Scn2a cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Scn2a
Entrez Gene ID	24766
Full Name	sodium voltage-gated channel alpha subunit 2
Synonyms	NachII,Nav1.2,RII/RIIA,RNSCPIIR,SCN,Scn2a1,Scn2a2,ScpII
General protein information	Preferred Names sodium voltage-gated channel alpha subunit 2 Names sodium channel protein type 2 subunit alpha RIIA sodium channel protein sodium channel protein type II subunit alpha sodium channel protein, brain II subunit alpha sodium channel voltage-gated type II alpha polypeptide sodium channel, voltage-gated, type 2, alpha 1 polypeptide sodium channel, voltage-gated, type 2, alpha 1 subunit sodium channel, voltage-gated, type II, alpha 1 sodium channel, voltage-gated, type II, alpha subunit voltage-gated sodium channel subunit alpha Nav1.2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3q21
Summary	Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with four repeat domains, each of which is composed of six membrane-spanning segments, and one or more regulatory beta subunits. Voltage-gated sodium channels are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. In humans, variants of this gene are associated with seizure disorders and autism spectrum disorder. Mice homozygous for a knockout mutation die with severe hypoxia and extensive neuronal cell death, while gain of function mutations result in progressive seizure disorder. [provided by RefSeq, Nov 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012647.1	NP_036779.1	sodium channel protein type 2 subunit alpha

Pathways from BioSystems

Homologies

Homo sapiens (human)	SCN2A	NP_001035233.1
Gallus gallus (chicken)	SCN2A	XP_004942844.1
	SCN2A	XP_001099916.1
Canis lupus familiaris (dog)	SCN2A	XP_535939.2
Rattus norvegicus (Norway rat)	Scn2a1	NP_036779.1
Drosophila melanogaster (fruit fly)	para	NP_001188624.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004707	XP_554647.3
Xenopus tropicalis (tropical clawed frog)	scn3a	XP_002939317.2
Mus musculus (house mouse)	Scn2a1	NP_001092768.1
Bos taurus (cattle)	SCN2A	NP_001137581.1
Pan troglodytes (chimpanzee)	SCN2A	XP_001153227.1
Danio rerio (zebrafish)	scn1lab	NP_001038360.1

Gene Ontology
Bibliography

Related articles in PubMed

Sodium channel subtypes are differentially localized to pre- and post-synaptic sites in rat hippocampus.
Johnson KW, Herold KF, Milner TA, Hemmings HC Jr, Platholi J
The Journal of comparative neurology525(16)3563-3578(2017 Nov)

Oligodendroglial excitability mediated by glutamatergic inputs and Nav1.2 activation.
Berret E, Barron T, Xu J, Debner E, Kim EJ, Kim JH
Nature communications8(1)557(2017 09)

Opposing Effects on Na
Ben-Shalom R, Keeshen CM, Berrios KN, An JY, Sanders SJ, Bender KJ
Biological psychiatry82(3)224-232(2017 Aug)

Calcium triggers reversal of calmodulin on nested anti-parallel sites in the IQ motif of the neuronal voltage-dependent sodium channel Na
Hovey L, Fowler CA, Mahling R, Lin Z, Miller MS, Marx DC, Yoder JB, Kim EH, Tefft KM, Waite BC, Feldkamp MD, Yu L, Shea MA
Biophysical chemistry2241-19(2017 05)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Knockdown of Nav1.2 channels in pre-oligodendrocyte alters their morphology, reduces axon-oligodendrocyte interactions and impairs myelination.
Title: Oligodendroglial excitability mediated by glutamatergic inputs and Nav1.2 activation.

The polarity of (Ca(2+))2-CaMC relative to the IQ motif of NaV1.2 was opposite to that seen in apo CaMC-Nav1.2IQp (2KXW), revealing that CaMC recognizes nested, anti-parallel sites in Nav1.2IQp. (CaMC is C-domain residues of CaM, calmodulin).
Title: Calcium triggers reversal of calmodulin on nested anti-parallel sites in the IQ motif of the neuronal voltage-dependent sodium channel Na

Here, the authors show that hypoxia activates the Small Ubiquitin-like Modifier (SUMO) pathway in rat cerebellar granule neurons (CGN) and that SUMOylation of NaV1.2 channels increases sodium current.
Title: SUMOylation of Na

miR-9 suppressed the trafficking of Nav1.1/Nav1.2 from cytoplasm to cell membrane. miR-9 overexpression inhibited Navbeta2 expression by targeting its coding sequence domain.
Title: MicroRNA-9 induces defective trafficking of Nav1.1 and Nav1.2 by targeting Nav?2 protein coding region in rat with chronic brain hypoperfusion.

