Flrt3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Flrt3
Entrez Gene ID	71436
Full Name	fibronectin leucine rich transmembrane protein 3
Synonyms	5530600M07Rik,C430047I10Rik,mKIAA1469
General protein information	Preferred Names fibronectin leucine rich transmembrane protein 3 Names leucine-rich repeat transmembrane protein FLRT3
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 2 Map Location: 2\|2 F3

mRNA and Protein(s)

mRNA	Protein	Name
NM_001172160.1	NP_001165631.1	leucine-rich repeat transmembrane protein FLRT3 precursor
NM_178382.4	NP_848469.1	leucine-rich repeat transmembrane protein FLRT3 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	FLRT3	XP_525271.1
Gallus gallus (chicken)	FLRT3	XP_004940218.1
Danio rerio (zebrafish)	flrt3	NP_001243575.1
Xenopus tropicalis (tropical clawed frog)	flrt3	NP_001116922.1
Homo sapiens (human)	FLRT3	NP_037413.1
	FLRT3	XP_001084137.1
Rattus norvegicus (Norway rat)	Flrt3	NP_001119763.1
Canis lupus familiaris (dog)	FLRT3	XP_857948.1
Bos taurus (cattle)	FLRT3	NP_001179603.1
Mus musculus (house mouse)	Flrt3	NP_001165631.1

Gene Ontology
Bibliography

Related articles in PubMed

Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.
Memic F, Knoflach V, Morarach K, Sadler R, Laranjeira C, Hjerling-Leffler J, Sundstr?m E, Pachnis V, Marklund U
Gastroenterology(2017 Oct)

Regulation of Cerebral Cortex Folding by Controlling Neuronal Migration via FLRT Adhesion Molecules.
Del Toro D, Ruff T, Cederfj?ll E, Villalba A, Seyit-Bremer G, Borrell V, Klein R
Cell169(4)621-635.e16(2017 May)

Yeast Two-Hybrid Screening for Proteins that Interact with the Extracellular Domain of Amyloid Precursor Protein.
Yu Y, Li Y, Zhang Y
Neuroscience bulletin32(2)171-6(2016 Apr)

Structural and Mechanistic Insights into the Latrophilin3-FLRT3 Complex that Mediates Glutamatergic Synapse Development.
Ranaivoson FM, Liu Q, Martini F, Bergami F, von Daake S, Li S, Lee D, Demeler B, Hendrickson WA, Comoletti D
Structure (London, England : 1993)23(9)1665-77(2015 Sep)

FLRT structure: balancing repulsion and cell adhesion in cortical and vascular development.
Seiradake E, del Toro D, Nagel D, Cop F, H?rtl R, Ruff T, Seyit-Bremer G, Harlos K, Border EC, Acker-Palmer A, Jones EY, Klein R
Neuron84(2)370-85(2014 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Mice with deletions of FLRT1 and FLRT3 adhesion molecules develop macroscopic sulci with preserved layered organization and radial glial morphology. Cortex folding in these mutants does not require progenitor cell amplification but is dependent on changes in neuron migration.
Title: Regulation of Cerebral Cortex Folding by Controlling Neuronal Migration via FLRT Adhesion Molecules.

The crystal structure of the OLF/FLRT3 complex shows that LPHN3-OLF in the closed state binds with high affinity to the concave face of FLRT3-LRR with a combination of hydrophobic and charged residues.
Title: Structural and Mechanistic Insights into the Latrophilin3-FLRT3 Complex that Mediates Glutamatergic Synapse Development.

FLRT3 is a modulator of Netrin-1 response in axons.FLRT3 is a Robo1 coreceptor.FLRT3 is a Robo1-interacting protein that determines Netrin-1 attraction in developing axons.
Title: FLRT3 is a Robo1-interacting protein that determines Netrin-1 attraction in developing axons.

Flrt3 was highly expressed initially in the midbrain.
Title: Flrt2 and Flrt3 have overlapping and non-overlapping expression during craniofacial development.

