UCP2 cDNA ORF clone, Ovis aries(sheep)

Gene
Clones
gRNAs

Summary

Gene Symbol	UCP2
Entrez Gene ID	101104932
Full Name	uncoupling protein 2
Gene Type	protein-coding
Organism	Ovis aries(sheep)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001280682.1	NP_001267611.1	mitochondrial uncoupling protein 2

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

The differential effects of the timing of maternal nutrient restriction in the ovine placenta on glucocorticoid sensitivity, uncoupling protein 2, peroxisome proliferator-activated receptor-gamma and cell proliferation.
Yiallourides M, Sebert SP, Wilson V, Sharkey D, Rhind SM, Symonds ME, Budge H
Reproduction (Cambridge, England)138(3)601-8(2009 Sep)

Increased uncoupling protein-2 mRNA abundance and glucocorticoid action in adipose tissue in the sheep fetus during late gestation is dependent on plasma cortisol and triiodothyronine.
Gnanalingham MG, Mostyn A, Forhead AJ, Fowden AL, Symonds ME, Stephenson T
The Journal of physiology567(Pt 1)283-92(2005 Aug)

Ontogeny and nutritional programming of uncoupling protein-2 and glucocorticoid receptor mRNA in the ovine lung.
Gnanalingham MG, Mostyn A, Dandrea J, Yakubu DP, Symonds ME, Stephenson T
The Journal of physiology565(Pt 1)159-69(2005 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Upregulation of PPARG and UCP2 would promote placental fatty acid metabolism thereby limiting glucose utilization.
Title: The differential effects of the timing of maternal nutrient restriction in the ovine placenta on glucocorticoid sensitivity, uncoupling protein 2, peroxisome proliferator-activated receptor-gamma and cell proliferation.

plasma cortisol and T3 are both required for the late gestation rise in UCP2 mRNA and differentially regulate glucocorticoid action in fetal adipose tissue in the sheep during late gestation
Title: Increased uncoupling protein-2 mRNA abundance and glucocorticoid action in adipose tissue in the sheep fetus during late gestation is dependent on plasma cortisol and triiodothyronine.

These findings suggest that the developmental ontogeny of UCP2 mRNA in the ovine lung is under local glucocorticoid hormone action and that maternal nutrient restriction has consequences for UCP2 and GR in the lung irrespective of its timing.
Title: Ontogeny and nutritional programming of uncoupling protein-2 and glucocorticoid receptor mRNA in the ovine lung.

The following UCP2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the UCP2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OSm21496	NM_001280682.1 Latest version!	Ovis aries uncoupling protein 2 (UCP2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

UCP2 ( NM_001280682.1 ) cDNA ORF clone, Ovis aries(sheep) -> NP_001267611.1 Ovis aries uncoupling protein 2 (UCP2), mRNA.

Price & Availability↑

CloneID	OSm21496
Clone ID Related Accession (Same CDS sequence)	NM_001280682.1
Accession Version	NM_001280682.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 930bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-04
Organism	Ovis aries(sheep)
Product	mitochondrial uncoupling protein 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from KC355436.1. On Jul 23, 2013 this sequence version replaced XM_004016313.1. ##Evidence-Data-START## Transcript exon combination :: KC355436.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA104494974, SAMEA104494976 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END##