In NaV1.2, Cys910 is disulfide-bonded to Cys918 and Cys912.
Title: Probing the Redox States of Sodium Channel Cysteines at the Binding Site of ?O?-Conotoxin GVIIJ.

The following Scn2a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Scn2a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13017	NM_012647.1 Latest version!	Rattus norvegicus sodium voltage-gated channel alpha subunit 2 (Scn2a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	30	$1770.30 $2529.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Scn2a ( NM_012647.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036779.1 Rattus norvegicus sodium voltage-gated channel alpha subunit 2 (Scn2a), mRNA.

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CloneID	ORa13017
Clone ID Related Accession (Same CDS sequence)	NM_012647.1
Accession Version	NM_012647.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 6018bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Rattus norvegicus(Norway rat)
Product	sodium channel protein type 2 subunit alpha
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X03639.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X03639.1, M22254.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGCACGGT CAGTGCTGGT ACCTCCAGGA CCTGACAGCT TCCGCTTCTT TACCAGGGAA 
TCCCTTGCTG CTATCGAACA GCGCATTGCA GAAGAGAAAG CTAAGAGACC CAAACAGGAA 
CGCAAGGACG AAGACGATGA AAATGGCCCA AAGCCAAATA GTGACTTGGA AGCAGGAAAA 
TCCCTTCCTT TTATTTATGG AGACATTCCT CCAGAGATGG TGTCAGAACC ACTGGAGGAC 
CTGGACCCCT ACTATATCAA TAAGAAAACC TTTATAGTAT TGAATAAGGG GAAAGCAATC 
TCGCGGTTCA GCGCCACCTC TGCCCTGTAC ATTTTAACTC CCTTCAACCC CATTAGAAAA 
TTAGCTATTA AGATTTTGGT ACATTCTTTA TTCAATGTGC TTATCATGTG CACAATTCTT 
ACCAACTGTG TGTTTATGAC CATGAGTAAC CCTCCAGACT GGACAAAGAA TGTGGAGTAT 
ACTTTTACAG GAATTTATAC TTTTGAATCA CTTATTAAAA TCCTTGCAAG GGGCTTTTGT 
CTAGAAGATT TCACATTTCT ACGGAATCCC TGGAATTGGT TGGATTTCAC AGTCATTACT 
TTTGCGTATG TAACAGAATT TGTAAACCTA GGCAATGTTT CAGCTCTTCG AACTTTCAGA 
GTCTTGAGAG CTTTGAAAAC TATTTCTGTA ATTCCAGGCC TGAAGACTAT CGTGGGGGCC 
CTGATCCAGT CAGTGAAGAA GCTCTCTGAC GTCATGATCC TCACCGTGTT CTGTCTCAGT 
GTCTTTGCTC TAATCGGGCT GCAGCTCTTC ATGGGCAACC TGAGGAATAA ATGCTTGCAG 
TGGCCCCCAG ACAATTCTAC CTTTGAAATA AATATCACTT CCTTCTTTAA TAACTCATTG 
GATTGGAATG GTACTGCCTT CAATAGGACG GTGAACATGT TTAACTGGGA CGAATATATT 
GAAGATAAAA GTCACTTTTA TTTTTTGGAA GGACAAAACG ATGCTCTGCT TTGTGGGAAC 
