Sec62 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sec62
Entrez Gene ID	69276
Full Name	SEC62 homolog (S. cerevisiae)
Synonyms	3100002M17Rik,AI844545,AW545092,Dtrp1,HTP1,Tloc1
General protein information	Preferred Names SEC62 homolog (S. cerevisiae) Names translocation protein SEC62 TP-1 translocation protein 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 3 Map Location: 3\|3 A3

mRNA and Protein(s)

mRNA	Protein	Name
XM_006535534.3	XP_006535597.1	translocation protein SEC62 isoform X1
NM_027016.2	NP_081292.1	translocation protein SEC62 isoform 2
NM_001357528.1	NP_001344457.1	translocation protein SEC62 isoform 1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	SEC62	NP_001192533.1
Gallus gallus (chicken)	SEC62	NP_001012620.1
Homo sapiens (human)	SEC62	NP_003253.1
Rattus norvegicus (Norway rat)	Sec62	NP_001029301.1
Xenopus tropicalis (tropical clawed frog)	sec62	NP_001121518.1
Danio rerio (zebrafish)	sec62	NP_001020701.1
	SEC62	XP_001090325.1
Canis lupus familiaris (dog)	SEC62	XP_851757.2
Pan troglodytes (chimpanzee)	SEC62	XP_001162878.1
Mus musculus (house mouse)	Sec62	NP_081292.1

Gene Ontology
Bibliography

Related articles in PubMed

Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery.
Fumagalli F, Noack J, Bergmann TJ, Cebollero E, Pisoni GB, Fasana E, Fregno I, Galli C, Loi M, Sold? T, D'Antuono R, Raimondi A, Jung M, Melnyk A, Schorr S, Schreiber A, Simonelli L, Varani L, Wilson-Zbinden C, Zerbe O, Hofmann K, Peter M, Quadroni M, Zimmermann R, Molinari M
Nature cell biology18(11)1173-1184(2016 Nov)

Initial evidence for Sec62 as a prognostic marker in advanced head and neck squamous cell carcinoma.
Wemmert S, Lindner Y, Linxweiler J, Wagenpfeil S, Bohle R, Niewald M, Schick B
Oncology letters11(3)1661-1670(2016 Mar)

Mammalian SRP receptor switches the Sec61 translocase from Sec62 to SRP-dependent translocation.
Jadhav B, McKenna M, Johnson N, High S, Sinning I, Pool MR
Nature communications610133(2015 Dec)

Cotranslational stabilization of Sec62/63 within the ER Sec61 translocon is controlled by distinct substrate-driven translocation events.
Conti BJ, Devaraneni PK, Yang Z, David LL, Skach WR
Molecular cell58(2)269-83(2015 Apr)

The Sec62-Sec63 translocon facilitates translocation of the C-terminus of membrane proteins.
Jung SJ, Kim JE, Reithinger JH, Kim H
Journal of cell science127(Pt 19)4270-8(2014 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

identify Sec62 as a critical molecular component in maintenance and recovery of endoplasmic reticulum homeostasis
Title: Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery.

Interaction of ribosomes and Sec62 with the core Sec61 translocon is mutually exclusive.
Title: Mammalian SRP receptor switches the Sec61 translocase from Sec62 to SRP-dependent translocation.

The Sec62 protein plays a role in post-translational transport of presecretory proteins into endoplasmic reticulum.
Title: Different effects of Sec61?, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells.

