Fam20c cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fam20c
Entrez Gene ID	80752
Full Name	family with sequence similarity 20, member C
Synonyms	C76981,DMP-4,DMP4,GEF-CK,mKIAA4081
General protein information	Preferred Names family with sequence similarity 20, member C Names extracellular serine/threonine protein kinase FAM20C dentin matrix protein 4 golgi-enriched fraction casein kinase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5\|5 G2

mRNA and Protein(s)

mRNA	Protein	Name
NM_030565.6	NP_085042.2	extracellular serine/threonine protein kinase FAM20C isoform 1 precursor
XM_006504775.3	XP_006504838.1	extracellular serine/threonine protein kinase FAM20C isoform X1
NM_001359593.1	NP_001346522.1	extracellular serine/threonine protein kinase FAM20C isoform 2

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	FAM20C	XP_005621279.1
Danio rerio (zebrafish)	LOC792520	XP_001332042.4
Danio rerio (zebrafish)	fam20cb	XP_688892.5
Bos taurus (cattle)	FAM20C	XP_002698221.1
Mus musculus (house mouse)	Fam20c	NP_085042.2
Xenopus tropicalis (tropical clawed frog)	LOC100498448	XP_002931990.1
Homo sapiens (human)	FAM20C	NP_064608.2
Gallus gallus (chicken)	FAM20C	XP_414753.4
Pan troglodytes (chimpanzee)	LOC740357	XP_001142331.2
	FAM20C	XP_001083623.1
Rattus norvegicus (Norway rat)	Fam20c	NP_001012238.1

Gene Ontology
Bibliography

Related articles in PubMed

Abrogation of Fam20c altered cell behaviors and BMP signaling of immortalized dental mesenchymal cells.
Liu C, Zhou N, Wang Y, Zhang H, Jani P, Wang X, Lu Y, Li N, Xiao J, Qin C
Experimental cell research(2018 Jan)

Specific ablation of mouse Fam20C in cells expressing type I collagen leads to skeletal defects and hypophosphatemia.
Liu P, Ma S, Zhang H, Liu C, Lu Y, Chen L, Qin C
Scientific reports7(1)3590(2017 Jun)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

family with sequence similarity member 20C is the primary, but not the only, kinase for the SIBLINGs
Title: Family with sequence similarity member 20C is the primary but not the only kinase for the small-integrin-binding ligand N-linked glycoproteins in bone.

we have successfully generated the immortalized mouse floxed Fam20c dental papilla mesenchymal and osteoblast cell lines.
Title: Immortalized Mouse Floxed Fam20c Dental Papillar Mesenchymal and Osteoblast Cell Lines Retain Their Primary Characteristics.

Successful generation of Fam20C-GFP transgenic mice will provide a unique model for studying Fam20C gene expression and the biological function of this gene during odontogenesis and osteogenesis
Title: Characterization of Fam20C expression in odontogenesis and osteogenesis using transgenic mice.

Fam20A potentiates Fam20C kinase activity and promotes the phosphorylation of enamel matrix proteins in vitro.
Title: A secretory kinase complex regulates extracellular protein phosphorylation.

Loss of Fam20C function leads to periodontal disease in mice
Title: Inactivation of Fam20C in cells expressing type I collagen causes periodontal disease in mice.

