Gimap5 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gimap5
Entrez Gene ID	246774
Full Name	GTPase, IMAP family member 5
Synonyms	IAN4,Ian4l1,Ian5,lyp
General protein information	Preferred Names GTPase, IMAP family member 5 Names GTPase IMAP family member 5 IAN-4 immune associated nucleotide 4 like 1 immunity-associated nucleotide 4 protein immunity-associated nucleotide 4-like 1 protein lymphopenia
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q24
Summary	an immune associated protein that may be associated with insulin-dependent diabetes in rats [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_145680.3	NP_663713.1	GTPase IMAP family member 5 isoform 2
XM_006236457.3	XP_006236519.1	GTPase IMAP family member 5 isoform X1
XM_008762871.2	XP_008761093.1	GTPase IMAP family member 5 isoform X2
XM_006236458.3	XP_006236520.1	GTPase IMAP family member 5 isoform X2
NM_001033913.1	NP_001029085.1	GTPase IMAP family member 5 isoform 1

Pathways from BioSystems

Homologies

	LOC713835	XP_001099132.2
Bos taurus (cattle)	LOC530077	XP_002687089.1
Gallus gallus (chicken)	GIMAP5	XP_418519.1
Homo sapiens (human)	GIMAP1-GIMAP5	NP_001186506.1
Bos taurus (cattle)	LOC511617	NP_001073729.1
Gallus gallus (chicken)	GIMAP1	XP_004939122.1
Pan troglodytes (chimpanzee)	GIMAP5	XP_001135659.2
Canis lupus familiaris (dog)	GIMAP5	XP_005629728.1
Mus musculus (house mouse)	Gimap5	NP_778200.1
Mus musculus (house mouse)	Gimap3	NP_112537.2
Rattus norvegicus (Norway rat)	Gimap5	NP_663713.1

Gene Ontology
Bibliography

Related articles in PubMed

Distinct roles of T-cell lymphopenia and the microbial flora for gastrointestinal and CNS autoimmunity.
Fischer HJ, Witte AK, Walter L, Gr?ne HJ, van den Brandt J, Reichardt HM
FASEB journal : official publication of the Federation of American Societies for Experimental Biology30(5)1724-32(2016 05)

TCR and IL-7 Signaling Are Altered in the Absence of Functional GTPase of the Immune Associated Nucleotide Binding Protein 5 (GIMAP5).
Chen XL, Serrano D, Ghobadi F, Mayhue M, Hoebe K, Ilangumaran S, Ramanathan S
PloS one11(3)e0151837(2016)

GTPase of the immune-associated nucleotide-binding protein 5 (GIMAP5) regulates calcium influx in T-lymphocytes by promoting mitochondrial calcium accumulation.
Chen XL, Serrano D, Mayhue M, Wieden HJ, Stankova J, Boulay G, Ilangumaran S, Ramanathan S
The Biochemical journal449(2)353-64(2013 Jan)

BB rat Gimap gene expression in sorted lymphoid T and B cells.
Moralejo DH, Fuller JM, Rutledge EA, Van Yserloo B, Ettinger RA, Jensen R, Osborne W, Kwitek A, Lernmark A
Life sciences89(19-20)748-54(2011 Nov)

Differential effects of leptin receptor mutation on male and female BBDR Gimap5-/Gimap5- spontaneously diabetic rats.
Moralejo DH, Hansen CT, Treuting P, Hessner MJ, Fuller JM, Van Yserloo B, Jensen R, Osborne W, Kwitek AE, Lernmark A
Physiological genomics41(1)9-20(2010 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These findings confirm a critical albeit differential role of T-cell lymphopenia in the susceptibility to organ-specific autoimmune responses.
Title: Distinct roles of T-cell lymphopenia and the microbial flora for gastrointestinal and CNS autoimmunity.

functional Gimap5 is required for optimal signaling through TCR and IL-7R in T cells.
Title: TCR and IL-7 Signaling Are Altered in the Absence of Functional GTPase of the Immune Associated Nucleotide Binding Protein 5 (GIMAP5).

Data indicate that reduced Ca2+ influx in GTPase of the immune-associated nucleotide-binding protein 5 (GIMAP5)-deficient T-cells is associated with the inability of their mitochondria to sequester Ca2+ following capacitative entry.
Title: GTPase of the immune-associated nucleotide-binding protein 5 (GIMAP5) regulates calcium influx in T-lymphocytes by promoting mitochondrial calcium accumulation.

results suggest that lack of the Gimap5 protein in the DR.(lyp/lyp) congenic rat was associated with impaired expression of the entire family of Gimap genes and may regulate T cell homeostasis in the peripheral lymphoid organs.
Title: BB rat Gimap gene expression in sorted lymphoid T and B cells.

