Tm7sf2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tm7sf2
Entrez Gene ID	73166
Full Name	transmembrane 7 superfamily member 2
Synonyms	3110041O18Rik,ANG1,C14SR,Dhcr14
General protein information	Preferred Names transmembrane 7 superfamily member 2 Names delta(14)-sterol reductase C-14 sterol reductase delta-14-SR sterol C14-reductase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 19 Map Location: 19\|19 A

mRNA and Protein(s)

mRNA	Protein	Name
NM_028454.2	NP_082730.2	delta(14)-sterol reductase TM7SF2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	TM7SF2	XP_003313172.1
	TM7SF2	XP_001118188.2
Arabidopsis thaliana (thale cress)	FK	NP_566975.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003745	XP_310276.4
Xenopus tropicalis (tropical clawed frog)	tm7sf2	NP_001106597.1
Homo sapiens (human)	TM7SF2	NP_003264.2
Canis lupus familiaris (dog)	TM7SF2	XP_533236.2
Bos taurus (cattle)	TM7SF2	NP_777047.2
Rattus norvegicus (Norway rat)	Tm7sf2	NP_001013089.1
Mus musculus (house mouse)	Tm7sf2	NP_082730.2
Danio rerio (zebrafish)	tm7sf2	NP_001008597.1

Gene Ontology
Bibliography

Related articles in PubMed

Impaired cell proliferation in regenerating liver of 3 ?-hydroxysterol ?14-reductase (TM7SF2) knock-out mice.
Bartoli D, Piobbico D, Bellet MM, Bennati AM, Roberti R, Della Fazia MA, Servillo G
Cell cycle (Georgetown, Tex.)15(16)2164-2173(2016 Aug)

A compendium of expression patterns of cholesterol biosynthetic enzymes in the mouse embryo.
?i?ecio?lu M, Budak H, Geffers L, ?ankaya M, ?iftci M, Thaller C, Eichele G, K?frevio?lu ??, ?zdemir H
Journal of lipid research56(8)1551-9(2015 Aug)

The loss of Tm7sf gene accelerates skin papilloma formation in mice.
Bellezza I, Gatticchi L, del Sordo R, Peirce MJ, Sidoni A, Roberti R, Minelli A
Scientific reports59471(2015 Mar)

The Tm7sf2 Gene Deficiency Protects Mice against Endotoxin-Induced Acute Kidney Injury.
Gatticchi L, Bellezza I, Del Sordo R, Peirce MJ, Sidoni A, Roberti R, Minelli A
PloS one10(11)e0141885(2015)

A novel role for Tm7sf2 gene in regulating TNF? expression.
Bellezza I, Roberti R, Gatticchi L, Del Sordo R, Rambotti MG, Marchetti MC, Sidoni A, Minelli A
PloS one8(7)e68017(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Tm7sf2 deficiency during liver regeneration alters lipid metabolism and generates a stress condition, which, in turn, transiently unbalances hepatocytes cell cycle progression.
Title: Impaired cell proliferation in regenerating liver of 3 ?-hydroxysterol ?14-reductase (TM7SF2) knock-out mice.

the loss of Tm7sf2 alters the expression of proteins involved in epidermal differentiation by reducing the levels of cholesterol sulfate
Title: The loss of Tm7sf gene accelerates skin papilloma formation in mice.

The Tm7sf2 insufficiency is responsible for the inhibition of the NF-kappaB signaling.
Title: The Tm7sf2 Gene Deficiency Protects Mice against Endotoxin-Induced Acute Kidney Injury.

These results show a significant increase in renal TNFalpha expression after tunicamycin exposure and in the oedematogenic response in Tm7sf2(-/-) mice.
Title: A novel role for Tm7sf2 gene in regulating TNF? expression.

several genes involved in cell-cycle progression are downregulated in the liver of Tm7sf2((-/-)) mice, whereas genes involved in xenobiotic metabolism are upregulated.
Title: Disruption of the gene encoding 3beta-hydroxysterol Delta-reductase (Tm7sf2) in mice does not impair cholesterol biosynthesis.

The following Tm7sf2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tm7sf2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu14064	NM_028454.2 Latest version!	Mus musculus transmembrane 7 superfamily member 2 (Tm7sf2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tm7sf2 ( NM_028454.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_082730.2 Mus musculus transmembrane 7 superfamily member 2 (Tm7sf2), mRNA.

