Trpc5 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Trpc5
Entrez Gene ID	140933
Full Name	transient receptor potential cation channel, subfamily C, member 5
Synonyms	Trrp5
General protein information	Preferred Names transient receptor potential cation channel, subfamily C, member 5 Names short transient receptor potential channel 5 transient receptor protein 5
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: X Map Location: Xq34
Summary	mouse homolog is a nonselective cation channel [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017601900.1	XP_017457389.1	short transient receptor potential channel 5 isoform X1
NM_080898.2	NP_543174.1	short transient receptor potential channel 5

Pathways from BioSystems

Homologies

Bos taurus (cattle)	TRPC5	NP_001160046.1
Gallus gallus (chicken)	TRPC5	XP_420310.2
Canis lupus familiaris (dog)	TRPC5	XP_853241.1
Rattus norvegicus (Norway rat)	Trpc5	NP_543174.1
Homo sapiens (human)	TRPC5	NP_036603.1
Pan troglodytes (chimpanzee)	TRPC5	XP_003317691.1
	TRPC5	XP_001101078.1
Danio rerio (zebrafish)	LOC555897	XP_683649.2
Mus musculus (house mouse)	Trpc5	NP_033454.1
Xenopus tropicalis (tropical clawed frog)	trpc5	XP_002938829.1

Gene Ontology
Bibliography

Related articles in PubMed

TRPC5 channels participate in pressure-sensing in aortic baroreceptors.
Lau OC, Shen B, Wong CO, Tjong YW, Lo CY, Wang HC, Huang Y, Yung WH, Chen YC, Fung ML, Rudd JA, Yao X
Nature communications711947(2016 Jul)

Transient Receptor Potential Canonical (TRPC)/Orai1-dependent Store-operated Ca2+ Channels: NEW TARGETS OF ALDOSTERONE IN CARDIOMYOCYTES.
Sabourin J, Bartoli F, Antigny F, Gomez AM, Benitah JP
The Journal of biological chemistry291(25)13394-409(2016 Jun)

The possible relationship between expressions of TRPC3/5 channels and cognitive changes in rat model of chronic unpredictable stress.
Qin X, Liu Y, Zhu M, Yang Z
Behavioural brain research290180-6(2015 Sep)

Inhibition of the TRPC5 ion channel protects the kidney filter.
Schaldecker T, Kim S, Tarabanis C, Tian D, Hakroush S, Castonguay P, Ahn W, Wallentin H, Heid H, Hopkins CR, Lindsley CW, Riccio A, Buvall L, Weins A, Greka A
The Journal of clinical investigation123(12)5298-309(2013 Dec)

Conserved gating elements in TRPC4 and TRPC5 channels.
Beck A, Speicher T, Stoerger C, Sell T, Dettmer V, Jusoh SA, Abdulmughni A, Cavali? A, Philipp SE, Zhu MX, Helms V, Wissenbach U, Flockerzi V
The Journal of biological chemistry288(27)19471-83(2013 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Aldosterone specifically increased the mRNA and/or protein levels of Orai1, TRPC1, -C4, -C5, and stromal interaction molecule 1 through mineralocorticoid receptor activation
Title: Transient Receptor Potential Canonical (TRPC)/Orai1-dependent Store-operated Ca2+ Channels: NEW TARGETS OF ALDOSTERONE IN CARDIOMYOCYTES.

there is an association between expressions of TRPC3/5 and cognitive changes in CUS rat model; mechanism may be that the different expressions of TRPC3/5 can cause morphological changes of the neurons in hippocampus
Title: The possible relationship between expressions of TRPC3/5 channels and cognitive changes in rat model of chronic unpredictable stress.

the S4-S5 linker is a critical constituent of TRPC4/C5 channel gating and that disturbance of its sequence allows channel opening independent of any sensor domain.
Title: Conserved gating elements in TRPC4 and TRPC5 channels.

TRPC5 acts as a novel and specific mediator for neurotrophin (NT)-3 to regulate dendrite development through calcium/calmodulin-dependent protein kinase (CaMK)IIalpha.
Title: TRPC5 channel is the mediator of neurotrophin-3 in regulating dendritic growth via CaMKII? in rat hippocampal neurons.

co-expression of TRPC5 with TRPC1 suppressed the effect of TRPC1 on neurite outgrowth
Title: Opposite regulatory effects of TRPC1 and TRPC5 on neurite outgrowth in PC12 cells.

The following Trpc5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Trpc5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00271	NM_080898.2 Latest version!	Rattus norvegicus transient receptor potential cation channel, subfamily C, member 5 (Trpc5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$475.30 $679.00
ORa62997	XM_017601900.1 Latest version!	Rattus norvegicus transient receptor potential cation channel, subfamily C, member 5 (Trpc5), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Trpc5 ( NM_080898.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_543174.1 Rattus norvegicus transient receptor potential cation channel, subfamily C, member 5 (Trpc5), mRNA.

