Ptpn6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ptpn6
Entrez Gene ID	116689
Full Name	protein tyrosine phosphatase, non-receptor type 6
Synonyms	Ptph6,Shp-1
General protein information	Preferred Names protein tyrosine phosphatase, non-receptor type 6 Names tyrosine-protein phosphatase non-receptor type 6 SH2 phosphatase 1 protein-tyrosine phosphatase SHP-1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q42
Summary	plays a role in activation and proliferation of glial cells and astrocytes [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053908.1	NP_446360.1	tyrosine-protein phosphatase non-receptor type 6

Pathways from BioSystems

Homologies

Bos taurus (cattle)	PTPN6	NP_001091486.1
Danio rerio (zebrafish)	ptpn6	NP_956254.1
Gallus gallus (chicken)	PTPN6	NP_001026655.1
Homo sapiens (human)	PTPN6	NP_536858.1
Pan troglodytes (chimpanzee)	PTPN6	XP_001163468.2
Canis lupus familiaris (dog)	PTPN6	XP_005637268.1
Rattus norvegicus (Norway rat)	Ptpn6	NP_446360.1
Xenopus tropicalis (tropical clawed frog)	ptpn6	NP_001116928.1
	PTPN6	XP_001110915.1
Mus musculus (house mouse)	Ptpn6	NP_038573.2

Gene Ontology
Bibliography

Related articles in PubMed

Shp-1 dephosphorylates TRPV1 in dorsal root ganglion neurons and alleviates CFA-induced inflammatory pain in rats.
Xiao X, Zhao XT, Xu LC, Yue LP, Liu FY, Cai J, Liao FF, Kong JG, Xing GG, Yi M, Wan Y
Pain156(4)597-608(2015 Apr)

Increased SHP-1 protein expression by high glucose levels reduces nephrin phosphorylation in podocytes.
Denhez B, Lizotte F, Guimond MO, Jones N, Takano T, Geraldes P
The Journal of biological chemistry290(1)350-8(2015 Jan)

Andrographolide induces vascular smooth muscle cell apoptosis through a SHP-1-PP2A-p38MAPK-p53 cascade.
Chen YY, Hsieh CY, Jayakumar T, Lin KH, Chou DS, Lu WJ, Hsu MJ, Sheu JR
Scientific reports45651(2014 Jul)

Modulation in the expression of SHP-1, SHP-2 and PTP1B due to the inhibition of MAPKs, cAMP and neutrophils early on in the development of cerulein-induced acute pancreatitis in rats.
Garc?a-Hern?ndez V, Sarmiento N, S?nchez-Bernal C, Matell?n L, Calvo JJ, S?nchez-Yag?e J
Biochimica et biophysica acta1842(2)192-201(2014 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Shp-1 increased in DRGs of rats with CFA-induced inflammatory pain, which was involved in protecting against excessive thermal hyperalgesia.
Title: Shp-1 dephosphorylates TRPV1 in dorsal root ganglion neurons and alleviates CFA-induced inflammatory pain in rats.

Rat nephrin Tyr1127 and Tyr1152 are essential for SHP-1 induced nephrin dephosphorylation under high-glucose conditions.
Title: Increased SHP-1 protein expression by high glucose levels reduces nephrin phosphorylation in podocytes.

Andrographolide activates the PP2A-p38MAPK-p53-Bax cascade.
Title: Andrographolide induces vascular smooth muscle cell apoptosis through a SHP-1-PP2A-p38MAPK-p53 cascade.

Data indicate that protein tyrosine phosphatases SHP-1, SHP-2 and PTP1B overexpressed during the development of cerulein -induced acute pancreatitis can be modulated by extracellular signal-regulated kinases (ERK1/2) and c-Jun NH2-terminal kinase (JNK).
Title: Modulation in the expression of SHP-1, SHP-2 and PTP1B due to the inhibition of MAPKs, cAMP and neutrophils early on in the development of cerulein-induced acute pancreatitis in rats.

