Atp5if1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Atp5if1
Entrez Gene ID	25392
Full Name	ATP synthase inhibitory factor subunit 1
Synonyms	Atpi,Atpif1,IF1PA
General protein information	Preferred Names ATP synthase inhibitory factor subunit 1 Names ATPase inhibitor, mitochondrial ATPase inhibitor (rat mitochondrial IF1 protein) ATPase inhibitory factor 1 IF(1) IF1 inhibitor of F(1)F(o)-ATPase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q36
Summary	inhibits ATP hydrolysis catalyzed by the mitochondrial ATP synthase/ATPase complex [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012915.2	NP_037047.2	ATPase inhibitor, mitochondrial precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	ATPIF1	XP_003339032.1
Danio rerio (zebrafish)	atpif1a	NP_001082990.1
Rattus norvegicus (Norway rat)	Atpif1	NP_037047.2
	ATPIF1	XP_001113002.1
Canis lupus familiaris (dog)	ATPIF1	XP_865710.1
Homo sapiens (human)	ATPIF1	NP_057395.1
Bos taurus (cattle)	ATPIF1	NP_787010.1
Mus musculus (house mouse)	Atpif1	NP_031538.2
Danio rerio (zebrafish)	atpif1b	NP_001038324.1
Xenopus tropicalis (tropical clawed frog)	atpif1	NP_001135565.1

Gene Ontology
Bibliography

Related articles in PubMed

Neuroprotective coordination of cell mitophagy by the ATPase Inhibitory Factor 1.
Matic I, Cocco S, Ferraina C, Martin-Jimenez R, Florenzano F, Crosby J, Lupi R, Amadoro G, Russell C, Pignataro G, Annunziato L, Abramov AY, Campanella M
Pharmacological research10356-68(2016 Jan)

Potential role of subunit c of F0F1-ATPase and subunit c of storage body in the mitochondrial permeability transition. Effect of the phosphorylation status of subunit c on pore opening.
Azarashvili T, Odinokova I, Bakunts A, Ternovsky V, Krestinina O, Tyynel? J, Saris NE
Cell calcium55(2)69-77(2014 Feb)

Genome-wide RNAi screen identifies ATPase inhibitory factor 1 (ATPIF1) as essential for PARK2 recruitment and mitophagy.
Lefebvre V, Du Q, Baird S, Ng AC, Nascimento M, Campanella M, McBride HM, Screaton RA
Autophagy9(11)1770-9(2013 Nov)

Mitochondrial Atpif1 regulates haem synthesis in developing erythroblasts.
Shah DI, Takahashi-Makise N, Cooney JD, Li L, Schultz IJ, Pierce EL, Narla A, Seguin A, Hattangadi SM, Medlock AE, Langer NB, Dailey TA, Hurst SN, Faccenda D, Wiwczar JM, Heggers SK, Vogin G, Chen W, Chen C, Campagna DR, Brugnara C, Zhou Y, Ebert BL, Danial NN, Fleming MD, Ward DM, Campanella M, Dailey HA, Kaplan J, Paw BH
Nature491(7425)608-12(2012 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These data suggest that in mammalian neurons mitochondria adapt to respiratory stress by upregulating IF1, which exerts a protective role by coordinating pro-survival cell mitophagy and bioenergetics resilience
Title: Neuroprotective coordination of cell mitophagy by the ATPase Inhibitory Factor 1.

The subunit c of F0F1-ATPase is a structural and/or regulatory component of the mPTP complex, whose activity might be modulated bycalcium-dependent phosphorylation.
Title: Potential role of subunit c of F0F1-ATPase and subunit c of storage body in the mitochondrial permeability transition. Effect of the phosphorylation status of subunit c on pore opening.

Hypoxia-inducible factor 1alpha regulates the expression of the mitochondrial ATPase inhibitor protein (IF1) in rat liver.
Title: Hypoxia-inducible factor 1? regulates the expression of the mitochondrial ATPase inhibitor protein (IF1) in rat liver.

Findings support that the mitochondrial content of IF1 controls the activity of oxidative phosphorylation mediating the shift of cancer cells to an enhanced aerobic glycolysis.
Title: Up-regulation of the ATPase inhibitory factor 1 (IF1) of the mitochondrial H+-ATP synthase in human tumors mediates the metabolic shift of cancer cells to a Warburg phenotype.

The ectopic F(O)F(1) ATP synthase of rat liver is modulated in acute cholestasis by the inhibitor protein IF1.
Title: The ectopic F(O)F(1) ATP synthase of rat liver is modulated in acute cholestasis by the inhibitor protein IF1.