AGCTCGGATG CTGGACAGTG TCCAGAAGGA TACATCTGTG TGAAGGCTGG GAGAAACCCC 
AACTACGGCT ACACAAGTTT TGACACCTTC AGCTGGGCCT TCTTGTCCTT ATTTCGTCTC 
ATGACTCAAG ACTTCTGGGA AAACCTTTAT CAGCTGACCT TGCGTGCTGC CGGGAAAACA 
TACATGATAT TTTTTGTGCT GGTCATTTTC TTGGGCTCAT TCTACCTGAT AAATTTGATC 
CTGGCTGTGG TGGCCATGGC CTACGAGGAA CAGAACCAGG CCACACTGGA GGAGGCTGAA 
CAGAAGGAGG CAGAGTTTCA GCAGATGCTG GAGCAACTGA AGAAGCAGCA GGAGGAAGCT 
CAGGCAGCAG CTGCAGCAGC GTCCGCAGAA TCCAGAGACT TCAGCGGGGC AGGCGGGATA 
GGTGTTTTCT CGGAGAGTTC GTCAGTAGCC TCAAAGTTAA GTTCCAAAAG TGAAAAGGAG 
TTGAAAAACA GAAGAAAGAA AAAGAAACAG AAAGAACAGG CTGGGGAGGA AGAGAAGGAA 
GACGCGGTGC GGAAATCTGC CTCTGAGGAC AGCATACGAA AGAAAGGCTT CCAGTTTTCC 
CTGGAAGGAA GTAGATTGAC CTACGAGAAG AGATTTTCCT CTCCGCACCA GTCTCTCTTG 
AGCATCCGAG GCTCCCTATT TTCTCCAAGA CGCAACAGTA GAGCAAGCCT TTTCAACTTC 
AAAGGTCGAG TGAAGGATAT TGGTTCCGAA AATGACTTTG CAGACGATGA ACACAGCACA 
TTTGAGGACA ACGACAGCAG AAGAGACTCT CTATTTGTAC CACACAGACA TGGAGAAAGG 
CGTCCTAGCA ATGTCAGCCA GGCCAGCCGT GCCTCCCGGG GGATACCCAC TCTACCCATG 
AATGGGAAGA TGCACAGTGC AGTGGACTGC AACGGTGTGG TGTCCCTGGT TGGAGGCCCC 
TCTGCGCTCA CATCGCCTGT GGGGCAGCTG CTGCCGGAGG GCACAACTAC TGAGACAGAA 
ATAAGGAAGA GGAGATCCAG TTCTTACCAC GTCTCTATGG ACTTGTTGGA AGACCCTTCA 
AGGCAAAGGG CAATGAGTAT GGCCAGTATT TTGACGAACA CTATGGAAGA ACTTGAAGAA 
TCCAGACAGA AATGCCCACC CTGCTGGTAT AAATTTGCTA ATATGTGCCT GATTTGGGAC 
TGTTGTAAGC CATGGCTAAA GGTAAAACAC GTTGTCAATC TGGTAGTGAT GGATCCATTT 
GTTGACCTGG CCATCACCAT CTGCATTGTG TTAAATACGC TCTTCATGGC CATGGAGCAC 
TACCCCATGA CTGAGCAGTT CAGCAGTGTG CTGTCTGTTG GGAATTTGGT CTTCACTGGG 
ATCTTCACGG CAGAAATGTT TCTCAAGATA ATAGCCATGG ATCCATATTA TTACTTCCAA 
GAAGGCTGGA ATATCTTTGA TGGCTTTATA GTGAGCCTTA GTTTAATGGA ACTCGGCTTG 
GCGAATGTGG AAGGATTGTC AGTTCTCCGA TCATTCCGGC TGCTTAGAGT CTTCAAGTTG 
GCAAAGTCCT GGCCCACACT GAACATGCTC ATTAAGATCA TCGGCAACTC GGTGGGTGCA 
CTGGGCAACC TGACCCTGGT GCTGGCCATC ATCGTCTTCA TTTTTGCCGT GGTCGGCATG 
CAGCTGTTTG GAAAGAGCTA CAAGGAGTGT GTCTGTAAGA TTTCCAATGA TTGTGAGCTC 
CCGCGCTGGC ACATGCACCA CTTCTTCCAC TCCTTCCTGA TCGTGTTTCG AGTCCTGTGT 
GGGGAGTGGA TAGAGACCAT GTGGGACTGC ATGGAGGTCG CGGGCCAGAC CATGTGCCTT 
ACTGTCTTCA TGATGGTCAT GGTGATTGGG AACCTTGTTG TCCTGAACCT CTTCTTGGCC 
TTGCTCCTCA GTTCTTTCAG CTCAGACAAC CTGGCTGCCA CAGATGACGA TAACGAAATG 
AACAACCTCC AGATAGCCGT GGGAAGGATG CAGAAGGGAA TTGATTTTGT TAAAAGGAAG 