Price & Availability↑

CloneID	ORa00271
Clone ID Related Accession (Same CDS sequence)	NM_080898.2
Accession Version	NM_080898.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2925bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-09-01
Organism	Rattus norvegicus(Norway rat)
Product	short transient receptor potential channel 5
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from EF672039.1. On Jul 29, 2007 this sequence version replaced NM_080898.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: EF672039.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCCCAGC TGTACTACAA GAAGGTCAAC TACTCACCAT ACAGAGACCG CATCCCCCTC 
CAAATCGTGA GGGCTGAGAC TGAGCTGTCT GCTGAGGAGA AAGCTTTCCT TAGTGCTGTG 
GAGAAGGGGG ACTATGCCAC CGTGAAGCAG GCACTGCAGG AGGCCGAGAT CTACTACAAT 
GTCAACATCA ACTGCATGGA TCCTTTGGGC AGGAGCGCCC TACTCATTGC CATTGAGAAT 
GAGAACTTAG AGATCATGGA GCTACTGCTG AACCACAGTG TGTATGTGGG CGATGCATTA 
CTCTATGCCA TCCGCAAGGA GGTGGTAGGA GCTGTGGAAC TTCTGCTCAG CTACAGGAAG 
CCAAGTGGAG AGAAGCAGGT TCCCACTCTG ATGATGGACA CCCAGTTCTC TGAGTTCACA 
CCAGACATCA CACCCATCAT GTTGGCAGCC CACACCAACA ACTATGAAAT CATCAAATTG 
CTTGTCCAAA AGCGTGTCAC TATCCCACGG CCCCACCAAA TCCGCTGCAA CTGTGTGGAG 
TGTGTGTCCA GTTCAGAAGT AGACAGCCTA CGTCATTCAA GGTCCCGACT GAACATATAC 
AAGGCACTGG CAAGCCCTTC GCTCATCGCC TTATCAAGTG AGGACCCTAT CCTCACAGCA 
TTCCGGCTGG GCTGGGAACT CAAGGAGCTG AGCAAGGTGG AAAATGAGTT CAAGGCTGAG 
TATGAGGAGC TCTCCCAACA GTGTAAGCTC TTTGCCAAGG ACCTGCTGGA TCAAGCTCGG 
AGCTCCCGAG AACTGGAGAT CATTCTCAAC CATCGAGATG ACCACAGCGA AGAACTTGAC 
CCACAGAAGT ACCATGACCT GGCCAAGCTG AAGGTGGCAA TCAAATATCA CCAGAAAGAG 
TTTGTCGCTC AGCCAAACTG TCAACAATTG CTGGCCACCT TGTGGTACGA TGGCTTCCCT 
GGATGGCGAA GAAAACACTG GGTAGTCAAG CTTCTAACCT GCATGACCAT TGGATTCCTG 
TTTCCTATGC TGTCCATAGC CTATCTGATC TCACCCAGAA GCAACCTTGG GCTTTTCATC 
AAGAAACCCT TTATCAAGTT CATCTGCCAC ACAGCATCCT ATCTGACCTT CCTCTTCATG 
CTTCTCCTGG CTTCTCAGCA TATTGTCAGA ACAGACCTCC ATGTTCAAGG ACCTCCCCCA 
ACTGTCGTGG AATGGATGAT ACTGCCTTGG GTTCTAGGTT TCATCTGGGG GGAAATAAAG 
GAAATGTGGG ATGGTGGATT CACTGAATAC ATCCATGATT GGTGGAATTT GATGGATTTT 
GCAATGAACT CCCTCTACCT GGCAACTATT TCCTTGAAGA TTGTGGCCTA TGTCAAGTAT 
AATGGTTCTC GTCCAAGGGA AGAATGGGAA ATGTGGCACC CGACTCTGAT TGCGGAAGCA 
CTCTTCGCGA TATCGAACAT TTTAAGTTCC TTGCGTCTCA TATCCTTGTT CACAGCCAAC 
TCCCACTTAG GGCCTCTGCA GATCTCCTTG GGACGCATGC TGCTTGATAT ACTCAAATTT 
CTCTTTATCT ACTGCCTAGT ACTACTGGCT TTTGCCAACG GACTGAACCA GCTTTATTTT 