The following Sec62 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sec62 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu03421	NM_027016.2 Latest version!	Mus musculus SEC62 homolog (S. cerevisiae) (Sec62), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
OMu31421	NM_001357528.1 Latest version!	Mus musculus SEC62 homolog (S. cerevisiae) (Sec62), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OMu31421	XM_006535534.3 Latest version!	Mus musculus SEC62 homolog (S. cerevisiae) (Sec62), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sec62 ( NM_027016.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_081292.1 Mus musculus SEC62 homolog (S. cerevisiae) (Sec62), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu03421
Clone ID Related Accession (Same CDS sequence)	NM_027016.2
Accession Version	NM_027016.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1197bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-16
Organism	Mus musculus(house mouse)
Product	translocation protein SEC62 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC158135.5 and DV657309.1. On Jan 5, 2006 this sequence version replaced NM_027016.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660821.99913.1, SRR1660819.25612.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164132 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGAAC GCAGGCGACA CAAGAAGCGG ATCCAGGAAG TTGGTGAACC ATCTAAAGAA 
GAGAAGGCTG TAGCCAAATA TCTTCGATTC AACTGTCCAA CAAAATCCAC CAACATGATG 
GGTCATCGGG TTGACTATTT TATTGCTTCA AAAGCAGTGG AGTGCCTCTT GGATTCAAAG 
TGGGCCAAGG CCAAGAAAGG AGAGGACGCT TTATTTACAA CCAGGGAGTC TGTGGTCGAC 
TACTGCAACA GGCTTTTAAA GAAACAGTTT TTCCATCGGG CCCTAAAAGT AATGAAAATG 
AAATATGATA AAGACGTAAA AAAAGAAAAA GATAAAGGGA AATCAGAAAG TGGGAAAGAA 
GATGATAAAA AGAGCAAGAA AGAAAGTGTT AAAGAAGAAA AAACAAAAAA GGAAAAAGAA 
AAAAAGAAAG ATGGTGAAAA GGAAGATTCC AAAAAGGAGG AAACTCCAGG AACTCCAAAA 
AAGAAGGAAA CTAAGAAAAA ATTCAAACTT GAGCCACATG ATGATCAAGT TTTTCTGGAT 
GGAAATGAGG TTTTTGTGTG GATCTATGAC CCAGTTCACA TTAAAACATT TGTCATGGGA 
TTAATTCTTG TGATTGCAGT AATAGCAGCC ACCCTCTTCC CTCTCTGGCC AGCAGAAATG 
AGAGTAGGTG TTTATTACCT CAGTGTGGGC GCAGGCTGTT TTGTAGCCAG CATTCTTCTC 
CTTGCTATTG CTCGCTGCAT CCTGTTTCTC ATCATCTGGC TGATAACTGG AGGAAGGCAC 
CACTTTTGGT TCCTGCCAAA CCTGACTGCT GACGTGGGCT TCATTGACTC CTTCAGGCCC 
CTGTACACAC ATGAGTACAA AGGACCAAAA GCAGACTTAA AGAAGGATGA GAAATCTGAA 
ACCAAAAAGC AGCAGAAGTC CGACAGTGAG GAAAAGTCAG ACAGTGAGAA AAAGGAGGAT 
GAGGAAGGGA AAGGAGCTCC GGCAGACCAT GGACCAGAAG GCTCGGGCGG AGAGCGGCAC 
TCAGACACGG ACAGTGACAG GCGGGAAGAC GACCGCTCGC AACACAGTAG CGGGAACGGG 
AATGATTTTG AAATGATCAC GAAGGAGGAG CTGGAGCAGC AGACAGATGG GGATTGTGAT 
GAGGAGGATG ACGACAAAGA TGGAGAGGTG CCTAAATCTG CACATGAGAA ATCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_081292.1
CDS	473..1669
Translation	MAERRRHKKRIQEVGEPSKEEKAVAKYLRFNCPTKSTNMMGHRVDYFIASKAVECLLDSKWAKAKKGEDALFTTRESVVDYCNRLLKKQFFHRALKVMKMKYDKDVKKEKDKGKSESGKEDDKKSKKESVKEEKTKKEKEKKKDGEKEDSKKEETPGTPKKKETKKKFKLEPHDDQVFLDGNEVFVWIYDPVHIKTFVMGLILVIAVIAATLFPLWPAEMRVGVYYLSVGAGCFVASILLLAIARCILFLIIWLITGGRHHFWFLPNLTADVGFIDSFRPLYTHEYKGPKADLKKDEKSETKKQQKSDSEEKSDSEKKEDEEGKGAPADHGPEGSGGERHSDTDSDRREDDRSQHSSGNGNDFEMITKEELEQQTDGDCDEEDDDKDGEVPKSAHEKS

