Kcnk6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Kcnk6
Entrez Gene ID	116491
Full Name	potassium channel, two pore domain subfamily K, member 6
Synonyms	Twik-2,Twik2
General protein information	Preferred Names potassium channel, two pore domain subfamily K, member 6 Names potassium channel, subfamily K, member 6 potassium inwardly-rectifying channel, subfamily K, member 6
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q21
Summary	outward rectifiying K+ channel [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053806.2	NP_446258.2	potassium channel, subfamily K, member 6

Pathways from BioSystems

Homologies

Homo sapiens (human)	KCNK6	NP_004814.1
Bos taurus (cattle)	KCNK6	NP_001192374.1
Mus musculus (house mouse)	Kcnk6	NP_001028697.2
Rattus norvegicus (Norway rat)	Kcnk6	NP_446258.2
Rattus norvegicus (Norway rat)	LOC100909725	XP_003748860.1
Xenopus tropicalis (tropical clawed frog)	kcnk6	NP_001120420.1
Pan troglodytes (chimpanzee)	KCNK6	XP_524250.2
Canis lupus familiaris (dog)	KCNK6	XP_005616683.1
Danio rerio (zebrafish)	kcnk6	NP_001025245.2

Gene Ontology
Bibliography

Related articles in PubMed

Endothelium-dependent relaxations in the aorta from K(2p)6.1 knockout mice.
Lloyd EE, Pandit LM, Crossland RF, Marrelli SP, Bryan RM Jr
American journal of physiology. Regulatory, integrative and comparative physiology305(1)R60-7(2013 Jul)

Disruption of K(2P)6.1 produces vascular dysfunction and hypertension in mice.
Lloyd EE, Crossland RF, Phillips SC, Marrelli SP, Reddy AK, Taffet GE, Hartley CJ, Bryan RM Jr
Hypertension (Dallas, Tex. : 1979)58(4)672-8(2011 Oct)

cGMP does not activate two-pore domain K+ channels in cerebrovascular smooth muscle.
Lloyd EE, Marrelli SP, Bryan RM Jr
American journal of physiology. Heart and circulatory physiology296(6)H1774-80(2009 Jun)

Distribution of two-pore-domain potassium channels in the adult rat vestibular periphery.
Popper P, Winkler J, Erbe CB, Lerch-Gaggl A, Siebeneich W, Wackym PA
Hearing research246(1-2)1-8(2008 Dec)

TWIK-2, an inactivating 2P domain K+ channel.
Patel AJ, Maingret F, Magnone V, Fosset M, Lazdunski M, Honor? E
The Journal of biological chemistry275(37)28722-30(2000 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Although K(2P) channels are highly expressed, K(2P) currents are not activated via the NO/cGMP pathway in rat middle cerebral artery smooth muscle, despite the presence of numerous putative PKG phosphorylation sites
Title: cGMP does not activate two-pore domain K+ channels in cerebrovascular smooth muscle.

K(2P)6.1 (TWIK 2) immunoreactivity was detected in nerve terminals, blood vessels hair cells and transitional cells of the crista ampullaris and in the somata and neuron fibers of Scarpa's ganglia.
Title: Distribution of two-pore-domain potassium channels in the adult rat vestibular periphery.

The following Kcnk6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kcnk6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa10699	NM_053806.2 Latest version!	Rattus norvegicus potassium channel, two pore domain subfamily K, member 6 (Kcnk6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Kcnk6 ( NM_053806.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_446258.2 Rattus norvegicus potassium channel, two pore domain subfamily K, member 6 (Kcnk6), mRNA.

Price & Availability↑

CloneID	ORa10699
Clone ID Related Accession (Same CDS sequence)	NM_053806.2
Accession Version	NM_053806.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 942bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-27
Organism	Rattus norvegicus(Norway rat)
Product	potassium channel, subfamily K, member 6
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF281304.1, AC118147.6 and BF405813.1. On Oct 11, 2007 this sequence version replaced NM_053806.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA2689594, SAMEA2689595 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCGGCGGG GCGCGCTCCT GGCTAGCGCC CTGGTCGCCT ACGCCGGGTA CCTGGCGCTC 
GGCGCGCTGC TTGTGGCGCG GCTGGAGCGG CCGCACGAAG CCCGGCTGCG GGCAGAGCTG 
GGGACGCTGC GGGAGCAGCT GCTGCGGCAC AGCCCGTGCG TGGCGGCTCA CGCCCTGGAC 
GCCTTCGTGG AGCGGGTGCT GGCGGCAGGA CGGCTGGGGC GCGCAGTGCT GGCCAACGCA 
TCGGGACCCG CCAACGCTTC GGACCCCGCG TGGGACTTTG CCTCGGCGCT CTTCTTCGCC 
AGCACGCTAG TCACCACCGT GGGCTATGGC TACACGACCC CACTGACGGA TGCAGGCAAA 
GCCTTCTCCA TCGTTTTTGC ACTCCTGGGC GTGCCTATCA CCATGCTACT TCTGACTGCC 
TCAGCCCAGC GCCTGTCACT GCTGCTCACC CACGCACCCC TGTCCTGGCT GAGCCTGCGC 
TGGGGCTGGC ACCCGCAGCG GGCAGCCCGC TGGCACCTGG TGGCCCTACT GATGGTCATA 
GTGGCTATAT TTTTCCTGAT CCCGGCTGCG GTCTTCGCCT ACCTTGAGGA GGCCTGGAGC 
TTTCTGGATG CTTTCTATTT CTGCTTCATC TCTCTGTCCA CCATTGGCCT GGGGGACTAT 
GTGCCTGGGG AAGCCCCGGG CCAGCCTTAC CGATCCCTCT ACAAGGTGCT TGTCACAGCA 
TACCTCTTCC TCGGCCTTGT TGCCATGGTG CTGGTGTTGC AGACTTTCCG CCGTGTTTCT 
GACCTCCATG GCCTCACTGA ACTCATCTTG CTGCCGGATC CCGACCCTGC CAGGCTCCAC 
CAGGATGAGG ATGACCAGGT GGACATTCTG GATGCCCGGA CAGATCTGCA TCAGCATCTC 
TCTGCTGCCT CCCACGCTAA TTACGCCTCC ATCCCCAGGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_446258.2
CDS	1..942
Translation	MRRGALLASALVAYAGYLALGALLVARLERPHEARLRAELGTLREQLLRHSPCVAAHALDAFVERVLAAGRLGRAVLANASGPANASDPAWDFASALFFASTLVTTVGYGYTTPLTDAGKAFSIVFALLGVPITMLLLTASAQRLSLLLTHAPLSWLSLRWGWHPQRAARWHLVALLMVIVAIFFLIPAAVFAYLEEAWSFLDAFYFCFISLSTIGLGDYVPGEAPGQPYRSLYKVLVTAYLFLGLVAMVLVLQTFRRVSDLHGLTELILLPDPDPARLHQDEDDQVDILDARTDLHQHLSAASHANYASIPR