Data demonstrate that FLRT3 plays a key role in controlling cell adhesion and tissue morphogenesis in the developing mouse embryo.
Title: Ventral closure, headfold fusion and definitive endoderm migration defects in mouse embryos lacking the fibronectin leucine-rich transmembrane protein FLRT3.

The following Flrt3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Flrt3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu12859	NM_178382.4 Latest version!	Mus musculus fibronectin leucine rich transmembrane protein 3 (Flrt3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$321.30 $459.00
OMu12859	NM_001172160.1 Latest version!	Mus musculus fibronectin leucine rich transmembrane protein 3 (Flrt3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$321.30 $459.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Flrt3 ( NM_001172160.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001165631.1 Mus musculus fibronectin leucine rich transmembrane protein 3 (Flrt3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu12859
Clone ID Related Accession (Same CDS sequence)	NM_001172160.1 , NM_178382.4
Accession Version	NM_001172160.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1950bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	leucine-rich repeat transmembrane protein FLRT3 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL928700.7, AK129369.1, AK031464.1, AV157204.2 and BG091701.1. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK129369.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849382, SAMN00849387 [ECO:0000348] ##Evidence-Data-END##

ATGATCAGCC CAGCCTGGAG CCTCTTCCTC ATCGGGACTA AAATTGGGCT GTTCTTCCAA 
GTGGCACCTC TGTCAGTTGT GGCTAAATCC TGTCCATCTG TATGTCGCTG TGACGCAGGC 
TTCATTTACT GTAACGATCG CTCTCTGACA TCCATTCCAG TGGGAATTCC GGAGGATGCT 
ACAACACTCT ACCTTCAGAA CAACCAAATA AACAATGTTG GGATTCCTTC CGATTTGAAG 
AACTTGCTGA AAGTACAAAG AATATACCTA TACCACAACA GTTTAGATGA ATTCCCTACC 
AACCTTCCAA AGTATGTCAA AGAGTTACAT TTGCAAGAGA ATAACATAAG GACTATCACC 
TATGATTCAC TTTCGAAAAT TCCGTATCTG GAAGAGTTAC ACTTGGATGA TAACTCAGTC 
TCGGCTGTTA GCATCGAAGA GGGAGCATTT CGAGACAGTA ACTATCTGCG GCTGCTTTTT 
CTGTCCCGTA ACCACCTTAG CACAATCCCG GGGGGCTTGC CCAGGACTAT TGAGGAATTA 
CGCCTGGATG ACAATCGCAT ATCAACGATC TCTTCCCCAT CACTTCATGG TCTCACAAGC 
