Fyn cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fyn
Entrez Gene ID	25150
Full Name	FYN proto-oncogene, Src family tyrosine kinase
General protein information	Preferred Names FYN proto-oncogene, Src family tyrosine kinase Names tyrosine-protein kinase Fyn FYN oncogene related to SRC, FGR, YES p59-Fyn proto-oncogene c-Fyn proto-oncogene tyrosine-protein kinase Fyn
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 20 Map Location: 20q12
Summary	may mediate tyrosine phosphorylation of Cbl protein in cerebellum in response to ethanol administration [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017601549.1	XP_017457038.1	tyrosine-protein kinase Fyn isoform X1
XM_006256522.1	XP_006256584.1	tyrosine-protein kinase Fyn isoform X2
NM_012755.1	NP_036887.1	tyrosine-protein kinase Fyn

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	fynb	NP_001025140.1
Homo sapiens (human)	FYN	NP_694592.1
Pan troglodytes (chimpanzee)	FYN	XP_001159342.1
	FYN	XP_001085015.1
Bos taurus (cattle)	FYN	NP_001071440.1
Gallus gallus (chicken)	FYN	NP_990680.1
Caenorhabditis elegans (roundworm)	src-1	NP_490866.4
Canis lupus familiaris (dog)	FYN	XP_005627774.1
Mus musculus (house mouse)	Fyn	NP_032080.2
Xenopus tropicalis (tropical clawed frog)	fyn	XP_002936976.2
Rattus norvegicus (Norway rat)	Fyn	NP_036887.1

Gene Ontology
Bibliography

Related articles in PubMed

BDNF Contributes to Spinal Long-Term Potentiation and Mechanical Hypersensitivity Via Fyn-Mediated Phosphorylation of NMDA Receptor GluN2B Subunit at Tyrosine 1472 in Rats Following Spinal Nerve Ligation.
Li S, Cai J, Feng ZB, Jin ZR, Liu BH, Zhao HY, Jing HB, Wei TJ, Yang GN, Liu LY, Cui YJ, Xing GG
Neurochemical research42(10)2712-2729(2017 Oct)

An Essential Role of Fyn in the Modulation of Metabotropic Glutamate Receptor 1 in Neurons.
Jin DZ, Mao LM, Wang JQ
eNeuro4(4)(2017 Jul-Aug)

Potentiation of Synaptic GluN2B NMDAR Currents by Fyn Kinase Is Gated through BDNF-Mediated Disinhibition in Spinal Pain Processing.
Hildebrand ME, Xu J, Dedek A, Li Y, Sengar AS, Beggs S, Lombroso PJ, Salter MW
Cell reports17(10)2753-2765(2016 12)

Dynamically Coupled Residues within the SH2 Domain of FYN Are Key to Unlocking Its Activity.
Huculeci R, Cilia E, Lyczek A, Buts L, Houben K, Seeliger MA, van Nuland N, Lenaerts T
Structure (London, England : 1993)24(11)1947-1959(2016 11)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

We find that BDNF mediates NMDAR potentiation through activation of TrkB and phosphorylation of the GluN2B subunit by the Src-family kinase Fyn
Title: Potentiation of Synaptic GluN2B NMDAR Currents by Fyn Kinase Is Gated through BDNF-Mediated Disinhibition in Spinal Pain Processing.

results indicate that D2Rs inhibit SFK (mainly Fyn) phosphorylation in the striatum
Title: Dopamine D2 receptors are involved in the regulation of Fyn and metabotropic glutamate receptor 5 phosphorylation in the rat striatum in vivo.

Results identified Fyn kinase as a molecular mediator of BDNF signaling that activates Erk1/2 and promotes oligodendrocyte myelination
Title: Fyn is an intermediate kinase that BDNF utilizes to promote oligodendrocyte myelination.

Study demonstrated that D1Rs regulate Fyn and downstream NMDA receptors in striatal neurons in vivo, acetylcholine through activating M4Rs inhibited Fyn and NMDA receptors in their sensitivity to D1R signaling
Title: Dopaminergic and cholinergic regulation of Fyn tyrosine kinase phosphorylation in the rat striatum in?vivo.