Obesity and type 2 diabetes in the BioBreeding diabetes-resistant (BBDR) rat result in islet expansion associated with protection from T1D in female but not male BBDR(lepr-/lepr-,Gimap5-/Gimap5-) congenic rats.
Title: Differential effects of leptin receptor mutation on male and female BBDR Gimap5-/Gimap5- spontaneously diabetic rats.

The following Gimap5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gimap5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa13745	NM_001033913.1 Latest version!	Rattus norvegicus GTPase, IMAP family member 5 (Gimap5), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
ORa13745	XM_006236457.3 Latest version!	Rattus norvegicus GTPase, IMAP family member 5 (Gimap5), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
ORa13805	NM_145680.3 Latest version!	Rattus norvegicus GTPase, IMAP family member 5 (Gimap5), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa13805	XM_006236458.3 Latest version!	Rattus norvegicus GTPase, IMAP family member 5 (Gimap5), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa13805	XM_008762871.2 Latest version!	Rattus norvegicus GTPase, IMAP family member 5 (Gimap5), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gimap5 ( NM_001033913.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001029085.1 Rattus norvegicus GTPase, IMAP family member 5 (Gimap5), transcript variant 1, mRNA.

Price & Availability↑

CloneID	ORa13745
Clone ID Related Accession (Same CDS sequence)	XM_006236457.3 , NM_001033913.1
Accession Version	NM_001033913.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 981bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-06
Organism	Rattus norvegicus(Norway rat)
Product	GTPase IMAP family member 5 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AY550018.1. Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY550018.1, CK475069.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689594, SAMEA2689597 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGGACC ATGGCTTTGA GGAACTATCC ACAAGGACCC ATGACCTCAA CGTCAGAAGA 
CTCACTAAGG GAAACATAAA CTTTCTCTTG TCTACAGGAC AAGAAACCTA CAGTGTAGAA 
GACTCTGGCC TCCTGAGGAT CCTCCTGGTG GGTAAATCTG GCTGCGGAAA AAGTGCCACA 
GGGAACAGCA TTCTCCGCAG ACCAGCGTTC GAGTCCAGGC TCAGAGGCCA GTCTGTGACC 
AGGACCAGTC AGGCAGAGAT GGGCACATGG GAGGGAAGGA GCTTCCTAGT GGTGGACACG 
CCCCCCATCT TCGAGTCAAA GATCCAGAAC CAAGACATGG ACAAGGACAT TGGGAACTGC 
TACCTGATGT GTGCCCCAGG ACCCCATGTG TTGTTGCTGG TGACCCAACT GGGACGCTAC 
ACAGTCGAAG ATGCCATGGC TGTGAGGATG GTGAAGCAGA TCTTTGGGGT AGGGGTCATG 
AGGTACATGA TTGTCCTCTT CACCCACAAG GAAGACCTGG CAGATGAGTC CTTGGAAGAG 
TTTGTGACCC ACACAGGCAA CCTCGACCTG CACAGACTGG TTCAGGAGTG TGGGAGGAGG 
TACTGTGCCT TTAATAACAA GGCTTCTGGG GAGGAGCAGC AGGGGCAGCT GGCAGAGCTC 
ATGGCCCTGG TGAGAAGACT GGAACAGGAG CATGAGGGCT CCTTCCACAG CAATGACCTC 
TTCGTTTATA CTCAGGTGTT CCTTAGAGGT GGCTACAGTG AACACCAGGA GCCATACAAG 
TTCTACCTGA CCAAGGTGAG GCAGGAGGTA GAGAAGCAGA AGAGGGAGCT GGAGGAGCAG 
GAGGGCAGCT GGATGGCTAA AATGCTTTGC AGAGTCACGT CCTGCTTGGA CTGGCACATT 
GCAGTGTCTG TTCTTCTTAT TGTTCTTGGT CTGACCCTTC TCATCACTTT AATTAATATG 
TACATTGGCA GGTGGAAATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001029085.1
CDS	374..1354
Translation	MEDHGFEELSTRTHDLNVRRLTKGNINFLLSTGQETYSVEDSGLLRILLVGKSGCGKSATGNSILRRPAFESRLRGQSVTRTSQAEMGTWEGRSFLVVDTPPIFESKIQNQDMDKDIGNCYLMCAPGPHVLLLVTQLGRYTVEDAMAVRMVKQIFGVGVMRYMIVLFTHKEDLADESLEEFVTHTGNLDLHRLVQECGRRYCAFNNKASGEEQQGQLAELMALVRRLEQEHEGSFHSNDLFVYTQVFLRGGYSEHQEPYKFYLTKVRQEVEKQKRELEEQEGSWMAKMLCRVTSCLDWHIAVSVLLIVLGLTLLITLINMYIGRWK