CTGAAACGCC TGGTTTTAGA TGGAAACTTG TTGAACAACC ATGGTTTGGG TGACAAAGTT 
TTCTTCAACT TAGTAAACTT AACAGAGCTG TCCCTGGTGA GGAATTCCTT GACAGCAGCG 
CCAGTGAACC TTCCCGGCAC AAGCCTGAGG AAGCTTTACC TTCAAGACAA CCATATCAAC 
CGGGTACCCC CAAATGCTTT TTCTTATTTA AGGCAGCTGT ATCGACTCGA TATGTCTAAT 
AATAACCTAA GCAATTTACC TCAGGGTATC TTTGATGATT TGGACAATAT AACCCAACTG 
ATTCTTCGCA ACAATCCTTG GTATTGTGGA TGCAAGATGA AATGGGTACG AGACTGGTTA 
CAGTCGCTAC CGGTGAAGGT CAATGTGCGT GGGCTCATGT GCCAAGCCCC AGAAAAGGTC 
CGTGGAATGG CTATCAAGGA CCTCAGTGCA GAACTGTTTG ATTGTAAAGA CAGTGGGATT 
GTGAGCACCA TTCAGATAAC CACTGCAATA CCCAACACAG CATATCCTGC TCAAGGACAG 
TGGCCAGCTC CTGTGACCAA ACAACCAGAT ATTAAAAACC CCAAGCTCAT TAAGGATCAG 
CGAACTACAG GCAGCCCCTC ACGGAAAACA ATTTTAATTA CTGTGAAATC TGTCACCCCT 
GACACAATCC ACATATCCTG GAGACTTGCT CTGCCTATGA CTGCTCTGCG ACTCAGCTGG 
CTTAAACTGG GCCATAGCCC AGCCTTTGGA TCTATAACAG AAACAATCGT AACAGGAGAA 
CGCAGTGAAT ACTTGGTCAC CGCCCTAGAA CCTGAATCAC CCTATAGAGT ATGCATGGTT 
CCCATGGAAA CCAGTAACCT TTACCTGTTT GATGAAACAC CTGTTTGTAT TGAGACCCAA 
ACTGCCCCTC TTCGAATGTA CAACCCCACA ACCACCCTCA ATCGAGAGCA AGAGAAAGAA 
CCTTACAAAA ATCCAAATTT ACCTTTGGCT GCCATCATTG GTGGGGCTGT GGCCCTGGTA 
AGCATCGCCC TCCTTGCTTT GGTGTGTTGG TATGTGCATA GGAACGGGTC ACTGTTTTCA 
CGGAACTGTG CGTACAGCAA AGGGCGGAGG AGAAAGGATG ACTATGCAGA AGCCGGTACT 
AAGAAAGACA ACTCCATCCT GGAAATCAGG GAAACTTCTT TCCAGATGCT ACCGATAAGC 
AATGAACCCA TCTCCAAGGA GGAGTTTGTA ATACACACCA TATTTCCTCC GAATGGGATG 
AATCTGTACA AGAACAACCT CAGTGAGAGC AGTAGTAACC GGAGCTACAG AGACAGTGGC 
ATCCCAGACT CGGACCACTC ACACTCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001165631.1
CDS	1029..2978
Translation	MISPAWSLFLIGTKIGLFFQVAPLSVVAKSCPSVCRCDAGFIYCNDRSLTSIPVGIPEDATTLYLQNNQINNVGIPSDLKNLLKVQRIYLYHNSLDEFPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPGGLPRTIEELRLDDNRISTISSPSLHGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPVNLPGTSLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNNPWYCGCKMKWVRDWLQSLPVKVNVRGLMCQAPEKVRGMAIKDLSAELFDCKDSGIVSTIQITTAIPNTAYPAQGQWPAPVTKQPDIKNPKLIKDQRTTGSPSRKTILITVKSVTPDTIHISWRLALPMTALRLSWLKLGHSPAFGSITETIVTGERSEYLVTALEPESPYRVCMVPMETSNLYLFDETPVCIETQTAPLRMYNPTTTLNREQEKEPYKNPNLPLAAIIGGAVALVSIALLALVCWYVHRNGSLFSRNCAYSKGRRRKDDYAEAGTKKDNSILEIRETSFQMLPISNEPISKEEFVIHTIFPPNGMNLYKNNLSESSSNRSYRDSGIPDSDHSHS

