Gimap3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gimap3
Entrez Gene ID	83408
Full Name	GTPase, IMAP family member 3
Synonyms	2010110D23Rik,Gimap5,Ian4
General protein information	Preferred Names GTPase, IMAP family member 3 Names GTPase IMAP family member 3 IAN-4 immune associated nucleotide 4 immunity-associated nucleotide 4 protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6\|6 B2.3
Summary	This gene encodes a mitochondrial membrane protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. The expression of this gene is induced in BCR/ABL-expressing cells. The encoded protein lacks an N-terminal mitochondrial signal sequence. Experimental studies showed that mitochondrial localization relies on the C-terminal transmembrane domain. In humans, the IAN subfamily genes are located in a cluster at 7q36.1 [provided by RefSeq, Jul 2008].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031247.3	NP_112537.2	GTPase IMAP family member 3

Pathways from BioSystems

Homologies

	LOC713835	XP_001099132.2
Bos taurus (cattle)	LOC530077	XP_002687089.1
Gallus gallus (chicken)	GIMAP5	XP_418519.1
Homo sapiens (human)	GIMAP1-GIMAP5	NP_001186506.1
Bos taurus (cattle)	LOC511617	NP_001073729.1
Gallus gallus (chicken)	GIMAP1	XP_004939122.1
Pan troglodytes (chimpanzee)	GIMAP5	XP_001135659.2
Canis lupus familiaris (dog)	GIMAP5	XP_005629728.1
Mus musculus (house mouse)	Gimap5	NP_778200.1
Mus musculus (house mouse)	Gimap3	NP_112537.2
Rattus norvegicus (Norway rat)	Gimap5	NP_663713.1

Gene Ontology
Bibliography

Related articles in PubMed

Quantitative changes in Gimap3 and Gimap5 expression modify mitochondrial DNA segregation in mice.
Jokinen R, Lahtinen T, Marttinen P, My?h?nen M, Ruotsalainen P, Yeung N, Shvetsova A, Kastaniotis AJ, Hiltunen JK, ?hman T, Nyman TA, Weiler H, Battersby BJ
Genetics200(1)221-35(2015 May)

Gimap3 and Gimap5 cooperate to maintain T-cell numbers in the mouse.
Yano K, Carter C, Yoshida N, Abe T, Yamada A, Nitta T, Ishimaru N, Takada K, Butcher GW, Takahama Y
European journal of immunology44(2)561-72(2014 Feb)

Gimap3 regulates tissue-specific mitochondrial DNA segregation.
Jokinen R, Marttinen P, Sandell HK, Manninen T, Teerenhovi H, Wai T, Teoli D, Loredo-Osti JC, Shoubridge EA, Battersby BJ
PLoS genetics6(10)e1001161(2010 Oct)

IAN family critically regulates survival and development of T lymphocytes.
Nitta T, Nasreen M, Seike T, Goji A, Ohigashi I, Miyazaki T, Ohta T, Kanno M, Takahama Y
PLoS biology4(4)e103(2006 Apr)

Comparative analysis of the human gimap gene cluster encoding a novel GTPase family.
Kr?cken J, Schroetel RM, M?ller IU, Sa?dani N, Marinovski P, Benten WP, Stamm O, Wunderlich F
Gene341291-304(2004 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

quantitative changes in expression of Gimap3 and the paralogue Gimap5 affect mtDNA segregation in hematopoietic tissues. Gimap3 localizes to the endoplasmic reticulum and not mitochondria.
Title: Quantitative changes in Gimap3 and Gimap5 expression modify mitochondrial DNA segregation in mice.

The defects in T-cell cellularity were more severe in mice lacking both Gimap3 and Gimap5.
Title: Gimap3 and Gimap5 cooperate to maintain T-cell numbers in the mouse.

Data shsow that Gimap3 is important for T cell development and survival, suggesting that leukocyte survival may be a key factor in the genetic regulation of mtDNA sequence variants and in modulating human mitochondrial diseases.
Title: Gimap3 regulates tissue-specific mitochondrial DNA segregation.