Price & Availability↑

CloneID	OMu14064
Clone ID Related Accession (Same CDS sequence)	NM_028454.2
Accession Version	NM_028454.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1257bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-10
Organism	Mus musculus(house mouse)
Product	delta(14)-sterol reductase TM7SF2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK040016.1, AF480070.1, BY551700.1 and AI846153.1. On Nov 3, 2006 this sequence version replaced NM_028454.1. ##Evidence-Data-START## Transcript exon combination :: AK014166.1, AF480070.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849386 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACTTCTC GTGAGGCCTC CCAGGCCCCA CTGGAATTCG GGGGGCCGTT GGGCGTCGCG 
GCTTTACTGA TCCTGCTGCC TGCCACCATG TTCCACCTGC TCCTGGCGGC TCGCTCGGGC 
CCGGCGCGCC TCCTGGCCCT ACCGGCCTAT CTGCCTGGGC TGGAGGAGCT GTGGAGCCCA 
TGGGCTCTGC TGCTATTGTT CATCTGGCTC GGCCTGCAGG TGGCGCTCTA TTTGCTGCCT 
GCACGCAAGG TGGCCGAAGG CCTGGAACTG AAGGACAAGA GTCGCCTGCG CTACCCTATT 
AATGGCTTCC AGGCTCTGGT GCTAACAGCC CTGTTGATGG GGCTGGGGGT GTCAGTGGGG 
CTGCCCCTGG GGGCACTCCC TGGAATGCTC CTGCCCTTGG CCTTTGCGAC CACTCTCACC 
AGCTTTATCT TCAGCCTCCT CCTCTATGCG AAGGCTTTGG TAGCTCCTGC CTCAGCCCTG 
GCTCCTGGGG GAAACTCAGG AAATTCCATG TATGACTTCT TTCTTGGACG GGAGCTGAAC 
CCTCGCCTCG GTTCCTTTGA CTTCAAATAT TTCTGTGAGC TGAGACCTGG CCTCATTGGC 
TGGGTTTTCA TTAACCTGGC CCTGCTGATG CAGGAGGCAG AGCTTCGGGG GAGTCCTTCC 
CTGGCTATGT GGCTGGTCAA TGGCTTCCAG TTGCTGTATG TGGGTGATGC CCTCTGGTAT 
GAGGAGTCTG TCCTCACCAC CATGGACATA ATACATGATG GTTTTGGCTT CATGCTGGTC 
TTTGGAGATC TAGCTTGGGT ACCATTCACC TACAGCCTGC AGGCCCAGTT CCTGTTGTAC 
CATCCACAGC CTCTGGGGTT GCCCATGGCC TTGCTCATCT GCCTCCTTAA GGTTATTGGT 
TACTACATCT TCCGAGGGGC CAACTCCCAG AAAAACACAT TCAGGAAGAA TCCTTCTGAC 
CCCAGCGTGG CTGGTCTTGA GACCATCCCG ACTGCCACGG GGAGGCAGCT GCTGGTGTCT 
GGGTGGTGGG GTATGGTTCG ACACCCCAAC TACCTGGGAG ATCTCATCAT GGCTCTGGCA 
TGGTCTTTGC CCTGTGGGCT ATCCCATCTG CTGCCCTACT TCTACGTCCT CTACTTCACT 
GCACTGCTGG TGCACCGCGA GGCCAGAGAT GAGCAGCAGT GCCTCCAAAA GTATGGCCGT 
GCCTGGCAGG AGTACTGCAA GCGTGTGCCT TACCGAATCA TACCCTATGT CTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_082730.2
CDS	131..1387
Translation	MTSREASQAPLEFGGPLGVAALLILLPATMFHLLLAARSGPARLLALPAYLPGLEELWSPWALLLLFIWLGLQVALYLLPARKVAEGLELKDKSRLRYPINGFQALVLTALLMGLGVSVGLPLGALPGMLLPLAFATTLTSFIFSLLLYAKALVAPASALAPGGNSGNSMYDFFLGRELNPRLGSFDFKYFCELRPGLIGWVFINLALLMQEAELRGSPSLAMWLVNGFQLLYVGDALWYEESVLTTMDIIHDGFGFMLVFGDLAWVPFTYSLQAQFLLYHPQPLGLPMALLICLLKVIGYYIFRGANSQKNTFRKNPSDPSVAGLETIPTATGRQLLVSGWWGMVRHPNYLGDLIMALAWSLPCGLSHLLPYFYVLYFTALLVHREARDEQQCLQKYGRAWQEYCKRVPYRIIPYVY

Target ORF information:

RefSeq Version	NM_028454.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus transmembrane 7 superfamily member 2 (Tm7sf2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_028454.2

