Cnnm4 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cnnm4
Entrez Gene ID	94220
Full Name	cyclin M4
Synonyms	5430430O18Rik,Acdp4
General protein information	Preferred Names cyclin M4 Names metal transporter CNNM4 ancient conserved domain protein 4 ancient conserved domain-containing protein 4 mACDP4
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1 B\|1 15.28 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_033570.2	NP_291048.2	metal transporter CNNM4 precursor

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	cnnm2	NP_001090672.1
Bos taurus (cattle)	CNNM4	NP_001192825.1
Mus musculus (house mouse)	Cnnm4	NP_291048.2
Danio rerio (zebrafish)	LOC100329789	XP_005155491.1
Danio rerio (zebrafish)	LOC793848	XP_005165113.1
Homo sapiens (human)	CNNM4	NP_064569.3
Canis lupus familiaris (dog)	CNNM4	XP_538467.3
Rattus norvegicus (Norway rat)	Cnnm4	NP_001257979.1
Gallus gallus (chicken)	LOC425706	XP_003643479.1

Gene Ontology
Bibliography

Related articles in PubMed

The Mg2+ transporter CNNM4 regulates sperm Ca2+ homeostasis and is essential for reproduction.
Yamazaki D, Miyata H, Funato Y, Fujihara Y, Ikawa M, Miki H
Journal of cell science129(9)1940-9(2016 05)

Membrane protein CNNM4-dependent Mg2+ efflux suppresses tumor progression.
Funato Y, Yamazaki D, Mizukami S, Du L, Kikuchi K, Miki H
The Journal of clinical investigation124(12)5398-410(2014 Dec)

Basolateral Mg2+ extrusion via CNNM4 mediates transcellular Mg2+ transport across epithelia: a mouse model.
Yamazaki D, Funato Y, Miura J, Sato S, Toyosawa S, Furutani K, Kurachi Y, Omori Y, Furukawa T, Tsuda T, Kuwabata S, Mizukami S, Kikuchi K, Miki H
PLoS genetics9(12)e1003983(2013)

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Okazaki N, F-Kikuno R, Ohara R, Inamoto S, Koseki H, Hiraoka S, Saga Y, Seino S, Nishimura M, Kaisho T, Hoshino K, Kitamura H, Nagase T, Ohara O, Koga H
DNA research : an international journal for rapid publication of reports on genes and genomes11(3)205-18(2004 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results suggest a new role of CNNM4 in sperm Ca(2+) homeostasis.
Title: The Mg2+ transporter CNNM4 regulates sperm Ca2+ homeostasis and is essential for reproduction.

these results indicate that CNNM4-dependent Mg(2+) efflux suppresses tumor progression by regulating energy metabolism.
Title: Membrane protein CNNM4-dependent Mg2+ efflux suppresses tumor progression.

The following Cnnm4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cnnm4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu21212	NM_033570.2 Latest version!	Mus musculus cyclin M4 (Cnnm4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$454.30 $649.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cnnm4 ( NM_033570.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_291048.2 Mus musculus cyclin M4 (Cnnm4), mRNA.