TACTATGAGA CCAGAGCTAT TGATGAACCT AACAACTGCA AAGGAATCCG GTGTGAAAAA 
CAGAACAACG CCTTCTCCAC GCTCTTTGAA ACCCTTCAGT CACTCTTCTG GTCTGTGTTT 
GGCCTTTTAA ACCTCTATGT TACCAATGTG AAGGCCCGGC ATGAATTCAC GGAGTTTGTG 
GGAGCTACTA TGTTTGGGAC ATACAACGTC ATCTCCCTGG TAGTGCTACT GAACATGCTC 
ATTGCCATGA TGAACAACTC CTACCAGCTC ATTGCCGACC ATGCTGATAT TGAGTGGAAG 
TTTGCGAGAA CGAAGCTCTG GATGAGTTAC TTTGATGAAG GTGGCACCTT ACCACCTCCT 
TTCAACATCA TCCCCAGCCC CAAATCATTT CTCTATCTTG GCAACTGGTT CAACAACACC 
TTCTGTCCCA AGAGAGACCC CGATGGGAGA CGAAGGAGGC ACAACTTGAG AAGCTTCACA 
GAACGTCATG CTGACAGCCT GATCCAAAAT CAACATTATC AGGAAGTTAT CAGAAATCTA 
GTCAAGAGAT ATGTGGCTGC CATGATAAGA AACTCGAAAA CAAATGAGGG GCTAACAGAA 
GAAAATTTTA AGGAATTAAA GCAGGACATT TCCAGCTTTC GATACGAAGT ACTTGACCTC 
TTGGGAAATA GAAAACATCC AAGAAGAAGC TTTTCCACTA GCAGCGCTGA ATTCTCTCAA 
AGGGATGATA CCAATGATGG CAGTGGTGGG GCTCGGGCCA AATCTAAGAG TGTCTCTTTC 
AATTTAGGCT GCAAGAAAAA GGCCTGCCAG GGAGCACCTC TCATCAGAAC CATGCCAAGA 
GCTAGTGGTG CCCAAGGAAA GCCGAAAGCT GAGTCGTCAG GCAAACGGTC CTTCATGGGT 
CCCTCTTTCA AGAAACTGGG TCTCCTGTTC TCCAAGTTTA ATGGTCAGAC CTCTGAACCT 
ACTTCGGAGC CAATGTACAC AATCTCTGAT GGCATCGCAC AGCAGCACTC TATGTGGCAG 
GACATCAGAT ATTCTCAGAT GGAGAAAGGG AAGGCAGAGG CCTGTTCGCA AAGTGAGATG 
AACCTCAGTG AGGTAGAGTT AGGTGAAATC CGGGGTGCTG CTCGGAGCAG TGAATGCCCC 
CTAGCCTGTT CCAGCTCTCT TCACTGTGCA TCCGGCATCT GCTCCTCAAA TTCGAAACTT 
TTAGACTCAT CAGAGGACGT ATTTGAAACT TGGGGAGAGG CCTGTGACTT GCTCATGCAC 
AAATGGGGTG ATGGACAGGA AGAACAAGTT ACAACTCGGC TCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_543174.1
CDS	1..2925
Translation	MAQLYYKKVNYSPYRDRIPLQIVRAETELSAEEKAFLSAVEKGDYATVKQALQEAEIYYNVNINCMDPLGRSALLIAIENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLLSYRKPSGEKQVPTLMMDTQFSEFTPDITPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVECVSSSEVDSLRHSRSRLNIYKALASPSLIALSSEDPILTAFRLGWELKELSKVENEFKAEYEELSQQCKLFAKDLLDQARSSRELEIILNHRDDHSEELDPQKYHDLAKLKVAIKYHQKEFVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTCMTIGFLFPMLSIAYLISPRSNLGLFIKKPFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGEIKEMWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSPKSFLYLGNWFNNTFCPKRDPDGRRRRHNLRSFTERHADSLIQNQHYQEVIRNLVKRYVAAMIRNSKTNEGLTEENFKELKQDISSFRYEVLDLLGNRKHPRRSFSTSSAEFSQRDDTNDGSGGARAKSKSVSFNLGCKKKACQGAPLIRTMPRASGAQGKPKAESSGKRSFMGPSFKKLGLLFSKFNGQTSEPTSEPMYTISDGIAQQHSMWQDIRYSQMEKGKAEACSQSEMNLSEVELGEIRGAARSSECPLACSSSLHCASGICSSNSKLLDSSEDVFETWGEACDLLMHKWGDGQEEQVTTRL