The Fyn-mediated NR2B tyrosine phosphorylation, can enhance NMDA receptor function.
Title: Postsynaptic density protein 95-regulated NR2B tyrosine phosphorylation and interactions of Fyn with NR2B in levodopa-induced dyskinesia rat models.

The following Fyn gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fyn cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa00844	NM_012755.1 Latest version!	Rattus norvegicus FYN proto-oncogene, Src family tyrosine kinase (Fyn), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$314.30 $449.00
ORa39504	XM_006256522.1 Latest version!	Rattus norvegicus FYN proto-oncogene, Src family tyrosine kinase (Fyn), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
ORa60042	XM_017601549.1 Latest version!	Rattus norvegicus FYN proto-oncogene, Src family tyrosine kinase (Fyn), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fyn ( NM_012755.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036887.1 Rattus norvegicus FYN proto-oncogene, Src family tyrosine kinase (Fyn), mRNA.

Price & Availability↑

CloneID	ORa00844
Clone ID Related Accession (Same CDS sequence)	NM_012755.1
Accession Version	NM_012755.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1614bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Rattus norvegicus(Norway rat)
Product	tyrosine-protein kinase Fyn
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U35365.1. On Jun 25, 2006 this sequence version replaced XM_001062721.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U35365.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGGCTGTG TGCAATGTAA GGATAAAGAA GCAGCGAAAC TGACGGAGGA GAGGGACGGC 
AGCCTGAACC AGAGCTCTGG GTACCGCTAT GGCACAGACC CCACCCCTCA GCACTACCCC 
AGCTTCGGTG TGACCTCCAT CCCGAACTAC AACAACTTCC ACGCAGCCGG GGGCCAGGGA 
CTCACGGTCT TTGGGGGTGT GAACTCCTCC TCTCACACCG GGACCCTGCG TACTAGAGGA 
GGGACAGGAG TGACACTATT TGTGGCACTT TATGACTATG AAGCACGGAC AGAAGATGAC 
CTGAGTTTTC ACAAAGGAGA AAAATTTCAA ATATTGAACA GCTCGGAAGG AGACTGGTGG 
GAAGCCCGCT CCTTGACAAC TGGGGAAACT GGTTACATTC CTAGCAACTA CGTGGCTCCA 
GTTGACTCCA TCCAGGCAGA AGAGTGGTAC TTTGGAAAAC TTGGCCGCAA GGATGCTGAG 
AGACAGCTCC TGTCCTTTGG AAACCCAAGA GGTACCTTTC TTATCCGCGA GAGCGAAACC 
ACCAAAGGTG CCTACTCCCT CTCCATCCGA GACTGGGACG ACATGAAGGG AGACCATGTC 
AAACATTACA AAATCCGCAA GCTTGACAAC GGCGGGTACT ACATCACCAC GAGGGCCCAG 
TTTGAGACCC TTCAGCAGCT TGTACAGCAT TACTCAGAGA GAGCCGCGGG TCTCTGCTGC 
CGTCTAGTAG TTCCCTGTCA CAAAGGGATG CCAAGGCTTA CCGATCTGTC TGTCAAAACC 
AAAGATGTCT GGGAAATCCC TCGAGAATCC CTGCAGTTGA TCAAGAGACT GGGAAATGGG 
CAGTTTGGGG AAGTATGGAT GGGTACCTGG AATGGAAACA CAAAAGTAGC CATAAAGACT 
CTTAAGCCAG GCACAATGTC CCCGGAATCC TTCCTGGAGG AAGCACAGAT CATGAAGAAG 
CTGAAGCACG ACAAGCTGGT GCAGCTCTAT GCAGTTGTGT CCGAAGAGCC CATTTACATT 
GTCACGGAAT ACATGAACAA AGGAAGTTTG CTCGACTTCT TAAAAGACGG TGAAGGACGG 
GCTCTGAAAT TGCCAAACCT CGTGGACATG GCGGCACAGG TTGCTGCAGG AATGGCTTAC 
ATCGAACGCA TGAATTATAT CCACAGAGAT CTGCGGTCAG CTAACATTCT GGTGGGGAAC 
GGACTCATTT GCAAGATTGC TGACTTCGGA TTGGCCCGGT TGATTGAAGA CAATGAGTAC 
ACAGCCAGAC AAGGTGCAAA GTTTCCCATT AAGTGGACAG CCCCCGAAGC GGCCCTGTAT 
GGAAGGTTCA CAATCAAGTC TGACGTGTGG TCCTTTGGAA TCTTACTCAC AGAGCTGGTC 
ACCAAAGGCA GAGTGCCGTA CCCAGGCATG AACAACCGTG AGGTGCTGGA GCAGGTGGAG 
AGAGGCTACA GGATGCCCTG CCCGCAGGAC TGCCCGATCT CCCTGCACGA GCTCATGATC 
CACTGCTGGA AAAAGGATCC GGAGGAGCGC CCCACTTTCG AGTACTTGCA GGGCTTCCTG 
GAGGACTACT TTACCGCCAC AGAGCCCCAG TATCAGCCCG GTGAAAACCT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036887.1
CDS	231..1844
Translation	MGCVQCKDKEAAKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQGFLEDYFTATEPQYQPGENL

Target ORF information:

RefSeq Version	NM_012755.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus FYN proto-oncogene, Src family tyrosine kinase (Fyn), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012755.1

ORF Insert Sequence:

ATGGGCTGTG TGCAATGTAA GGATAAAGAA GCAGCGAAAC TGACGGAGGA GAGGGACGGC 
AGCCTGAACC AGAGCTCTGG GTACCGCTAT GGCACAGACC CCACCCCTCA GCACTACCCC 
AGCTTCGGTG TGACCTCCAT CCCGAACTAC AACAACTTCC ACGCAGCCGG GGGCCAGGGA 
CTCACGGTCT TTGGGGGTGT GAACTCCTCC TCTCACACCG GGACCCTGCG TACTAGAGGA 
GGGACAGGAG TGACACTATT TGTGGCACTT TATGACTATG AAGCACGGAC AGAAGATGAC 
CTGAGTTTTC ACAAAGGAGA AAAATTTCAA ATATTGAACA GCTCGGAAGG AGACTGGTGG 
GAAGCCCGCT CCTTGACAAC TGGGGAAACT GGTTACATTC CTAGCAACTA CGTGGCTCCA 
GTTGACTCCA TCCAGGCAGA AGAGTGGTAC TTTGGAAAAC TTGGCCGCAA GGATGCTGAG 
AGACAGCTCC TGTCCTTTGG AAACCCAAGA GGTACCTTTC TTATCCGCGA GAGCGAAACC 
ACCAAAGGTG CCTACTCCCT CTCCATCCGA GACTGGGACG ACATGAAGGG AGACCATGTC 
AAACATTACA AAATCCGCAA GCTTGACAAC GGCGGGTACT ACATCACCAC GAGGGCCCAG 
TTTGAGACCC TTCAGCAGCT TGTACAGCAT TACTCAGAGA GAGCCGCGGG TCTCTGCTGC 
CGTCTAGTAG TTCCCTGTCA CAAAGGGATG CCAAGGCTTA CCGATCTGTC TGTCAAAACC 
AAAGATGTCT GGGAAATCCC TCGAGAATCC CTGCAGTTGA TCAAGAGACT GGGAAATGGG 
CAGTTTGGGG AAGTATGGAT GGGTACCTGG AATGGAAACA CAAAAGTAGC CATAAAGACT 
CTTAAGCCAG GCACAATGTC CCCGGAATCC TTCCTGGAGG AAGCACAGAT CATGAAGAAG 
CTGAAGCACG ACAAGCTGGT GCAGCTCTAT GCAGTTGTGT CCGAAGAGCC CATTTACATT 
GTCACGGAAT ACATGAACAA AGGAAGTTTG CTCGACTTCT TAAAAGACGG TGAAGGACGG 
GCTCTGAAAT TGCCAAACCT CGTGGACATG GCGGCACAGG TTGCTGCAGG AATGGCTTAC 
ATCGAACGCA TGAATTATAT CCACAGAGAT CTGCGGTCAG CTAACATTCT GGTGGGGAAC 
GGACTCATTT GCAAGATTGC TGACTTCGGA TTGGCCCGGT TGATTGAAGA CAATGAGTAC 
ACAGCCAGAC AAGGTGCAAA GTTTCCCATT AAGTGGACAG CCCCCGAAGC GGCCCTGTAT 
GGAAGGTTCA CAATCAAGTC TGACGTGTGG TCCTTTGGAA TCTTACTCAC AGAGCTGGTC 
ACCAAAGGCA GAGTGCCGTA CCCAGGCATG AACAACCGTG AGGTGCTGGA GCAGGTGGAG 
AGAGGCTACA GGATGCCCTG CCCGCAGGAC TGCCCGATCT CCCTGCACGA GCTCATGATC 
CACTGCTGGA AAAAGGATCC GGAGGAGCGC CCCACTTTCG AGTACTTGCA GGGCTTCCTG 
GAGGACTACT TTACCGCCAC AGAGCCCCAG TATCAGCCCG GTGAAAACCT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Fyn ( XM_006256522.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006256584.1 Rattus norvegicus FYN proto-oncogene, Src family tyrosine kinase (Fyn), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa39504
Clone ID Related Accession (Same CDS sequence)	XM_006256522.1