Target ORF information:

RefSeq Version	NM_001033913.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus GTPase, IMAP family member 5 (Gimap5), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001033913.1

ORF Insert Sequence:

ATGGAGGACC ATGGCTTTGA GGAACTATCC ACAAGGACCC ATGACCTCAA CGTCAGAAGA 
CTCACTAAGG GAAACATAAA CTTTCTCTTG TCTACAGGAC AAGAAACCTA CAGTGTAGAA 
GACTCTGGCC TCCTGAGGAT CCTCCTGGTG GGTAAATCTG GCTGCGGAAA AAGTGCCACA 
GGGAACAGCA TTCTCCGCAG ACCAGCGTTC GAGTCCAGGC TCAGAGGCCA GTCTGTGACC 
AGGACCAGTC AGGCAGAGAT GGGCACATGG GAGGGAAGGA GCTTCCTAGT GGTGGACACG 
CCCCCCATCT TCGAGTCAAA GATCCAGAAC CAAGACATGG ACAAGGACAT TGGGAACTGC 
TACCTGATGT GTGCCCCAGG ACCCCATGTG TTGTTGCTGG TGACCCAACT GGGACGCTAC 
ACAGTCGAAG ATGCCATGGC TGTGAGGATG GTGAAGCAGA TCTTTGGGGT AGGGGTCATG 
AGGTACATGA TTGTCCTCTT CACCCACAAG GAAGACCTGG CAGATGAGTC CTTGGAAGAG 
TTTGTGACCC ACACAGGCAA CCTCGACCTG CACAGACTGG TTCAGGAGTG TGGGAGGAGG 
TACTGTGCCT TTAATAACAA GGCTTCTGGG GAGGAGCAGC AGGGGCAGCT GGCAGAGCTC 
ATGGCCCTGG TGAGAAGACT GGAACAGGAG CATGAGGGCT CCTTCCACAG CAATGACCTC 
TTCGTTTATA CTCAGGTGTT CCTTAGAGGT GGCTACAGTG AACACCAGGA GCCATACAAG 
TTCTACCTGA CCAAGGTGAG GCAGGAGGTA GAGAAGCAGA AGAGGGAGCT GGAGGAGCAG 
GAGGGCAGCT GGATGGCTAA AATGCTTTGC AGAGTCACGT CCTGCTTGGA CTGGCACATT 
GCAGTGTCTG TTCTTCTTAT TGTTCTTGGT CTGACCCTTC TCATCACTTT AATTAATATG 
TACATTGGCA GGTGGAAATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Gimap5 ( XM_006236457.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006236519.1 Rattus norvegicus GTPase, IMAP family member 5 (Gimap5), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa13745
Clone ID Related Accession (Same CDS sequence)	XM_006236457.3 , NM_001033913.1
Accession Version	XM_006236457.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 981bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	GTPase IMAP family member 5 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005103.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006236457.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGGACC ATGGCTTTGA GGAACTATCC ACAAGGACCC ATGACCTCAA CGTCAGAAGA 
CTCACTAAGG GAAACATAAA CTTTCTCTTG TCTACAGGAC AAGAAACCTA CAGTGTAGAA 
GACTCTGGCC TCCTGAGGAT CCTCCTGGTG GGTAAATCTG GCTGCGGAAA AAGTGCCACA 
GGGAACAGCA TTCTCCGCAG ACCAGCGTTC GAGTCCAGGC TCAGAGGCCA GTCTGTGACC 
AGGACCAGTC AGGCAGAGAT GGGCACATGG GAGGGAAGGA GCTTCCTAGT GGTGGACACG 
CCCCCCATCT TCGAGTCAAA GATCCAGAAC CAAGACATGG ACAAGGACAT TGGGAACTGC 
TACCTGATGT GTGCCCCAGG ACCCCATGTG TTGTTGCTGG TGACCCAACT GGGACGCTAC 
ACAGTCGAAG ATGCCATGGC TGTGAGGATG GTGAAGCAGA TCTTTGGGGT AGGGGTCATG 
AGGTACATGA TTGTCCTCTT CACCCACAAG GAAGACCTGG CAGATGAGTC CTTGGAAGAG 
TTTGTGACCC ACACAGGCAA CCTCGACCTG CACAGACTGG TTCAGGAGTG TGGGAGGAGG 
TACTGTGCCT TTAATAACAA GGCTTCTGGG GAGGAGCAGC AGGGGCAGCT GGCAGAGCTC 
ATGGCCCTGG TGAGAAGACT GGAACAGGAG CATGAGGGCT CCTTCCACAG CAATGACCTC 
TTCGTTTATA CTCAGGTGTT CCTTAGAGGT GGCTACAGTG AACACCAGGA GCCATACAAG 
TTCTACCTGA CCAAGGTGAG GCAGGAGGTA GAGAAGCAGA AGAGGGAGCT GGAGGAGCAG 
GAGGGCAGCT GGATGGCTAA AATGCTTTGC AGAGTCACGT CCTGCTTGGA CTGGCACATT 
GCAGTGTCTG TTCTTCTTAT TGTTCTTGGT CTGACCCTTC TCATCACTTT AATTAATATG 
TACATTGGCA GGTGGAAATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006236519.1
CDS	691..1671
Translation	MEDHGFEELSTRTHDLNVRRLTKGNINFLLSTGQETYSVEDSGLLRILLVGKSGCGKSATGNSILRRPAFESRLRGQSVTRTSQAEMGTWEGRSFLVVDTPPIFESKIQNQDMDKDIGNCYLMCAPGPHVLLLVTQLGRYTVEDAMAVRMVKQIFGVGVMRYMIVLFTHKEDLADESLEEFVTHTGNLDLHRLVQECGRRYCAFNNKASGEEQQGQLAELMALVRRLEQEHEGSFHSNDLFVYTQVFLRGGYSEHQEPYKFYLTKVRQEVEKQKRELEEQEGSWMAKMLCRVTSCLDWHIAVSVLLIVLGLTLLITLINMYIGRWK

