased with time in major structures, but the localization varied between the different subtypes. SSTR3-4 was co-localized with insulin and pancreatic polypeptide.
Title: Somatostatin receptor 1-5; expression profiles during rat development.

sstr4 activation modulates G-protein coupled inward rectifying potassium channels and voltage stimulated calcium signals in dorsal root ganglion neurons, mechanisms thought to contribute to the analgesic propoerties sstr4 agonists
Title: Somatostatin 4 receptor activation modulates G-protein coupled inward rectifying potassium channels and voltage stimulated calcium signals in dorsal root ganglion neurons.

Activity-regulated somatostatin expression reduces dendritic spine density and lowers excitatory synaptic transmission via postsynaptic somatostatin receptor 4
Title: Activity-regulated somatostatin expression reduces dendritic spine density and lowers excitatory synaptic transmission via postsynaptic somatostatin receptor 4.

Somatostatin stimulates the migration of hepatic oval cells within injured liver through SSTR4, and this action appears to be mediated by the PI3K pathway.
Title: Somatostatin stimulates the migration of hepatic oval cells in the injured rat liver.

Somatostatin receptor subtype 4 is expressed specifically in retinal ganglion cells. Action potentials are reduced during inhibition.
Title: Modulation of voltage-gated ion channels in rat retinal ganglion cells mediated by somatostatin receptor subtype 4.

The following Sstr4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sstr4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00050	NM_013036.2 Latest version!	Rattus norvegicus somatostatin receptor 4 (Sstr4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sstr4 ( NM_013036.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037168.1 Rattus norvegicus somatostatin receptor 4 (Sstr4), mRNA.

Price & Availability↑

CloneID	ORa00050
Clone ID Related Accession (Same CDS sequence)	NM_013036.2
Accession Version	NM_013036.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1155bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-15
Organism	Rattus norvegicus(Norway rat)
Product	somatostatin receptor type 4
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U04738.1. On Dec 20, 2003 this sequence version replaced NM_013036.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U04738.1 [ECO:0000332] ##Evidence-Data-END##

ATGAACACGC CTGCAACTCT GCCCCTGGGG GGCGAGGACA CCACCTGGAC CCCTGGGATC 
AACGCCAGCT GGGCTCCGGA TGAGGAGGAG GATGCAGTGC GGTCCGACGG CACGGGGACA 
GCGGGCATGG TAACTATCCA GTGCATCTAT GCGCTCGTGT GTCTGGTGGG CCTGGTAGGA 
AACGCCCTGG TCATATTCGT GATCCTACGC TATGCCAAAA TGAAGACAGC CACCAACATC 
TACCTGCTCA ACCTGGCCGT CGCTGATGAG CTCTTCATGC TCAGTGTGCC ATTTGTGGCC 
TCGGCGGCTG CCCTGCGCCA CTGGCCGTTC GGGGCGGTGC TGTGCCGCGC AGTGCTTAGT 
GTGGACGGCC TTAACATGTT CACGAGTGTC TTCTGCCTCA CAGTGCTCAG CGTGGATCGC 
TATGTGGCTG TAGTGCACCC TCTGCGAGCT GCCACCTACC GGCGGCCCAG CGTGGCCAAG 
CTAATCAACC TGGGAGTGTG GCTAGCATCC TTGCTGGTCA CCCTGCCCAT CGCAGTCTTC 
GCTGACACTA GGCCAGCTCG TGGGGGTGAG GCAGTAGCTT GCAACCTGCA CTGGCCTCAC 
CCGGCCTGGT CTGCAGTCTT TGTGATCTAT ACTTTTTTGC TGGGCTTCCT ACTCCCGGTT 
CTGGCTATCG GATTATGTTA CCTGCTTATC GTGGGCAAGA TGCGTGCTGT GGCCCTGCGG 
GCTGGCTGGC AACAACGGAG GCGCTCAGAG AAGAAGATCA CTAGGCTCGT GCTAATGGTG 
GTGACTGTCT TTGTGCTATG CTGGATGCCA TTCTATGTAG TGCAGCTTCT GAATCTGTTT 
GTCACCAGCC TCGATGCCAC TGTCAACCAT GTGTCCCTCA TCCTCAGCTA TGCCAACAGC 
TGTGCCAACC CGATTCTCTA TGGTTTCCTC TCAGACAACT TCCGACGCTC TTTCCAGCGG 
GTTCTGTGCC TGCGCTGCTG TCTCCTGGAA ACAACTGGAG GTGCTGAGGA AGAGCCCCTG 
GACTACTATG CTACTGCTCT CAAAAGCAGA GGTGGCCCAG GATGCATATG CCCTCCATTG 
CCCTGCCAGC AGGAGCCCAT GCAAGCAGAA CCTGCCTGCA AGCGAGTCCC TTTCACCAAG 
ACCACTACTT TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037168.1
CDS	59..1213
Translation	MNTPATLPLGGEDTTWTPGINASWAPDEEEDAVRSDGTGTAGMVTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHWPHPAWSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTSLDATVNHVSLILSYANSCANPILYGFLSDNFRRSFQRVLCLRCCLLETTGGAEEEPLDYYATALKSRGGPGCICPPLPCQQEPMQAEPACKRVPFTKTTTF