Accession Version	XM_006256522.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1728bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	tyrosine-protein kinase Fyn isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005119.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGCTCCG GAACCGAGCG CCACGCCACG CAGGGTCAGT CCTACTGCTG GTTTAGAAGA 
CATGTGGTGT ATATAACGTT TGTGATAGTT GGTGGAAATT TGGGAGCTTG GATAATGGGC 
TGTGTGCAAT GTAAGGATAA AGAAGCAGCG AAACTGACGG AGGAGAGGGA CGGCAGCCTG 
AACCAGAGCT CTGGGTACCG CTATGGCACA GACCCCACCC CTCAGCACTA CCCCAGCTTC 
GGTGTGACCT CCATCCCGAA CTACAACAAC TTCCACGCAG CCGGGGGCCA GGGACTCACG 
GTCTTTGGGG GTGTGAACTC CTCCTCTCAC ACCGGGACCC TGCGTACTAG AGGAGGGACA 
GGAGTGACAC TATTTGTGGC ACTTTATGAC TATGAAGCAC GGACAGAAGA TGACCTGAGT 
TTTCACAAAG GAGAAAAATT TCAAATATTG AACAGCTCGG AAGGAGACTG GTGGGAAGCC 
CGCTCCTTGA CAACTGGGGA AACTGGTTAC ATTCCTAGCA ACTACGTGGC TCCAGTTGAC 
TCCATCCAGG CAGAAGAGTG GTACTTTGGA AAACTTGGCC GCAAGGATGC TGAGAGACAG 
CTCCTGTCCT TTGGAAACCC AAGAGGTACC TTTCTTATCC GCGAGAGCGA AACCACCAAA 
GGTGCCTACT CCCTCTCCAT CCGAGACTGG GACGACATGA AGGGAGACCA CGTCAAACAT 
TACAAAATCC GCAAGCTTGA CAACGGCGGG TACTACATCA CCACGAGGGC CCAGTTTGAG 
ACCCTTCAGC AGCTTGTACA GCATTACTCA GAGAGAGCCG CGGGTCTCTG CTGCCGTCTA 
GTAGTTCCCT GTCACAAAGG GATGCCAAGG CTTACCGATC TGTCTGTCAA AACCAAAGAT 
GTCTGGGAAA TCCCTCGAGA ATCCCTGCAG TTGATCAAGA GACTGGGAAA TGGGCAGTTT 
GGGGAAGTAT GGATGGGTAC CTGGAATGGA AACACAAAAG TAGCCATAAA GACTCTTAAG 
CCAGGCACAA TGTCCCCGGA ATCCTTCCTG GAGGAAGCAC AGATCATGAA GAAGCTGAAG 
CACGACAAGC TGGTGCAGCT CTATGCAGTT GTGTCCGAAG AGCCCATTTA CATTGTCACG 
GAATACATGA ACAAAGGAAG TTTGCTCGAC TTCTTAAAAG ACGGTGAAGG ACGGGCTCTG 
AAATTGCCAA ACCTCGTGGA CATGGCGGCA CAGGTTGCTG CAGGAATGGC TTACATCGAA 
CGCATGAATT ATATCCACAG AGATCTGCGG TCAGCTAACA TTCTGGTGGG GAACGGACTC 
ATTTGCAAGA TTGCTGACTT CGGATTGGCC CGGTTGATTG AAGACAATGA GTACACAGCC 
AGACAAGGTG CAAAGTTTCC CATTAAGTGG ACAGCCCCCG AAGCGGCCCT GTATGGAAGG 
TTCACAATCA AGTCTGACGT GTGGTCCTTT GGAATCTTAC TCACAGAGCT GGTCACCAAA 
GGCAGAGTGC CGTACCCAGG CATGAACAAC CGTGAGGTGC TGGAGCAGGT GGAGAGAGGC 
TACAGGATGC CCTGCCCGCA GGACTGCCCG ATCTCCCTGC ACGAGCTCAT GATCCACTGC 
TGGAAAAAGG ATCCGGAGGA GCGCCCCACT TTCGAGTACT TGCAGGGCTT CCTGGAGGAC 
TACTTTACCG CCACAGAGCC CCAGTATCAG CCCGGTGAAA ACCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006256584.1
CDS	404..2131
Translation	MCSGTERHATQGQSYCWFRRHVVYITFVIVGGNLGAWIMGCVQCKDKEAAKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQGFLEDYFTATEPQYQPGENL

Target ORF information:

RefSeq Version	XM_006256522.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus FYN proto-oncogene, Src family tyrosine kinase (Fyn), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006256522.1

ORF Insert Sequence:

ATGTGCTCCG GAACCGAGCG CCACGCCACG CAGGGTCAGT CCTACTGCTG GTTTAGAAGA 
CATGTGGTGT ATATAACGTT TGTGATAGTT GGTGGAAATT TGGGAGCTTG GATAATGGGC 
TGTGTGCAAT GTAAGGATAA AGAAGCAGCG AAACTGACGG AGGAGAGGGA CGGCAGCCTG 
AACCAGAGCT CTGGGTACCG CTATGGCACA GACCCCACCC CTCAGCACTA CCCCAGCTTC 
GGTGTGACCT CCATCCCGAA CTACAACAAC TTCCACGCAG CCGGGGGCCA GGGACTCACG 
GTCTTTGGGG GTGTGAACTC CTCCTCTCAC ACCGGGACCC TGCGTACTAG AGGAGGGACA 
GGAGTGACAC TATTTGTGGC ACTTTATGAC TATGAAGCAC GGACAGAAGA TGACCTGAGT 
TTTCACAAAG GAGAAAAATT TCAAATATTG AACAGCTCGG AAGGAGACTG GTGGGAAGCC 
CGCTCCTTGA CAACTGGGGA AACTGGTTAC ATTCCTAGCA ACTACGTGGC TCCAGTTGAC 
TCCATCCAGG CAGAAGAGTG GTACTTTGGA AAACTTGGCC GCAAGGATGC TGAGAGACAG 
CTCCTGTCCT TTGGAAACCC AAGAGGTACC TTTCTTATCC GCGAGAGCGA AACCACCAAA 
GGTGCCTACT CCCTCTCCAT CCGAGACTGG GACGACATGA AGGGAGACCA CGTCAAACAT 
TACAAAATCC GCAAGCTTGA CAACGGCGGG TACTACATCA CCACGAGGGC CCAGTTTGAG 
ACCCTTCAGC AGCTTGTACA GCATTACTCA GAGAGAGCCG CGGGTCTCTG CTGCCGTCTA 
GTAGTTCCCT GTCACAAAGG GATGCCAAGG CTTACCGATC TGTCTGTCAA AACCAAAGAT 
GTCTGGGAAA TCCCTCGAGA ATCCCTGCAG TTGATCAAGA GACTGGGAAA TGGGCAGTTT 
GGGGAAGTAT GGATGGGTAC CTGGAATGGA AACACAAAAG TAGCCATAAA GACTCTTAAG 
CCAGGCACAA TGTCCCCGGA ATCCTTCCTG GAGGAAGCAC AGATCATGAA GAAGCTGAAG 
CACGACAAGC TGGTGCAGCT CTATGCAGTT GTGTCCGAAG AGCCCATTTA CATTGTCACG 
GAATACATGA ACAAAGGAAG TTTGCTCGAC TTCTTAAAAG ACGGTGAAGG ACGGGCTCTG 
AAATTGCCAA ACCTCGTGGA CATGGCGGCA CAGGTTGCTG CAGGAATGGC TTACATCGAA 
CGCATGAATT ATATCCACAG AGATCTGCGG TCAGCTAACA TTCTGGTGGG GAACGGACTC 
ATTTGCAAGA TTGCTGACTT CGGATTGGCC CGGTTGATTG AAGACAATGA GTACACAGCC 
AGACAAGGTG CAAAGTTTCC CATTAAGTGG ACAGCCCCCG AAGCGGCCCT GTATGGAAGG 
TTCACAATCA AGTCTGACGT GTGGTCCTTT GGAATCTTAC TCACAGAGCT GGTCACCAAA 
GGCAGAGTGC CGTACCCAGG CATGAACAAC CGTGAGGTGC TGGAGCAGGT GGAGAGAGGC 
TACAGGATGC CCTGCCCGCA GGACTGCCCG ATCTCCCTGC ACGAGCTCAT GATCCACTGC 
TGGAAAAAGG ATCCGGAGGA GCGCCCCACT TTCGAGTACT TGCAGGGCTT CCTGGAGGAC 
TACTTTACCG CCACAGAGCC CCAGTATCAG CCCGGTGAAA ACCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Fyn ( XM_017601549.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017457038.1 Rattus norvegicus FYN proto-oncogene, Src family tyrosine kinase (Fyn), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa60042