The following Atp5if1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Atp5if1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12400	NM_012915.2 Latest version!	Rattus norvegicus ATP synthase inhibitory factor subunit 1 (Atp5if1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Atp5if1 ( NM_012915.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037047.2 Rattus norvegicus ATP synthase inhibitory factor subunit 1 (Atp5if1), mRNA.

Price & Availability↑

CloneID	ORa12400
Clone ID Related Accession (Same CDS sequence)	NM_012915.2
Accession Version	NM_012915.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 324bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Rattus norvegicus(Norway rat)
Product	ATPase inhibitor, mitochondrial precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D13122.1. On Oct 20, 2005 this sequence version replaced NM_012915.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D13122.1, BF557657.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906347, SAMN01906348 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END##

ATGGCAGGCT CGGCGTTGGC GGTTCGGGCT CGGCTCGGTG TCTGGGGTAT GAGGGTCCTG 
CAAACCCGAG GCTTCGGCTC GGACTCGTCG GAGAGCATGG ATTCGGGCGC TGGCTCCATC 
CGAGAAGCTG GTGGGGCCTT CGGGAAACGA GAGAAGGCTG AAGAGGATCG GTACTTCCGA 
GAGAAGACTA GAGAGCAGCT GGCTGCCTTG AAGAAGCACC ATGAAGATGA GATTGACCAC 
CATTCGAAGG AGATAGAGCG TCTGCAAAAA CAGATCGAAC GGCATAAGAA GAAGATTAAA 
TACCTAAAGA ATAGTGAGCA TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037047.2
CDS	40..363
Translation	MAGSALAVRARLGVWGMRVLQTRGFGSDSSESMDSGAGSIREAGGAFGKREKAEEDRYFREKTREQLAALKKHHEDEIDHHSKEIERLQKQIERHKKKIKYLKNSEH

Target ORF information:

RefSeq Version	NM_012915.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ATP synthase inhibitory factor subunit 1 (Atp5if1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012915.2

ORF Insert Sequence:

ATGGCAGGCT CGGCGTTGGC GGTTCGGGCT CGGCTCGGTG TCTGGGGTAT GAGGGTCCTG 
CAAACCCGAG GCTTCGGCTC GGACTCGTCG GAGAGCATGG ATTCGGGCGC TGGCTCCATC 
CGAGAAGCTG GTGGGGCCTT CGGGAAACGA GAGAAGGCTG AAGAGGATCG GTACTTCCGA 
GAGAAGACTA GAGAGCAGCT GGCTGCCTTG AAGAAGCACC ATGAAGATGA GATTGACCAC 
CATTCGAAGG AGATAGAGCG TCTGCAAAAA CAGATCGAAC GGCATAAGAA GAAGATTAAA 
TACCTAAAGA ATAGTGAGCA TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Neuroprotective coordination of cell mitophagy by the ATPase Inhibitory Factor 1.
Pharmacological research10356-68(2016 Jan)
Matic I,Cocco S,Ferraina C,Martin-Jimenez R,Florenzano F,Crosby J,Lupi R,Amadoro G,Russell C,Pignataro G,Annunziato L,Abramov AY,Campanella M

Potential role of subunit c of F0F1-ATPase and subunit c of storage body in the mitochondrial permeability transition. Effect of the phosphorylation status of subunit c on pore opening.
Cell calcium55(2)69-77(2014 Feb)
Azarashvili T,Odinokova I,Bakunts A,Ternovsky V,Krestinina O,Tyynel? J,Saris NE

Genome-wide RNAi screen identifies ATPase inhibitory factor 1 (ATPIF1) as essential for PARK2 recruitment and mitophagy.
Autophagy9(11)1770-9(2013 Nov)
Lefebvre V,Du Q,Baird S,Ng AC,Nascimento M,Campanella M,McBride HM,Screaton RA

Mitochondrial Atpif1 regulates haem synthesis in developing erythroblasts.
Nature491(7425)608-12(2012 Nov)
Shah DI,Takahashi-Makise N,Cooney JD,Li L,Schultz IJ,Pierce EL,Narla A,Seguin A,Hattangadi SM,Medlock AE,Langer NB,Dailey TA,Hurst SN,Faccenda D,Wiwczar JM,Heggers SK,Vogin G,Chen W,Chen C,Campagna DR,Brugnara C,Zhou Y,Ebert BL,Danial NN,Fleming MD,Ward DM,Campanella M,Dailey HA,Kaplan J,Paw BH

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Atp5if1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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