ATACGTGAAT TCATTCAGAA AGCCTTTGTC AGAAAGCAGA AAGCTTTAGA TGAAATCAAA 
CCGCTGGAAG ATCTGAATAA CAAGAAAGAC AGTTGTATCT CCAACCACAC GACCATAGAA 
ATAGGCAAGG ACCTCAATTA CCTCAAAGAT GGAAACGGGA CGACCAGTGG CATAGGCAGC 
AGTGTGGAGA AGTATGTGGT AGATGAGAGT GATTACATGT CGTTCATAAA CAACCCCAGC 
CTCACCGTGA CTGTGCCCAT CGCCCTTGGA GAGTCTGACT TTGAAAACTT AAACACGGAA 
GAATTCAGTA GTGAGTCAGA TATGGAAGAA AGCAAGGAGA AATTGAATGC AACTAGCTCA 
TCTGAGGGCA GTACGGTTGA TATAGGCGCT CCGGCAGAGG GAGAGCAGCC AGAGGCCGAA 
CCGGAAGAAT CGCTTGAACC GGAAGCGTGT TTCACAGAAG ACTGTGTGAG AAAGTTCAAG 
TGTTGTCAGA TAAGCATAGA AGAGGGCAAA GGCAAGCTCT GGTGGAACTT GAGGAAAACG 
TGCTACAAGA TAGTAGAGCA TAACTGGTTT GAAACCTTCA TCGTTTTTAT GATTCTGCTC 
AGCAGTGGTG CTCTGGCCTT TGAAGACATT TATATTGAGC AGCGAAAGAC CATCAAGACC 
ATGCTGGAGT ATGCTGACAA GGTTTTCACT TATATCTTCA TCCTGGAGAT GCTTCTAAAG 
TGGGTGGCCT ATGGTTTCCA AATGTATTTC ACCAATGCCT GGTGCTGGCT GGACTTCCTG 
ATCGTTGATG TCTCCTTGGT TAGCTTAACT GCAAATGCCT TGGGCTATTC GGAACTTGGT 
GCCATCAAGT CCCTCCGAAC GTTAAGAGCT CTGAGACCTC TACGAGCCTT ATCCCGATTT 
GAAGGAATGA GGGTTGTTGT AAACGCTCTC TTAGGCGCCA TCCCCTCCAT AATGAACGTA 
CTTCTGGTCT GCCTGATCTT TTGGCTAATA TTCAGTATCA TGGGGGTGAA TCTCTTTGCT 
GGCAAGTTCT ACCATTGCAT CAACTACACC ACGGGGGAAA TGTTTGATGT GAGCGTGGTC 
AACAACTACA GTGAATGCCA AGCTCTCATT GAGAGCAATC AGACGGCCAG GTGGAAGAAC 
GTGAAGGTCA ACTTCGATAA CGTGGGACTC GGATACCTTT CTCTGCTCCA AGTAGCCACC 
TTTAAAGGAT GGATGGATAT CATGTATGCA GCTGTTGACT CAAGAAATGT AGAACTGCAG 
CCCAAATACG AAGACAATCT CTACATGTAC CTTTACTTTG TCATCTTCAT CATCTTCGGC 
TCATTCTTCA CCCTGAACCT GTTCATTGGT GTCATCATAG ACAACTTCAA CCAGCAGAAG 
AAGAAGTTTG GAGGTCAAGA CATCTTTATG ACAGAAGAAC AGAAGAAATA CTACAATGCA 
ATGAAGAAGC TCGGCTCCAA GAAACCGCAG AAGCCCATTC CTCGGCCTGC AAACAAATTT 
CAAGGGATGG TCTTTGATTT TGTAACCAAA CAAGTCTTTG ACATCAGCAT CATGATCCTC 
ATCTGCCTCA ACATGGTGAC CATGATGGTG GAAACGGACG ACCAGAGTCA GGAGATGACC 
AACATCCTGT ACTGGATCAA CCTGGTGTTC ATTGTCCTGT TCACGGGCGA GTGTGTGCTG 
AAGCTCATCT CCCTCCGCCA TTATTATTTC ACCATCGGCT GGAATATTTT TGATTTTGTG 
GTAGTCATCC TCTCCATTGT AGGAATGTTT CTCGCGGAGC TGATAGAGAA GTATTTCGTG 
TCCCCTACCC TGTTCCGAGT CATCCGCCTG GCCAGGATTG GACGAATCCT ACGCCTGATC 
AAAGGCGCCA AGGGGATCCG CACTCTGCTC TTTGCTCTGA TGATGTCCCT TCCTGCGCTG 
TTCAACATCG GCCTCCTGCT TTTCCTGGTC ATGTTCATCT ACGCCATCTT TGGGATGTCC 
AACTTTGCCT ACGTTAAGAG GGAAGTTGGA ATTGATGACA TGTTCAACTT TGAGACTTTT 
GGCAACAGCA TGATCTGCCT GTTCCAAATC ACCACCTCTG CCGGCTGGGA CGGACTGCTG 