Price & Availability↑

CloneID	OMu21212
Clone ID Related Accession (Same CDS sequence)	NM_033570.2
Accession Version	NM_033570.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2316bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	metal transporter CNNM4 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CJ168962.1, AK173209.1 and AK164200.1. On Dec 11, 2007 this sequence version replaced NM_033570.1. ##Evidence-Data-START## Transcript exon combination :: AK173209.1, AF216963.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGCGCCGG GGGGCGGGGG CGGGCGGCGG GACGGCTGGC CGGCCCGAGG GCGCCTCCTC 
CTGGCTGCGC TGCTGCTGCT ATGGACGCGG GCGGCCAGCG GCCAGAGCAG CCCCCAGCAG 
AGCGTGATCC TAGGCATGAG GCTAGCGAGC TGCAACAAGT CGTGCGGGAT GAACCCGGAT 
GGCATCATCT TCGTGTCCGA GGGCAGCACG GTGAACTTGA GGCTCTATGG CCACAGCCTG 
GGCGATATCT CCAGCAACCT GATCTCCTTC ACCGAGGTGG ACGACGCCGA GGCGGTCCAC 
AACTCCACCA ACTGCCTGGA GCTCACCAAG GACTTAGTGG TCCAGCGGCT GGTCAACGTG 
AGCCGCGGGA ACACGTCGGG GATGCTAGTG GTGATTACCA AGTTCCTGCG GAGGAGCGAG 
AACATGAAGC TGTACGCGCT GTGCACCCGG CCCCGGGCCG ACGGGCCCTG GACCAGATGG 
ACGGACAAGG ACTCCCTGCT CTTCATGGTG GAGGAGCATG GGAGGTTTCT GCCGCTCTGG 
CTGCACATCC TTCTCGTTAT GGTGCTGTTG GTGCTGTCGG GCATCTTTTC TGGCCTCAAC 
CTGGGGCTTA TGGCCCTGGA CCCGATGGAG CTGCGCATCG TGCAGAACTG TGGAACTGAG 
AAGGAGAGAA AGTATGCTCG CAAGATAGAG CCCATCAGGC GCAAGGGCAA CTACCTGCTC 
TGCTCGCTGC TCCTGGGGAA CGTGCTAGTC AACACCTCCC TCACCATCCT TCTAGACAAC 
CTCATCGGGT CTGGCATCAT GGCAGTGGCC TCCTCTACCA TTGGCATTGT CATCTTTGGG 
GAGATCTTAC CTCAAGCCCT GTGCTCCCGG CACGGGCTGG CTGTGGGTGC CAACACTATT 
GTTCTCACCA AAGTCTTTAT GCTCCTCACT TTTCCCTTGA GTTTCCCCAT TAGCAAACTC 
CTGGACTTCG TCTTAGGTCA GGAGATTCGC ACTGTTTACA ATCGGGAGAA GCTGATGGAG 
ATGTTGAAGG TGACAGAGCC CTATAATGAC TTGGTGAAGG AGGAGTTAAA TATGATCCAG 
GGTGCCCTGG AACTAAGGAC CAAAACTGTG GAGGATATCA TGACCCAGCT ACACGACTGC 
TTCATGATCC GCAGTGATGC CATTCTGGAC TTCAACACCA TGTCGGAGAT TATGGAGAGT 
GGCTACACTC GCATTCCTGT GTTTGAAGAT GAGCAATCCA ATATTGTAGA TATCCTGTAT 
GTCAAAGACT TGGCTTTTGT TGACCCGGAT GACTGCACCC CGCTCAAGAC CATCACTCGC 