Target ORF information:

RefSeq Version	NM_001172160.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus fibronectin leucine rich transmembrane protein 3 (Flrt3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001172160.1

ORF Insert Sequence:

ATGATCAGCC CAGCCTGGAG CCTCTTCCTC ATCGGGACTA AAATTGGGCT GTTCTTCCAA 
GTGGCACCTC TGTCAGTTGT GGCTAAATCC TGTCCATCTG TATGTCGCTG TGACGCAGGC 
TTCATTTACT GTAACGATCG CTCTCTGACA TCCATTCCAG TGGGAATTCC GGAGGATGCT 
ACAACACTCT ACCTTCAGAA CAACCAAATA AACAATGTTG GGATTCCTTC CGATTTGAAG 
AACTTGCTGA AAGTACAAAG AATATACCTA TACCACAACA GTTTAGATGA ATTCCCTACC 
AACCTTCCAA AGTATGTCAA AGAGTTACAT TTGCAAGAGA ATAACATAAG GACTATCACC 
TATGATTCAC TTTCGAAAAT TCCGTATCTG GAAGAGTTAC ACTTGGATGA TAACTCAGTC 
TCGGCTGTTA GCATCGAAGA GGGAGCATTT CGAGACAGTA ACTATCTGCG GCTGCTTTTT 
CTGTCCCGTA ACCACCTTAG CACAATCCCG GGGGGCTTGC CCAGGACTAT TGAGGAATTA 
CGCCTGGATG ACAATCGCAT ATCAACGATC TCTTCCCCAT CACTTCATGG TCTCACAAGC 
CTGAAACGCC TGGTTTTAGA TGGAAACTTG TTGAACAACC ATGGTTTGGG TGACAAAGTT 
TTCTTCAACT TAGTAAACTT AACAGAGCTG TCCCTGGTGA GGAATTCCTT GACAGCAGCG 
CCAGTGAACC TTCCCGGCAC AAGCCTGAGG AAGCTTTACC TTCAAGACAA CCATATCAAC 
CGGGTACCCC CAAATGCTTT TTCTTATTTA AGGCAGCTGT ATCGACTCGA TATGTCTAAT 
AATAACCTAA GCAATTTACC TCAGGGTATC TTTGATGATT TGGACAATAT AACCCAACTG 
ATTCTTCGCA ACAATCCTTG GTATTGTGGA TGCAAGATGA AATGGGTACG AGACTGGTTA 
CAGTCGCTAC CGGTGAAGGT CAATGTGCGT GGGCTCATGT GCCAAGCCCC AGAAAAGGTC 
CGTGGAATGG CTATCAAGGA CCTCAGTGCA GAACTGTTTG ATTGTAAAGA CAGTGGGATT 
GTGAGCACCA TTCAGATAAC CACTGCAATA CCCAACACAG CATATCCTGC TCAAGGACAG 
TGGCCAGCTC CTGTGACCAA ACAACCAGAT ATTAAAAACC CCAAGCTCAT TAAGGATCAG 
CGAACTACAG GCAGCCCCTC ACGGAAAACA ATTTTAATTA CTGTGAAATC TGTCACCCCT 
GACACAATCC ACATATCCTG GAGACTTGCT CTGCCTATGA CTGCTCTGCG ACTCAGCTGG 
CTTAAACTGG GCCATAGCCC AGCCTTTGGA TCTATAACAG AAACAATCGT AACAGGAGAA 
CGCAGTGAAT ACTTGGTCAC CGCCCTAGAA CCTGAATCAC CCTATAGAGT ATGCATGGTT 
CCCATGGAAA CCAGTAACCT TTACCTGTTT GATGAAACAC CTGTTTGTAT TGAGACCCAA 
ACTGCCCCTC TTCGAATGTA CAACCCCACA ACCACCCTCA ATCGAGAGCA AGAGAAAGAA 
CCTTACAAAA ATCCAAATTT ACCTTTGGCT GCCATCATTG GTGGGGCTGT GGCCCTGGTA 
AGCATCGCCC TCCTTGCTTT GGTGTGTTGG TATGTGCATA GGAACGGGTC ACTGTTTTCA 
CGGAACTGTG CGTACAGCAA AGGGCGGAGG AGAAAGGATG ACTATGCAGA AGCCGGTACT 
AAGAAAGACA ACTCCATCCT GGAAATCAGG GAAACTTCTT TCCAGATGCT ACCGATAAGC 
AATGAACCCA TCTCCAAGGA GGAGTTTGTA ATACACACCA TATTTCCTCC GAATGGGATG 
AATCTGTACA AGAACAACCT CAGTGAGAGC AGTAGTAACC GGAGCTACAG AGACAGTGGC 
ATCCCAGACT CGGACCACTC ACACTCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Flrt3 ( NM_178382.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_848469.1 Mus musculus fibronectin leucine rich transmembrane protein 3 (Flrt3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu12859
Clone ID Related Accession (Same CDS sequence)	NM_001172160.1 , NM_178382.4
Accession Version	NM_178382.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1950bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	leucine-rich repeat transmembrane protein FLRT3 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL928700.7, AK031464.1, AV157204.2 and BG091701.1. On Feb 5, 2010 this sequence version replaced NM_178382.3. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK031464.1, AK161100.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164138, SAMN01164142 [ECO:0000348] ##Evidence-Data-END##