Target ORF information:

RefSeq Version	NM_080898.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus transient receptor potential cation channel, subfamily C, member 5 (Trpc5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_080898.2

ORF Insert Sequence:

ATGGCCCAGC TGTACTACAA GAAGGTCAAC TACTCACCAT ACAGAGACCG CATCCCCCTC 
CAAATCGTGA GGGCTGAGAC TGAGCTGTCT GCTGAGGAGA AAGCTTTCCT TAGTGCTGTG 
GAGAAGGGGG ACTATGCCAC CGTGAAGCAG GCACTGCAGG AGGCCGAGAT CTACTACAAT 
GTCAACATCA ACTGCATGGA TCCTTTGGGC AGGAGCGCCC TACTCATTGC CATTGAGAAT 
GAGAACTTAG AGATCATGGA GCTACTGCTG AACCACAGTG TGTATGTGGG CGATGCATTA 
CTCTATGCCA TCCGCAAGGA GGTGGTAGGA GCTGTGGAAC TTCTGCTCAG CTACAGGAAG 
CCAAGTGGAG AGAAGCAGGT TCCCACTCTG ATGATGGACA CCCAGTTCTC TGAGTTCACA 
CCAGACATCA CACCCATCAT GTTGGCAGCC CACACCAACA ACTATGAAAT CATCAAATTG 
CTTGTCCAAA AGCGTGTCAC TATCCCACGG CCCCACCAAA TCCGCTGCAA CTGTGTGGAG 
TGTGTGTCCA GTTCAGAAGT AGACAGCCTA CGTCATTCAA GGTCCCGACT GAACATATAC 
AAGGCACTGG CAAGCCCTTC GCTCATCGCC TTATCAAGTG AGGACCCTAT CCTCACAGCA 
TTCCGGCTGG GCTGGGAACT CAAGGAGCTG AGCAAGGTGG AAAATGAGTT CAAGGCTGAG 
TATGAGGAGC TCTCCCAACA GTGTAAGCTC TTTGCCAAGG ACCTGCTGGA TCAAGCTCGG 
AGCTCCCGAG AACTGGAGAT CATTCTCAAC CATCGAGATG ACCACAGCGA AGAACTTGAC 
CCACAGAAGT ACCATGACCT GGCCAAGCTG AAGGTGGCAA TCAAATATCA CCAGAAAGAG 
TTTGTCGCTC AGCCAAACTG TCAACAATTG CTGGCCACCT TGTGGTACGA TGGCTTCCCT 
GGATGGCGAA GAAAACACTG GGTAGTCAAG CTTCTAACCT GCATGACCAT TGGATTCCTG 
TTTCCTATGC TGTCCATAGC CTATCTGATC TCACCCAGAA GCAACCTTGG GCTTTTCATC 
AAGAAACCCT TTATCAAGTT CATCTGCCAC ACAGCATCCT ATCTGACCTT CCTCTTCATG 
CTTCTCCTGG CTTCTCAGCA TATTGTCAGA ACAGACCTCC ATGTTCAAGG ACCTCCCCCA 
ACTGTCGTGG AATGGATGAT ACTGCCTTGG GTTCTAGGTT TCATCTGGGG GGAAATAAAG 
GAAATGTGGG ATGGTGGATT CACTGAATAC ATCCATGATT GGTGGAATTT GATGGATTTT 
GCAATGAACT CCCTCTACCT GGCAACTATT TCCTTGAAGA TTGTGGCCTA TGTCAAGTAT 
AATGGTTCTC GTCCAAGGGA AGAATGGGAA ATGTGGCACC CGACTCTGAT TGCGGAAGCA 
CTCTTCGCGA TATCGAACAT TTTAAGTTCC TTGCGTCTCA TATCCTTGTT CACAGCCAAC 
TCCCACTTAG GGCCTCTGCA GATCTCCTTG GGACGCATGC TGCTTGATAT ACTCAAATTT 
CTCTTTATCT ACTGCCTAGT ACTACTGGCT TTTGCCAACG GACTGAACCA GCTTTATTTT 
TACTATGAGA CCAGAGCTAT TGATGAACCT AACAACTGCA AAGGAATCCG GTGTGAAAAA 
CAGAACAACG CCTTCTCCAC GCTCTTTGAA ACCCTTCAGT CACTCTTCTG GTCTGTGTTT 
GGCCTTTTAA ACCTCTATGT TACCAATGTG AAGGCCCGGC ATGAATTCAC GGAGTTTGTG 
GGAGCTACTA TGTTTGGGAC ATACAACGTC ATCTCCCTGG TAGTGCTACT GAACATGCTC 
ATTGCCATGA TGAACAACTC CTACCAGCTC ATTGCCGACC ATGCTGATAT TGAGTGGAAG 
TTTGCGAGAA CGAAGCTCTG GATGAGTTAC TTTGATGAAG GTGGCACCTT ACCACCTCCT 
TTCAACATCA TCCCCAGCCC CAAATCATTT CTCTATCTTG GCAACTGGTT CAACAACACC 
TTCTGTCCCA AGAGAGACCC CGATGGGAGA CGAAGGAGGC ACAACTTGAG AAGCTTCACA 
GAACGTCATG CTGACAGCCT GATCCAAAAT CAACATTATC AGGAAGTTAT CAGAAATCTA 
GTCAAGAGAT ATGTGGCTGC CATGATAAGA AACTCGAAAA CAAATGAGGG GCTAACAGAA 
GAAAATTTTA AGGAATTAAA GCAGGACATT TCCAGCTTTC GATACGAAGT ACTTGACCTC 