TTCTACAACC ACCCGGTACA TTTTGTTTTT CATGACACCA AGCTGGATGC CATGCTAGAG 
GAATTTAAGA AGGGCAAGTC CCACCTGGCC ATCGTGCAGA AGGTGAACAA TGAGGGCGAG 
GGCGACCCCT TCTACGAGGT GCTGGGCCTG GTCACTCTGG AGGACGTCAT CGAGGAGATC 
ATCAAGTCCG AGATCCTCGA TGAGTCGGAC ATGTACACTG ATAATCGGAC CCGGAAACGG 
GTGTCCGTGA AAAACAAGCG TGACTTCTCT GCCTTCAAGG ACACTGACAA TGAACTCAAA 
GTGAAAATCT CACCTCAGCT TCTTCTGGCT GCTCATCGCT TCCTGGCCAC AGAGGTGCCC 
CAGTTTAGCC CCTCTCTGAT GTCAGAGAAG ATCCTGCTCC GGCTGCTCAA GTACCCCGAC 
GTCATTCAGG AGCTCAGGTT CAATGAGCAC AACAGGTACT GCGTTCGCCA CTACCTGTAC 
ACCCGGAACA AGCCGGCCGA TTGCTTCGTC CTCATCCTGC AGGGGAAGGT GGAGGTAGAA 
GCAGGCAAGG AGAACATGAA GTTTGAGACG GGCGCCTTCT CGTACTATGG AACCATGGCA 
CTCTCCGTGG CACCCCCAGA CCGGTCCCCA GCCCTCCCAA CTCCACTCAG CCGCTCAGCT 
TCCCTCAGTT ACCCGGACCG CAACACAGAC TTGACATCCA CCTCCCTGGC AGGCAGCAAC 
CAGTTTGGCA GCTGCATTCT GGGCCAGTAT GTCTCTGACT TCAGTGTGCG GGCGCTCACG 
GACCTGCAGT ACATTAAGAT CACAAGGCAG CAGTACCAGA ATGGGCTGAT GGCCTCCCGC 
ATGGACAACA GCCCCCAGCC TACCTTCGAT GGCTGTGCCA CCTGCTCAGA GAACTTTATG 
GAGAGGCCTG AGCTGCCCCC GGTGGACGAG ACCACGACTC TTCTCAATGA ACGCAACTCG 
TTGCTGCACA GAGCCTCCGA AGAGGAAACC ATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_291048.2
CDS	97..2412
Translation	MAPGGGGGRRDGWPARGRLLLAALLLLWTRAASGQSSPQQSVILGMRLASCNKSCGMNPDGIIFVSEGSTVNLRLYGHSLGDISSNLISFTEVDDAEAVHNSTNCLELTKDLVVQRLVNVSRGNTSGMLVVITKFLRRSENMKLYALCTRPRADGPWTRWTDKDSLLFMVEEHGRFLPLWLHILLVMVLLVLSGIFSGLNLGLMALDPMELRIVQNCGTEKERKYARKIEPIRRKGNYLLCSLLLGNVLVNTSLTILLDNLIGSGIMAVASSTIGIVIFGEILPQALCSRHGLAVGANTIVLTKVFMLLTFPLSFPISKLLDFVLGQEIRTVYNREKLMEMLKVTEPYNDLVKEELNMIQGALELRTKTVEDIMTQLHDCFMIRSDAILDFNTMSEIMESGYTRIPVFEDEQSNIVDILYVKDLAFVDPDDCTPLKTITRFYNHPVHFVFHDTKLDAMLEEFKKGKSHLAIVQKVNNEGEGDPFYEVLGLVTLEDVIEEIIKSEILDESDMYTDNRTRKRVSVKNKRDFSAFKDTDNELKVKISPQLLLAAHRFLATEVPQFSPSLMSEKILLRLLKYPDVIQELRFNEHNRYCVRHYLYTRNKPADCFVLILQGKVEVEAGKENMKFETGAFSYYGTMALSVAPPDRSPALPTPLSRSASLSYPDRNTDLTSTSLAGSNQFGSCILGQYVSDFSVRALTDLQYIKITRQQYQNGLMASRMDNSPQPTFDGCATCSENFMERPELPPVDETTTLLNERNSLLHRASEEETI