ATGATCAGCC CAGCCTGGAG CCTCTTCCTC ATCGGGACTA AAATTGGGCT GTTCTTCCAA 
GTGGCACCTC TGTCAGTTGT GGCTAAATCC TGTCCATCTG TATGTCGCTG TGACGCAGGC 
TTCATTTACT GTAACGATCG CTCTCTGACA TCCATTCCAG TGGGAATTCC GGAGGATGCT 
ACAACACTCT ACCTTCAGAA CAACCAAATA AACAATGTTG GGATTCCTTC CGATTTGAAG 
AACTTGCTGA AAGTACAAAG AATATACCTA TACCACAACA GTTTAGATGA ATTCCCTACC 
AACCTTCCAA AGTATGTCAA AGAGTTACAT TTGCAAGAGA ATAACATAAG GACTATCACC 
TATGATTCAC TTTCGAAAAT TCCGTATCTG GAAGAGTTAC ACTTGGATGA TAACTCAGTC 
TCGGCTGTTA GCATCGAAGA GGGAGCATTT CGAGACAGTA ACTATCTGCG GCTGCTTTTT 
CTGTCCCGTA ACCACCTTAG CACAATCCCG GGGGGCTTGC CCAGGACTAT TGAGGAATTA 
CGCCTGGATG ACAATCGCAT ATCAACGATC TCTTCCCCAT CACTTCATGG TCTCACAAGC 
CTGAAACGCC TGGTTTTAGA TGGAAACTTG TTGAACAACC ATGGTTTGGG TGACAAAGTT 
TTCTTCAACT TAGTAAACTT AACAGAGCTG TCCCTGGTGA GGAATTCCTT GACAGCAGCG 
CCAGTGAACC TTCCCGGCAC AAGCCTGAGG AAGCTTTACC TTCAAGACAA CCATATCAAC 
CGGGTACCCC CAAATGCTTT TTCTTATTTA AGGCAGCTGT ATCGACTCGA TATGTCTAAT 
AATAACCTAA GCAATTTACC TCAGGGTATC TTTGATGATT TGGACAATAT AACCCAACTG 
ATTCTTCGCA ACAATCCTTG GTATTGTGGA TGCAAGATGA AATGGGTACG AGACTGGTTA 
CAGTCGCTAC CGGTGAAGGT CAATGTGCGT GGGCTCATGT GCCAAGCCCC AGAAAAGGTC 
CGTGGAATGG CTATCAAGGA CCTCAGTGCA GAACTGTTTG ATTGTAAAGA CAGTGGGATT 
GTGAGCACCA TTCAGATAAC CACTGCAATA CCCAACACAG CATATCCTGC TCAAGGACAG 
TGGCCAGCTC CTGTGACCAA ACAACCAGAT ATTAAAAACC CCAAGCTCAT TAAGGATCAG 
CGAACTACAG GCAGCCCCTC ACGGAAAACA ATTTTAATTA CTGTGAAATC TGTCACCCCT 
GACACAATCC ACATATCCTG GAGACTTGCT CTGCCTATGA CTGCTCTGCG ACTCAGCTGG 
CTTAAACTGG GCCATAGCCC AGCCTTTGGA TCTATAACAG AAACAATCGT AACAGGAGAA 
CGCAGTGAAT ACTTGGTCAC CGCCCTAGAA CCTGAATCAC CCTATAGAGT ATGCATGGTT 
CCCATGGAAA CCAGTAACCT TTACCTGTTT GATGAAACAC CTGTTTGTAT TGAGACCCAA 
ACTGCCCCTC TTCGAATGTA CAACCCCACA ACCACCCTCA ATCGAGAGCA AGAGAAAGAA 
CCTTACAAAA ATCCAAATTT ACCTTTGGCT GCCATCATTG GTGGGGCTGT GGCCCTGGTA 
AGCATCGCCC TCCTTGCTTT GGTGTGTTGG TATGTGCATA GGAACGGGTC ACTGTTTTCA 
CGGAACTGTG CGTACAGCAA AGGGCGGAGG AGAAAGGATG ACTATGCAGA AGCCGGTACT 
AAGAAAGACA ACTCCATCCT GGAAATCAGG GAAACTTCTT TCCAGATGCT ACCGATAAGC 
AATGAACCCA TCTCCAAGGA GGAGTTTGTA ATACACACCA TATTTCCTCC GAATGGGATG 
AATCTGTACA AGAACAACCT CAGTGAGAGC AGTAGTAACC GGAGCTACAG AGACAGTGGC 
ATCCCAGACT CGGACCACTC ACACTCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_848469.1
CDS	476..2425
Translation	MISPAWSLFLIGTKIGLFFQVAPLSVVAKSCPSVCRCDAGFIYCNDRSLTSIPVGIPEDATTLYLQNNQINNVGIPSDLKNLLKVQRIYLYHNSLDEFPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPGGLPRTIEELRLDDNRISTISSPSLHGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPVNLPGTSLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNNPWYCGCKMKWVRDWLQSLPVKVNVRGLMCQAPEKVRGMAIKDLSAELFDCKDSGIVSTIQITTAIPNTAYPAQGQWPAPVTKQPDIKNPKLIKDQRTTGSPSRKTILITVKSVTPDTIHISWRLALPMTALRLSWLKLGHSPAFGSITETIVTGERSEYLVTALEPESPYRVCMVPMETSNLYLFDETPVCIETQTAPLRMYNPTTTLNREQEKEPYKNPNLPLAAIIGGAVALVSIALLALVCWYVHRNGSLFSRNCAYSKGRRRKDDYAEAGTKKDNSILEIRETSFQMLPISNEPISKEEFVIHTIFPPNGMNLYKNNLSESSSNRSYRDSGIPDSDHSHS