Clone ID Related Accession (Same CDS sequence)	XM_017601549.1
Accession Version	XM_017601549.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1605bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	tyrosine-protein kinase Fyn isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005119.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGCTGTG TGCAATGTAA GGATAAAGAA GCAGCGAAAC TGACGGAGGA GAGGGACGGC 
AGCCTGAACC AGAGCTCTGG GTACCGCTAT GGCACAGACC CCACCCCTCA GCACTACCCC 
AGCTTCGGTG TGACCTCCAT CCCGAACTAC AACAACTTCC ACGCAGCCGG GGGCCAGGGA 
CTCACGGTCT TTGGGGGTGT GAACTCCTCC TCTCACACCG GGACCCTGCG TACTAGAGGA 
GGGACAGGAG TGACACTATT TGTGGCACTT TATGACTATG AAGCACGGAC AGAAGATGAC 
CTGAGTTTTC ACAAAGGAGA AAAATTTCAA ATATTGAACA GCTCGGAAGG AGACTGGTGG 
GAAGCCCGCT CCTTGACAAC TGGGGAAACT GGTTACATTC CTAGCAACTA CGTGGCTCCA 
GTTGACTCCA TCCAGGCAGA AGAGTGGTAC TTTGGAAAAC TTGGCCGCAA GGATGCTGAG 
AGACAGCTCC TGTCCTTTGG AAACCCAAGA GGTACCTTTC TTATCCGCGA GAGCGAAACC 
ACCAAAGGTG CCTACTCCCT CTCCATCCGA GACTGGGACG ACATGAAGGG AGACCACGTC 
AAACATTACA AAATCCGCAA GCTTGACAAC GGCGGGTACT ACATCACCAC GAGGGCCCAG 
TTTGAGACCC TTCAGCAGCT TGTACAGCAT TACTCAGAGA AAGCTGATGG TTTGTGTTTT 
AACTTAACTG TGATTTCATC AAGTTGTACC CCACAAACTT CTGGATTGGC TAAAGATGCT 
TGGGAAGTTG CACGTGACTC GTTGTTTCTG GAGAAGAAGC TGGGGCAGGG GTGTTTCGCT 
GAAGTGTGGC TTGGTACCTG GAATGGAAAC ACAAAAGTAG CCATAAAGAC TCTTAAGCCA 
GGCACAATGT CCCCGGAATC CTTCCTGGAG GAAGCACAGA TCATGAAGAA GCTGAAGCAC 
GACAAGCTGG TGCAGCTCTA TGCAGTTGTG TCCGAAGAGC CCATTTACAT TGTCACGGAA 
TACATGAACA AAGGAAGTTT GCTCGACTTC TTAAAAGACG GTGAAGGACG GGCTCTGAAA 
TTGCCAAACC TCGTGGACAT GGCGGCACAG GTTGCTGCAG GAATGGCTTA CATCGAACGC 
ATGAATTATA TCCACAGAGA TCTGCGGTCA GCTAACATTC TGGTGGGGAA CGGACTCATT 
TGCAAGATTG CTGACTTCGG ATTGGCCCGG TTGATTGAAG ACAATGAGTA CACAGCCAGA 
CAAGGTGCAA AGTTTCCCAT TAAGTGGACA GCCCCCGAAG CGGCCCTGTA TGGAAGGTTC 
ACAATCAAGT CTGACGTGTG GTCCTTTGGA ATCTTACTCA CAGAGCTGGT CACCAAAGGC 
AGAGTGCCGT ACCCAGGCAT GAACAACCGT GAGGTGCTGG AGCAGGTGGA GAGAGGCTAC 
AGGATGCCCT GCCCGCAGGA CTGCCCGATC TCCCTGCACG AGCTCATGAT CCACTGCTGG 
AAAAAGGATC CGGAGGAGCG CCCCACTTTC GAGTACTTGC AGGGCTTCCT GGAGGACTAC 
TTTACCGCCA CAGAGCCCCA GTATCAGCCC GGTGAAAACC TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017457038.1
CDS	12..1616
Translation	MGCVQCKDKEAAKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSEKADGLCFNLTVISSSCTPQTSGLAKDAWEVARDSLFLEKKLGQGCFAEVWLGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQGFLEDYFTATEPQYQPGENL

Target ORF information:

RefSeq Version	XM_017601549.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus FYN proto-oncogene, Src family tyrosine kinase (Fyn), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017601549.1

ORF Insert Sequence:

ATGGGCTGTG TGCAATGTAA GGATAAAGAA GCAGCGAAAC TGACGGAGGA GAGGGACGGC 
AGCCTGAACC AGAGCTCTGG GTACCGCTAT GGCACAGACC CCACCCCTCA GCACTACCCC 
AGCTTCGGTG TGACCTCCAT CCCGAACTAC AACAACTTCC ACGCAGCCGG GGGCCAGGGA 
CTCACGGTCT TTGGGGGTGT GAACTCCTCC TCTCACACCG GGACCCTGCG TACTAGAGGA 
GGGACAGGAG TGACACTATT TGTGGCACTT TATGACTATG AAGCACGGAC AGAAGATGAC 
CTGAGTTTTC ACAAAGGAGA AAAATTTCAA ATATTGAACA GCTCGGAAGG AGACTGGTGG 
GAAGCCCGCT CCTTGACAAC TGGGGAAACT GGTTACATTC CTAGCAACTA CGTGGCTCCA 
GTTGACTCCA TCCAGGCAGA AGAGTGGTAC TTTGGAAAAC TTGGCCGCAA GGATGCTGAG 
AGACAGCTCC TGTCCTTTGG AAACCCAAGA GGTACCTTTC TTATCCGCGA GAGCGAAACC 
ACCAAAGGTG CCTACTCCCT CTCCATCCGA GACTGGGACG ACATGAAGGG AGACCACGTC 
AAACATTACA AAATCCGCAA GCTTGACAAC GGCGGGTACT ACATCACCAC GAGGGCCCAG 
TTTGAGACCC TTCAGCAGCT TGTACAGCAT TACTCAGAGA AAGCTGATGG TTTGTGTTTT 
AACTTAACTG TGATTTCATC AAGTTGTACC CCACAAACTT CTGGATTGGC TAAAGATGCT 
TGGGAAGTTG CACGTGACTC GTTGTTTCTG GAGAAGAAGC TGGGGCAGGG GTGTTTCGCT 
GAAGTGTGGC TTGGTACCTG GAATGGAAAC ACAAAAGTAG CCATAAAGAC TCTTAAGCCA 
GGCACAATGT CCCCGGAATC CTTCCTGGAG GAAGCACAGA TCATGAAGAA GCTGAAGCAC 
GACAAGCTGG TGCAGCTCTA TGCAGTTGTG TCCGAAGAGC CCATTTACAT TGTCACGGAA 
TACATGAACA AAGGAAGTTT GCTCGACTTC TTAAAAGACG GTGAAGGACG GGCTCTGAAA 
TTGCCAAACC TCGTGGACAT GGCGGCACAG GTTGCTGCAG GAATGGCTTA CATCGAACGC 
ATGAATTATA TCCACAGAGA TCTGCGGTCA GCTAACATTC TGGTGGGGAA CGGACTCATT 