GCCCCTATAC TAAATAGCGG ACCTCCTGAC TGTGACCCTG AAAAAGATCA CCCTGGAAGC 
TCGGTGAAGG GGGACTGTGG GAACCCATCT GTGGGGATTT TCTTTTTTGT CAGCTACATC 
ATCATATCCT TCCTGGTGGT GGTGAACATG TACATCGCTG TCATCCTGGA GAACTTCAGC 
GTCGCCACCG AAGAAAGTGC AGAGCCTCTG AGTGAGGACG ACTTTGAGAT GTTCTACGAG 
GTCTGGGAGA AGTTCGACCC TGACGCCACT CAGTTCATAG AGTTCTGCAA GCTTTCTGAC 
TTTGCAGCTG CCCTGGATCC TCCCCTCCTC ATCGCAAAGC CAAACAAAGT CCAGCTCATT 
GCCATGGACC TGCCCATGGT GAGTGGAGAC CGCATCCACT GCCTGGACAT CTTGTTTGCT 
TTTACAAAGC GGGTCCTGGG CGAGAGTGGA GAGATGGACG CTCTTCGAAT CCAGATGGAA 
GAAAGGTTCA TGGCTTCCAA CCCCTCCAAG GTCTCTTATG AGCCCATTAC CACCACCCTG 
AAACGGAAAC AAGAGGAGGT GTCTGCTATT GTCATCCAGC GAGCATACAG GCGGTATCTC 
CTGAAGCAGA AAGTTAAGAA AGTTTCGTCT ATCTATAAAA AAGACAAAGG TAAAGAAGAC 
GAGGGAACGC CCATCAAAGA AGACATCATC ACAGATAAAC TGAACGAGAA TTCAACTCCA 
GAGAAGACTG ATGTGACACC TTCCACAACT TCTCCACCTT CCTACGATAG CGTGACGAAA 
CCGGAGAAGG AAAAATTTGA AAAGGACAAA TCAGAAAAAG AGGACAAAGG GAAAGATATC 
AGGGAAAGTA AAAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036779.1
CDS	211..6228
Translation	MARSVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGKSLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAISRFSATSALYILTPFNPIRKLAIKILVHSLFNVLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFTFLRNPWNWLDFTVITFAYVTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSTFEINITSFFNNSLDWNGTAFNRTVNMFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGIGVFSESSSVASKLSSKSEKELKNRRKKKKQKEQAGEEEKEDAVRKSASEDSIRKKGFQFSLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFNFKGRVKDIGSENDFADDEHSTFEDNDSRRDSLFVPHRHGERRPSNVSQASRASRGIPTLPMNGKMHSAVDCNGVVSLVGGPSALTSPVGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPSRQRAMSMASILTNTMEELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHHFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRKIREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIALGESDFENLNTEEFSSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEAEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQMYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVVNNYSECQALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPEKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFCKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIVIQRAYRRYLLKQKVKKVSSIYKKDKGKEDEGTPIKEDIITDKLNENSTPEKTDVTPSTTSPPSYDSVTKPEKEKFEKDKSEKEDKGKDIRESKK