Target ORF information:

RefSeq Version	NM_178382.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus fibronectin leucine rich transmembrane protein 3 (Flrt3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_178382.4

ORF Insert Sequence:

ATGATCAGCC CAGCCTGGAG CCTCTTCCTC ATCGGGACTA AAATTGGGCT GTTCTTCCAA 
GTGGCACCTC TGTCAGTTGT GGCTAAATCC TGTCCATCTG TATGTCGCTG TGACGCAGGC 
TTCATTTACT GTAACGATCG CTCTCTGACA TCCATTCCAG TGGGAATTCC GGAGGATGCT 
ACAACACTCT ACCTTCAGAA CAACCAAATA AACAATGTTG GGATTCCTTC CGATTTGAAG 
AACTTGCTGA AAGTACAAAG AATATACCTA TACCACAACA GTTTAGATGA ATTCCCTACC 
AACCTTCCAA AGTATGTCAA AGAGTTACAT TTGCAAGAGA ATAACATAAG GACTATCACC 
TATGATTCAC TTTCGAAAAT TCCGTATCTG GAAGAGTTAC ACTTGGATGA TAACTCAGTC 
TCGGCTGTTA GCATCGAAGA GGGAGCATTT CGAGACAGTA ACTATCTGCG GCTGCTTTTT 
CTGTCCCGTA ACCACCTTAG CACAATCCCG GGGGGCTTGC CCAGGACTAT TGAGGAATTA 
CGCCTGGATG ACAATCGCAT ATCAACGATC TCTTCCCCAT CACTTCATGG TCTCACAAGC 
CTGAAACGCC TGGTTTTAGA TGGAAACTTG TTGAACAACC ATGGTTTGGG TGACAAAGTT 
TTCTTCAACT TAGTAAACTT AACAGAGCTG TCCCTGGTGA GGAATTCCTT GACAGCAGCG 
CCAGTGAACC TTCCCGGCAC AAGCCTGAGG AAGCTTTACC TTCAAGACAA CCATATCAAC 
CGGGTACCCC CAAATGCTTT TTCTTATTTA AGGCAGCTGT ATCGACTCGA TATGTCTAAT 
AATAACCTAA GCAATTTACC TCAGGGTATC TTTGATGATT TGGACAATAT AACCCAACTG 
ATTCTTCGCA ACAATCCTTG GTATTGTGGA TGCAAGATGA AATGGGTACG AGACTGGTTA 
CAGTCGCTAC CGGTGAAGGT CAATGTGCGT GGGCTCATGT GCCAAGCCCC AGAAAAGGTC 
CGTGGAATGG CTATCAAGGA CCTCAGTGCA GAACTGTTTG ATTGTAAAGA CAGTGGGATT 
GTGAGCACCA TTCAGATAAC CACTGCAATA CCCAACACAG CATATCCTGC TCAAGGACAG 
TGGCCAGCTC CTGTGACCAA ACAACCAGAT ATTAAAAACC CCAAGCTCAT TAAGGATCAG 
CGAACTACAG GCAGCCCCTC ACGGAAAACA ATTTTAATTA CTGTGAAATC TGTCACCCCT 
GACACAATCC ACATATCCTG GAGACTTGCT CTGCCTATGA CTGCTCTGCG ACTCAGCTGG 
CTTAAACTGG GCCATAGCCC AGCCTTTGGA TCTATAACAG AAACAATCGT AACAGGAGAA 
CGCAGTGAAT ACTTGGTCAC CGCCCTAGAA CCTGAATCAC CCTATAGAGT ATGCATGGTT 