Target ORF information:

RefSeq Version	NM_027016.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus SEC62 homolog (S. cerevisiae) (Sec62), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_027016.2

ORF Insert Sequence:

ATGGCGGAAC GCAGGCGACA CAAGAAGCGG ATCCAGGAAG TTGGTGAACC ATCTAAAGAA 
GAGAAGGCTG TAGCCAAATA TCTTCGATTC AACTGTCCAA CAAAATCCAC CAACATGATG 
GGTCATCGGG TTGACTATTT TATTGCTTCA AAAGCAGTGG AGTGCCTCTT GGATTCAAAG 
TGGGCCAAGG CCAAGAAAGG AGAGGACGCT TTATTTACAA CCAGGGAGTC TGTGGTCGAC 
TACTGCAACA GGCTTTTAAA GAAACAGTTT TTCCATCGGG CCCTAAAAGT AATGAAAATG 
AAATATGATA AAGACGTAAA AAAAGAAAAA GATAAAGGGA AATCAGAAAG TGGGAAAGAA 
GATGATAAAA AGAGCAAGAA AGAAAGTGTT AAAGAAGAAA AAACAAAAAA GGAAAAAGAA 
AAAAAGAAAG ATGGTGAAAA GGAAGATTCC AAAAAGGAGG AAACTCCAGG AACTCCAAAA 
AAGAAGGAAA CTAAGAAAAA ATTCAAACTT GAGCCACATG ATGATCAAGT TTTTCTGGAT 
GGAAATGAGG TTTTTGTGTG GATCTATGAC CCAGTTCACA TTAAAACATT TGTCATGGGA 
TTAATTCTTG TGATTGCAGT AATAGCAGCC ACCCTCTTCC CTCTCTGGCC AGCAGAAATG 
AGAGTAGGTG TTTATTACCT CAGTGTGGGC GCAGGCTGTT TTGTAGCCAG CATTCTTCTC 
CTTGCTATTG CTCGCTGCAT CCTGTTTCTC ATCATCTGGC TGATAACTGG AGGAAGGCAC 
CACTTTTGGT TCCTGCCAAA CCTGACTGCT GACGTGGGCT TCATTGACTC CTTCAGGCCC 
CTGTACACAC ATGAGTACAA AGGACCAAAA GCAGACTTAA AGAAGGATGA GAAATCTGAA 
ACCAAAAAGC AGCAGAAGTC CGACAGTGAG GAAAAGTCAG ACAGTGAGAA AAAGGAGGAT 
GAGGAAGGGA AAGGAGCTCC GGCAGACCAT GGACCAGAAG GCTCGGGCGG AGAGCGGCAC 
TCAGACACGG ACAGTGACAG GCGGGAAGAC GACCGCTCGC AACACAGTAG CGGGAACGGG 
AATGATTTTG AAATGATCAC GAAGGAGGAG CTGGAGCAGC AGACAGATGG GGATTGTGAT 
GAGGAGGATG ACGACAAAGA TGGAGAGGTG CCTAAATCTG CACATGAGAA ATCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Sec62 ( NM_001357528.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001344457.1 Mus musculus SEC62 homolog (S. cerevisiae) (Sec62), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu31421
Clone ID Related Accession (Same CDS sequence)	XM_006535534.3 , NM_001357528.1
Accession Version	NM_001357528.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1233bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-25
Organism	Mus musculus(house mouse)