ORF Insert Sequence:

ATGACTTCTC GTGAGGCCTC CCAGGCCCCA CTGGAATTCG GGGGGCCGTT GGGCGTCGCG 
GCTTTACTGA TCCTGCTGCC TGCCACCATG TTCCACCTGC TCCTGGCGGC TCGCTCGGGC 
CCGGCGCGCC TCCTGGCCCT ACCGGCCTAT CTGCCTGGGC TGGAGGAGCT GTGGAGCCCA 
TGGGCTCTGC TGCTATTGTT CATCTGGCTC GGCCTGCAGG TGGCGCTCTA TTTGCTGCCT 
GCACGCAAGG TGGCCGAAGG CCTGGAACTG AAGGACAAGA GTCGCCTGCG CTACCCTATT 
AATGGCTTCC AGGCTCTGGT GCTAACAGCC CTGTTGATGG GGCTGGGGGT GTCAGTGGGG 
CTGCCCCTGG GGGCACTCCC TGGAATGCTC CTGCCCTTGG CCTTTGCGAC CACTCTCACC 
AGCTTTATCT TCAGCCTCCT CCTCTATGCG AAGGCTTTGG TAGCTCCTGC CTCAGCCCTG 
GCTCCTGGGG GAAACTCAGG AAATTCCATG TATGACTTCT TTCTTGGACG GGAGCTGAAC 
CCTCGCCTCG GTTCCTTTGA CTTCAAATAT TTCTGTGAGC TGAGACCTGG CCTCATTGGC 
TGGGTTTTCA TTAACCTGGC CCTGCTGATG CAGGAGGCAG AGCTTCGGGG GAGTCCTTCC 
CTGGCTATGT GGCTGGTCAA TGGCTTCCAG TTGCTGTATG TGGGTGATGC CCTCTGGTAT 
GAGGAGTCTG TCCTCACCAC CATGGACATA ATACATGATG GTTTTGGCTT CATGCTGGTC 
TTTGGAGATC TAGCTTGGGT ACCATTCACC TACAGCCTGC AGGCCCAGTT CCTGTTGTAC 
CATCCACAGC CTCTGGGGTT GCCCATGGCC TTGCTCATCT GCCTCCTTAA GGTTATTGGT 
TACTACATCT TCCGAGGGGC CAACTCCCAG AAAAACACAT TCAGGAAGAA TCCTTCTGAC 
CCCAGCGTGG CTGGTCTTGA GACCATCCCG ACTGCCACGG GGAGGCAGCT GCTGGTGTCT 
GGGTGGTGGG GTATGGTTCG ACACCCCAAC TACCTGGGAG ATCTCATCAT GGCTCTGGCA 
TGGTCTTTGC CCTGTGGGCT ATCCCATCTG CTGCCCTACT TCTACGTCCT CTACTTCACT 
GCACTGCTGG TGCACCGCGA GGCCAGAGAT GAGCAGCAGT GCCTCCAAAA GTATGGCCGT 
GCCTGGCAGG AGTACTGCAA GCGTGTGCCT TACCGAATCA TACCCTATGT CTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Impaired cell proliferation in regenerating liver of 3 ?-hydroxysterol ?14-reductase (TM7SF2) knock-out mice.
Cell cycle (Georgetown, Tex.)15(16)2164-2173(2016 Aug)
Bartoli D,Piobbico D,Bellet MM,Bennati AM,Roberti R,Della Fazia MA,Servillo G

A compendium of expression patterns of cholesterol biosynthetic enzymes in the mouse embryo.
Journal of lipid research56(8)1551-9(2015 Aug)
?i?ecio?lu M,Budak H,Geffers L,?ankaya M,?iftci M,Thaller C,Eichele G,K?frevio?lu ??,?zdemir H

The loss of Tm7sf gene accelerates skin papilloma formation in mice.
Scientific reports59471(2015 Mar)
Bellezza I,Gatticchi L,del Sordo R,Peirce MJ,Sidoni A,Roberti R,Minelli A

The Tm7sf2 Gene Deficiency Protects Mice against Endotoxin-Induced Acute Kidney Injury.
PloS one10(11)e0141885(2015)
Gatticchi L,Bellezza I,Del Sordo R,Peirce MJ,Sidoni A,Roberti R,Minelli A

A novel role for Tm7sf2 gene in regulating TNF? expression.
PloS one8(7)e68017(2013)
Bellezza I,Roberti R,Gatticchi L,Del Sordo R,Rambotti MG,Marchetti MC,Sidoni A,Minelli A

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

Tm7sf2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報