TTGGGAAATA GAAAACATCC AAGAAGAAGC TTTTCCACTA GCAGCGCTGA ATTCTCTCAA 
AGGGATGATA CCAATGATGG CAGTGGTGGG GCTCGGGCCA AATCTAAGAG TGTCTCTTTC 
AATTTAGGCT GCAAGAAAAA GGCCTGCCAG GGAGCACCTC TCATCAGAAC CATGCCAAGA 
GCTAGTGGTG CCCAAGGAAA GCCGAAAGCT GAGTCGTCAG GCAAACGGTC CTTCATGGGT 
CCCTCTTTCA AGAAACTGGG TCTCCTGTTC TCCAAGTTTA ATGGTCAGAC CTCTGAACCT 
ACTTCGGAGC CAATGTACAC AATCTCTGAT GGCATCGCAC AGCAGCACTC TATGTGGCAG 
GACATCAGAT ATTCTCAGAT GGAGAAAGGG AAGGCAGAGG CCTGTTCGCA AAGTGAGATG 
AACCTCAGTG AGGTAGAGTT AGGTGAAATC CGGGGTGCTG CTCGGAGCAG TGAATGCCCC 
CTAGCCTGTT CCAGCTCTCT TCACTGTGCA TCCGGCATCT GCTCCTCAAA TTCGAAACTT 
TTAGACTCAT CAGAGGACGT ATTTGAAACT TGGGGAGAGG CCTGTGACTT GCTCATGCAC 
AAATGGGGTG ATGGACAGGA AGAACAAGTT ACAACTCGGC TCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Trpc5 ( XM_017601900.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017457389.1 Rattus norvegicus transient receptor potential cation channel, subfamily C, member 5 (Trpc5), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa62997
Clone ID Related Accession (Same CDS sequence)	XM_017601900.1
Accession Version	XM_017601900.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2922bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	short transient receptor potential channel 5 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005120.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCCAGC TGTACTACAA GAAGGTCAAC TACTCACCAT ACAGAGACCG CATCCCCCTC 
CAAATCGTGA GGGCTGAGAC TGAGCTGTCT GCTGAGGAGA AAGCTTTCCT TAGTGCTGTG 
GAGAAGGGGG ACTATGCCAC CGTGAAGCAG GCACTGCAGA GCCGAGATCT ACTACAATGT 
CAACATCACT GCATGGATCC TTTGGGCAGG AGCGCCCTAC TCATTGCCAT TGAGAATGAG 
AACTTAGAGA TCATGGAGCT ACTGCTGAAC CACAGTGTGT ATGTGGGCGA TGCATTACTC 
TATGCCATCC GCAAGGAGGT GGTAGGAGCT GTGGAACTTC TGCTCAGCTA CAGGAAGCCA 
AGTGGAGAGA AGCAGGTTCC CACTCTGATG ATGGACACCC AGTTCTCTGA GTTCACACCA 
GACATCACAC CCATCATGTT GGCAGCCCAC ACCAACAACT ATGAAATCAT CAAATTGCTT 
GTCCAAAAGC GTGTCACTAT CCCACGGCCC CACCAAATCC GCTGCAACTG TGTGGAGTGT 
GTGTCCAGTT CAGAAGTAGA CAGCCTACGT CATTCAAGGT CCCGACTGAA CATATACAAG 
GCACTGGCAA GCCCTTCGCT CATCGCCTTA TCAAGTGAGG ACCCTATCCT CACAGCATTC 
CGGCTGGGCT GGGAACTCAA GGAGCTGAGC AAGGTGGAAA ATGAGTTCAA GGCTGAGTAT 
GAGGAGCTCT CCCAACAGTG TAAGCTCTTT GCCAAGGACC TGCTGGATCA AGCTCGGAGC 
TCCCGAGAAC TGGAGATCAT TCTCAACCAT CGAGATGACC ACAGCGAAGA ACTTGACCCA 
CAGAAGTACC ATGACCTGGC CAAGCTGAAG GTGGCAATCA AATATCACCA GAAAGAGTTT 
GTCGCTCAGC CAAACTGTCA ACAATTGCTG GCCACCTTGT GGTACGATGG CTTCCCTGGA 
TGGCGAAGAA AACACTGGGT AGTCAAGCTT CTAACCTGCA TGACCATTGG ATTCCTGTTT 
CCTATGCTGT CCATAGCCTA TCTGATCTCA CCCAGAAGCA ACCTTGGGCT TTTCATCAAG 
AAACCCTTTA TCAAGTTCAT CTGCCACACA GCATCCTATC TGACCTTCCT CTTCATGCTT 
CTCCTGGCTT CTCAGCATAT TGTCAGAACA GACCTCCATG TTCAAGGACC TCCCCCAACT 
GTCGTGGAAT GGATGATACT GCCTTGGGTT CTAGGTTTCA TCTGGGGGGA AATAAAGGAA 