Product	translocation protein SEC62 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC158135.5. On Nov 4, 2017 this sequence version replaced XM_006535534.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660811.220860.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164132 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGAAC GCAGGCGACA CAAGAAGCGG ATCCAGGAAG TTGGTGAACC ATCTAAAGAA 
GAGAAGGCTG TAGCCAAATA TCTTCGATTC AACTGTCCAA CAAAATCCAC CAACATGATG 
GGTCATCGGG TTGACTATTT TATTGCTTCA AAAGCAGTGG AGTGCCTCTT GGATTCAAAG 
TGGGCCAAGG CCAAGAAAGG AGAGGACGCT TTATTTACAA CCAGGGAGTC TGTGGTCGAC 
TACTGCAACA GGCTTTTAAA GAAACAGTTT TTCCATCGGG CCCTAAAAGT AATGAAAATG 
AAATATGATA AAGACGTAAA AAAAGAAAAA GATAAAGGGA AATCAGAAAG TGGGAAAGAA 
GATGATAAAA AGAGCAAGAA AGAAAGTGTT AAAGAAGAAA AAACAAAAAA GGAAAAAGAA 
AAAAAGAAAG ATGGTGAAAA GGAAGATTCC AAAAAGGAGG AAACTCCAGG AACTCCAAAA 
AAGAAGGAAA CTAAGAAAAA ATTCAAACTT GAGCCACATG ATGATCAAGT TTTTCTGGAT 
GGAAATGAGG TTTTTGTGTG GATCTATGAC CCAGTTCACA TTAAAACATT TGTCATGGGA 
TTAATTCTTG TGATTGCAGT AATAGCAGCC ACCCTCTTCC CTCTCTGGCC AGCAGAAATG 
AGAGTAGGTG TTTATTACCT CAGTGTGGGC GCAGGCTGTT TTGTAGCCAG CATTCTTCTC 
CTTGCTATTG CTCGCTGCAT CCTGTTTCTC ATCATCTGGC TGATAACTGG AGGAAGGCAC 
CACTTTTGGT TCCTGCCAAA CCTGACTGCT GACGTGGGCT TCATTGACTC CTTCAGGCCC 
CTGTACACAC ATGAGTACAA AGGACCAAAA GCAGACTTAA AGAAGGATGA GAAATCTGAA 
ACCAAAAAGC AGCAGAAGTC CGACAGTGAG GAAAAGTCAG ACAGTGAGAA AAAGGAGGAT 
GAGGAAGGGA AAGGAGCTCC GGCAGACCAT GGACCAGAAG GCTCGGGCGG AGAGCGGCAC 
TCAGACACGG ACAGTGACAG GCGGGAAGAC GACCGCTCGC AACACAGTAG CGGGAACGGG 
AATGATTTTG AAATGATCAC GAAGGAGGAG CTGGAGCAGC AGACAGATGG GGATTGTGAT 
GAGGAGGATG ACGACAAAGA TGGAGAGCTT AGGAAATCCC AACTGACCTG TGCGTTCAAT 
CCAGAGAAAG GCGGTCATCT CCAGCAGAAG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001344457.1
CDS	473..1705
Translation	MAERRRHKKRIQEVGEPSKEEKAVAKYLRFNCPTKSTNMMGHRVDYFIASKAVECLLDSKWAKAKKGEDALFTTRESVVDYCNRLLKKQFFHRALKVMKMKYDKDVKKEKDKGKSESGKEDDKKSKKESVKEEKTKKEKEKKKDGEKEDSKKEETPGTPKKKETKKKFKLEPHDDQVFLDGNEVFVWIYDPVHIKTFVMGLILVIAVIAATLFPLWPAEMRVGVYYLSVGAGCFVASILLLAIARCILFLIIWLITGGRHHFWFLPNLTADVGFIDSFRPLYTHEYKGPKADLKKDEKSETKKQQKSDSEEKSDSEKKEDEEGKGAPADHGPEGSGGERHSDTDSDRREDDRSQHSSGNGNDFEMITKEELEQQTDGDCDEEDDDKDGELRKSQLTCAFNPEKGGHLQQK

Target ORF information:

RefSeq Version	NM_001357528.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus SEC62 homolog (S. cerevisiae) (Sec62), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001357528.1

ORF Insert Sequence:

ATGGCGGAAC GCAGGCGACA CAAGAAGCGG ATCCAGGAAG TTGGTGAACC ATCTAAAGAA 
GAGAAGGCTG TAGCCAAATA TCTTCGATTC AACTGTCCAA CAAAATCCAC CAACATGATG 
GGTCATCGGG TTGACTATTT TATTGCTTCA AAAGCAGTGG AGTGCCTCTT GGATTCAAAG 
TGGGCCAAGG CCAAGAAAGG AGAGGACGCT TTATTTACAA CCAGGGAGTC TGTGGTCGAC 
TACTGCAACA GGCTTTTAAA GAAACAGTTT TTCCATCGGG CCCTAAAAGT AATGAAAATG 
AAATATGATA AAGACGTAAA AAAAGAAAAA GATAAAGGGA AATCAGAAAG TGGGAAAGAA 
GATGATAAAA AGAGCAAGAA AGAAAGTGTT AAAGAAGAAA AAACAAAAAA GGAAAAAGAA 
AAAAAGAAAG ATGGTGAAAA GGAAGATTCC AAAAAGGAGG AAACTCCAGG AACTCCAAAA 
AAGAAGGAAA CTAAGAAAAA ATTCAAACTT GAGCCACATG ATGATCAAGT TTTTCTGGAT 
GGAAATGAGG TTTTTGTGTG GATCTATGAC CCAGTTCACA TTAAAACATT TGTCATGGGA 
TTAATTCTTG TGATTGCAGT AATAGCAGCC ACCCTCTTCC CTCTCTGGCC AGCAGAAATG 
AGAGTAGGTG TTTATTACCT CAGTGTGGGC GCAGGCTGTT TTGTAGCCAG CATTCTTCTC 
CTTGCTATTG CTCGCTGCAT CCTGTTTCTC ATCATCTGGC TGATAACTGG AGGAAGGCAC 
CACTTTTGGT TCCTGCCAAA CCTGACTGCT GACGTGGGCT TCATTGACTC CTTCAGGCCC 
CTGTACACAC ATGAGTACAA AGGACCAAAA GCAGACTTAA AGAAGGATGA GAAATCTGAA 
ACCAAAAAGC AGCAGAAGTC CGACAGTGAG GAAAAGTCAG ACAGTGAGAA AAAGGAGGAT 
GAGGAAGGGA AAGGAGCTCC GGCAGACCAT GGACCAGAAG GCTCGGGCGG AGAGCGGCAC 
TCAGACACGG ACAGTGACAG GCGGGAAGAC GACCGCTCGC AACACAGTAG CGGGAACGGG 
AATGATTTTG AAATGATCAC GAAGGAGGAG CTGGAGCAGC AGACAGATGG GGATTGTGAT 
GAGGAGGATG ACGACAAAGA TGGAGAGCTT AGGAAATCCC AACTGACCTG TGCGTTCAAT 
CCAGAGAAAG GCGGTCATCT CCAGCAGAAG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Sec62 ( XM_006535534.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006535597.1 Mus musculus SEC62 homolog (S. cerevisiae) (Sec62), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu31421
Clone ID Related Accession (Same CDS sequence)	XM_006535534.3 , NM_001357528.1
Accession Version	XM_006535534.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1233bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(House mouse)
Product	translocation protein SEC62 isoform X1