SHP-1 as an off-switch of PDGFR signaling appears to emerge as a valuable molecular target to trigger as to prevent hepatic stellate cells (HSC) proliferation and the fibrogenic effects of HSC activation.
Title: The tyrosine phosphatase SHP-1 inhibits proliferation of activated hepatic stellate cells by impairing PDGF receptor signaling.

The following Ptpn6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ptpn6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12934	NM_053908.1 Latest version!	Rattus norvegicus protein tyrosine phosphatase, non-receptor type 6 (Ptpn6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$363.30 $519.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ptpn6 ( NM_053908.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_446360.1 Rattus norvegicus protein tyrosine phosphatase, non-receptor type 6 (Ptpn6), mRNA.

Price & Availability↑

CloneID	ORa12934
Clone ID Related Accession (Same CDS sequence)	NM_053908.1
Accession Version	NM_053908.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1842bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	tyrosine-protein phosphatase non-receptor type 6
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U77038.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U77038.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGCTGTCCC GCGGGTGGTT TCACCGGGAC CTCAGTGGGC CTGATGCCGA GACCCTGCTC 
AAGGGCCGGG GAGTCCCTGG GAGCTTCCTG GCTCGGCCCA GTCGCAAGAA CCAGGGTGAC 
TTCTCCCTCT CAGTCAGGGT GGATGACCAG GTGACTCATA TTCGGATCCA GAACTCAGGG 
GACTTCTATG ACCTGTATGG AGGGGAGAAG TTTGCGACGT CGACAGAGCT GGTGGAGTAT 
TACACTCAGC AGCAGGGCAT CCTGCAGGAC CGAGACGGCA CCATCATCCA CCTCAAGTAC 
CCACTGAACT GCTCGGACCC CACCAGCGAG AGGTGGTATC ATGGTCACAT GTCTGGAGGG 
CAGGCAGAGT CACTGCTGCA GGCCAAGGGC GAGCCCTGGA CATTTCTTGT GCGTGAGAGT 
CTCAGCCAAC CTGGTGATTT TGTGCTCTCT GTGCTCAATG ACCAGCCCAA GGCTGCCCCG 
GGTTCCCCGC TCAGGGTCAC GCACATCAAG GTTATGTGTG AGGGTGGACG ATACACTGTG 
GGTGGCTCAG AGACATTCGA CAGCCTCACA GACCTGGTGG AGCACTTCAA GAAGACGGGG 
ATTGAGGAGG CCTCAGGTGC CTTTGTCTAC CTGAGGCAGC CTTACTATGC CACTCGGGTA 