Target ORF information:

RefSeq Version	NM_053806.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus potassium channel, two pore domain subfamily K, member 6 (Kcnk6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053806.2

ORF Insert Sequence:

ATGCGGCGGG GCGCGCTCCT GGCTAGCGCC CTGGTCGCCT ACGCCGGGTA CCTGGCGCTC 
GGCGCGCTGC TTGTGGCGCG GCTGGAGCGG CCGCACGAAG CCCGGCTGCG GGCAGAGCTG 
GGGACGCTGC GGGAGCAGCT GCTGCGGCAC AGCCCGTGCG TGGCGGCTCA CGCCCTGGAC 
GCCTTCGTGG AGCGGGTGCT GGCGGCAGGA CGGCTGGGGC GCGCAGTGCT GGCCAACGCA 
TCGGGACCCG CCAACGCTTC GGACCCCGCG TGGGACTTTG CCTCGGCGCT CTTCTTCGCC 
AGCACGCTAG TCACCACCGT GGGCTATGGC TACACGACCC CACTGACGGA TGCAGGCAAA 
GCCTTCTCCA TCGTTTTTGC ACTCCTGGGC GTGCCTATCA CCATGCTACT TCTGACTGCC 
TCAGCCCAGC GCCTGTCACT GCTGCTCACC CACGCACCCC TGTCCTGGCT GAGCCTGCGC 
TGGGGCTGGC ACCCGCAGCG GGCAGCCCGC TGGCACCTGG TGGCCCTACT GATGGTCATA 
GTGGCTATAT TTTTCCTGAT CCCGGCTGCG GTCTTCGCCT ACCTTGAGGA GGCCTGGAGC 
TTTCTGGATG CTTTCTATTT CTGCTTCATC TCTCTGTCCA CCATTGGCCT GGGGGACTAT 
GTGCCTGGGG AAGCCCCGGG CCAGCCTTAC CGATCCCTCT ACAAGGTGCT TGTCACAGCA 
TACCTCTTCC TCGGCCTTGT TGCCATGGTG CTGGTGTTGC AGACTTTCCG CCGTGTTTCT 
GACCTCCATG GCCTCACTGA ACTCATCTTG CTGCCGGATC CCGACCCTGC CAGGCTCCAC 
CAGGATGAGG ATGACCAGGT GGACATTCTG GATGCCCGGA CAGATCTGCA TCAGCATCTC 
TCTGCTGCCT CCCACGCTAA TTACGCCTCC ATCCCCAGGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Endothelium-dependent relaxations in the aorta from K(2p)6.1 knockout mice.
American journal of physiology. Regulatory, integrative and comparative physiology305(1)R60-7(2013 Jul)
Lloyd EE,Pandit LM,Crossland RF,Marrelli SP,Bryan RM Jr

Disruption of K(2P)6.1 produces vascular dysfunction and hypertension in mice.
Hypertension (Dallas, Tex. : 1979)58(4)672-8(2011 Oct)
Lloyd EE,Crossland RF,Phillips SC,Marrelli SP,Reddy AK,Taffet GE,Hartley CJ,Bryan RM Jr

cGMP does not activate two-pore domain K+ channels in cerebrovascular smooth muscle.
American journal of physiology. Heart and circulatory physiology296(6)H1774-80(2009 Jun)
Lloyd EE,Marrelli SP,Bryan RM Jr

Distribution of two-pore-domain potassium channels in the adult rat vestibular periphery.
Hearing research246(1-2)1-8(2008 Dec)
Popper P,Winkler J,Erbe CB,Lerch-Gaggl A,Siebeneich W,Wackym PA

TWIK-2, an inactivating 2P domain K+ channel.
The Journal of biological chemistry275(37)28722-30(2000 Sep)
Patel AJ,Maingret F,Magnone V,Fosset M,Lazdunski M,Honor? E

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Kcnk6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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