TGCAAGATTG CTGACTTCGG ATTGGCCCGG TTGATTGAAG ACAATGAGTA CACAGCCAGA 
CAAGGTGCAA AGTTTCCCAT TAAGTGGACA GCCCCCGAAG CGGCCCTGTA TGGAAGGTTC 
ACAATCAAGT CTGACGTGTG GTCCTTTGGA ATCTTACTCA CAGAGCTGGT CACCAAAGGC 
AGAGTGCCGT ACCCAGGCAT GAACAACCGT GAGGTGCTGG AGCAGGTGGA GAGAGGCTAC 
AGGATGCCCT GCCCGCAGGA CTGCCCGATC TCCCTGCACG AGCTCATGAT CCACTGCTGG 
AAAAAGGATC CGGAGGAGCG CCCCACTTTC GAGTACTTGC AGGGCTTCCT GGAGGACTAC 
TTTACCGCCA CAGAGCCCCA GTATCAGCCC GGTGAAAACC TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

BDNF Contributes to Spinal Long-Term Potentiation and Mechanical Hypersensitivity Via Fyn-Mediated Phosphorylation of NMDA Receptor GluN2B Subunit at Tyrosine 1472 in Rats Following Spinal Nerve Ligation.
Neurochemical research42(10)2712-2729(2017 Oct)
Li S,Cai J,Feng ZB,Jin ZR,Liu BH,Zhao HY,Jing HB,Wei TJ,Yang GN,Liu LY,Cui YJ,Xing GG

An Essential Role of Fyn in the Modulation of Metabotropic Glutamate Receptor 1 in Neurons.
eNeuro4(4)(2017 Jul-Aug)
Jin DZ,Mao LM,Wang JQ

Potentiation of Synaptic GluN2B NMDAR Currents by Fyn Kinase Is Gated through BDNF-Mediated Disinhibition in Spinal Pain Processing.
Cell reports17(10)2753-2765(2016 12)
Hildebrand ME,Xu J,Dedek A,Li Y,Sengar AS,Beggs S,Lombroso PJ,Salter MW

Dynamically Coupled Residues within the SH2 Domain of FYN Are Key to Unlocking Its Activity.
Structure (London, England : 1993)24(11)1947-1959(2016 11)
Huculeci R,Cilia E,Lyczek A,Buts L,Houben K,Seeliger MA,van Nuland N,Lenaerts T

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Fyn cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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