AATGCAGCAG ACATTGAGAA CCGGGTCTTG GAACTGAACA AGAAGCAGGA GTCAGAGGAC 
ACAGCCAAGG CCGGCTTCTG GGAGGAGTTT GAGAGTCTGC AAAAGCAAGA GGCAAAGAAC 
TTGCACCAGC GTCTGGAAGG GCAGCGGCCG GAGAACAAGA GCAAGAACCG CTACAAGAAC 
ATTCTTCCCT TTGACCACAG CCGAGTGATC CTGCAGGGAC GTGACAGTAA CATCCCAGGG 
TCTGATTACA TCAATGCCAA CTACGTTAAG AACCAGCTGC TAGGTCCGGA TGAGAACTCT 
AAGACCTACA TCGCCAGTCA GGGCTGTCTG GACGCTACCG TCAATGACTT CTGGCAGATG 
GCTTGGCAGG AGAACACTCG TGTCATCGTC ATGACTACCA GAGAGGTGGA GAAAGGCCGG 
AACAAATGTG TCCCATACTG GCCTGAGGTG GGCACTCAGC GCGTCTATGG GCTCTACTCT 
GTGACCAACT GTAAAGAGCA TGACACAGCA GAGTACAAAC TTCGAACATT GCAGATCTCC 
CCACTGGACA ATGGGGACCT GGTTCGGGAG ATATGGCACT ACCAGTACCT GAGCTGGCCT 
GACCATGGGG TTCCCAGTGA GCCTGGAGGT GTCCTCAGCT TTCTGGATCA GATCAACCAG 
CGGCAGGAAA GTTTGCCTCA CGCGGGGCCC ATCATTGTGC ATTGCAGCGC TGGCATCGGC 
CGCACCGGCA CCATCATCGT CATTGATATG CTCATGGAGA GCGTCTCCAC CAAGGGGCTA 
GACTGTGACA TTGACATCCA GAAGACCATC CAGATGGTAC GGGCACAGCG CTCTGGCATG 
GTGCAGACAG AGGCACAGTA CAAGTTTATT TATGTGGCCA TCGCCCAGTT CATCGAAACA 
ACCAAGAAGA AACTGGAGAT CATACAATCC CAGAGGGGCC AGGAGTCGGA GTATGGGAAC 
ATCACCTACC CTCCGGCTTT GAGGAGTGCC CACGCCAAAG CCTCCCGTAC CTCGTCCAAA 
CACAAGGAGG AGGTGTACGA AAACGTGCAT AGCAAGAACA AGAAGGAAGA GAAAGTAAAG 
AAGCAGCGAT CGGCAGACAA GGAGAAGAAC AAAGGTTCTC TCAAGAGGAA CATCAGCCTT 
ACTCCGTGCA GAGGCCTCCG CTGGGCAGAC AGAGACCTGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_446360.1
CDS	180..2021
Translation	MLSRGWFHRDLSGPDAETLLKGRGVPGSFLARPSRKNQGDFSLSVRVDDQVTHIRIQNSGDFYDLYGGEKFATSTELVEYYTQQQGILQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQAESLLQAKGEPWTFLVRESLSQPGDFVLSVLNDQPKAAPGSPLRVTHIKVMCEGGRYTVGGSETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEAKNLHQRLEGQRPENKSKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYVKNQLLGPDENSKTYIASQGCLDATVNDFWQMAWQENTRVIVMTTREVEKGRNKCVPYWPEVGTQRVYGLYSVTNCKEHDTAEYKLRTLQISPLDNGDLVREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMESVSTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEIIQSQRGQESEYGNITYPPALRSAHAKASRTSSKHKEEVYENVHSKNKKEEKVKKQRSADKEKNKGSLKRNISLTPCRGLRWADRDL

