Scnm1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Scnm1
Entrez Gene ID	69269
Full Name	sodium channel modifier 1
Synonyms	3110001I17Rik,Scnm1-ps
General protein information	Preferred Names sodium channel modifier 1 Names sodium channel modifier 1 sodium channel modifier 1, pseudogene
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 3 Map Location: 3 F2.1\|3 40.74 cM
Summary	Mutations in the voltage-gated sodium channel gene Scn8a lead to neurological problems in mice. For one particular mutation, Scn8amedJ, mice live to adulthood but have tremors and muscle weakness, among other problems, in all strains except those derived from C57BL6 mice. In these strains, the product of the Scnm1 gene (229 aa) partially overcomes the effects of the Scn8amedJ mutation. However, in C57BL6-derived mice, a one nt change in the penultimate exon creates a premature stop codon, truncating the Scnm1 protein at 186 aa. This truncated protein lacks the ability to overcome the effects of the Scn8amedJ mutation, and these mice suffer paralysis and juvenile death. [provided by RefSeq, Jul 2009].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017319716.1	XP_017175205.1	sodium channel modifier 1 isoform X2
XM_017319715.2	XP_017175204.1	sodium channel modifier 1 isoform X1
NM_001163573.1	NP_001157045.1	sodium channel modifier 1 isoform 2
XM_017319716.2	XP_017175205.1	sodium channel modifier 1 isoform X2
XM_017319715.1	XP_017175204.1	sodium channel modifier 1 isoform X1
NM_027013.2	NP_081289.2	sodium channel modifier 1 isoform 1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	SCNM1	XP_003432300.1
Danio rerio (zebrafish)	scnm1	NP_001001813.1
Xenopus tropicalis (tropical clawed frog)	scnm1	XP_002937309.2
Bos taurus (cattle)	SCNM1	NP_001029426.1
Rattus norvegicus (Norway rat)	Scnm1	NP_001101166.1
Gallus gallus (chicken)	LOC425744	XP_003642719.1
Mus musculus (house mouse)	Scnm1	NP_081289.2
Homo sapiens (human)	SCNM1	NP_076946.1
Pan troglodytes (chimpanzee)	SCNM1	XP_513787.3
	SCNM1	XP_001105184.1
Gallus gallus (chicken)	SCNM1	XP_003642737.1

Gene Ontology
Bibliography

Related articles in PubMed

Widespread and dynamic translational control of red blood cell development.
Alvarez-Dominguez JR, Zhang X, Hu W
Blood129(5)619-629(2017 02)

A targeted deleterious allele of the splicing factor SCNM1 in the mouse.
Howell VM, de Haan G, Bergren S, Jones JM, Culiat CT, Michaud EJ, Frankel WN, Meisler MH
Genetics180(3)1419-27(2008 Nov)

Evidence for a direct role of the disease modifier SCNM1 in splicing.
Howell VM, Jones JM, Bergren SK, Li L, Billi AC, Avenarius MR, Meisler MH
Human molecular genetics16(20)2506-16(2007 Oct)

Efficient gene-driven germ-line point mutagenesis of C57BL/6J mice.
Michaud EJ, Culiat CT, Klebig ML, Barker PE, Cain KT, Carpenter DJ, Easter LL, Foster CM, Gardner AW, Guo ZY, Houser KJ, Hughes LA, Kerley MK, Liu Z, Olszewski RE, Pinn I, Shaw GD, Shinpock SG, Wymore AM, Rinchik EM, Johnson DK
BMC genomics6164(2005 Nov)

High-resolution mapping of the sodium channel modifier Scnm1 on mouse chromosome 3 and identification of a 1.3-kb recombination hot spot.
Buchner DA, Trudeau M, George AL Jr, Sprunger LK, Meisler MH
Genomics82(4)452-9(2003 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Scnm1 is the first example of a modifier gene which influences disease severity through a trans-effect on splicing of the disease gene transcript.
Title: Evidence for a direct role of the disease modifier SCNM1 in splicing.

Variation between inbred strains of mice can be used to identify modifier genes affecting the susceptibility to inherited disease. The severity of the neurological disorder is determined by the modifier locus Scnm1.
Title: High-resolution mapping of the sodium channel modifier Scnm1 on mouse chromosome 3 and identification of a 1.3-kb recombination hot spot.