CCCATGGAAA CCAGTAACCT TTACCTGTTT GATGAAACAC CTGTTTGTAT TGAGACCCAA 
ACTGCCCCTC TTCGAATGTA CAACCCCACA ACCACCCTCA ATCGAGAGCA AGAGAAAGAA 
CCTTACAAAA ATCCAAATTT ACCTTTGGCT GCCATCATTG GTGGGGCTGT GGCCCTGGTA 
AGCATCGCCC TCCTTGCTTT GGTGTGTTGG TATGTGCATA GGAACGGGTC ACTGTTTTCA 
CGGAACTGTG CGTACAGCAA AGGGCGGAGG AGAAAGGATG ACTATGCAGA AGCCGGTACT 
AAGAAAGACA ACTCCATCCT GGAAATCAGG GAAACTTCTT TCCAGATGCT ACCGATAAGC 
AATGAACCCA TCTCCAAGGA GGAGTTTGTA ATACACACCA TATTTCCTCC GAATGGGATG 
AATCTGTACA AGAACAACCT CAGTGAGAGC AGTAGTAACC GGAGCTACAG AGACAGTGGC 
ATCCCAGACT CGGACCACTC ACACTCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.
Gastroenterology(2017 Oct)
Memic F,Knoflach V,Morarach K,Sadler R,Laranjeira C,Hjerling-Leffler J,Sundstr?m E,Pachnis V,Marklund U

Regulation of Cerebral Cortex Folding by Controlling Neuronal Migration via FLRT Adhesion Molecules.
Cell169(4)621-635.e16(2017 May)
Del Toro D,Ruff T,Cederfj?ll E,Villalba A,Seyit-Bremer G,Borrell V,Klein R

Yeast Two-Hybrid Screening for Proteins that Interact with the Extracellular Domain of Amyloid Precursor Protein.
Neuroscience bulletin32(2)171-6(2016 Apr)
Yu Y,Li Y,Zhang Y

Structural and Mechanistic Insights into the Latrophilin3-FLRT3 Complex that Mediates Glutamatergic Synapse Development.
Structure (London, England : 1993)23(9)1665-77(2015 Sep)
Ranaivoson FM,Liu Q,Martini F,Bergami F,von Daake S,Li S,Lee D,Demeler B,Hendrickson WA,Comoletti D

FLRT structure: balancing repulsion and cell adhesion in cortical and vascular development.
Neuron84(2)370-85(2014 Oct)
Seiradake E,del Toro D,Nagel D,Cop F,H?rtl R,Ruff T,Seyit-Bremer G,Harlos K,Border EC,Acker-Palmer A,Jones EY,Klein R

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Flrt3 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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