Cpb1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cpb1
Entrez Gene ID	76703
Full Name	carboxypeptidase B1 (tissue)
Synonyms	0910001A18Rik,1810063F02Rik,2210008M23Rik,AI504870
General protein information	Preferred Names carboxypeptidase B1 (tissue) Names carboxypeptidase B
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 3 Map Location: 3 A2\|3 6.29 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_029706.2	NP_083982.1	carboxypeptidase B precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	CPB1	NP_001098820.1
Rattus norvegicus (Norway rat)	Cpb1	NP_036665.1
Pan troglodytes (chimpanzee)	CPB1	XP_516808.2
	CPB1	XP_001110220.1
Danio rerio (zebrafish)	cpb1	NP_001103491.1
Xenopus tropicalis (tropical clawed frog)	LOC100494117	XP_002937383.2
Mus musculus (house mouse)	Cpb1	NP_083982.1
Gallus gallus (chicken)	CPB1	NP_001264374.1
Homo sapiens (human)	CPB1	NP_001862.2
Canis lupus familiaris (dog)	CPB1	NP_001003005.1
Drosophila melanogaster (fruit fly)	CG4017	NP_609309.1

Gene Ontology
Bibliography

Related articles in PubMed

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

von Hippel-Lindau gene disruption in mouse pancreatic progenitors and its consequences on endocrine differentiation in vivo: importance of HIF1-? and VEGF-A upregulation.
Soggia A, Ramond C, Akiyama H, Scharfmann R, Duvillie B
Diabetologia57(11)2348-56(2014 Nov)

The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis.
Hale MA, Swift GH, Hoang CQ, Deering TG, Masui T, Lee YK, Xue J, MacDonald RJ
Development (Cambridge, England)141(16)3123-33(2014 Aug)

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H
Nucleic acids research42(Database issue)D802-9(2014 Jan)

Site-specific carboxypeptidase B1 tyrosine nitration and pathophysiological implications following its physical association with nitric oxide synthase-3 in experimental sepsis.
Chatterjee S, Lardinois O, Bonini MG, Bhattacharjee S, Stadler K, Corbett J, Deterding LJ, Tomer KB, Kadiiska M, Mason RP
Journal of immunology (Baltimore, Md. : 1950)183(6)4055-66(2009 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CPB1 colocalization, coupling, and proximity to NOS-3 in the sinus-lining cells of spleen red pulp could explain the site-specific tyrosine nitration and inactivation of CPB1
Title: Site-specific carboxypeptidase B1 tyrosine nitration and pathophysiological implications following its physical association with nitric oxide synthase-3 in experimental sepsis.

The following Cpb1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cpb1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu07358	NM_029706.2 Latest version!	Mus musculus carboxypeptidase B1 (tissue) (Cpb1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cpb1 ( NM_029706.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_083982.1 Mus musculus carboxypeptidase B1 (tissue) (Cpb1), mRNA.