The following Fam20c gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fam20c cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu36363	NM_001359593.1 Latest version!	Mus musculus family with sequence similarity 20, member C (Fam20c), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OMu36363	XM_006504775.3 Latest version!	Mus musculus family with sequence similarity 20, member C (Fam20c), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OMu08297	NM_030565.6 Latest version!	Mus musculus family with sequence similarity 20, member C (Fam20c), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$216.30 $309.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fam20c ( NM_001359593.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001346522.1 Mus musculus family with sequence similarity 20, member C (Fam20c), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu36363
Clone ID Related Accession (Same CDS sequence)	XM_006504775.3 , NM_001359593.1
Accession Version	NM_001359593.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 969bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-06
Organism	Mus musculus(house mouse)
Product	extracellular serine/threonine protein kinase FAM20C isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC165444.2, AK149780.1 and AC113533.14. On Jan 13, 2018 this sequence version replaced XM_006504775.3. Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK149780.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGTCAG GGGGCACGCA GCTGAAGCTC ATCATGACCT TCCAGAATTA CGGGCAGGCG 
CTATTCAAAC CCATGAAGCA GACGAGAGAG CAGGAGACGC CGCCTGACTT TTTTTATTTC 
TCTGACTATG AGAGGCACAA TGCGGAGATC GCTGCCTTCC ACCTGGACAG GATCCTGGAT 
TTCCGCAGAG TCCCTCCAGT GGCTGGTAGG ATGATCAACA TGACCAAGGA GATCCGGGAT 
GTGACGCGGG ATAAGAAGCT ATGGAGAACT TTCTTTGTGT CTCCAGCCAA CAACATCTGT 
TTCTACGGGG AGTGTTCCTA CTACTGTTCC ACCGAGCATG CCCTGTGTGG GAGGCCCGAC 
CAGATCGAAG GATCCCTGGC GGCCTTCCTG CCTGACCTGT CGCTGGCCAA GAGGAAGACA 
TGGCGGAACC CCTGGCGTCG TTCCTACCAC AAGCGAAAGA AGGCAGAGTG GGAAGTCGAC 
CCTGATTACT GTGAGGAGGT GAAGCAGACG CCACCCTACG ACAGTGGCCA CCGAATCCTG 
GACATCATGG ATATGACCGT CTTTGATTTC CTCATGGGGA ACATGGATCG GCATCACTAC 
GAGACCTTTG AGAAGTTCGG GAATGAGACC TTCATCATCC ACTTGGACAA CGGGCGCGGG 
TTTGGGAAAT ACTCACACGA TGAGCTTTCC ATTCTCGCTC CTCTTCATCA GTGCTGCAGG 
ATCAGGAGGT CCACCTACCT GAGACTGCAG CTGCTGGCCA AAGAGGAACA CAAACTGAGC 
CTGCTGATGG CCGAGTCCCT GCAGCATGAC AAGGTGGCAC CCGTGCTCTA CCAGCTGCAT 
CTGGAGGCCC TGGACCGGCG GTTGCGCATA GTGCTGCAGG CTGTGCGAGA CTGTGTGGAG 
AAGGACGGGC TGAGCAGTGT GGTGGAGGAC GACCTAGCCA CTGAGCACAG AGCCTCCACG 
GAGAGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001346522.1
CDS	1405..2373
Translation	MKSGGTQLKLIMTFQNYGQALFKPMKQTREQETPPDFFYFSDYERHNAEIAAFHLDRILDFRRVPPVAGRMINMTKEIRDVTRDKKLWRTFFVSPANNICFYGECSYYCSTEHALCGRPDQIEGSLAAFLPDLSLAKRKTWRNPWRRSYHKRKKAEWEVDPDYCEEVKQTPPYDSGHRILDIMDMTVFDFLMGNMDRHHYETFEKFGNETFIIHLDNGRGFGKYSHDELSILAPLHQCCRIRRSTYLRLQLLAKEEHKLSLLMAESLQHDKVAPVLYQLHLEALDRRLRIVLQAVRDCVEKDGLSSVVEDDLATEHRASTER

Target ORF information:

RefSeq Version	NM_001359593.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus family with sequence similarity 20, member C (Fam20c), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001359593.1

ORF Insert Sequence:

ATGAAGTCAG GGGGCACGCA GCTGAAGCTC ATCATGACCT TCCAGAATTA CGGGCAGGCG 
CTATTCAAAC CCATGAAGCA GACGAGAGAG CAGGAGACGC CGCCTGACTT TTTTTATTTC 
TCTGACTATG AGAGGCACAA TGCGGAGATC GCTGCCTTCC ACCTGGACAG GATCCTGGAT 
TTCCGCAGAG TCCCTCCAGT GGCTGGTAGG ATGATCAACA TGACCAAGGA GATCCGGGAT 
GTGACGCGGG ATAAGAAGCT ATGGAGAACT TTCTTTGTGT CTCCAGCCAA CAACATCTGT 
TTCTACGGGG AGTGTTCCTA CTACTGTTCC ACCGAGCATG CCCTGTGTGG GAGGCCCGAC 
CAGATCGAAG GATCCCTGGC GGCCTTCCTG CCTGACCTGT CGCTGGCCAA GAGGAAGACA 
TGGCGGAACC CCTGGCGTCG TTCCTACCAC AAGCGAAAGA AGGCAGAGTG GGAAGTCGAC 
CCTGATTACT GTGAGGAGGT GAAGCAGACG CCACCCTACG ACAGTGGCCA CCGAATCCTG 
GACATCATGG ATATGACCGT CTTTGATTTC CTCATGGGGA ACATGGATCG GCATCACTAC 
GAGACCTTTG AGAAGTTCGG GAATGAGACC TTCATCATCC ACTTGGACAA CGGGCGCGGG 
TTTGGGAAAT ACTCACACGA TGAGCTTTCC ATTCTCGCTC CTCTTCATCA GTGCTGCAGG 
ATCAGGAGGT CCACCTACCT GAGACTGCAG CTGCTGGCCA AAGAGGAACA CAAACTGAGC 
CTGCTGATGG CCGAGTCCCT GCAGCATGAC AAGGTGGCAC CCGTGCTCTA CCAGCTGCAT 
CTGGAGGCCC TGGACCGGCG GTTGCGCATA GTGCTGCAGG CTGTGCGAGA CTGTGTGGAG 
AAGGACGGGC TGAGCAGTGT GGTGGAGGAC GACCTAGCCA CTGAGCACAG AGCCTCCACG 
GAGAGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Fam20c ( XM_006504775.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006504838.1 Mus musculus family with sequence similarity 20, member C (Fam20c), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu36363
Clone ID Related Accession (Same CDS sequence)	XM_006504775.3 , NM_001359593.1
Accession Version	XM_006504775.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 969bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	extracellular serine/threonine protein kinase FAM20C isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000071.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006504775.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGTCAG GGGGCACGCA GCTGAAGCTC ATCATGACCT TCCAGAATTA CGGGCAGGCG 
CTATTCAAAC CCATGAAGCA GACGAGAGAG CAGGAGACGC CGCCTGACTT TTTTTATTTC 
TCTGACTATG AGAGGCACAA TGCGGAGATC GCTGCCTTCC ACCTGGACAG GATCCTGGAT 
TTCCGCAGAG TCCCTCCAGT GGCTGGTAGG ATGATCAACA TGACCAAGGA GATCCGGGAT 
GTGACGCGGG ATAAGAAGCT ATGGAGAACT TTCTTTGTGT CTCCAGCCAA CAACATCTGT 
TTCTACGGGG AGTGTTCCTA CTACTGTTCC ACCGAGCATG CCCTGTGTGG GAGGCCCGAC 
CAGATCGAAG GATCCCTGGC GGCCTTCCTG CCTGACCTGT CGCTGGCCAA GAGGAAGACA 
TGGCGGAACC CCTGGCGTCG TTCCTACCAC AAGCGAAAGA AGGCAGAGTG GGAAGTCGAC 
CCTGATTACT GTGAGGAGGT GAAGCAGACG CCACCCTACG ACAGTGGCCA CCGAATCCTG 
GACATCATGG ATATGACCGT CTTTGATTTC CTCATGGGGA ACATGGATCG GCATCACTAC 
GAGACCTTTG AGAAGTTCGG GAATGAGACC TTCATCATCC ACTTGGACAA CGGGCGCGGG 
TTTGGGAAAT ACTCACACGA TGAGCTTTCC ATTCTCGCTC CTCTTCATCA GTGCTGCAGG 
ATCAGGAGGT CCACCTACCT GAGACTGCAG CTGCTGGCCA AAGAGGAACA CAAACTGAGC 
CTGCTGATGG CCGAGTCCCT GCAGCATGAC AAGGTGGCAC CCGTGCTCTA CCAGCTGCAT 
CTGGAGGCCC TGGACCGGCG GTTGCGCATA GTGCTGCAGG CTGTGCGAGA CTGTGTGGAG 
AAGGACGGGC TGAGCAGTGT GGTGGAGGAC GACCTAGCCA CTGAGCACAG AGCCTCCACG 
GAGAGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006504838.1
CDS	2177..3145
Translation	MKSGGTQLKLIMTFQNYGQALFKPMKQTREQETPPDFFYFSDYERHNAEIAAFHLDRILDFRRVPPVAGRMINMTKEIRDVTRDKKLWRTFFVSPANNICFYGECSYYCSTEHALCGRPDQIEGSLAAFLPDLSLAKRKTWRNPWRRSYHKRKKAEWEVDPDYCEEVKQTPPYDSGHRILDIMDMTVFDFLMGNMDRHHYETFEKFGNETFIIHLDNGRGFGKYSHDELSILAPLHQCCRIRRSTYLRLQLLAKEEHKLSLLMAESLQHDKVAPVLYQLHLEALDRRLRIVLQAVRDCVEKDGLSSVVEDDLATEHRASTER

Target ORF information:

RefSeq Version	XM_006504775.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus family with sequence similarity 20, member C (Fam20c), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006504775.3

ORF Insert Sequence:

ATGAAGTCAG GGGGCACGCA GCTGAAGCTC ATCATGACCT TCCAGAATTA CGGGCAGGCG 
CTATTCAAAC CCATGAAGCA GACGAGAGAG CAGGAGACGC CGCCTGACTT TTTTTATTTC 
TCTGACTATG AGAGGCACAA TGCGGAGATC GCTGCCTTCC ACCTGGACAG GATCCTGGAT 
TTCCGCAGAG TCCCTCCAGT GGCTGGTAGG ATGATCAACA TGACCAAGGA GATCCGGGAT 
GTGACGCGGG ATAAGAAGCT ATGGAGAACT TTCTTTGTGT CTCCAGCCAA CAACATCTGT 
TTCTACGGGG AGTGTTCCTA CTACTGTTCC ACCGAGCATG CCCTGTGTGG GAGGCCCGAC 
CAGATCGAAG GATCCCTGGC GGCCTTCCTG CCTGACCTGT CGCTGGCCAA GAGGAAGACA 
TGGCGGAACC CCTGGCGTCG TTCCTACCAC AAGCGAAAGA AGGCAGAGTG GGAAGTCGAC 
CCTGATTACT GTGAGGAGGT GAAGCAGACG CCACCCTACG ACAGTGGCCA CCGAATCCTG 
GACATCATGG ATATGACCGT CTTTGATTTC CTCATGGGGA ACATGGATCG GCATCACTAC 
GAGACCTTTG AGAAGTTCGG GAATGAGACC TTCATCATCC ACTTGGACAA CGGGCGCGGG 
TTTGGGAAAT ACTCACACGA TGAGCTTTCC ATTCTCGCTC CTCTTCATCA GTGCTGCAGG 
ATCAGGAGGT CCACCTACCT GAGACTGCAG CTGCTGGCCA AAGAGGAACA CAAACTGAGC 
CTGCTGATGG CCGAGTCCCT GCAGCATGAC AAGGTGGCAC CCGTGCTCTA CCAGCTGCAT 
CTGGAGGCCC TGGACCGGCG GTTGCGCATA GTGCTGCAGG CTGTGCGAGA CTGTGTGGAG 
AAGGACGGGC TGAGCAGTGT GGTGGAGGAC GACCTAGCCA CTGAGCACAG AGCCTCCACG 
GAGAGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Fam20c ( NM_030565.6 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_085042.2 Mus musculus family with sequence similarity 20, member C (Fam20c), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu08297
Clone ID Related Accession (Same CDS sequence)	NM_030565.6
Accession Version	NM_030565.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1740bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-06
Organism	Mus musculus(house mouse)
Product	extracellular serine/threonine protein kinase FAM20C isoform 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC165444.2 and AC113533.14. On Feb 7, 2008 this sequence version replaced NM_030565.5. Transcript Variant: This variant (1) encodes the longer isoform (1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK154810.1, SRR1660817.254814.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGATGA TACTGGTGCG CAGGTTTCGC GTGCTCATCC TGGTAGTATT CCTACTGGCT 
TGCGCTTTGC ACATTGCTGT TGACCTGCTA CCCAAGCTGG ACCGACGCGC CACGCGATCC 
TCCGGGGAGC CCGGTTGCTC CTGCGCTCAG CCGGCAGCAG AGGCAGCTGG TCCAGGCTGG 
GCCCAGGCAA GGAGCAGACC GGGGGAGTCC GCCGGTGGCG ACGCAGGCTG GCCCAACAAA 
CACACACTGC GCATCCTGCA AGACTTCAGC TCAGATCCAG CCTCTAACCT AACCTCCCAC 
