Cyth2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cyth2
Entrez Gene ID	116692
Full Name	cytohesin 2
Synonyms	Arno,Pscd2,Sec7,Sec7B
General protein information	Preferred Names cytohesin 2 Names cytohesin-2 ARF nucleotide binding site opener CLM2 PH, SEC7 and coiled-coil domain-containing protein 2 SEC7 homolog B pleckstrin homology, Sec7 and coiled-coil domains 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q22
Summary	may play a role in transport from the Golgi apparatus to secretory vesicles [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006228964.3	XP_006229026.1	cytohesin-2 isoform X1
XM_008759304.2	XP_008757526.1	cytohesin-2 isoform X2
NM_053911.2	NP_446363.1	cytohesin-2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CYTH2	XP_001154812.2
Canis lupus familiaris (dog)	CYTH2	XP_852119.2
Danio rerio (zebrafish)	si:dkey-283b15.4	XP_697830.6
Homo sapiens (human)	CYTH2	NP_059431.1
	CYTH2	XP_002801373.1
Mus musculus (house mouse)	Cyth2	NP_035311.1
Xenopus tropicalis (tropical clawed frog)	cyth1	XP_002935045.2
Bos taurus (cattle)	CYTH2	NP_001070562.1
Rattus norvegicus (Norway rat)	Cyth2	NP_446363.1

Gene Ontology
Bibliography

Related articles in PubMed

The N termini of a-subunit isoforms are involved in signaling between vacuolar H+-ATPase (V-ATPase) and cytohesin-2.
Hosokawa H, Dip PV, Merkulova M, Bakulina A, Zhuang Z, Khatri A, Jian X, Keating SM, Bueler SA, Rubinstein JL, Randazzo PA, Ausiello DA, Gr?ber G, Marshansky V
The Journal of biological chemistry288(8)5896-913(2013 Feb)

FRMD4A regulates epithelial polarity by connecting Arf6 activation with the PAR complex.
Ikenouchi J, Umeda M
Proceedings of the National Academy of Sciences of the United States of America107(2)748-53(2010 Jan)

A Role for ARF6 and ARNO in the regulation of endosomal dynamics in neurons.
Hern?ndez-Deviez D, Mackay-Sim A, Wilson JM
Traffic (Copenhagen, Denmark)8(12)1750-64(2007 Dec)

Structural basis and mechanism of autoregulation in 3-phosphoinositide-dependent Grp1 family Arf GTPase exchange factors.
DiNitto JP, Delprato A, Gabe Lee MT, Cronin TC, Huang S, Guilherme A, Czech MP, Lambright DG
Molecular cell28(4)569-83(2007 Nov)

The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane.
Hofmann I, Thompson A, Sanderson CM, Munro S
Current biology : CB17(8)711-6(2007 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The N termini of a-subunit isoforms are involved in signaling between vacuolar H+-ATPase (V-ATPase) and cytohesin-2
Title: The N termini of a-subunit isoforms are involved in signaling between vacuolar H+-ATPase (V-ATPase) and cytohesin-2.

endotubin labels a distinct endosomal structure in neurons; and ARNO and ARF6 mediate neurite extension through the regulation of this compartment
Title: A Role for ARF6 and ARNO in the regulation of endosomal dynamics in neurons.

cytohesin 2 binds to IPCEF1, which modifies its activity
Title: Interaction protein for cytohesin exchange factors 1 (IPCEF1) binds cytohesin 2 and modifies its activity.

The following Cyth2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cyth2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa13022	NM_053911.2 Latest version!	Rattus norvegicus cytohesin 2 (Cyth2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa22664	XM_006228964.3 Latest version!	Rattus norvegicus cytohesin 2 (Cyth2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa44051	XM_008759304.2 Latest version!	Rattus norvegicus cytohesin 2 (Cyth2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cyth2 ( NM_053911.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_446363.1 Rattus norvegicus cytohesin 2 (Cyth2), mRNA.