Price & Availability↑

CloneID	OMu07358
Clone ID Related Accession (Same CDS sequence)	NM_029706.2
Accession Version	NM_029706.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1248bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-31
Organism	Mus musculus(house mouse)
Product	carboxypeptidase B precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BQ831426.1, AK003061.1, AK008678.1 and AC158937.5. On Jan 23, 2016 this sequence version replaced NM_029706.1. ##Evidence-Data-START## Transcript exon combination :: AK003061.1, BC138759.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849388 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTTGCTGC TACTGGCCCT GGTGAGTGTG GCCCTGGCTC ATGCTTCTGA GGAGAACTTT 
GATGGCAACC GGGTGTTCCG TGTCAGTGTA CATGATGAAG ATGACGTCAG CTTAATTCAG 
GAACTAGCCA ACACCAAACA GATTGATTTC TGGAAACCAG ATTCTGCTAC ACAAGTGAAA 
CCTCTTACTA CAGTTGACTT TCATGTTAAA GCAGAAGATG TCGTTGATGT GGAGAACTTT 
CTCGAGGAGA ATGAAGTTCT CTATGAGGTA TTGATAAGCA ACGTGAAACA TATTCTGGAA 
TCCCAGTTTG ACAGCCACAC CCGTGCAAGT GGACACAGCT ACACCAAGTA CAACAACTGG 
GAAACGATAG AGGCATGGAT TCAACAAGTT GCCAATGATA ATCCAGACCT TGTTTCTAAG 
AGAGTCATTG GAACCACATT TGAAGGACGT AACATGTATG TTCTCAAGAT TGGCAAAGAT 
AGACCAAATA AGCCTGCCTT CTTCATCGAC TGTGGTTTCC ACGCAAGAGA GTGGATTTCT 
CCTGCATTCT GTCAGTGGTT TGTGAGAGAG GCTGTCCGTA CCTATAAACA AGAGATCCAC 
ATGAAACGAC TTCTTGACGA ACTGGACTTT TATGTTCTGC CTGTGGTCAA CATTGACGGC 
TATGTCTACA CATGGGCTAA GGACCGAATG TGGAGAAAAA CCCGCTCTAC TACGGCTGGA 
AGTTCCTGCT TTGGTGTAGA CCCCAACAGA AATTTTGATG CTGGCTGGTG TGAAGTGGGA 
GCTTCTCGGA GTCCCTGCTC TGACACTTAC TGTGGACCAA CTCCAGAGTC AGAAAAAGAG 
ACAAAGGCCC TGGCAGATTT CATCCGCCAG AACCTCTCCT CCATCAAGGC CTATCTGACC 
GTCCACTCCT ACTCACAGAT GATGCTCTAT CCTTACTCCT ACGACTATAA GCTGCCCGAG 
AACTATGAGG AGCTGAATGC CCTGGTGAAA GGTGCAGCAA AGGAGCTTTC CACTCTGCAT 
GGCACCAAGT ACACATATGG CCCAGGAGCT ACAACGATCT ATCCTGCTGC TGGGGGATCT 
GACGACTGGG CTTATGATCA GGGAATCAAA TATTCCTTTA CCTTTGAACT CCGGGATAAA 
GGCTTCTTTG GCTTTCTGCT TCCTGAGTCT CAGATCCGCC AAACCTGTGA GGAGACAATG 
CTTGCAGTCA AGTACATTGC CAATTATGTC CTAGAGCATC CATATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_083982.1
CDS	84..1331
Translation	MLLLLALVSVALAHASEENFDGNRVFRVSVHDEDDVSLIQELANTKQIDFWKPDSATQVKPLTTVDFHVKAEDVVDVENFLEENEVLYEVLISNVKHILESQFDSHTRASGHSYTKYNNWETIEAWIQQVANDNPDLVSKRVIGTTFEGRNMYVLKIGKDRPNKPAFFIDCGFHAREWISPAFCQWFVREAVRTYKQEIHMKRLLDELDFYVLPVVNIDGYVYTWAKDRMWRKTRSTTAGSSCFGVDPNRNFDAGWCEVGASRSPCSDTYCGPTPESEKETKALADFIRQNLSSIKAYLTVHSYSQMMLYPYSYDYKLPENYEELNALVKGAAKELSTLHGTKYTYGPGATTIYPAAGGSDDWAYDQGIKYSFTFELRDKGFFGFLLPESQIRQTCEETMLAVKYIANYVLEHPY

Target ORF information:

RefSeq Version	NM_029706.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus carboxypeptidase B1 (tissue) (Cpb1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_029706.2

ORF Insert Sequence:

ATGTTGCTGC TACTGGCCCT GGTGAGTGTG GCCCTGGCTC ATGCTTCTGA GGAGAACTTT 
GATGGCAACC GGGTGTTCCG TGTCAGTGTA CATGATGAAG ATGACGTCAG CTTAATTCAG 
GAACTAGCCA ACACCAAACA GATTGATTTC TGGAAACCAG ATTCTGCTAC ACAAGTGAAA 
CCTCTTACTA CAGTTGACTT TCATGTTAAA GCAGAAGATG TCGTTGATGT GGAGAACTTT 
CTCGAGGAGA ATGAAGTTCT CTATGAGGTA TTGATAAGCA ACGTGAAACA TATTCTGGAA 
TCCCAGTTTG ACAGCCACAC CCGTGCAAGT GGACACAGCT ACACCAAGTA CAACAACTGG 
GAAACGATAG AGGCATGGAT TCAACAAGTT GCCAATGATA ATCCAGACCT TGTTTCTAAG 
AGAGTCATTG GAACCACATT TGAAGGACGT AACATGTATG TTCTCAAGAT TGGCAAAGAT 
AGACCAAATA AGCCTGCCTT CTTCATCGAC TGTGGTTTCC ACGCAAGAGA GTGGATTTCT 
CCTGCATTCT GTCAGTGGTT TGTGAGAGAG GCTGTCCGTA CCTATAAACA AGAGATCCAC 
ATGAAACGAC TTCTTGACGA ACTGGACTTT TATGTTCTGC CTGTGGTCAA CATTGACGGC 
TATGTCTACA CATGGGCTAA GGACCGAATG TGGAGAAAAA CCCGCTCTAC TACGGCTGGA 
AGTTCCTGCT TTGGTGTAGA CCCCAACAGA AATTTTGATG CTGGCTGGTG TGAAGTGGGA 
GCTTCTCGGA GTCCCTGCTC TGACACTTAC TGTGGACCAA CTCCAGAGTC AGAAAAAGAG 
ACAAAGGCCC TGGCAGATTT CATCCGCCAG AACCTCTCCT CCATCAAGGC CTATCTGACC 
GTCCACTCCT ACTCACAGAT GATGCTCTAT CCTTACTCCT ACGACTATAA GCTGCCCGAG 
AACTATGAGG AGCTGAATGC CCTGGTGAAA GGTGCAGCAA AGGAGCTTTC CACTCTGCAT 
GGCACCAAGT ACACATATGG CCCAGGAGCT ACAACGATCT ATCCTGCTGC TGGGGGATCT 
GACGACTGGG CTTATGATCA GGGAATCAAA TATTCCTTTA CCTTTGAACT CCGGGATAAA 
GGCTTCTTTG GCTTTCTGCT TCCTGAGTCT CAGATCCGCC AAACCTGTGA GGAGACAATG 
CTTGCAGTCA AGTACATTGC CAATTATGTC CTAGAGCATC CATATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

von Hippel-Lindau gene disruption in mouse pancreatic progenitors and its consequences on endocrine differentiation in vivo: importance of HIF1-? and VEGF-A upregulation.
Diabetologia57(11)2348-56(2014 Nov)
Soggia A,Ramond C,Akiyama H,Scharfmann R,Duvillie B

The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis.
Development (Cambridge, England)141(16)3123-33(2014 Aug)
Hale MA,Swift GH,Hoang CQ,Deering TG,Masui T,Lee YK,Xue J,MacDonald RJ

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Nucleic acids research42(Database issue)D802-9(2014 Jan)
Koscielny G,Yaikhom G,Iyer V,Meehan TF,Morgan H,Atienza-Herrero J,Blake A,Chen CK,Easty R,Di Fenza A,Fiegel T,Grifiths M,Horne A,Karp NA,Kurbatova N,Mason JC,Matthews P,Oakley DJ,Qazi A,Regnart J,Retha A,Santos LA,Sneddon DJ,Warren J,Westerberg H,Wilson RJ,Melvin DG,Smedley D,Brown SD,Flicek P,Skarnes WC,Mallon AM,Parkinson H

Site-specific carboxypeptidase B1 tyrosine nitration and pathophysiological implications following its physical association with nitric oxide synthase-3 in experimental sepsis.
Journal of immunology (Baltimore, Md. : 1950)183(6)4055-66(2009 Sep)
Chatterjee S,Lardinois O,Bonini MG,Bhattacharjee S,Stadler K,Corbett J,Deterding LJ,Tomer KB,Kadiiska M,Mason RP

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Cpb1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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