IL10 cDNA ORF clone, Oryctolagus cuniculus(rabbit)

Gene
Clones
gRNAs

Summary

Gene Symbol	IL10
Entrez Gene ID	100008701
Full Name	interleukin 10
Synonyms	CSIF,IL-10
Gene Type	protein-coding
Organism	Oryctolagus cuniculus(rabbit)

mRNA and Protein(s)

mRNA	Protein	Name
XM_008268045.2	XP_008266267.1	interleukin-10 isoform X1
NM_001082045.1	NP_001075514.1	interleukin-10 precursor

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Genetic characterization of interleukins (IL-1?, IL-1?, IL-2, IL-4, IL-8, IL-10, IL-12A, IL-12B, IL-15 and IL-18) with relevant biological roles in lagomorphs.
Neves F, Abrantes J, Almeida T, de Matos AL, Costa PP, Esteves PJ
Innate immunity21(8)787-801(2015 Nov)

IL-10 gene polymorphisms and their association with immune traits in four rabbit populations.
Wan X, Mao L, Li T, Qin L, Pan Y, Li B, Wu X
The Journal of veterinary medical science76(3)369-75(2014 Mar)

[Expression of intercellular cell adhesion molecule-1, interleukin-10 and the activation of activator protein-1 in ventilator-induced lung injury in rabbits].
Zhang J, Tong ZH, Qin ZQ, Pang BS, Niu SJ, Wang C
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases33(8)587-92(2010 Aug)

The complete cDNA sequences of IL-2, IL-4, IL-6 AND IL-10 from the European rabbit (Oryctolagus cuniculus).
Perkins HD, van Leeuwen BH, Hardy CM, Kerr PJ
Cytokine12(6)555-65(2000 Jun)

Expression of the interferon-gamma and interleukin-10 genes in rabbit HTLV-I-transformed T-cell lines.
Isono T, Nagano Y, Seto A
Immunogenetics44(4)306-8(1996)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Single nucleotide polymorphisms on exon 3 were significantly associated with immune traits.
Title: IL-10 gene polymorphisms and their association with immune traits in four rabbit populations.

ICAM1 and IL10 were upregulated in ventilator-induced lung injury. Nuclear transcription factor AP-1 may be responsible for this upregulation.
Title: [Expression of intercellular cell adhesion molecule-1, interleukin-10 and the activation of activator protein-1 in ventilator-induced lung injury in rabbits].

The following IL10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IL10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OOb30317	NM_001082045.1 Latest version!	Oryctolagus cuniculus interleukin 10 (IL10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OOb17102	XM_008268045.2 Latest version!	Oryctolagus cuniculus interleukin 10 (IL10), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IL10 ( NM_001082045.1 ) cDNA ORF clone, Oryctolagus cuniculus(rabbit) -> NP_001075514.1 Oryctolagus cuniculus interleukin 10 (IL10), mRNA.

Price & Availability↑

CloneID	OOb30317
Clone ID Related Accession (Same CDS sequence)	NM_001082045.1
Accession Version	NM_001082045.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 537bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Oryctolagus cuniculus(rabbit)
Product	interleukin-10 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF088887.1. ##Evidence-Data-START## Transcript exon combination :: AF088887.1, AF068058.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00013649, SAMN00013655 [ECO:0000348] ##Evidence-Data-END##