The following Gimap3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gimap3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu19013	NM_031247.3 Latest version!	Mus musculus GTPase, IMAP family member 3 (Gimap3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gimap3 ( NM_031247.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_112537.2 Mus musculus GTPase, IMAP family member 3 (Gimap3), mRNA.

Price & Availability↑

CloneID	OMu19013
Clone ID Related Accession (Same CDS sequence)	NM_031247.3
Accession Version	NM_031247.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 906bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-07
Organism	Mus musculus(house mouse)
Product	GTPase IMAP family member 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CAAA01170199.1 and AF337052.1. On or before Dec 7, 2005 this sequence version replaced XM_904735.1, NM_031247.2. ##Evidence-Data-START## Transcript exon combination :: AF337052.1, AB164418.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAAACAC TTCAGAATGT TGTAACAGGC GGAAAGAAAG GTGGCTGCAC CTCAGGGTCA 
AGGCCACTGA GGATCCTCCT GGTGGGCAAA TCTGGCTGCG GTAAAAGCGC CACAGGGAAC 
AGCCTCCTCC GACGACCAGC ATTCGAGTCC AGGCTCAGAG GCCAGTCTGT GACAAGGACC 
AGCCAGGCAG AGACAGGCAC ATGGGAGGGG AGGAGCATCC TAGTGGTAGA CACACCCCCC 
ATCTTTGAGT CAAAGGCCCA GAACCAAGAC ATGGACAAGG ACATCGGAGA CTGCTACCTG 
CTGTGTGCCC CAGGCCCCCA TGTGTTGTTG CTGGTGACCC AGCTGGGACG CTTCACAGCT 
GAAGATGTCA TGGCTGTGAG GATGGTGAAG GAGGTCTTTG GGGTAGGGGT CATGAGGCAC 
ATGATCGTCC TCTTCACCCG CAAGGAAGAC CTGGCAGAGA AGTCCTTGGA AGAGTTTGTG 
ACCCACACTG ACAACCGCAG CCTGCGCAGC CTGGTTCAGG AGTGTGGGAG GAGGTACTGT 
GCCTTCAACA ACAGGGCCTC TGGGGAGGAG CAGCAAGGGC AGCTGGCAGA GCTCATGGCC 
CTGGTGAGGA GGCTGGAACA GGAGTGTGAA GGCTCCTTCC ACAGCAATGA CCTCTTCCTT 
CATGCCGAGA CACTCCTTAG AGAAGGTTAC AGTGTGCACC AGGAAGCCTA TAGGTGCTAC 
CTGGCCAAGG TGAGGCAGGA GGTGGAGAAA CAGAGGTGGG AGCTGGAGGA GCAGGAGGGC 
AGCTGGGTCC TCAAGGTCCT CCCCATAGGC AAAAAGTTGG AGGTGTTGCA TTCAGATTTT 
TGTTGGTATT TGGTGTTGGC CATATTAATC TTCTTCGTTT TCTTTTTTCT CTTATTTTAT 
GTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112537.2
CDS	615..1520
Translation	METLQNVVTGGKKGGCTSGSRPLRILLVGKSGCGKSATGNSLLRRPAFESRLRGQSVTRTSQAETGTWEGRSILVVDTPPIFESKAQNQDMDKDIGDCYLLCAPGPHVLLLVTQLGRFTAEDVMAVRMVKEVFGVGVMRHMIVLFTRKEDLAEKSLEEFVTHTDNRSLRSLVQECGRRYCAFNNRASGEEQQGQLAELMALVRRLEQECEGSFHSNDLFLHAETLLREGYSVHQEAYRCYLAKVRQEVEKQRWELEEQEGSWVLKVLPIGKKLEVLHSDFCWYLVLAILIFFVFFFLLFYV

Target ORF information:

RefSeq Version	NM_031247.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus GTPase, IMAP family member 3 (Gimap3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031247.3

ORF Insert Sequence:

ATGGAAACAC TTCAGAATGT TGTAACAGGC GGAAAGAAAG GTGGCTGCAC CTCAGGGTCA 
AGGCCACTGA GGATCCTCCT GGTGGGCAAA TCTGGCTGCG GTAAAAGCGC CACAGGGAAC 
AGCCTCCTCC GACGACCAGC ATTCGAGTCC AGGCTCAGAG GCCAGTCTGT GACAAGGACC 
AGCCAGGCAG AGACAGGCAC ATGGGAGGGG AGGAGCATCC TAGTGGTAGA CACACCCCCC 
ATCTTTGAGT CAAAGGCCCA GAACCAAGAC ATGGACAAGG ACATCGGAGA CTGCTACCTG 
CTGTGTGCCC CAGGCCCCCA TGTGTTGTTG CTGGTGACCC AGCTGGGACG CTTCACAGCT 
GAAGATGTCA TGGCTGTGAG GATGGTGAAG GAGGTCTTTG GGGTAGGGGT CATGAGGCAC 
ATGATCGTCC TCTTCACCCG CAAGGAAGAC CTGGCAGAGA AGTCCTTGGA AGAGTTTGTG 
ACCCACACTG ACAACCGCAG CCTGCGCAGC CTGGTTCAGG AGTGTGGGAG GAGGTACTGT 
GCCTTCAACA ACAGGGCCTC TGGGGAGGAG CAGCAAGGGC AGCTGGCAGA GCTCATGGCC 
CTGGTGAGGA GGCTGGAACA GGAGTGTGAA GGCTCCTTCC ACAGCAATGA CCTCTTCCTT 
CATGCCGAGA CACTCCTTAG AGAAGGTTAC AGTGTGCACC AGGAAGCCTA TAGGTGCTAC 
CTGGCCAAGG TGAGGCAGGA GGTGGAGAAA CAGAGGTGGG AGCTGGAGGA GCAGGAGGGC 
AGCTGGGTCC TCAAGGTCCT CCCCATAGGC AAAAAGTTGG AGGTGTTGCA TTCAGATTTT 
TGTTGGTATT TGGTGTTGGC CATATTAATC TTCTTCGTTT TCTTTTTTCT CTTATTTTAT 
GTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Quantitative changes in Gimap3 and Gimap5 expression modify mitochondrial DNA segregation in mice.
Genetics200(1)221-35(2015 May)
Jokinen R,Lahtinen T,Marttinen P,My?h?nen M,Ruotsalainen P,Yeung N,Shvetsova A,Kastaniotis AJ,Hiltunen JK,?hman T,Nyman TA,Weiler H,Battersby BJ

Gimap3 and Gimap5 cooperate to maintain T-cell numbers in the mouse.
European journal of immunology44(2)561-72(2014 Feb)
Yano K,Carter C,Yoshida N,Abe T,Yamada A,Nitta T,Ishimaru N,Takada K,Butcher GW,Takahama Y

Gimap3 regulates tissue-specific mitochondrial DNA segregation.
PLoS genetics6(10)e1001161(2010 Oct)
Jokinen R,Marttinen P,Sandell HK,Manninen T,Teerenhovi H,Wai T,Teoli D,Loredo-Osti JC,Shoubridge EA,Battersby BJ

IAN family critically regulates survival and development of T lymphocytes.
PLoS biology4(4)e103(2006 Apr)
Nitta T,Nasreen M,Seike T,Goji A,Ohigashi I,Miyazaki T,Ohta T,Kanno M,Takahama Y

Comparative analysis of the human gimap gene cluster encoding a novel GTPase family.
Gene341291-304(2004 Oct)
Kr?cken J,Schroetel RM,M?ller IU,Sa?dani N,Marinovski P,Benten WP,Stamm O,Wunderlich F

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Gimap3 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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