Price & Availability↑

CloneID	ORa13022
Clone ID Related Accession (Same CDS sequence)	NM_053911.2
Accession Version	NM_053911.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1203bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	cytohesin-2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from U83896.1 and BC070928.1. On Oct 5, 2005 this sequence version replaced NM_053911.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U83896.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGGACG GTGTCTACGA GCCCCCAGAC TTGACTCCAG AGGAGCGCAT GGAGCTGGAG 
AACATCCGTC GGCGAAAGCA GGAGCTGCTG GTGGAGATCC AGCGCCTCCG GGAAGAGCTA 
AGTGAAGCTA TGAGCGAAGT GGAGGGTCTG GAGGCCAATG AGGGCAGTAA GACCTTGCAG 
CGGAACCGGA AGATGGCAAT GGGCCGGAAG AAATTCAACA TGGACCCCAA AAAGGGGATC 
CAATTCTTGG TGGAGCATGA ACTTCTACAG AACACACCTG AGGAAATTGC CCGCTTCCTG 
TACAAGGGCG AGGGGCTGAA CAAGACAGCC ATTGGGGACT ACCTAGGGGA AAGGGAAGAG 
CTGAACCTGT CTGTGCTCCA TGCTTTTGTG GATCTACATG AGTTCACCGA CCTCAATCTG 
GTTCAGGCCC TCCGGCAATT CCTGTGGAGC TTTCGCCTCC CTGGAGAGGC TCAGAAAATT 
GACCGAATGA TGGAGGCCTT TGCCCAGAGA TATTGCTTAT GTAATCCCGG GGTCTTCCAG 
TCCACAGACA CCTGCTACGT GTTGTCCTTC GCTGTGATCA TGCTGAACAC CAGCCTTCAC 
AATCCCAATG TCAGGGACAA GCCGGGCCTG GAGCGCTTTG TGGCCATGAA CCGAGGCATC 
AATGAGGGTG GGGACCTGCC TGAGGACCTT CTCAGGAACC TCTATGACAG CATCCGAAAC 
GAGCCCTTCA AAATCCCTGA GGATGATGGG AATGATCTCA CCCACACCTT CTTCAACCCA 
GACCGAGAGG GCTGGCTCCT AAAGCTGGGA GGGGGCCGGG TGAAGACTTG GAAGCGTCGC 
TGGTTCATCC TCACAGACAA CTGCCTCTAC TACTTTGAGT ACACTACGGA CAAGGAGCCC 
AGAGGGATCA TCCCCCTAGA GAACCTGAGC ATTCGTGAGG TGGATGATCC TCGGAAGCCG 
AACTGCTTTG AGCTTTACAT TCCCAACAAT AAGGGACAGC TCATCAAAGC CTGCAAAACG 
GAGGCTGATG GTCGGGTAGT AGAGGGGAAC CACATGGTGT ACCGAATCTC AGCACCCACA 
CAGGAGGAGA AAGACGAGTG GATCAAGTCC ATCCAGGCTG CTGTAAGCGT GGACCCCTTC 
TACGAGATGT TGGCAGCAAG AAAGAAGCGG ATTTCTGTGA AGAAGAAGCA AGAACAACCC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_446363.1
CDS	184..1386
Translation	MEDGVYEPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTLQRNRKMAMGRKKFNMDPKKGIQFLVEHELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREELNLSVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEDLLRNLYDSIRNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKKKQEQP

Target ORF information:

RefSeq Version	NM_053911.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cytohesin 2 (Cyth2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053911.2

ORF Insert Sequence:

ATGGAGGACG GTGTCTACGA GCCCCCAGAC TTGACTCCAG AGGAGCGCAT GGAGCTGGAG 
AACATCCGTC GGCGAAAGCA GGAGCTGCTG GTGGAGATCC AGCGCCTCCG GGAAGAGCTA 
AGTGAAGCTA TGAGCGAAGT GGAGGGTCTG GAGGCCAATG AGGGCAGTAA GACCTTGCAG 
CGGAACCGGA AGATGGCAAT GGGCCGGAAG AAATTCAACA TGGACCCCAA AAAGGGGATC 
CAATTCTTGG TGGAGCATGA ACTTCTACAG AACACACCTG AGGAAATTGC CCGCTTCCTG 
TACAAGGGCG AGGGGCTGAA CAAGACAGCC ATTGGGGACT ACCTAGGGGA AAGGGAAGAG 
CTGAACCTGT CTGTGCTCCA TGCTTTTGTG GATCTACATG AGTTCACCGA CCTCAATCTG 
GTTCAGGCCC TCCGGCAATT CCTGTGGAGC TTTCGCCTCC CTGGAGAGGC TCAGAAAATT 
GACCGAATGA TGGAGGCCTT TGCCCAGAGA TATTGCTTAT GTAATCCCGG GGTCTTCCAG 
TCCACAGACA CCTGCTACGT GTTGTCCTTC GCTGTGATCA TGCTGAACAC CAGCCTTCAC 
AATCCCAATG TCAGGGACAA GCCGGGCCTG GAGCGCTTTG TGGCCATGAA CCGAGGCATC 
AATGAGGGTG GGGACCTGCC TGAGGACCTT CTCAGGAACC TCTATGACAG CATCCGAAAC 
GAGCCCTTCA AAATCCCTGA GGATGATGGG AATGATCTCA CCCACACCTT CTTCAACCCA 
GACCGAGAGG GCTGGCTCCT AAAGCTGGGA GGGGGCCGGG TGAAGACTTG GAAGCGTCGC 
TGGTTCATCC TCACAGACAA CTGCCTCTAC TACTTTGAGT ACACTACGGA CAAGGAGCCC 
AGAGGGATCA TCCCCCTAGA GAACCTGAGC ATTCGTGAGG TGGATGATCC TCGGAAGCCG 
AACTGCTTTG AGCTTTACAT TCCCAACAAT AAGGGACAGC TCATCAAAGC CTGCAAAACG 
GAGGCTGATG GTCGGGTAGT AGAGGGGAAC CACATGGTGT ACCGAATCTC AGCACCCACA 
CAGGAGGAGA AAGACGAGTG GATCAAGTCC ATCCAGGCTG CTGTAAGCGT GGACCCCTTC 
TACGAGATGT TGGCAGCAAG AAAGAAGCGG ATTTCTGTGA AGAAGAAGCA AGAACAACCC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cyth2 ( XM_006228964.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006229026.1 Rattus norvegicus cytohesin 2 (Cyth2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa22664
Clone ID Related Accession (Same CDS sequence)	XM_006228964.3
Accession Version	XM_006228964.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1200bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	cytohesin-2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006228964.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGGACG GTGTCTACGA GCCCCCAGAC TTGACTCCAG AGGAGCGCAT GGAGCTGGAG 
AACATCCGTC GGCGAAAGCA GGAGCTGCTG GTGGAGATCC AGCGCCTCCG GGAAGAGCTA 
AGTGAAGCTA TGAGCGAAGT GGAGGGTCTG GAGGCCAATG AGGGCAGTAA GACCTTGCAG 
CGGAACCGGA AGATGGCAAT GGGCCGGAAG AAATTCAACA TGGACCCCAA AAAGGGGATC 
CAATTCTTGG TGGAGCATGA ACTTCTACAG AACACACCTG AGGAAATTGC CCGCTTCCTG 
TACAAGGGCG AGGGGCTGAA CAAGACAGCC ATTGGGGACT ACCTAGGGGA AAGGGAAGAG 
CTGAACCTGT CTGTGCTCCA TGCTTTTGTG GATCTACATG AGTTCACCGA CCTCAATCTG 
GTTCAGGCCC TCCGGCAATT CCTGTGGAGC TTTCGCCTCC CTGGAGAGGC TCAGAAAATT 
GACCGAATGA TGGAGGCCTT TGCCCAGAGA TATTGCTTAT GTAATCCCGG GGTCTTCCAG 
TCCACAGACA CCTGCTACGT GTTGTCCTTC GCTGTGATCA TGCTGAACAC CAGCCTTCAC 
AATCCCAATG TCAGGGACAA GCCGGGCCTG GAGCGCTTTG TGGCCATGAA CCGAGGCATC 
AATGAGGGTG GGGACCTGCC TGAGGACCTT CTCAGGAACC TCTATGACAG CATCCGAAAC 
GAGCCCTTCA AAATCCCTGA GGATGATGGG AATGATCTCA CCCACACCTT CTTCAACCCA 
GACCGAGAGG GCTGGCTCCT AAAGCTGGGG GGCCGGGTGA AGACTTGGAA GCGTCGCTGG 
TTCATCCTCA CAGACAACTG CCTCTACTAC TTTGAGTACA CTACGGACAA GGAGCCCAGA 
GGGATCATCC CCCTAGAGAA CCTGAGCATT CGTGAGGTGG ATGATCCTCG GAAGCCGAAC 
TGCTTTGAGC TTTACATTCC CAACAATAAG GGACAGCTCA TCAAAGCCTG CAAAACGGAG 
GCTGATGGTC GGGTAGTAGA GGGGAACCAC ATGGTGTACC GAATCTCAGC ACCCACACAG 
GAGGAGAAAG ACGAGTGGAT CAAGTCCATC CAGGCTGCTG TAAGCGTGGA CCCCTTCTAC 
GAGATGTTGG CAGCAAGAAA GAAGCGGATT TCTGTGAAGA AGAAGCAAGA ACAACCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006229026.1
CDS	405..1604
Translation	MEDGVYEPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTLQRNRKMAMGRKKFNMDPKKGIQFLVEHELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREELNLSVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEDLLRNLYDSIRNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKKKQEQP

Target ORF information:

RefSeq Version	XM_006228964.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cytohesin 2 (Cyth2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006228964.3

ORF Insert Sequence:

ATGGAGGACG GTGTCTACGA GCCCCCAGAC TTGACTCCAG AGGAGCGCAT GGAGCTGGAG 
AACATCCGTC GGCGAAAGCA GGAGCTGCTG GTGGAGATCC AGCGCCTCCG GGAAGAGCTA 
AGTGAAGCTA TGAGCGAAGT GGAGGGTCTG GAGGCCAATG AGGGCAGTAA GACCTTGCAG 
CGGAACCGGA AGATGGCAAT GGGCCGGAAG AAATTCAACA TGGACCCCAA AAAGGGGATC 
CAATTCTTGG TGGAGCATGA ACTTCTACAG AACACACCTG AGGAAATTGC CCGCTTCCTG 
TACAAGGGCG AGGGGCTGAA CAAGACAGCC ATTGGGGACT ACCTAGGGGA AAGGGAAGAG 
CTGAACCTGT CTGTGCTCCA TGCTTTTGTG GATCTACATG AGTTCACCGA CCTCAATCTG 
GTTCAGGCCC TCCGGCAATT CCTGTGGAGC TTTCGCCTCC CTGGAGAGGC TCAGAAAATT 
GACCGAATGA TGGAGGCCTT TGCCCAGAGA TATTGCTTAT GTAATCCCGG GGTCTTCCAG 
TCCACAGACA CCTGCTACGT GTTGTCCTTC GCTGTGATCA TGCTGAACAC CAGCCTTCAC 
AATCCCAATG TCAGGGACAA GCCGGGCCTG GAGCGCTTTG TGGCCATGAA CCGAGGCATC 
AATGAGGGTG GGGACCTGCC TGAGGACCTT CTCAGGAACC TCTATGACAG CATCCGAAAC 
GAGCCCTTCA AAATCCCTGA GGATGATGGG AATGATCTCA CCCACACCTT CTTCAACCCA 
GACCGAGAGG GCTGGCTCCT AAAGCTGGGG GGCCGGGTGA AGACTTGGAA GCGTCGCTGG 
TTCATCCTCA CAGACAACTG CCTCTACTAC TTTGAGTACA CTACGGACAA GGAGCCCAGA 
GGGATCATCC CCCTAGAGAA CCTGAGCATT CGTGAGGTGG ATGATCCTCG GAAGCCGAAC 
TGCTTTGAGC TTTACATTCC CAACAATAAG GGACAGCTCA TCAAAGCCTG CAAAACGGAG 
GCTGATGGTC GGGTAGTAGA GGGGAACCAC ATGGTGTACC GAATCTCAGC ACCCACACAG 
GAGGAGAAAG ACGAGTGGAT CAAGTCCATC CAGGCTGCTG TAAGCGTGGA CCCCTTCTAC 
GAGATGTTGG CAGCAAGAAA GAAGCGGATT TCTGTGAAGA AGAAGCAAGA ACAACCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cyth2 ( XM_008759304.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008757526.1 Rattus norvegicus cytohesin 2 (Cyth2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa44051
Clone ID Related Accession (Same CDS sequence)	XM_008759304.2