ATGCMCAGCT CAGCMSTGCT ATGTTGCCTG GTCTTCCTGG GTGGGACAGG GGCCAGCCGA 
GGCCAGGACA CCCCTGCTGA GAACAGCTGC ATTCACTTTC CAGGCGGCCT GCCCCACATG 
CTCCGCGAGC TCCGTGCTGC CTTTGGCAGG GTGAAGACTT TCTTTCAATC GAAGGATCAG 
CTGAACAGCA TGTTGTTAAC CGAGTCCCTG CTGGAGGACC TTAAGGGTTA CCTGGGATGC 
CAAGCCTTGT CGGAGATGAT CCAGTTTTAC CTGAAGGACG TGATGCCGCA AGCTGAGAAC 
CACAGTCCAG CCATCAGGGA GCACGTGAAC TCCCTGGGGG AAAACCTGAA GACCCTCAGG 
CTGAGGCTGC GACAATGTCA CCGATTTCTC CCCTGTGAAA ACAAGAGCAA GGCAGTGGAG 
CAGGTGAAGA GCGCCTTCAG CAAGCTGCAA GAGGAAGGCG TCTACAAAGC CATGAGTGAG 
TTTGACATCT TCATCAACTA CATAGAAACC TACATGACAA TGAAGATAAA AAGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001075514.1
CDS	1..537
Translation	MnullSSnullnullLCCLVFLGGTGASRGQDTPAENSCIHFPGGLPHMLRELRAAFGRVKTFFQSKDQLNSMLLTESLLEDLKGYLGCQALSEMIQFYLKDVMPQAENHSPAIREHVNSLGENLKTLRLRLRQCHRFLPCENKSKAVEQVKSAFSKLQEEGVYKAMSEFDIFINYIETYMTMKIKS

Target ORF information:

RefSeq Version	NM_001082045.1
Organism	Oryctolagus cuniculus(rabbit)
Definition	Oryctolagus cuniculus interleukin 10 (IL10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001082045.1

ORF Insert Sequence:

ATGCMCAGCT CAGCMSTGCT ATGTTGCCTG GTCTTCCTGG GTGGGACAGG GGCCAGCCGA 
GGCCAGGACA CCCCTGCTGA GAACAGCTGC ATTCACTTTC CAGGCGGCCT GCCCCACATG 
CTCCGCGAGC TCCGTGCTGC CTTTGGCAGG GTGAAGACTT TCTTTCAATC GAAGGATCAG 
CTGAACAGCA TGTTGTTAAC CGAGTCCCTG CTGGAGGACC TTAAGGGTTA CCTGGGATGC 
CAAGCCTTGT CGGAGATGAT CCAGTTTTAC CTGAAGGACG TGATGCCGCA AGCTGAGAAC 
CACAGTCCAG CCATCAGGGA GCACGTGAAC TCCCTGGGGG AAAACCTGAA GACCCTCAGG 
CTGAGGCTGC GACAATGTCA CCGATTTCTC CCCTGTGAAA ACAAGAGCAA GGCAGTGGAG 
CAGGTGAAGA GCGCCTTCAG CAAGCTGCAA GAGGAAGGCG TCTACAAAGC CATGAGTGAG 
TTTGACATCT TCATCAACTA CATAGAAACC TACATGACAA TGAAGATAAA AAGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IL10 ( XM_008268045.2 ) cDNA ORF clone, Oryctolagus cuniculus(rabbit) -> XP_008266267.1 Oryctolagus cuniculus interleukin 10 (IL10), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OOb17102
Clone ID Related Accession (Same CDS sequence)	XM_008268045.2
Accession Version	XM_008268045.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 597bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-22
Organism	Oryctolagus cuniculus(rabbit)
Product	interleukin-10 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_013684.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Jun 23, 2016 this sequence version replaced XM_008268045.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Oryctolagus cuniculus Annotation Release 102 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTCAGCT CAGCTCTGCT ATGTTGCCTG GTCTTCCTGG GTGGGACAGG GGCCAGCCGA 
GGCCAGGACA CCCCTGCTGA GAACAGCTGC ATTCACTTTC CAGGCGGCCT GCCCCACATG 
CTCCGCGAGC TCCGTGCTGC CTTTGGCAGG GTGAAGACTT TCTTTCAATC GAAGGATCAG 
CTGAACAGCA TGTTGTTAAC CGAGTCCCTG CTGGAGGACC TTAAGGGTTA CCTGGGATGC 
CAAGCCTTGT CGGAGATGAT CCAGTTTTAC CTGAAGGACG TGATGCCGCA AGCTGAGAAC 
CACAGTCCAG CCATCAGGGA GCACGTGAAC TCCCTGGGGG AAAACCTGAA GACCCTCAGG 
CTGAGGCTGC GACAATGTCA CCGATTTCTC CCCTGTGAAA ACAAGAGCAA GGCAGTGGAG 
CAGGTGAAGA GCGCCTTCAG CAAGCTGCAA GAGGAAGGCG TCTACAAAGC CATGAGCAGA 
GCAAGAGAAT CTTCCATCCA CTGGTTCACT CCTCAAATAC CTGTAAAAAC TGGAGCTGGG 
CCATGTAGAA GCCAGGAGAA CTCCATCCGG GTCTCCCGTA CGGGTAGCAT GGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008266267.1
CDS	111..707
Translation	MLSSALLCCLVFLGGTGASRGQDTPAENSCIHFPGGLPHMLRELRAAFGRVKTFFQSKDQLNSMLLTESLLEDLKGYLGCQALSEMIQFYLKDVMPQAENHSPAIREHVNSLGENLKTLRLRLRQCHRFLPCENKSKAVEQVKSAFSKLQEEGVYKAMSRARESSIHWFTPQIPVKTGAGPCRSQENSIRVSRTGSMD