Target ORF information:

RefSeq Version	XM_006236457.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus GTPase, IMAP family member 5 (Gimap5), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006236457.3

ORF Insert Sequence:

ATGGAGGACC ATGGCTTTGA GGAACTATCC ACAAGGACCC ATGACCTCAA CGTCAGAAGA 
CTCACTAAGG GAAACATAAA CTTTCTCTTG TCTACAGGAC AAGAAACCTA CAGTGTAGAA 
GACTCTGGCC TCCTGAGGAT CCTCCTGGTG GGTAAATCTG GCTGCGGAAA AAGTGCCACA 
GGGAACAGCA TTCTCCGCAG ACCAGCGTTC GAGTCCAGGC TCAGAGGCCA GTCTGTGACC 
AGGACCAGTC AGGCAGAGAT GGGCACATGG GAGGGAAGGA GCTTCCTAGT GGTGGACACG 
CCCCCCATCT TCGAGTCAAA GATCCAGAAC CAAGACATGG ACAAGGACAT TGGGAACTGC 
TACCTGATGT GTGCCCCAGG ACCCCATGTG TTGTTGCTGG TGACCCAACT GGGACGCTAC 
ACAGTCGAAG ATGCCATGGC TGTGAGGATG GTGAAGCAGA TCTTTGGGGT AGGGGTCATG 
AGGTACATGA TTGTCCTCTT CACCCACAAG GAAGACCTGG CAGATGAGTC CTTGGAAGAG 
TTTGTGACCC ACACAGGCAA CCTCGACCTG CACAGACTGG TTCAGGAGTG TGGGAGGAGG 
TACTGTGCCT TTAATAACAA GGCTTCTGGG GAGGAGCAGC AGGGGCAGCT GGCAGAGCTC 
ATGGCCCTGG TGAGAAGACT GGAACAGGAG CATGAGGGCT CCTTCCACAG CAATGACCTC 
TTCGTTTATA CTCAGGTGTT CCTTAGAGGT GGCTACAGTG AACACCAGGA GCCATACAAG 
TTCTACCTGA CCAAGGTGAG GCAGGAGGTA GAGAAGCAGA AGAGGGAGCT GGAGGAGCAG 
GAGGGCAGCT GGATGGCTAA AATGCTTTGC AGAGTCACGT CCTGCTTGGA CTGGCACATT 
GCAGTGTCTG TTCTTCTTAT TGTTCTTGGT CTGACCCTTC TCATCACTTT AATTAATATG 
TACATTGGCA GGTGGAAATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Gimap5 ( NM_145680.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_663713.1 Rattus norvegicus GTPase, IMAP family member 5 (Gimap5), transcript variant 2, mRNA.