TCCTTGGAGA AGCTGCCTTC TGCAGCAGAG CCGGTGGATC ACGCTCCGCG GGGTCAGGAG 
CCCCGTTCCC CGCCACCCCG TGACCCAGCG CATCGGCCGC TGCTTCGAGA CCCGGGGCCC 
CGACCGCGGG TACCGCCCCC TGGCCCCAGC GGGGACGGAT CGCTCTTAGC CAAGTTGTTT 
GAGCACCCTC TCTACCAGGG GGCTGTGCCT CCTCTGACAG AGGACGACGT CCTGTTTAAT 
GTGAACAGCG ACATCAGGTT TAACCCCAAG GCAGCAGAGA ATCCTGACTG GCCGCATGAA 
GGTGCTGAAG GCGCAGAATT CTTGCCCACT GGTGAGGCAG CTGTGAACCT CTATCCCAAC 
TGGCTCAAAT TCCACATTGG CATCAACCGG TATGAGCTGT ACTCCAGACA CAACCCAGCC 
ATCGATGCCT TACTGCGGGA CCTCGGCTCT CAGAAGATCA CCAGCGTCGC CATGAAGTCA 
GGGGGCACGC AGCTGAAGCT CATCATGACC TTCCAGAATT ACGGGCAGGC GCTATTCAAA 
CCCATGAAGC AGACGAGAGA GCAGGAGACG CCGCCTGACT TTTTTTATTT CTCTGACTAT 
GAGAGGCACA ATGCGGAGAT CGCTGCCTTC CACCTGGACA GGATCCTGGA TTTCCGCAGA 
GTCCCTCCAG TGGCTGGTAG GATGATCAAC ATGACCAAGG AGATCCGGGA TGTGACGCGG 
GATAAGAAGC TATGGAGAAC TTTCTTTGTG TCTCCAGCCA ACAACATCTG TTTCTACGGG 
GAGTGTTCCT ACTACTGTTC CACCGAGCAT GCCCTGTGTG GGAGGCCCGA CCAGATCGAA 
GGATCCCTGG CGGCCTTCCT GCCTGACCTG TCGCTGGCCA AGAGGAAGAC ATGGCGGAAC 
CCCTGGCGTC GTTCCTACCA CAAGCGAAAG AAGGCAGAGT GGGAAGTCGA CCCTGATTAC 
TGTGAGGAGG TGAAGCAGAC GCCACCCTAC GACAGTGGCC ACCGAATCCT GGACATCATG 
GATATGACCG TCTTTGATTT CCTCATGGGG AACATGGATC GGCATCACTA CGAGACCTTT 
GAGAAGTTCG GGAATGAGAC CTTCATCATC CACTTGGACA ACGGGCGCGG GTTTGGGAAA 
TACTCACACG ATGAGCTTTC CATTCTCGCT CCTCTTCATC AGTGCTGCAG GATCAGGAGG 
TCCACCTACC TGAGACTGCA GCTGCTGGCC AAAGAGGAAC ACAAACTGAG CCTGCTGATG 
GCCGAGTCCC TGCAGCATGA CAAGGTGGCA CCCGTGCTCT ACCAGCTGCA TCTGGAGGCC 
CTGGACCGGC GGTTGCGCAT AGTGCTGCAG GCTGTGCGAG ACTGTGTGGA GAAGGACGGG 
CTGAGCAGTG TGGTGGAGGA CGACCTAGCC ACTGAGCACA GAGCCTCCAC GGAGAGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_085042.2
CDS	556..2295
Translation	MKMILVRRFRVLILVVFLLACALHIAVDLLPKLDRRATRSSGEPGCSCAQPAAEAAGPGWAQARSRPGESAGGDAGWPNKHTLRILQDFSSDPASNLTSHSLEKLPSAAEPVDHAPRGQEPRSPPPRDPAHRPLLRDPGPRPRVPPPGPSGDGSLLAKLFEHPLYQGAVPPLTEDDVLFNVNSDIRFNPKAAENPDWPHEGAEGAEFLPTGEAAVNLYPNWLKFHIGINRYELYSRHNPAIDALLRDLGSQKITSVAMKSGGTQLKLIMTFQNYGQALFKPMKQTREQETPPDFFYFSDYERHNAEIAAFHLDRILDFRRVPPVAGRMINMTKEIRDVTRDKKLWRTFFVSPANNICFYGECSYYCSTEHALCGRPDQIEGSLAAFLPDLSLAKRKTWRNPWRRSYHKRKKAEWEVDPDYCEEVKQTPPYDSGHRILDIMDMTVFDFLMGNMDRHHYETFEKFGNETFIIHLDNGRGFGKYSHDELSILAPLHQCCRIRRSTYLRLQLLAKEEHKLSLLMAESLQHDKVAPVLYQLHLEALDRRLRIVLQAVRDCVEKDGLSSVVEDDLATEHRASTER