Target ORF information:

RefSeq Version	XM_008268045.2
Organism	Oryctolagus cuniculus(rabbit)
Definition	Oryctolagus cuniculus interleukin 10 (IL10), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008268045.2

ORF Insert Sequence:

ATGCTCAGCT CAGCTCTGCT ATGTTGCCTG GTCTTCCTGG GTGGGACAGG GGCCAGCCGA 
GGCCAGGACA CCCCTGCTGA GAACAGCTGC ATTCACTTTC CAGGCGGCCT GCCCCACATG 
CTCCGCGAGC TCCGTGCTGC CTTTGGCAGG GTGAAGACTT TCTTTCAATC GAAGGATCAG 
CTGAACAGCA TGTTGTTAAC CGAGTCCCTG CTGGAGGACC TTAAGGGTTA CCTGGGATGC 
CAAGCCTTGT CGGAGATGAT CCAGTTTTAC CTGAAGGACG TGATGCCGCA AGCTGAGAAC 
CACAGTCCAG CCATCAGGGA GCACGTGAAC TCCCTGGGGG AAAACCTGAA GACCCTCAGG 
CTGAGGCTGC GACAATGTCA CCGATTTCTC CCCTGTGAAA ACAAGAGCAA GGCAGTGGAG 
CAGGTGAAGA GCGCCTTCAG CAAGCTGCAA GAGGAAGGCG TCTACAAAGC CATGAGCAGA 
GCAAGAGAAT CTTCCATCCA CTGGTTCACT CCTCAAATAC CTGTAAAAAC TGGAGCTGGG 
CCATGTAGAA GCCAGGAGAA CTCCATCCGG GTCTCCCGTA CGGGTAGCAT GGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genetic characterization of interleukins (IL-1?, IL-1?, IL-2, IL-4, IL-8, IL-10, IL-12A, IL-12B, IL-15 and IL-18) with relevant biological roles in lagomorphs.
Innate immunity21(8)787-801(2015 Nov)
Neves F,Abrantes J,Almeida T,de Matos AL,Costa PP,Esteves PJ

IL-10 gene polymorphisms and their association with immune traits in four rabbit populations.
The Journal of veterinary medical science76(3)369-75(2014 Mar)
Wan X,Mao L,Li T,Qin L,Pan Y,Li B,Wu X

[Expression of intercellular cell adhesion molecule-1, interleukin-10 and the activation of activator protein-1 in ventilator-induced lung injury in rabbits].
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases33(8)587-92(2010 Aug)
Zhang J,Tong ZH,Qin ZQ,Pang BS,Niu SJ,Wang C

The complete cDNA sequences of IL-2, IL-4, IL-6 AND IL-10 from the European rabbit (Oryctolagus cuniculus).
Cytokine12(6)555-65(2000 Jun)
Perkins HD,van Leeuwen BH,Hardy CM,Kerr PJ

Expression of the interferon-gamma and interleukin-10 genes in rabbit HTLV-I-transformed T-cell lines.
Immunogenetics44(4)306-8(1996)
Isono T,Nagano Y,Seto A