Price & Availability↑

CloneID	ORa13805
Clone ID Related Accession (Same CDS sequence)	NM_145680.3 , XM_008762871.2 , XM_006236458.3
Accession Version	NM_145680.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 927bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-06
Organism	Rattus norvegicus(Norway rat)
Product	GTPase IMAP family member 5 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AY055776.3 and AY550018.1. On Oct 19, 2005 this sequence version replaced NM_145680.2. Transcript Variant: This variant (2) uses an alternate splice site in the 5' coding region, compared to variant 1, that results in the use of an upstream start codon. It encodes isoform 2 which has a shorter and distinct N-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY055776.3, DQ125352.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAAGGCC TTCAGAAGAG CACATATGGA ACTATAGTTG AAGGACAAGA AACCTACAGT 
GTAGAAGACT CTGGCCTCCT GAGGATCCTC CTGGTGGGTA AATCTGGCTG CGGAAAAAGT 
GCCACAGGGA ACAGCATTCT CCGCAGACCA GCGTTCGAGT CCAGGCTCAG AGGCCAGTCT 
GTGACCAGGA CCAGTCAGGC AGAGATGGGC ACATGGGAGG GAAGGAGCTT CCTAGTGGTG 
GACACGCCCC CCATCTTCGA GTCAAAGATC CAGAACCAAG ACATGGACAA GGACATTGGG 
AACTGCTACC TGATGTGTGC CCCAGGACCC CATGTGTTGT TGCTGGTGAC CCAACTGGGA 
CGCTACACAG TCGAAGATGC CATGGCTGTG AGGATGGTGA AGCAGATCTT TGGGGTAGGG 
GTCATGAGGT ACATGATTGT CCTCTTCACC CACAAGGAAG ACCTGGCAGA TGAGTCCTTG 
GAAGAGTTTG TGACCCACAC AGGCAACCTC GACCTGCACA GACTGGTTCA GGAGTGTGGG 
AGGAGGTACT GTGCCTTTAA TAACAAGGCT TCTGGGGAGG AGCAGCAGGG GCAGCTGGCA 
GAGCTCATGG CCCTGGTGAG AAGACTGGAA CAGGAGCATG AGGGCTCCTT CCACAGCAAT 
GACCTCTTCG TTTATACTCA GGTGTTCCTT AGAGGTGGCT ACAGTGAACA CCAGGAGCCA 
TACAAGTTCT ACCTGACCAA GGTGAGGCAG GAGGTAGAGA AGCAGAAGAG GGAGCTGGAG 
GAGCAGGAGG GCAGCTGGAT GGCTAAAATG CTTTGCAGAG TCACGTCCTG CTTGGACTGG 
CACATTGCAG TGTCTGTTCT TCTTATTGTT CTTGGTCTGA CCCTTCTCAT CACTTTAATT 
AATATGTACA TTGGCAGGTG GAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_663713.1
CDS	253..1179
Translation	MEGLQKSTYGTIVEGQETYSVEDSGLLRILLVGKSGCGKSATGNSILRRPAFESRLRGQSVTRTSQAEMGTWEGRSFLVVDTPPIFESKIQNQDMDKDIGNCYLMCAPGPHVLLLVTQLGRYTVEDAMAVRMVKQIFGVGVMRYMIVLFTHKEDLADESLEEFVTHTGNLDLHRLVQECGRRYCAFNNKASGEEQQGQLAELMALVRRLEQEHEGSFHSNDLFVYTQVFLRGGYSEHQEPYKFYLTKVRQEVEKQKRELEEQEGSWMAKMLCRVTSCLDWHIAVSVLLIVLGLTLLITLINMYIGRWK

Target ORF information:

RefSeq Version	NM_145680.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus GTPase, IMAP family member 5 (Gimap5), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145680.3

ORF Insert Sequence:

ATGGAAGGCC TTCAGAAGAG CACATATGGA ACTATAGTTG AAGGACAAGA AACCTACAGT 
GTAGAAGACT CTGGCCTCCT GAGGATCCTC CTGGTGGGTA AATCTGGCTG CGGAAAAAGT 
GCCACAGGGA ACAGCATTCT CCGCAGACCA GCGTTCGAGT CCAGGCTCAG AGGCCAGTCT 
GTGACCAGGA CCAGTCAGGC AGAGATGGGC ACATGGGAGG GAAGGAGCTT CCTAGTGGTG 
GACACGCCCC CCATCTTCGA GTCAAAGATC CAGAACCAAG ACATGGACAA GGACATTGGG 
AACTGCTACC TGATGTGTGC CCCAGGACCC CATGTGTTGT TGCTGGTGAC CCAACTGGGA 
CGCTACACAG TCGAAGATGC CATGGCTGTG AGGATGGTGA AGCAGATCTT TGGGGTAGGG 
GTCATGAGGT ACATGATTGT CCTCTTCACC CACAAGGAAG ACCTGGCAGA TGAGTCCTTG 
GAAGAGTTTG TGACCCACAC AGGCAACCTC GACCTGCACA GACTGGTTCA GGAGTGTGGG 
AGGAGGTACT GTGCCTTTAA TAACAAGGCT TCTGGGGAGG AGCAGCAGGG GCAGCTGGCA 
GAGCTCATGG CCCTGGTGAG AAGACTGGAA CAGGAGCATG AGGGCTCCTT CCACAGCAAT 
GACCTCTTCG TTTATACTCA GGTGTTCCTT AGAGGTGGCT ACAGTGAACA CCAGGAGCCA 
TACAAGTTCT ACCTGACCAA GGTGAGGCAG GAGGTAGAGA AGCAGAAGAG GGAGCTGGAG 
GAGCAGGAGG GCAGCTGGAT GGCTAAAATG CTTTGCAGAG TCACGTCCTG CTTGGACTGG 
CACATTGCAG TGTCTGTTCT TCTTATTGTT CTTGGTCTGA CCCTTCTCAT CACTTTAATT 
AATATGTACA TTGGCAGGTG GAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Gimap5 ( XM_008762871.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008761093.1 Rattus norvegicus GTPase, IMAP family member 5 (Gimap5), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa13805
Clone ID Related Accession (Same CDS sequence)	NM_145680.3 , XM_008762871.2 , XM_006236458.3
Accession Version	XM_008762871.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 927bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	GTPase IMAP family member 5 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005103.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008762871.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAAGGCC TTCAGAAGAG CACATATGGA ACTATAGTTG AAGGACAAGA AACCTACAGT 
GTAGAAGACT CTGGCCTCCT GAGGATCCTC CTGGTGGGTA AATCTGGCTG CGGAAAAAGT 
GCCACAGGGA ACAGCATTCT CCGCAGACCA GCGTTCGAGT CCAGGCTCAG AGGCCAGTCT 
GTGACCAGGA CCAGTCAGGC AGAGATGGGC ACATGGGAGG GAAGGAGCTT CCTAGTGGTG 
GACACGCCCC CCATCTTCGA GTCAAAGATC CAGAACCAAG ACATGGACAA GGACATTGGG 
AACTGCTACC TGATGTGTGC CCCAGGACCC CATGTGTTGT TGCTGGTGAC CCAACTGGGA 
CGCTACACAG TCGAAGATGC CATGGCTGTG AGGATGGTGA AGCAGATCTT TGGGGTAGGG 
GTCATGAGGT ACATGATTGT CCTCTTCACC CACAAGGAAG ACCTGGCAGA TGAGTCCTTG 
GAAGAGTTTG TGACCCACAC AGGCAACCTC GACCTGCACA GACTGGTTCA GGAGTGTGGG 
AGGAGGTACT GTGCCTTTAA TAACAAGGCT TCTGGGGAGG AGCAGCAGGG GCAGCTGGCA 
GAGCTCATGG CCCTGGTGAG AAGACTGGAA CAGGAGCATG AGGGCTCCTT CCACAGCAAT 
GACCTCTTCG TTTATACTCA GGTGTTCCTT AGAGGTGGCT ACAGTGAACA CCAGGAGCCA 
TACAAGTTCT ACCTGACCAA GGTGAGGCAG GAGGTAGAGA AGCAGAAGAG GGAGCTGGAG 
GAGCAGGAGG GCAGCTGGAT GGCTAAAATG CTTTGCAGAG TCACGTCCTG CTTGGACTGG 
CACATTGCAG TGTCTGTTCT TCTTATTGTT CTTGGTCTGA CCCTTCTCAT CACTTTAATT 
AATATGTACA TTGGCAGGTG GAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008761093.1
CDS	658..1584
Translation	MEGLQKSTYGTIVEGQETYSVEDSGLLRILLVGKSGCGKSATGNSILRRPAFESRLRGQSVTRTSQAEMGTWEGRSFLVVDTPPIFESKIQNQDMDKDIGNCYLMCAPGPHVLLLVTQLGRYTVEDAMAVRMVKQIFGVGVMRYMIVLFTHKEDLADESLEEFVTHTGNLDLHRLVQECGRRYCAFNNKASGEEQQGQLAELMALVRRLEQEHEGSFHSNDLFVYTQVFLRGGYSEHQEPYKFYLTKVRQEVEKQKRELEEQEGSWMAKMLCRVTSCLDWHIAVSVLLIVLGLTLLITLINMYIGRWK

Target ORF information:

RefSeq Version	XM_008762871.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus GTPase, IMAP family member 5 (Gimap5), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008762871.2

ORF Insert Sequence:

ATGGAAGGCC TTCAGAAGAG CACATATGGA ACTATAGTTG AAGGACAAGA AACCTACAGT 
GTAGAAGACT CTGGCCTCCT GAGGATCCTC CTGGTGGGTA AATCTGGCTG CGGAAAAAGT 
GCCACAGGGA ACAGCATTCT CCGCAGACCA GCGTTCGAGT CCAGGCTCAG AGGCCAGTCT 
GTGACCAGGA CCAGTCAGGC AGAGATGGGC ACATGGGAGG GAAGGAGCTT CCTAGTGGTG 
GACACGCCCC CCATCTTCGA GTCAAAGATC CAGAACCAAG ACATGGACAA GGACATTGGG 
AACTGCTACC TGATGTGTGC CCCAGGACCC CATGTGTTGT TGCTGGTGAC CCAACTGGGA 
CGCTACACAG TCGAAGATGC CATGGCTGTG AGGATGGTGA AGCAGATCTT TGGGGTAGGG 
GTCATGAGGT ACATGATTGT CCTCTTCACC CACAAGGAAG ACCTGGCAGA TGAGTCCTTG 
GAAGAGTTTG TGACCCACAC AGGCAACCTC GACCTGCACA GACTGGTTCA GGAGTGTGGG 
AGGAGGTACT GTGCCTTTAA TAACAAGGCT TCTGGGGAGG AGCAGCAGGG GCAGCTGGCA 
GAGCTCATGG CCCTGGTGAG AAGACTGGAA CAGGAGCATG AGGGCTCCTT CCACAGCAAT 
GACCTCTTCG TTTATACTCA GGTGTTCCTT AGAGGTGGCT ACAGTGAACA CCAGGAGCCA 
TACAAGTTCT ACCTGACCAA GGTGAGGCAG GAGGTAGAGA AGCAGAAGAG GGAGCTGGAG 
GAGCAGGAGG GCAGCTGGAT GGCTAAAATG CTTTGCAGAG TCACGTCCTG CTTGGACTGG 
CACATTGCAG TGTCTGTTCT TCTTATTGTT CTTGGTCTGA CCCTTCTCAT CACTTTAATT 
AATATGTACA TTGGCAGGTG GAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Gimap5 ( XM_006236458.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006236520.1 Rattus norvegicus GTPase, IMAP family member 5 (Gimap5), transcript variant X3, mRNA.

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CloneID	ORa13805
Clone ID Related Accession (Same CDS sequence)	NM_145680.3 , XM_008762871.2 , XM_006236458.3
Accession Version	XM_006236458.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 927bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	GTPase IMAP family member 5 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005103.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006236458.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAAGGCC TTCAGAAGAG CACATATGGA ACTATAGTTG AAGGACAAGA AACCTACAGT 
GTAGAAGACT CTGGCCTCCT GAGGATCCTC CTGGTGGGTA AATCTGGCTG CGGAAAAAGT 
GCCACAGGGA ACAGCATTCT CCGCAGACCA GCGTTCGAGT CCAGGCTCAG AGGCCAGTCT 
GTGACCAGGA CCAGTCAGGC AGAGATGGGC ACATGGGAGG GAAGGAGCTT CCTAGTGGTG 
GACACGCCCC CCATCTTCGA GTCAAAGATC CAGAACCAAG ACATGGACAA GGACATTGGG 
AACTGCTACC TGATGTGTGC CCCAGGACCC CATGTGTTGT TGCTGGTGAC CCAACTGGGA 
CGCTACACAG TCGAAGATGC CATGGCTGTG AGGATGGTGA AGCAGATCTT TGGGGTAGGG 
GTCATGAGGT ACATGATTGT CCTCTTCACC CACAAGGAAG ACCTGGCAGA TGAGTCCTTG 
GAAGAGTTTG TGACCCACAC AGGCAACCTC GACCTGCACA GACTGGTTCA GGAGTGTGGG 
AGGAGGTACT GTGCCTTTAA TAACAAGGCT TCTGGGGAGG AGCAGCAGGG GCAGCTGGCA 
GAGCTCATGG CCCTGGTGAG AAGACTGGAA CAGGAGCATG AGGGCTCCTT CCACAGCAAT 
GACCTCTTCG TTTATACTCA GGTGTTCCTT AGAGGTGGCT ACAGTGAACA CCAGGAGCCA 
TACAAGTTCT ACCTGACCAA GGTGAGGCAG GAGGTAGAGA AGCAGAAGAG GGAGCTGGAG 
GAGCAGGAGG GCAGCTGGAT GGCTAAAATG CTTTGCAGAG TCACGTCCTG CTTGGACTGG 
CACATTGCAG TGTCTGTTCT TCTTATTGTT CTTGGTCTGA CCCTTCTCAT CACTTTAATT 
AATATGTACA TTGGCAGGTG GAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006236520.1
CDS	551..1477
Translation	MEGLQKSTYGTIVEGQETYSVEDSGLLRILLVGKSGCGKSATGNSILRRPAFESRLRGQSVTRTSQAEMGTWEGRSFLVVDTPPIFESKIQNQDMDKDIGNCYLMCAPGPHVLLLVTQLGRYTVEDAMAVRMVKQIFGVGVMRYMIVLFTHKEDLADESLEEFVTHTGNLDLHRLVQECGRRYCAFNNKASGEEQQGQLAELMALVRRLEQEHEGSFHSNDLFVYTQVFLRGGYSEHQEPYKFYLTKVRQEVEKQKRELEEQEGSWMAKMLCRVTSCLDWHIAVSVLLIVLGLTLLITLINMYIGRWK