Comment	MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000069.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006535534.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGGAAC GCAGGCGACA CAAGAAGCGG ATCCAGGAAG TTGGTGAACC ATCTAAAGAA 
GAGAAGGCTG TAGCCAAATA TCTTCGATTC AACTGTCCAA CAAAATCCAC CAACATGATG 
GGTCATCGGG TTGACTATTT TATTGCTTCA AAAGCAGTGG AGTGCCTCTT GGATTCAAAG 
TGGGCCAAGG CCAAGAAAGG AGAGGACGCT TTATTTACAA CCAGGGAGTC TGTGGTCGAC 
TACTGCAACA GGCTTTTAAA GAAACAGTTT TTCCATCGGG CCCTAAAAGT AATGAAAATG 
AAATATGATA AAGACGTAAA AAAAGAAAAA GATAAAGGGA AATCAGAAAG TGGGAAAGAA 
GATGATAAAA AGAGCAAGAA AGAAAGTGTT AAAGAAGAAA AAACAAAAAA GGAAAAAGAA 
AAAAAGAAAG ATGGTGAAAA GGAAGATTCC AAAAAGGAGG AAACTCCAGG AACTCCAAAA 
AAGAAGGAAA CTAAGAAAAA ATTCAAACTT GAGCCACATG ATGATCAAGT TTTTCTGGAT 
GGAAATGAGG TTTTTGTGTG GATCTATGAC CCAGTTCACA TTAAAACATT TGTCATGGGA 
TTAATTCTTG TGATTGCAGT AATAGCAGCC ACCCTCTTCC CTCTCTGGCC AGCAGAAATG 
AGAGTAGGTG TTTATTACCT CAGTGTGGGC GCAGGCTGTT TTGTAGCCAG CATTCTTCTC 
CTTGCTATTG CTCGCTGCAT CCTGTTTCTC ATCATCTGGC TGATAACTGG AGGAAGGCAC 
CACTTTTGGT TCCTGCCAAA CCTGACTGCT GACGTGGGCT TCATTGACTC CTTCAGGCCC 
CTGTACACAC ATGAGTACAA AGGACCAAAA GCAGACTTAA AGAAGGATGA GAAATCTGAA 
ACCAAAAAGC AGCAGAAGTC CGACAGTGAG GAAAAGTCAG ACAGTGAGAA AAAGGAGGAT 
GAGGAAGGGA AAGGAGCTCC GGCAGACCAT GGACCAGAAG GCTCGGGCGG AGAGCGGCAC 
TCAGACACGG ACAGTGACAG GCGGGAAGAC GACCGCTCGC AACACAGTAG CGGGAACGGG 
AATGATTTTG AAATGATCAC GAAGGAGGAG CTGGAGCAGC AGACAGATGG GGATTGTGAT 
GAGGAGGATG ACGACAAAGA TGGAGAGCTT AGGAAATCCC AACTGACCTG TGCGTTCAAT 
CCAGAGAAAG GCGGTCATCT CCAGCAGAAG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006535597.1
CDS	584..1816
Translation	MAERRRHKKRIQEVGEPSKEEKAVAKYLRFNCPTKSTNMMGHRVDYFIASKAVECLLDSKWAKAKKGEDALFTTRESVVDYCNRLLKKQFFHRALKVMKMKYDKDVKKEKDKGKSESGKEDDKKSKKESVKEEKTKKEKEKKKDGEKEDSKKEETPGTPKKKETKKKFKLEPHDDQVFLDGNEVFVWIYDPVHIKTFVMGLILVIAVIAATLFPLWPAEMRVGVYYLSVGAGCFVASILLLAIARCILFLIIWLITGGRHHFWFLPNLTADVGFIDSFRPLYTHEYKGPKADLKKDEKSETKKQQKSDSEEKSDSEKKEDEEGKGAPADHGPEGSGGERHSDTDSDRREDDRSQHSSGNGNDFEMITKEELEQQTDGDCDEEDDDKDGELRKSQLTCAFNPEKGGHLQQK