Accession Version	XM_008759304.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1155bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	cytohesin-2 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008759304.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGCTGG AGAACATCCG TCGGCGAAAG CAGGAGCTGC TGGTGGAGAT CCAGCGCCTC 
CGGGAAGAGC TAAGTGAAGC TATGAGCGAA GTGGAGGGTC TGGAGGCCAA TGAGGGCAGT 
AAGACCTTGC AGCGGAACCG GAAGATGGCA ATGGGCCGGA AGAAATTCAA CATGGACCCC 
AAAAAGGGGA TCCAATTCTT GGTGGAGCAT GAACTTCTAC AGAACACACC TGAGGAAATT 
GCCCGCTTCC TGTACAAGGG CGAGGGGCTG AACAAGACAG CCATTGGGGA CTACCTAGGG 
GAAAGGGAAG AGCTGAACCT GTCTGTGCTC CATGCTTTTG TGGATCTACA TGAGTTCACC 
GACCTCAATC TGGTTCAGGC CCTCCGGCAA TTCCTGTGGA GCTTTCGCCT CCCTGGAGAG 
GCTCAGAAAA TTGACCGAAT GATGGAGGCC TTTGCCCAGA GATATTGCTT ATGTAATCCC 
GGGGTCTTCC AGTCCACAGA CACCTGCTAC GTGTTGTCCT TCGCTGTGAT CATGCTGAAC 
ACCAGCCTTC ACAATCCCAA TGTCAGGGAC AAGCCGGGCC TGGAGCGCTT TGTGGCCATG 
AACCGAGGCA TCAATGAGGG TGGGGACCTG CCTGAGGACC TTCTCAGGAA CCTCTATGAC 
AGCATCCGAA ACGAGCCCTT CAAAATCCCT GAGGATGATG GGAATGATCT CACCCACACC 
TTCTTCAACC CAGACCGAGA GGGCTGGCTC CTAAAGCTGG GAGGGGGCCG GGTGAAGACT 
TGGAAGCGTC GCTGGTTCAT CCTCACAGAC AACTGCCTCT ACTACTTTGA GTACACTACG 
GACAAGGAGC CCAGAGGGAT CATCCCCCTA GAGAACCTGA GCATTCGTGA GGTGGATGAT 
CCTCGGAAGC CGAACTGCTT TGAGCTTTAC ATTCCCAACA ATAAGGGACA GCTCATCAAA 
GCCTGCAAAA CGGAGGCTGA TGGTCGGGTA GTAGAGGGGA ACCACATGGT GTACCGAATC 
TCAGCACCCA CACAGGAGGA GAAAGACGAG TGGATCAAGT CCATCCAGGC TGCTGTAAGC 
GTGGACCCCT TCTACGAGAT GTTGGCAGCA AGAAAGAAGC GGATTTCTGT GAAGAAGAAG 
CAAGAACAAC CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008757526.1
CDS	720..1874
Translation	MELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTLQRNRKMAMGRKKFNMDPKKGIQFLVEHELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREELNLSVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEDLLRNLYDSIRNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKKKQEQP

Target ORF information:

RefSeq Version	XM_008759304.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cytohesin 2 (Cyth2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008759304.2

ORF Insert Sequence:

ATGGAGCTGG AGAACATCCG TCGGCGAAAG CAGGAGCTGC TGGTGGAGAT CCAGCGCCTC 
CGGGAAGAGC TAAGTGAAGC TATGAGCGAA GTGGAGGGTC TGGAGGCCAA TGAGGGCAGT 
AAGACCTTGC AGCGGAACCG GAAGATGGCA ATGGGCCGGA AGAAATTCAA CATGGACCCC 
AAAAAGGGGA TCCAATTCTT GGTGGAGCAT GAACTTCTAC AGAACACACC TGAGGAAATT 
GCCCGCTTCC TGTACAAGGG CGAGGGGCTG AACAAGACAG CCATTGGGGA CTACCTAGGG 
GAAAGGGAAG AGCTGAACCT GTCTGTGCTC CATGCTTTTG TGGATCTACA TGAGTTCACC 
GACCTCAATC TGGTTCAGGC CCTCCGGCAA TTCCTGTGGA GCTTTCGCCT CCCTGGAGAG 
GCTCAGAAAA TTGACCGAAT GATGGAGGCC TTTGCCCAGA GATATTGCTT ATGTAATCCC 
GGGGTCTTCC AGTCCACAGA CACCTGCTAC GTGTTGTCCT TCGCTGTGAT CATGCTGAAC 
ACCAGCCTTC ACAATCCCAA TGTCAGGGAC AAGCCGGGCC TGGAGCGCTT TGTGGCCATG 
AACCGAGGCA TCAATGAGGG TGGGGACCTG CCTGAGGACC TTCTCAGGAA CCTCTATGAC 
AGCATCCGAA ACGAGCCCTT CAAAATCCCT GAGGATGATG GGAATGATCT CACCCACACC 
TTCTTCAACC CAGACCGAGA GGGCTGGCTC CTAAAGCTGG GAGGGGGCCG GGTGAAGACT 
TGGAAGCGTC GCTGGTTCAT CCTCACAGAC AACTGCCTCT ACTACTTTGA GTACACTACG 
GACAAGGAGC CCAGAGGGAT CATCCCCCTA GAGAACCTGA GCATTCGTGA GGTGGATGAT 
CCTCGGAAGC CGAACTGCTT TGAGCTTTAC ATTCCCAACA ATAAGGGACA GCTCATCAAA 
GCCTGCAAAA CGGAGGCTGA TGGTCGGGTA GTAGAGGGGA ACCACATGGT GTACCGAATC 
TCAGCACCCA CACAGGAGGA GAAAGACGAG TGGATCAAGT CCATCCAGGC TGCTGTAAGC 
GTGGACCCCT TCTACGAGAT GTTGGCAGCA AGAAAGAAGC GGATTTCTGT GAAGAAGAAG 
CAAGAACAAC CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The N termini of a-subunit isoforms are involved in signaling between vacuolar H+-ATPase (V-ATPase) and cytohesin-2.
The Journal of biological chemistry288(8)5896-913(2013 Feb)
Hosokawa H,Dip PV,Merkulova M,Bakulina A,Zhuang Z,Khatri A,Jian X,Keating SM,Bueler SA,Rubinstein JL,Randazzo PA,Ausiello DA,Gr?ber G,Marshansky V

FRMD4A regulates epithelial polarity by connecting Arf6 activation with the PAR complex.
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Hofmann I,Thompson A,Sanderson CM,Munro S

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Cyth2 cDNA ORF clone, Rattus norvegicus(Norway rat)

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