Target ORF information:

RefSeq Version	XM_006236458.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus GTPase, IMAP family member 5 (Gimap5), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006236458.3

ORF Insert Sequence:

ATGGAAGGCC TTCAGAAGAG CACATATGGA ACTATAGTTG AAGGACAAGA AACCTACAGT 
GTAGAAGACT CTGGCCTCCT GAGGATCCTC CTGGTGGGTA AATCTGGCTG CGGAAAAAGT 
GCCACAGGGA ACAGCATTCT CCGCAGACCA GCGTTCGAGT CCAGGCTCAG AGGCCAGTCT 
GTGACCAGGA CCAGTCAGGC AGAGATGGGC ACATGGGAGG GAAGGAGCTT CCTAGTGGTG 
GACACGCCCC CCATCTTCGA GTCAAAGATC CAGAACCAAG ACATGGACAA GGACATTGGG 
AACTGCTACC TGATGTGTGC CCCAGGACCC CATGTGTTGT TGCTGGTGAC CCAACTGGGA 
CGCTACACAG TCGAAGATGC CATGGCTGTG AGGATGGTGA AGCAGATCTT TGGGGTAGGG 
GTCATGAGGT ACATGATTGT CCTCTTCACC CACAAGGAAG ACCTGGCAGA TGAGTCCTTG 
GAAGAGTTTG TGACCCACAC AGGCAACCTC GACCTGCACA GACTGGTTCA GGAGTGTGGG 
AGGAGGTACT GTGCCTTTAA TAACAAGGCT TCTGGGGAGG AGCAGCAGGG GCAGCTGGCA 
GAGCTCATGG CCCTGGTGAG AAGACTGGAA CAGGAGCATG AGGGCTCCTT CCACAGCAAT 
GACCTCTTCG TTTATACTCA GGTGTTCCTT AGAGGTGGCT ACAGTGAACA CCAGGAGCCA 
TACAAGTTCT ACCTGACCAA GGTGAGGCAG GAGGTAGAGA AGCAGAAGAG GGAGCTGGAG 
GAGCAGGAGG GCAGCTGGAT GGCTAAAATG CTTTGCAGAG TCACGTCCTG CTTGGACTGG 
CACATTGCAG TGTCTGTTCT TCTTATTGTT CTTGGTCTGA CCCTTCTCAT CACTTTAATT 
AATATGTACA TTGGCAGGTG GAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Distinct roles of T-cell lymphopenia and the microbial flora for gastrointestinal and CNS autoimmunity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology30(5)1724-32(2016 05)
Fischer HJ,Witte AK,Walter L,Gr?ne HJ,van den Brandt J,Reichardt HM

TCR and IL-7 Signaling Are Altered in the Absence of Functional GTPase of the Immune Associated Nucleotide Binding Protein 5 (GIMAP5).
PloS one11(3)e0151837(2016)
Chen XL,Serrano D,Ghobadi F,Mayhue M,Hoebe K,Ilangumaran S,Ramanathan S

GTPase of the immune-associated nucleotide-binding protein 5 (GIMAP5) regulates calcium influx in T-lymphocytes by promoting mitochondrial calcium accumulation.
The Biochemical journal449(2)353-64(2013 Jan)
Chen XL,Serrano D,Mayhue M,Wieden HJ,Stankova J,Boulay G,Ilangumaran S,Ramanathan S

BB rat Gimap gene expression in sorted lymphoid T and B cells.
Life sciences89(19-20)748-54(2011 Nov)
Moralejo DH,Fuller JM,Rutledge EA,Van Yserloo B,Ettinger RA,Jensen R,Osborne W,Kwitek A,Lernmark A

Differential effects of leptin receptor mutation on male and female BBDR Gimap5-/Gimap5- spontaneously diabetic rats.
Physiological genomics41(1)9-20(2010 Mar)
Moralejo DH,Hansen CT,Treuting P,Hessner MJ,Fuller JM,Van Yserloo B,Jensen R,Osborne W,Kwitek AE,Lernmark A

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Gimap5 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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