Target ORF information:

RefSeq Version	NM_033570.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus cyclin M4 (Cnnm4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033570.2

ORF Insert Sequence:

ATGGCGCCGG GGGGCGGGGG CGGGCGGCGG GACGGCTGGC CGGCCCGAGG GCGCCTCCTC 
CTGGCTGCGC TGCTGCTGCT ATGGACGCGG GCGGCCAGCG GCCAGAGCAG CCCCCAGCAG 
AGCGTGATCC TAGGCATGAG GCTAGCGAGC TGCAACAAGT CGTGCGGGAT GAACCCGGAT 
GGCATCATCT TCGTGTCCGA GGGCAGCACG GTGAACTTGA GGCTCTATGG CCACAGCCTG 
GGCGATATCT CCAGCAACCT GATCTCCTTC ACCGAGGTGG ACGACGCCGA GGCGGTCCAC 
AACTCCACCA ACTGCCTGGA GCTCACCAAG GACTTAGTGG TCCAGCGGCT GGTCAACGTG 
AGCCGCGGGA ACACGTCGGG GATGCTAGTG GTGATTACCA AGTTCCTGCG GAGGAGCGAG 
AACATGAAGC TGTACGCGCT GTGCACCCGG CCCCGGGCCG ACGGGCCCTG GACCAGATGG 
ACGGACAAGG ACTCCCTGCT CTTCATGGTG GAGGAGCATG GGAGGTTTCT GCCGCTCTGG 
CTGCACATCC TTCTCGTTAT GGTGCTGTTG GTGCTGTCGG GCATCTTTTC TGGCCTCAAC 
CTGGGGCTTA TGGCCCTGGA CCCGATGGAG CTGCGCATCG TGCAGAACTG TGGAACTGAG 
AAGGAGAGAA AGTATGCTCG CAAGATAGAG CCCATCAGGC GCAAGGGCAA CTACCTGCTC 
TGCTCGCTGC TCCTGGGGAA CGTGCTAGTC AACACCTCCC TCACCATCCT TCTAGACAAC 
CTCATCGGGT CTGGCATCAT GGCAGTGGCC TCCTCTACCA TTGGCATTGT CATCTTTGGG 
GAGATCTTAC CTCAAGCCCT GTGCTCCCGG CACGGGCTGG CTGTGGGTGC CAACACTATT 
GTTCTCACCA AAGTCTTTAT GCTCCTCACT TTTCCCTTGA GTTTCCCCAT TAGCAAACTC 
CTGGACTTCG TCTTAGGTCA GGAGATTCGC ACTGTTTACA ATCGGGAGAA GCTGATGGAG 
ATGTTGAAGG TGACAGAGCC CTATAATGAC TTGGTGAAGG AGGAGTTAAA TATGATCCAG 
GGTGCCCTGG AACTAAGGAC CAAAACTGTG GAGGATATCA TGACCCAGCT ACACGACTGC 
TTCATGATCC GCAGTGATGC CATTCTGGAC TTCAACACCA TGTCGGAGAT TATGGAGAGT 
GGCTACACTC GCATTCCTGT GTTTGAAGAT GAGCAATCCA ATATTGTAGA TATCCTGTAT 
GTCAAAGACT TGGCTTTTGT TGACCCGGAT GACTGCACCC CGCTCAAGAC CATCACTCGC 
TTCTACAACC ACCCGGTACA TTTTGTTTTT CATGACACCA AGCTGGATGC CATGCTAGAG 
GAATTTAAGA AGGGCAAGTC CCACCTGGCC ATCGTGCAGA AGGTGAACAA TGAGGGCGAG 
GGCGACCCCT TCTACGAGGT GCTGGGCCTG GTCACTCTGG AGGACGTCAT CGAGGAGATC 
ATCAAGTCCG AGATCCTCGA TGAGTCGGAC ATGTACACTG ATAATCGGAC CCGGAAACGG 
GTGTCCGTGA AAAACAAGCG TGACTTCTCT GCCTTCAAGG ACACTGACAA TGAACTCAAA 
GTGAAAATCT CACCTCAGCT TCTTCTGGCT GCTCATCGCT TCCTGGCCAC AGAGGTGCCC 
CAGTTTAGCC CCTCTCTGAT GTCAGAGAAG ATCCTGCTCC GGCTGCTCAA GTACCCCGAC 
GTCATTCAGG AGCTCAGGTT CAATGAGCAC AACAGGTACT GCGTTCGCCA CTACCTGTAC 
ACCCGGAACA AGCCGGCCGA TTGCTTCGTC CTCATCCTGC AGGGGAAGGT GGAGGTAGAA 
GCAGGCAAGG AGAACATGAA GTTTGAGACG GGCGCCTTCT CGTACTATGG AACCATGGCA 
CTCTCCGTGG CACCCCCAGA CCGGTCCCCA GCCCTCCCAA CTCCACTCAG CCGCTCAGCT 
TCCCTCAGTT ACCCGGACCG CAACACAGAC TTGACATCCA CCTCCCTGGC AGGCAGCAAC 
CAGTTTGGCA GCTGCATTCT GGGCCAGTAT GTCTCTGACT TCAGTGTGCG GGCGCTCACG 
GACCTGCAGT ACATTAAGAT CACAAGGCAG CAGTACCAGA ATGGGCTGAT GGCCTCCCGC 
ATGGACAACA GCCCCCAGCC TACCTTCGAT GGCTGTGCCA CCTGCTCAGA GAACTTTATG 
GAGAGGCCTG AGCTGCCCCC GGTGGACGAG ACCACGACTC TTCTCAATGA ACGCAACTCG 
TTGCTGCACA GAGCCTCCGA AGAGGAAACC ATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The Mg2+ transporter CNNM4 regulates sperm Ca2+ homeostasis and is essential for reproduction.
Journal of cell science129(9)1940-9(2016 05)
Yamazaki D,Miyata H,Funato Y,Fujihara Y,Ikawa M,Miki H

Membrane protein CNNM4-dependent Mg2+ efflux suppresses tumor progression.
The Journal of clinical investigation124(12)5398-410(2014 Dec)
Funato Y,Yamazaki D,Mizukami S,Du L,Kikuchi K,Miki H

Basolateral Mg2+ extrusion via CNNM4 mediates transcellular Mg2+ transport across epithelia: a mouse model.
PLoS genetics9(12)e1003983(2013)
Yamazaki D,Funato Y,Miura J,Sato S,Toyosawa S,Furutani K,Kurachi Y,Omori Y,Furukawa T,Tsuda T,Kuwabata S,Mizukami S,Kikuchi K,Miki H

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
DNA research : an international journal for rapid publication of reports on genes and genomes11(3)205-18(2004 Jun)
Okazaki N,F-Kikuno R,Ohara R,Inamoto S,Koseki H,Hiraoka S,Saga Y,Seino S,Nishimura M,Kaisho T,Hoshino K,Kitamura H,Nagase T,Ohara O,Koga H

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Cnnm4 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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