Target ORF information:

RefSeq Version	NM_012647.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus sodium voltage-gated channel alpha subunit 2 (Scn2a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012647.1

ORF Insert Sequence:

ATGGCACGGT CAGTGCTGGT ACCTCCAGGA CCTGACAGCT TCCGCTTCTT TACCAGGGAA 
TCCCTTGCTG CTATCGAACA GCGCATTGCA GAAGAGAAAG CTAAGAGACC CAAACAGGAA 
CGCAAGGACG AAGACGATGA AAATGGCCCA AAGCCAAATA GTGACTTGGA AGCAGGAAAA 
TCCCTTCCTT TTATTTATGG AGACATTCCT CCAGAGATGG TGTCAGAACC ACTGGAGGAC 
CTGGACCCCT ACTATATCAA TAAGAAAACC TTTATAGTAT TGAATAAGGG GAAAGCAATC 
TCGCGGTTCA GCGCCACCTC TGCCCTGTAC ATTTTAACTC CCTTCAACCC CATTAGAAAA 
TTAGCTATTA AGATTTTGGT ACATTCTTTA TTCAATGTGC TTATCATGTG CACAATTCTT 
ACCAACTGTG TGTTTATGAC CATGAGTAAC CCTCCAGACT GGACAAAGAA TGTGGAGTAT 
ACTTTTACAG GAATTTATAC TTTTGAATCA CTTATTAAAA TCCTTGCAAG GGGCTTTTGT 
CTAGAAGATT TCACATTTCT ACGGAATCCC TGGAATTGGT TGGATTTCAC AGTCATTACT 
TTTGCGTATG TAACAGAATT TGTAAACCTA GGCAATGTTT CAGCTCTTCG AACTTTCAGA 
GTCTTGAGAG CTTTGAAAAC TATTTCTGTA ATTCCAGGCC TGAAGACTAT CGTGGGGGCC 
CTGATCCAGT CAGTGAAGAA GCTCTCTGAC GTCATGATCC TCACCGTGTT CTGTCTCAGT 
GTCTTTGCTC TAATCGGGCT GCAGCTCTTC ATGGGCAACC TGAGGAATAA ATGCTTGCAG 
TGGCCCCCAG ACAATTCTAC CTTTGAAATA AATATCACTT CCTTCTTTAA TAACTCATTG 
GATTGGAATG GTACTGCCTT CAATAGGACG GTGAACATGT TTAACTGGGA CGAATATATT 
GAAGATAAAA GTCACTTTTA TTTTTTGGAA GGACAAAACG ATGCTCTGCT TTGTGGGAAC 
AGCTCGGATG CTGGACAGTG TCCAGAAGGA TACATCTGTG TGAAGGCTGG GAGAAACCCC 
AACTACGGCT ACACAAGTTT TGACACCTTC AGCTGGGCCT TCTTGTCCTT ATTTCGTCTC 
ATGACTCAAG ACTTCTGGGA AAACCTTTAT CAGCTGACCT TGCGTGCTGC CGGGAAAACA 
TACATGATAT TTTTTGTGCT GGTCATTTTC TTGGGCTCAT TCTACCTGAT AAATTTGATC 
CTGGCTGTGG TGGCCATGGC CTACGAGGAA CAGAACCAGG CCACACTGGA GGAGGCTGAA 
CAGAAGGAGG CAGAGTTTCA GCAGATGCTG GAGCAACTGA AGAAGCAGCA GGAGGAAGCT 
CAGGCAGCAG CTGCAGCAGC GTCCGCAGAA TCCAGAGACT TCAGCGGGGC AGGCGGGATA 
GGTGTTTTCT CGGAGAGTTC GTCAGTAGCC TCAAAGTTAA GTTCCAAAAG TGAAAAGGAG 
TTGAAAAACA GAAGAAAGAA AAAGAAACAG AAAGAACAGG CTGGGGAGGA AGAGAAGGAA 
GACGCGGTGC GGAAATCTGC CTCTGAGGAC AGCATACGAA AGAAAGGCTT CCAGTTTTCC 
CTGGAAGGAA GTAGATTGAC CTACGAGAAG AGATTTTCCT CTCCGCACCA GTCTCTCTTG 
AGCATCCGAG GCTCCCTATT TTCTCCAAGA CGCAACAGTA GAGCAAGCCT TTTCAACTTC 
AAAGGTCGAG TGAAGGATAT TGGTTCCGAA AATGACTTTG CAGACGATGA ACACAGCACA 
TTTGAGGACA ACGACAGCAG AAGAGACTCT CTATTTGTAC CACACAGACA TGGAGAAAGG 
CGTCCTAGCA ATGTCAGCCA GGCCAGCCGT GCCTCCCGGG GGATACCCAC TCTACCCATG 
AATGGGAAGA TGCACAGTGC AGTGGACTGC AACGGTGTGG TGTCCCTGGT TGGAGGCCCC 
TCTGCGCTCA CATCGCCTGT GGGGCAGCTG CTGCCGGAGG GCACAACTAC TGAGACAGAA 
ATAAGGAAGA GGAGATCCAG TTCTTACCAC GTCTCTATGG ACTTGTTGGA AGACCCTTCA 
AGGCAAAGGG CAATGAGTAT GGCCAGTATT TTGACGAACA CTATGGAAGA ACTTGAAGAA 