ATGTGGGATG GTGGATTCAC TGAATACATC CATGATTGGT GGAATTTGAT GGATTTTGCA 
ATGAACTCCC TCTACCTGGC AACTATTTCC TTGAAGATTG TGGCCTATGT CAAGTATAAT 
GGTTCTCGTC CAAGGGAAGA ATGGGAAATG TGGCACCCGA CTCTGATTGC GGAAGCACTC 
TTCGCGATAT CGAACATTTT AAGTTCCTTG CGTCTCATAT CCTTGTTCAC AGCCAACTCC 
CACTTAGGGC CTCTGCAGAT CTCCTTGGGA CGCATGCTGC TTGATATACT CAAATTTCTC 
TTTATCTACT GCCTAGTACT ACTGGCTTTT GCCAACGGAC TGAACCAGCT TTATTTTTAC 
TATGAGACCA GAGCTATTGA TGAACCTAAC AACTGCAAAG GAATCCGGTG TGAAAAACAG 
AACAACGCCT TCTCCACGCT CTTTGAAACC CTTCAGTCAC TCTTCTGGTC TGTGTTTGGC 
CTTTTAAACC TCTATGTTAC CAATGTGAAG GCCCGGCATG AATTCACGGA GTTTGTGGGA 
GCTACTATGT TTGGGACATA CAACGTCATC TCCCTGGTAG TGCTACTGAA CATGCTCATT 
GCCATGATGA ACAACTCCTA CCAGCTCATT GCCGACCATG CTGATATTGA GTGGAAGTTT 
GCGAGAACGA AGCTCTGGAT GAGTTACTTT GATGAAGGTG GCACCTTACC ACCTCCTTTC 
AACATCATCC CCAGCCCCAA ATCATTTCTC TATCTTGGCA ACTGGTTCAA CAACACCTTC 
TGTCCCAAGA GAGACCCCGA TGGGAGACGA AGGAGGCACA ACTTGAGAAG CTTCACAGAA 
CGTCATGCTG ACAGCCTGAT CCAAAATCAA CATTATCAGG AAGTTATCAG AAATCTAGTC 
AAGAGATATG TGGCTGCCAT GATAAGAAAC TCGAAAACAA ATGAGGGGCT AACAGAAGAA 
AATTTTAAGG AATTAAAGCA GGACATTTCC AGCTTTCGAT ACGAAGTACT TGACCTCTTG 
GGAAATAGAA AACATCCAAG AAGAAGCTTT TCCACTAGCA GCGCTGAATT CTCTCAAAGG 
GATGATACCA ATGATGGCAG TGGTGGGGCT CGGGCCAAAT CTAAGAGTGT CTCTTTCAAT 
TTAGGCTGCA AGAAAAAGGC CTGCCAGGGA GCACCTCTCA TCAGAACCAT GCCAAGAGCT 
AGTGGTGCCC AAGGAAAGCC GAAAGCTGAG TCGTCAGGCA AACGGTCCTT CATGGGTCCC 
TCTTTCAAGA AACTGGGTCT CCTGTTCTCC AAGTTTAATG GTCAGACCTC TGAACCTACT 
TCGGAGCCAA TGTACACAAT CTCTGATGGC ATCGCACAGC AGCACTCTAT GTGGCAGGAC 
ATCAGATATT CTCAGATGGA GAAAGGGAAG GCAGAGGCCT GTTCGCAAAG TGAGATGAAC 
CTCAGTGAGG TAGAGTTAGG TGAAATCCGG GGTGCTGCTC GGAGCAGTGA ATGCCCCCTA 
GCCTGTTCCA GCTCTCTTCA CTGTGCATCC GGCATCTGCT CCTCAAATTC GAAACTTTTA 
GACTCATCAG AGGACGTATT TGAAACTTGG GGAGAGGCCT GTGACTTGCT CATGCACAAA 
TGGGGTGATG GACAGGAAGA ACAAGTTACA ACTCGGCTCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017457389.1
CDS	308..3229
Translation	MAQLYYKKVNYSPYRDRIPLQIVRAETELSAEEKAFLSAVEKGDYATVKQALQSRDLLQCQHHCMDPLGRSALLIAIENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLLSYRKPSGEKQVPTLMMDTQFSEFTPDITPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVECVSSSEVDSLRHSRSRLNIYKALASPSLIALSSEDPILTAFRLGWELKELSKVENEFKAEYEELSQQCKLFAKDLLDQARSSRELEIILNHRDDHSEELDPQKYHDLAKLKVAIKYHQKEFVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTCMTIGFLFPMLSIAYLISPRSNLGLFIKKPFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGEIKEMWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSPKSFLYLGNWFNNTFCPKRDPDGRRRRHNLRSFTERHADSLIQNQHYQEVIRNLVKRYVAAMIRNSKTNEGLTEENFKELKQDISSFRYEVLDLLGNRKHPRRSFSTSSAEFSQRDDTNDGSGGARAKSKSVSFNLGCKKKACQGAPLIRTMPRASGAQGKPKAESSGKRSFMGPSFKKLGLLFSKFNGQTSEPTSEPMYTISDGIAQQHSMWQDIRYSQMEKGKAEACSQSEMNLSEVELGEIRGAARSSECPLACSSSLHCASGICSSNSKLLDSSEDVFETWGEACDLLMHKWGDGQEEQVTTRL