ATGGTTGGGT TCAAGGCCAC AGATGTGCCC CCTACAGCCA CTGTGAAGTT CCTGGGGGCA 
GGCACAGCTG CCTGCATTGC TGACCTCATC ACCTTTCCCC TGGATACTGC TAAAGTCCGG 
CTACAGATCC AAGGAGAAAG GCAGGGGCCA GTGCAGGCTG CGGCCAGTGC CCAGTACCGC 
GGGGTGCTGG GCACCATCCT GACCATGGTG CGCACCGAGG GCCCCCGCAG CCTCTACAGC 
GGGCTGGTCG CCGGCCTGCA GCGCCAGATG AGCTTCGCCT CCGTCCGCAT CGGCCTCTAC 
GACTCCGTCA AGCAGTTCTA CACCAAGGGC TCTGAGCATG CCGGCATCGG GAGTCGCCTC 
CTGGCAGGCA GCACCACCGG TGCCTTGGCC GTGGCCGTGG CCCAGCCAAC GGATGTGGTG 
AAGGTCCGGT TCCAAGCGCA GGCCCGGGCT GGAGCTGCCC GGAGGTACCA GAGCACTGTT 
GAGGCCTACA AAACCATTGC CCGAGAGGAG GGGTTTCGGG GACTCTGGAA AGGGACATCT 
CCCAATGTCG CTCGCAATGC CATTGTCAAC TGTGCTGAGC TGGTGACCTA CGACCTCATC 
AAGGACACTC TCCTGAAGGC CCACCTAATG ACAGACGACC TCCCTTGCCA CTTTACTTCT 
GCCTTCGGGG CGGGCTTCTG CACCACCGTC ATCGCCTCCC CTGTCGACGT GGTCAAGACG 
AGATACATGA ACTCTGCCCT GGGCCAGTAC AGCAGCGCTG GCCACTGTGC CCTCACCATG 
CTCCAGAAGG AGGGACCCCA AGCCTTCTAC AAAGGGTTCA TGCCCTCCTT TCTCCGCTTG 
GGATCCTGGA ACGTGGTGAT GTTCGTCACC TACGAGCAGC TGAAGCGGGC CCTCATGGCT 
GCCCGCGCTT CCCGGGAGGC TCCCTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001267611.1
CDS	368..1297
Translation	MVGFKATDVPPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQGERQGPVQAAASAQYRGVLGTILTMVRTEGPRSLYSGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHAGIGSRLLAGSTTGALAVAVAQPTDVVKVRFQAQARAGAARRYQSTVEAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVTYDLIKDTLLKAHLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTRYMNSALGQYSSAGHCALTMLQKEGPQAFYKGFMPSFLRLGSWNVVMFVTYEQLKRALMAARASREAPF

Target ORF information:

RefSeq Version	NM_001280682.1
Organism	Ovis aries(sheep)
Definition	Ovis aries uncoupling protein 2 (UCP2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001280682.1

ORF Insert Sequence:

ATGGTTGGGT TCAAGGCCAC AGATGTGCCC CCTACAGCCA CTGTGAAGTT CCTGGGGGCA 
GGCACAGCTG CCTGCATTGC TGACCTCATC ACCTTTCCCC TGGATACTGC TAAAGTCCGG 
CTACAGATCC AAGGAGAAAG GCAGGGGCCA GTGCAGGCTG CGGCCAGTGC CCAGTACCGC 
GGGGTGCTGG GCACCATCCT GACCATGGTG CGCACCGAGG GCCCCCGCAG CCTCTACAGC 
GGGCTGGTCG CCGGCCTGCA GCGCCAGATG AGCTTCGCCT CCGTCCGCAT CGGCCTCTAC 
GACTCCGTCA AGCAGTTCTA CACCAAGGGC TCTGAGCATG CCGGCATCGG GAGTCGCCTC 
CTGGCAGGCA GCACCACCGG TGCCTTGGCC GTGGCCGTGG CCCAGCCAAC GGATGTGGTG 
AAGGTCCGGT TCCAAGCGCA GGCCCGGGCT GGAGCTGCCC GGAGGTACCA GAGCACTGTT 
GAGGCCTACA AAACCATTGC CCGAGAGGAG GGGTTTCGGG GACTCTGGAA AGGGACATCT 
CCCAATGTCG CTCGCAATGC CATTGTCAAC TGTGCTGAGC TGGTGACCTA CGACCTCATC 
AAGGACACTC TCCTGAAGGC CCACCTAATG ACAGACGACC TCCCTTGCCA CTTTACTTCT 
GCCTTCGGGG CGGGCTTCTG CACCACCGTC ATCGCCTCCC CTGTCGACGT GGTCAAGACG 
AGATACATGA ACTCTGCCCT GGGCCAGTAC AGCAGCGCTG GCCACTGTGC CCTCACCATG 
CTCCAGAAGG AGGGACCCCA AGCCTTCTAC AAAGGGTTCA TGCCCTCCTT TCTCCGCTTG 
GGATCCTGGA ACGTGGTGAT GTTCGTCACC TACGAGCAGC TGAAGCGGGC CCTCATGGCT 
GCCCGCGCTT CCCGGGAGGC TCCCTTCTGA