Target ORF information:

RefSeq Version	NM_030565.6
Organism	Mus musculus(house mouse)
Definition	Mus musculus family with sequence similarity 20, member C (Fam20c), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030565.6

ORF Insert Sequence:

ATGAAGATGA TACTGGTGCG CAGGTTTCGC GTGCTCATCC TGGTAGTATT CCTACTGGCT 
TGCGCTTTGC ACATTGCTGT TGACCTGCTA CCCAAGCTGG ACCGACGCGC CACGCGATCC 
TCCGGGGAGC CCGGTTGCTC CTGCGCTCAG CCGGCAGCAG AGGCAGCTGG TCCAGGCTGG 
GCCCAGGCAA GGAGCAGACC GGGGGAGTCC GCCGGTGGCG ACGCAGGCTG GCCCAACAAA 
CACACACTGC GCATCCTGCA AGACTTCAGC TCAGATCCAG CCTCTAACCT AACCTCCCAC 
TCCTTGGAGA AGCTGCCTTC TGCAGCAGAG CCGGTGGATC ACGCTCCGCG GGGTCAGGAG 
CCCCGTTCCC CGCCACCCCG TGACCCAGCG CATCGGCCGC TGCTTCGAGA CCCGGGGCCC 
CGACCGCGGG TACCGCCCCC TGGCCCCAGC GGGGACGGAT CGCTCTTAGC CAAGTTGTTT 
GAGCACCCTC TCTACCAGGG GGCTGTGCCT CCTCTGACAG AGGACGACGT CCTGTTTAAT 
GTGAACAGCG ACATCAGGTT TAACCCCAAG GCAGCAGAGA ATCCTGACTG GCCGCATGAA 
GGTGCTGAAG GCGCAGAATT CTTGCCCACT GGTGAGGCAG CTGTGAACCT CTATCCCAAC 
TGGCTCAAAT TCCACATTGG CATCAACCGG TATGAGCTGT ACTCCAGACA CAACCCAGCC 
ATCGATGCCT TACTGCGGGA CCTCGGCTCT CAGAAGATCA CCAGCGTCGC CATGAAGTCA 
GGGGGCACGC AGCTGAAGCT CATCATGACC TTCCAGAATT ACGGGCAGGC GCTATTCAAA 
CCCATGAAGC AGACGAGAGA GCAGGAGACG CCGCCTGACT TTTTTTATTT CTCTGACTAT 
GAGAGGCACA ATGCGGAGAT CGCTGCCTTC CACCTGGACA GGATCCTGGA TTTCCGCAGA 
GTCCCTCCAG TGGCTGGTAG GATGATCAAC ATGACCAAGG AGATCCGGGA TGTGACGCGG 
GATAAGAAGC TATGGAGAAC TTTCTTTGTG TCTCCAGCCA ACAACATCTG TTTCTACGGG 
GAGTGTTCCT ACTACTGTTC CACCGAGCAT GCCCTGTGTG GGAGGCCCGA CCAGATCGAA 
GGATCCCTGG CGGCCTTCCT GCCTGACCTG TCGCTGGCCA AGAGGAAGAC ATGGCGGAAC 
CCCTGGCGTC GTTCCTACCA CAAGCGAAAG AAGGCAGAGT GGGAAGTCGA CCCTGATTAC 
TGTGAGGAGG TGAAGCAGAC GCCACCCTAC GACAGTGGCC ACCGAATCCT GGACATCATG 
GATATGACCG TCTTTGATTT CCTCATGGGG AACATGGATC GGCATCACTA CGAGACCTTT 
GAGAAGTTCG GGAATGAGAC CTTCATCATC CACTTGGACA ACGGGCGCGG GTTTGGGAAA 
TACTCACACG ATGAGCTTTC CATTCTCGCT CCTCTTCATC AGTGCTGCAG GATCAGGAGG 
TCCACCTACC TGAGACTGCA GCTGCTGGCC AAAGAGGAAC ACAAACTGAG CCTGCTGATG 
GCCGAGTCCC TGCAGCATGA CAAGGTGGCA CCCGTGCTCT ACCAGCTGCA TCTGGAGGCC 
CTGGACCGGC GGTTGCGCAT AGTGCTGCAG GCTGTGCGAG ACTGTGTGGA GAAGGACGGG 
CTGAGCAGTG TGGTGGAGGA CGACCTAGCC ACTGAGCACA GAGCCTCCAC GGAGAGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Abrogation of Fam20c altered cell behaviors and BMP signaling of immortalized dental mesenchymal cells.
Experimental cell research(2018 Jan)
Liu C,Zhou N,Wang Y,Zhang H,Jani P,Wang X,Lu Y,Li N,Xiao J,Qin C

Specific ablation of mouse Fam20C in cells expressing type I collagen leads to skeletal defects and hypophosphatemia.
Scientific reports7(1)3590(2017 Jun)
Liu P,Ma S,Zhang H,Liu C,Lu Y,Chen L,Qin C

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

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Fam20c cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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