Target ORF information:

RefSeq Version	XM_017601900.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus transient receptor potential cation channel, subfamily C, member 5 (Trpc5), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017601900.1

ORF Insert Sequence:

ATGGCCCAGC TGTACTACAA GAAGGTCAAC TACTCACCAT ACAGAGACCG CATCCCCCTC 
CAAATCGTGA GGGCTGAGAC TGAGCTGTCT GCTGAGGAGA AAGCTTTCCT TAGTGCTGTG 
GAGAAGGGGG ACTATGCCAC CGTGAAGCAG GCACTGCAGA GCCGAGATCT ACTACAATGT 
CAACATCACT GCATGGATCC TTTGGGCAGG AGCGCCCTAC TCATTGCCAT TGAGAATGAG 
AACTTAGAGA TCATGGAGCT ACTGCTGAAC CACAGTGTGT ATGTGGGCGA TGCATTACTC 
TATGCCATCC GCAAGGAGGT GGTAGGAGCT GTGGAACTTC TGCTCAGCTA CAGGAAGCCA 
AGTGGAGAGA AGCAGGTTCC CACTCTGATG ATGGACACCC AGTTCTCTGA GTTCACACCA 
GACATCACAC CCATCATGTT GGCAGCCCAC ACCAACAACT ATGAAATCAT CAAATTGCTT 
GTCCAAAAGC GTGTCACTAT CCCACGGCCC CACCAAATCC GCTGCAACTG TGTGGAGTGT 
GTGTCCAGTT CAGAAGTAGA CAGCCTACGT CATTCAAGGT CCCGACTGAA CATATACAAG 
GCACTGGCAA GCCCTTCGCT CATCGCCTTA TCAAGTGAGG ACCCTATCCT CACAGCATTC 
CGGCTGGGCT GGGAACTCAA GGAGCTGAGC AAGGTGGAAA ATGAGTTCAA GGCTGAGTAT 
GAGGAGCTCT CCCAACAGTG TAAGCTCTTT GCCAAGGACC TGCTGGATCA AGCTCGGAGC 
TCCCGAGAAC TGGAGATCAT TCTCAACCAT CGAGATGACC ACAGCGAAGA ACTTGACCCA 
CAGAAGTACC ATGACCTGGC CAAGCTGAAG GTGGCAATCA AATATCACCA GAAAGAGTTT 
GTCGCTCAGC CAAACTGTCA ACAATTGCTG GCCACCTTGT GGTACGATGG CTTCCCTGGA 
TGGCGAAGAA AACACTGGGT AGTCAAGCTT CTAACCTGCA TGACCATTGG ATTCCTGTTT 
CCTATGCTGT CCATAGCCTA TCTGATCTCA CCCAGAAGCA ACCTTGGGCT TTTCATCAAG 
AAACCCTTTA TCAAGTTCAT CTGCCACACA GCATCCTATC TGACCTTCCT CTTCATGCTT 
CTCCTGGCTT CTCAGCATAT TGTCAGAACA GACCTCCATG TTCAAGGACC TCCCCCAACT 
GTCGTGGAAT GGATGATACT GCCTTGGGTT CTAGGTTTCA TCTGGGGGGA AATAAAGGAA 
ATGTGGGATG GTGGATTCAC TGAATACATC CATGATTGGT GGAATTTGAT GGATTTTGCA 
ATGAACTCCC TCTACCTGGC AACTATTTCC TTGAAGATTG TGGCCTATGT CAAGTATAAT 
GGTTCTCGTC CAAGGGAAGA ATGGGAAATG TGGCACCCGA CTCTGATTGC GGAAGCACTC 
TTCGCGATAT CGAACATTTT AAGTTCCTTG CGTCTCATAT CCTTGTTCAC AGCCAACTCC 
CACTTAGGGC CTCTGCAGAT CTCCTTGGGA CGCATGCTGC TTGATATACT CAAATTTCTC 
TTTATCTACT GCCTAGTACT ACTGGCTTTT GCCAACGGAC TGAACCAGCT TTATTTTTAC 
TATGAGACCA GAGCTATTGA TGAACCTAAC AACTGCAAAG GAATCCGGTG TGAAAAACAG 
AACAACGCCT TCTCCACGCT CTTTGAAACC CTTCAGTCAC TCTTCTGGTC TGTGTTTGGC 
CTTTTAAACC TCTATGTTAC CAATGTGAAG GCCCGGCATG AATTCACGGA GTTTGTGGGA 
GCTACTATGT TTGGGACATA CAACGTCATC TCCCTGGTAG TGCTACTGAA CATGCTCATT 
GCCATGATGA ACAACTCCTA CCAGCTCATT GCCGACCATG CTGATATTGA GTGGAAGTTT 
GCGAGAACGA AGCTCTGGAT GAGTTACTTT GATGAAGGTG GCACCTTACC ACCTCCTTTC 
AACATCATCC CCAGCCCCAA ATCATTTCTC TATCTTGGCA ACTGGTTCAA CAACACCTTC 
TGTCCCAAGA GAGACCCCGA TGGGAGACGA AGGAGGCACA ACTTGAGAAG CTTCACAGAA 
CGTCATGCTG ACAGCCTGAT CCAAAATCAA CATTATCAGG AAGTTATCAG AAATCTAGTC 
AAGAGATATG TGGCTGCCAT GATAAGAAAC TCGAAAACAA ATGAGGGGCT AACAGAAGAA 
AATTTTAAGG AATTAAAGCA GGACATTTCC AGCTTTCGAT ACGAAGTACT TGACCTCTTG 
GGAAATAGAA AACATCCAAG AAGAAGCTTT TCCACTAGCA GCGCTGAATT CTCTCAAAGG 
GATGATACCA ATGATGGCAG TGGTGGGGCT CGGGCCAAAT CTAAGAGTGT CTCTTTCAAT 
TTAGGCTGCA AGAAAAAGGC CTGCCAGGGA GCACCTCTCA TCAGAACCAT GCCAAGAGCT 
AGTGGTGCCC AAGGAAAGCC GAAAGCTGAG TCGTCAGGCA AACGGTCCTT CATGGGTCCC 
TCTTTCAAGA AACTGGGTCT CCTGTTCTCC AAGTTTAATG GTCAGACCTC TGAACCTACT 
TCGGAGCCAA TGTACACAAT CTCTGATGGC ATCGCACAGC AGCACTCTAT GTGGCAGGAC 
ATCAGATATT CTCAGATGGA GAAAGGGAAG GCAGAGGCCT GTTCGCAAAG TGAGATGAAC 
CTCAGTGAGG TAGAGTTAGG TGAAATCCGG GGTGCTGCTC GGAGCAGTGA ATGCCCCCTA 
GCCTGTTCCA GCTCTCTTCA CTGTGCATCC GGCATCTGCT CCTCAAATTC GAAACTTTTA 
GACTCATCAG AGGACGTATT TGAAACTTGG GGAGAGGCCT GTGACTTGCT CATGCACAAA 
TGGGGTGATG GACAGGAAGA ACAAGTTACA ACTCGGCTCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