Target ORF information:

RefSeq Version	XM_006535534.3
Organism	Mus musculus(House mouse)
Definition	Mus musculus SEC62 homolog (S. cerevisiae) (Sec62), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006535534.3

ORF Insert Sequence:

ATGGCGGAAC GCAGGCGACA CAAGAAGCGG ATCCAGGAAG TTGGTGAACC ATCTAAAGAA 
GAGAAGGCTG TAGCCAAATA TCTTCGATTC AACTGTCCAA CAAAATCCAC CAACATGATG 
GGTCATCGGG TTGACTATTT TATTGCTTCA AAAGCAGTGG AGTGCCTCTT GGATTCAAAG 
TGGGCCAAGG CCAAGAAAGG AGAGGACGCT TTATTTACAA CCAGGGAGTC TGTGGTCGAC 
TACTGCAACA GGCTTTTAAA GAAACAGTTT TTCCATCGGG CCCTAAAAGT AATGAAAATG 
AAATATGATA AAGACGTAAA AAAAGAAAAA GATAAAGGGA AATCAGAAAG TGGGAAAGAA 
GATGATAAAA AGAGCAAGAA AGAAAGTGTT AAAGAAGAAA AAACAAAAAA GGAAAAAGAA 
AAAAAGAAAG ATGGTGAAAA GGAAGATTCC AAAAAGGAGG AAACTCCAGG AACTCCAAAA 
AAGAAGGAAA CTAAGAAAAA ATTCAAACTT GAGCCACATG ATGATCAAGT TTTTCTGGAT 
GGAAATGAGG TTTTTGTGTG GATCTATGAC CCAGTTCACA TTAAAACATT TGTCATGGGA 
TTAATTCTTG TGATTGCAGT AATAGCAGCC ACCCTCTTCC CTCTCTGGCC AGCAGAAATG 
AGAGTAGGTG TTTATTACCT CAGTGTGGGC GCAGGCTGTT TTGTAGCCAG CATTCTTCTC 
CTTGCTATTG CTCGCTGCAT CCTGTTTCTC ATCATCTGGC TGATAACTGG AGGAAGGCAC 
CACTTTTGGT TCCTGCCAAA CCTGACTGCT GACGTGGGCT TCATTGACTC CTTCAGGCCC 
CTGTACACAC ATGAGTACAA AGGACCAAAA GCAGACTTAA AGAAGGATGA GAAATCTGAA 
ACCAAAAAGC AGCAGAAGTC CGACAGTGAG GAAAAGTCAG ACAGTGAGAA AAAGGAGGAT 
GAGGAAGGGA AAGGAGCTCC GGCAGACCAT GGACCAGAAG GCTCGGGCGG AGAGCGGCAC 
TCAGACACGG ACAGTGACAG GCGGGAAGAC GACCGCTCGC AACACAGTAG CGGGAACGGG 
AATGATTTTG AAATGATCAC GAAGGAGGAG CTGGAGCAGC AGACAGATGG GGATTGTGAT 
GAGGAGGATG ACGACAAAGA TGGAGAGCTT AGGAAATCCC AACTGACCTG TGCGTTCAAT 
CCAGAGAAAG GCGGTCATCT CCAGCAGAAG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery.
Nature cell biology18(11)1173-1184(2016 Nov)
Fumagalli F,Noack J,Bergmann TJ,Cebollero E,Pisoni GB,Fasana E,Fregno I,Galli C,Loi M,Sold? T,D'Antuono R,Raimondi A,Jung M,Melnyk A,Schorr S,Schreiber A,Simonelli L,Varani L,Wilson-Zbinden C,Zerbe O,Hofmann K,Peter M,Quadroni M,Zimmermann R,Molinari M

Initial evidence for Sec62 as a prognostic marker in advanced head and neck squamous cell carcinoma.
Oncology letters11(3)1661-1670(2016 Mar)
Wemmert S,Lindner Y,Linxweiler J,Wagenpfeil S,Bohle R,Niewald M,Schick B

Mammalian SRP receptor switches the Sec61 translocase from Sec62 to SRP-dependent translocation.
Nature communications610133(2015 Dec)
Jadhav B,McKenna M,Johnson N,High S,Sinning I,Pool MR

Cotranslational stabilization of Sec62/63 within the ER Sec61 translocon is controlled by distinct substrate-driven translocation events.
Molecular cell58(2)269-83(2015 Apr)
Conti BJ,Devaraneni PK,Yang Z,David LL,Skach WR

The Sec62-Sec63 translocon facilitates translocation of the C-terminus of membrane proteins.
Journal of cell science127(Pt 19)4270-8(2014 Oct)
Jung SJ,Kim JE,Reithinger JH,Kim H