Target ORF information:

RefSeq Version	NM_013036.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus somatostatin receptor 4 (Sstr4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013036.2

ORF Insert Sequence:

ATGAACACGC CTGCAACTCT GCCCCTGGGG GGCGAGGACA CCACCTGGAC CCCTGGGATC 
AACGCCAGCT GGGCTCCGGA TGAGGAGGAG GATGCAGTGC GGTCCGACGG CACGGGGACA 
GCGGGCATGG TAACTATCCA GTGCATCTAT GCGCTCGTGT GTCTGGTGGG CCTGGTAGGA 
AACGCCCTGG TCATATTCGT GATCCTACGC TATGCCAAAA TGAAGACAGC CACCAACATC 
TACCTGCTCA ACCTGGCCGT CGCTGATGAG CTCTTCATGC TCAGTGTGCC ATTTGTGGCC 
TCGGCGGCTG CCCTGCGCCA CTGGCCGTTC GGGGCGGTGC TGTGCCGCGC AGTGCTTAGT 
GTGGACGGCC TTAACATGTT CACGAGTGTC TTCTGCCTCA CAGTGCTCAG CGTGGATCGC 
TATGTGGCTG TAGTGCACCC TCTGCGAGCT GCCACCTACC GGCGGCCCAG CGTGGCCAAG 
CTAATCAACC TGGGAGTGTG GCTAGCATCC TTGCTGGTCA CCCTGCCCAT CGCAGTCTTC 
GCTGACACTA GGCCAGCTCG TGGGGGTGAG GCAGTAGCTT GCAACCTGCA CTGGCCTCAC 
CCGGCCTGGT CTGCAGTCTT TGTGATCTAT ACTTTTTTGC TGGGCTTCCT ACTCCCGGTT 
CTGGCTATCG GATTATGTTA CCTGCTTATC GTGGGCAAGA TGCGTGCTGT GGCCCTGCGG 
GCTGGCTGGC AACAACGGAG GCGCTCAGAG AAGAAGATCA CTAGGCTCGT GCTAATGGTG 
GTGACTGTCT TTGTGCTATG CTGGATGCCA TTCTATGTAG TGCAGCTTCT GAATCTGTTT 
GTCACCAGCC TCGATGCCAC TGTCAACCAT GTGTCCCTCA TCCTCAGCTA TGCCAACAGC 
TGTGCCAACC CGATTCTCTA TGGTTTCCTC TCAGACAACT TCCGACGCTC TTTCCAGCGG 
GTTCTGTGCC TGCGCTGCTG TCTCCTGGAA ACAACTGGAG GTGCTGAGGA AGAGCCCCTG 
GACTACTATG CTACTGCTCT CAAAAGCAGA GGTGGCCCAG GATGCATATG CCCTCCATTG 
CCCTGCCAGC AGGAGCCCAT GCAAGCAGAA CCTGCCTGCA AGCGAGTCCC TTTCACCAAG 
ACCACTACTT TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Somatostatin receptor 1-5; expression profiles during rat development.
Upsala journal of medical sciences120(3)157-68(2015)
Ludvigsen E,Carlsson C,Tiensuu Janson E,Sandler S,Stridsberg M

Somatostatin 4 receptor activation modulates G-protein coupled inward rectifying potassium channels and voltage stimulated calcium signals in dorsal root ganglion neurons.
European journal of pharmacology736101-6(2014 Aug)
Gorham L,Just S,Doods H

Activity-regulated somatostatin expression reduces dendritic spine density and lowers excitatory synaptic transmission via postsynaptic somatostatin receptor 4.
The Journal of biological chemistry288(4)2501-9(2013 Jan)
Hou ZH,Yu X

Somatostatin stimulates the migration of hepatic oval cells in the injured rat liver.
Liver international : official journal of the International Association for the Study of the Liver32(2)312-20(2012 Feb)
Jung Y,Oh SH,Witek RP,Petersen BE

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Sstr4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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