Target ORF information:

RefSeq Version	NM_053908.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus protein tyrosine phosphatase, non-receptor type 6 (Ptpn6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053908.1

ORF Insert Sequence:

ATGCTGTCCC GCGGGTGGTT TCACCGGGAC CTCAGTGGGC CTGATGCCGA GACCCTGCTC 
AAGGGCCGGG GAGTCCCTGG GAGCTTCCTG GCTCGGCCCA GTCGCAAGAA CCAGGGTGAC 
TTCTCCCTCT CAGTCAGGGT GGATGACCAG GTGACTCATA TTCGGATCCA GAACTCAGGG 
GACTTCTATG ACCTGTATGG AGGGGAGAAG TTTGCGACGT CGACAGAGCT GGTGGAGTAT 
TACACTCAGC AGCAGGGCAT CCTGCAGGAC CGAGACGGCA CCATCATCCA CCTCAAGTAC 
CCACTGAACT GCTCGGACCC CACCAGCGAG AGGTGGTATC ATGGTCACAT GTCTGGAGGG 
CAGGCAGAGT CACTGCTGCA GGCCAAGGGC GAGCCCTGGA CATTTCTTGT GCGTGAGAGT 
CTCAGCCAAC CTGGTGATTT TGTGCTCTCT GTGCTCAATG ACCAGCCCAA GGCTGCCCCG 
GGTTCCCCGC TCAGGGTCAC GCACATCAAG GTTATGTGTG AGGGTGGACG ATACACTGTG 
GGTGGCTCAG AGACATTCGA CAGCCTCACA GACCTGGTGG AGCACTTCAA GAAGACGGGG 
ATTGAGGAGG CCTCAGGTGC CTTTGTCTAC CTGAGGCAGC CTTACTATGC CACTCGGGTA 
AATGCAGCAG ACATTGAGAA CCGGGTCTTG GAACTGAACA AGAAGCAGGA GTCAGAGGAC 
ACAGCCAAGG CCGGCTTCTG GGAGGAGTTT GAGAGTCTGC AAAAGCAAGA GGCAAAGAAC 
TTGCACCAGC GTCTGGAAGG GCAGCGGCCG GAGAACAAGA GCAAGAACCG CTACAAGAAC 
ATTCTTCCCT TTGACCACAG CCGAGTGATC CTGCAGGGAC GTGACAGTAA CATCCCAGGG 
TCTGATTACA TCAATGCCAA CTACGTTAAG AACCAGCTGC TAGGTCCGGA TGAGAACTCT 
AAGACCTACA TCGCCAGTCA GGGCTGTCTG GACGCTACCG TCAATGACTT CTGGCAGATG 
GCTTGGCAGG AGAACACTCG TGTCATCGTC ATGACTACCA GAGAGGTGGA GAAAGGCCGG 
AACAAATGTG TCCCATACTG GCCTGAGGTG GGCACTCAGC GCGTCTATGG GCTCTACTCT 
GTGACCAACT GTAAAGAGCA TGACACAGCA GAGTACAAAC TTCGAACATT GCAGATCTCC 
CCACTGGACA ATGGGGACCT GGTTCGGGAG ATATGGCACT ACCAGTACCT GAGCTGGCCT 
GACCATGGGG TTCCCAGTGA GCCTGGAGGT GTCCTCAGCT TTCTGGATCA GATCAACCAG 
CGGCAGGAAA GTTTGCCTCA CGCGGGGCCC ATCATTGTGC ATTGCAGCGC TGGCATCGGC 
CGCACCGGCA CCATCATCGT CATTGATATG CTCATGGAGA GCGTCTCCAC CAAGGGGCTA 
GACTGTGACA TTGACATCCA GAAGACCATC CAGATGGTAC GGGCACAGCG CTCTGGCATG 
GTGCAGACAG AGGCACAGTA CAAGTTTATT TATGTGGCCA TCGCCCAGTT CATCGAAACA 
ACCAAGAAGA AACTGGAGAT CATACAATCC CAGAGGGGCC AGGAGTCGGA GTATGGGAAC 
ATCACCTACC CTCCGGCTTT GAGGAGTGCC CACGCCAAAG CCTCCCGTAC CTCGTCCAAA 
CACAAGGAGG AGGTGTACGA AAACGTGCAT AGCAAGAACA AGAAGGAAGA GAAAGTAAAG 
AAGCAGCGAT CGGCAGACAA GGAGAAGAAC AAAGGTTCTC TCAAGAGGAA CATCAGCCTT 
ACTCCGTGCA GAGGCCTCCG CTGGGCAGAC AGAGACCTGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Shp-1 dephosphorylates TRPV1 in dorsal root ganglion neurons and alleviates CFA-induced inflammatory pain in rats.
Pain156(4)597-608(2015 Apr)
Xiao X,Zhao XT,Xu LC,Yue LP,Liu FY,Cai J,Liao FF,Kong JG,Xing GG,Yi M,Wan Y

Increased SHP-1 protein expression by high glucose levels reduces nephrin phosphorylation in podocytes.
The Journal of biological chemistry290(1)350-8(2015 Jan)
Denhez B,Lizotte F,Guimond MO,Jones N,Takano T,Geraldes P

Andrographolide induces vascular smooth muscle cell apoptosis through a SHP-1-PP2A-p38MAPK-p53 cascade.
Scientific reports45651(2014 Jul)
Chen YY,Hsieh CY,Jayakumar T,Lin KH,Chou DS,Lu WJ,Hsu MJ,Sheu JR

Modulation in the expression of SHP-1, SHP-2 and PTP1B due to the inhibition of MAPKs, cAMP and neutrophils early on in the development of cerulein-induced acute pancreatitis in rats.
Biochimica et biophysica acta1842(2)192-201(2014 Feb)
Garc?a-Hern?ndez V,Sarmiento N,S?nchez-Bernal C,Matell?n L,Calvo JJ,S?nchez-Yag?e J

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Ptpn6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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