TRPC5 channels participate in pressure-sensing in aortic baroreceptors.
Nature communications711947(2016 Jul)
Lau OC,Shen B,Wong CO,Tjong YW,Lo CY,Wang HC,Huang Y,Yung WH,Chen YC,Fung ML,Rudd JA,Yao X

Transient Receptor Potential Canonical (TRPC)/Orai1-dependent Store-operated Ca2+ Channels: NEW TARGETS OF ALDOSTERONE IN CARDIOMYOCYTES.
The Journal of biological chemistry291(25)13394-409(2016 Jun)
Sabourin J,Bartoli F,Antigny F,Gomez AM,Benitah JP

The possible relationship between expressions of TRPC3/5 channels and cognitive changes in rat model of chronic unpredictable stress.
Behavioural brain research290180-6(2015 Sep)
Qin X,Liu Y,Zhu M,Yang Z

Inhibition of the TRPC5 ion channel protects the kidney filter.
The Journal of clinical investigation123(12)5298-309(2013 Dec)
Schaldecker T,Kim S,Tarabanis C,Tian D,Hakroush S,Castonguay P,Ahn W,Wallentin H,Heid H,Hopkins CR,Lindsley CW,Riccio A,Buvall L,Weins A,Greka A

Conserved gating elements in TRPC4 and TRPC5 channels.
The Journal of biological chemistry288(27)19471-83(2013 Jul)
Beck A,Speicher T,Stoerger C,Sell T,Dettmer V,Jusoh SA,Abdulmughni A,Cavali? A,Philipp SE,Zhu MX,Helms V,Wissenbach U,Flockerzi V

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Trpc5 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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