TCCAGACAGA AATGCCCACC CTGCTGGTAT AAATTTGCTA ATATGTGCCT GATTTGGGAC 
TGTTGTAAGC CATGGCTAAA GGTAAAACAC GTTGTCAATC TGGTAGTGAT GGATCCATTT 
GTTGACCTGG CCATCACCAT CTGCATTGTG TTAAATACGC TCTTCATGGC CATGGAGCAC 
TACCCCATGA CTGAGCAGTT CAGCAGTGTG CTGTCTGTTG GGAATTTGGT CTTCACTGGG 
ATCTTCACGG CAGAAATGTT TCTCAAGATA ATAGCCATGG ATCCATATTA TTACTTCCAA 
GAAGGCTGGA ATATCTTTGA TGGCTTTATA GTGAGCCTTA GTTTAATGGA ACTCGGCTTG 
GCGAATGTGG AAGGATTGTC AGTTCTCCGA TCATTCCGGC TGCTTAGAGT CTTCAAGTTG 
GCAAAGTCCT GGCCCACACT GAACATGCTC ATTAAGATCA TCGGCAACTC GGTGGGTGCA 
CTGGGCAACC TGACCCTGGT GCTGGCCATC ATCGTCTTCA TTTTTGCCGT GGTCGGCATG 
CAGCTGTTTG GAAAGAGCTA CAAGGAGTGT GTCTGTAAGA TTTCCAATGA TTGTGAGCTC 
CCGCGCTGGC ACATGCACCA CTTCTTCCAC TCCTTCCTGA TCGTGTTTCG AGTCCTGTGT 
GGGGAGTGGA TAGAGACCAT GTGGGACTGC ATGGAGGTCG CGGGCCAGAC CATGTGCCTT 
ACTGTCTTCA TGATGGTCAT GGTGATTGGG AACCTTGTTG TCCTGAACCT CTTCTTGGCC 
TTGCTCCTCA GTTCTTTCAG CTCAGACAAC CTGGCTGCCA CAGATGACGA TAACGAAATG 
AACAACCTCC AGATAGCCGT GGGAAGGATG CAGAAGGGAA TTGATTTTGT TAAAAGGAAG 
ATACGTGAAT TCATTCAGAA AGCCTTTGTC AGAAAGCAGA AAGCTTTAGA TGAAATCAAA 
CCGCTGGAAG ATCTGAATAA CAAGAAAGAC AGTTGTATCT CCAACCACAC GACCATAGAA 
ATAGGCAAGG ACCTCAATTA CCTCAAAGAT GGAAACGGGA CGACCAGTGG CATAGGCAGC 
AGTGTGGAGA AGTATGTGGT AGATGAGAGT GATTACATGT CGTTCATAAA CAACCCCAGC 
CTCACCGTGA CTGTGCCCAT CGCCCTTGGA GAGTCTGACT TTGAAAACTT AAACACGGAA 
GAATTCAGTA GTGAGTCAGA TATGGAAGAA AGCAAGGAGA AATTGAATGC AACTAGCTCA 
TCTGAGGGCA GTACGGTTGA TATAGGCGCT CCGGCAGAGG GAGAGCAGCC AGAGGCCGAA 
CCGGAAGAAT CGCTTGAACC GGAAGCGTGT TTCACAGAAG ACTGTGTGAG AAAGTTCAAG 
TGTTGTCAGA TAAGCATAGA AGAGGGCAAA GGCAAGCTCT GGTGGAACTT GAGGAAAACG 
TGCTACAAGA TAGTAGAGCA TAACTGGTTT GAAACCTTCA TCGTTTTTAT GATTCTGCTC 
AGCAGTGGTG CTCTGGCCTT TGAAGACATT TATATTGAGC AGCGAAAGAC CATCAAGACC 
ATGCTGGAGT ATGCTGACAA GGTTTTCACT TATATCTTCA TCCTGGAGAT GCTTCTAAAG 
TGGGTGGCCT ATGGTTTCCA AATGTATTTC ACCAATGCCT GGTGCTGGCT GGACTTCCTG 
ATCGTTGATG TCTCCTTGGT TAGCTTAACT GCAAATGCCT TGGGCTATTC GGAACTTGGT 
GCCATCAAGT CCCTCCGAAC GTTAAGAGCT CTGAGACCTC TACGAGCCTT ATCCCGATTT 
GAAGGAATGA GGGTTGTTGT AAACGCTCTC TTAGGCGCCA TCCCCTCCAT AATGAACGTA 
CTTCTGGTCT GCCTGATCTT TTGGCTAATA TTCAGTATCA TGGGGGTGAA TCTCTTTGCT 
GGCAAGTTCT ACCATTGCAT CAACTACACC ACGGGGGAAA TGTTTGATGT GAGCGTGGTC 
AACAACTACA GTGAATGCCA AGCTCTCATT GAGAGCAATC AGACGGCCAG GTGGAAGAAC 
GTGAAGGTCA ACTTCGATAA CGTGGGACTC GGATACCTTT CTCTGCTCCA AGTAGCCACC 
TTTAAAGGAT GGATGGATAT CATGTATGCA GCTGTTGACT CAAGAAATGT AGAACTGCAG 
CCCAAATACG AAGACAATCT CTACATGTAC CTTTACTTTG TCATCTTCAT CATCTTCGGC 
TCATTCTTCA CCCTGAACCT GTTCATTGGT GTCATCATAG ACAACTTCAA CCAGCAGAAG 
AAGAAGTTTG GAGGTCAAGA CATCTTTATG ACAGAAGAAC AGAAGAAATA CTACAATGCA 
ATGAAGAAGC TCGGCTCCAA GAAACCGCAG AAGCCCATTC CTCGGCCTGC AAACAAATTT 
CAAGGGATGG TCTTTGATTT TGTAACCAAA CAAGTCTTTG ACATCAGCAT CATGATCCTC 
ATCTGCCTCA ACATGGTGAC CATGATGGTG GAAACGGACG ACCAGAGTCA GGAGATGACC 
AACATCCTGT ACTGGATCAA CCTGGTGTTC ATTGTCCTGT TCACGGGCGA GTGTGTGCTG 
AAGCTCATCT CCCTCCGCCA TTATTATTTC ACCATCGGCT GGAATATTTT TGATTTTGTG 
GTAGTCATCC TCTCCATTGT AGGAATGTTT CTCGCGGAGC TGATAGAGAA GTATTTCGTG 
TCCCCTACCC TGTTCCGAGT CATCCGCCTG GCCAGGATTG GACGAATCCT ACGCCTGATC 
AAAGGCGCCA AGGGGATCCG CACTCTGCTC TTTGCTCTGA TGATGTCCCT TCCTGCGCTG 
TTCAACATCG GCCTCCTGCT TTTCCTGGTC ATGTTCATCT ACGCCATCTT TGGGATGTCC 
AACTTTGCCT ACGTTAAGAG GGAAGTTGGA ATTGATGACA TGTTCAACTT TGAGACTTTT 
GGCAACAGCA TGATCTGCCT GTTCCAAATC ACCACCTCTG CCGGCTGGGA CGGACTGCTG 
GCCCCTATAC TAAATAGCGG ACCTCCTGAC TGTGACCCTG AAAAAGATCA CCCTGGAAGC 
TCGGTGAAGG GGGACTGTGG GAACCCATCT GTGGGGATTT TCTTTTTTGT CAGCTACATC 
ATCATATCCT TCCTGGTGGT GGTGAACATG TACATCGCTG TCATCCTGGA GAACTTCAGC 
GTCGCCACCG AAGAAAGTGC AGAGCCTCTG AGTGAGGACG ACTTTGAGAT GTTCTACGAG 
GTCTGGGAGA AGTTCGACCC TGACGCCACT CAGTTCATAG AGTTCTGCAA GCTTTCTGAC 
TTTGCAGCTG CCCTGGATCC TCCCCTCCTC ATCGCAAAGC CAAACAAAGT CCAGCTCATT 
GCCATGGACC TGCCCATGGT GAGTGGAGAC CGCATCCACT GCCTGGACAT CTTGTTTGCT 
TTTACAAAGC GGGTCCTGGG CGAGAGTGGA GAGATGGACG CTCTTCGAAT CCAGATGGAA 
GAAAGGTTCA TGGCTTCCAA CCCCTCCAAG GTCTCTTATG AGCCCATTAC CACCACCCTG 
AAACGGAAAC AAGAGGAGGT GTCTGCTATT GTCATCCAGC GAGCATACAG GCGGTATCTC 
CTGAAGCAGA AAGTTAAGAA AGTTTCGTCT ATCTATAAAA AAGACAAAGG TAAAGAAGAC 
GAGGGAACGC CCATCAAAGA AGACATCATC ACAGATAAAC TGAACGAGAA TTCAACTCCA 
GAGAAGACTG ATGTGACACC TTCCACAACT TCTCCACCTT CCTACGATAG CGTGACGAAA 
CCGGAGAAGG AAAAATTTGA AAAGGACAAA TCAGAAAAAG AGGACAAAGG GAAAGATATC 
AGGGAAAGTA AAAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Sodium channel subtypes are differentially localized to pre- and post-synaptic sites in rat hippocampus.
The Journal of comparative neurology525(16)3563-3578(2017 Nov)
Johnson KW,Herold KF,Milner TA,Hemmings HC Jr,Platholi J

Oligodendroglial excitability mediated by glutamatergic inputs and Nav1.2 activation.
Nature communications8(1)557(2017 09)
Berret E,Barron T,Xu J,Debner E,Kim EJ,Kim JH

Opposing Effects on Na
Biological psychiatry82(3)224-232(2017 Aug)
Ben-Shalom R,Keeshen CM,Berrios KN,An JY,Sanders SJ,Bender KJ

Calcium triggers reversal of calmodulin on nested anti-parallel sites in the IQ motif of the neuronal voltage-dependent sodium channel Na
Biophysical chemistry2241-19(2017 05)
Hovey L,Fowler CA,Mahling R,Lin Z,Miller MS,Marx DC,Yoder JB,Kim EH,Tefft KM,Waite BC,Feldkamp MD,Yu L,Shea MA

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Scn2a cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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