The following Scnm1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Scnm1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu03416	NM_027013.2 Latest version!	Mus musculus sodium channel modifier 1 (Scnm1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu09211	NM_001163573.1 Latest version!	Mus musculus sodium channel modifier 1 (Scnm1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu80697	XM_017319715.2 Latest version!	Mus musculus sodium channel modifier 1 (Scnm1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OMu80698	XM_017319716.2 Latest version!	Mus musculus sodium channel modifier 1 (Scnm1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OMu80698	XM_017319716.1	Mus musculus sodium channel modifier 1 (Scnm1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OMu80697	XM_017319715.1	Mus musculus sodium channel modifier 1 (Scnm1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Scnm1 ( NM_027013.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_081289.2 Mus musculus sodium channel modifier 1 (Scnm1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu03416
Clone ID Related Accession (Same CDS sequence)	NM_027013.2
Accession Version	NM_027013.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 561bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Mus musculus(house mouse)
Product	sodium channel modifier 1 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK013948.1 and BU756175.1. On Jul 24, 2009 this sequence version replaced NM_027013.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). The C-terminus of this isoform is truncated compared to that of the same variant in mouse strains not derived from C57BL6. This truncated isoform is not able to counteract the deleterious effects of the Scn8amedJ mutation whereas the longer isoform found in non-C57BL6 strains can partially overcome these effects. ##Evidence-Data-START## Transcript exon combination :: KY467430.1, AK013948.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849382, SAMN01164131 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCTTTTA AGAGGGAAGG GGACGACTGG AGTCAACTCA ATGTGCTCAA AAAACGGAGA 
GTTGGGGACC TGCTGGCTAG TTACATCCCT GAGGACGAGG CACTGATGCT GCGGGATGGA 
CGCTTTGCTT GTGCCATCTG CCCCCATCGA CCAGTACTAG ACACGCTGGC CATGTTGACA 
GCCCACCGTG CAGGCAAGAA GCATTTGTCC AGTCTGAAGC TTTTCTATGG CAAAAAGCAA 
ACAGGCAAGG GAACAGAGCA AAATCCAAGA CAGCAGAACG AATTGAAGAC AGAAAGCAAA 
ACTGAGGCTC CTTTGCTAAC CCAGACTCGA ATCATCACCC AGAATGCTCT ACACAGAGCT 
CCCCACTATA ACAGTTGCTG CCGGAGGAAG CACAGACCAG AAGCCCCTGC TCCCTCTGTC 
TCCAGTCCTC CTTTGCCAAC TGCAGAGGTC CAACTCCAGA GTGCAGAGAT CAGTAAGGAA 
CCTGAGCCTA GGGAGAGATC AGATGCCAAA GAGTCAGCAG CTCTCTTGGC CTCTGCACCC 
ATGAGCCCCA CCAAACGATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_081289.2
CDS	118..678
Translation	MSFKREGDDWSQLNVLKKRRVGDLLASYIPEDEALMLRDGRFACAICPHRPVLDTLAMLTAHRAGKKHLSSLKLFYGKKQTGKGTEQNPRQQNELKTESKTEAPLLTQTRIITQNALHRAPHYNSCCRRKHRPEAPAPSVSSPPLPTAEVQLQSAEISKEPEPRERSDAKESAALLASAPMSPTKR

Target ORF information:

RefSeq Version	NM_027013.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus sodium channel modifier 1 (Scnm1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_027013.2

ORF Insert Sequence:

ATGTCTTTTA AGAGGGAAGG GGACGACTGG AGTCAACTCA ATGTGCTCAA AAAACGGAGA 
GTTGGGGACC TGCTGGCTAG TTACATCCCT GAGGACGAGG CACTGATGCT GCGGGATGGA 
CGCTTTGCTT GTGCCATCTG CCCCCATCGA CCAGTACTAG ACACGCTGGC CATGTTGACA 
GCCCACCGTG CAGGCAAGAA GCATTTGTCC AGTCTGAAGC TTTTCTATGG CAAAAAGCAA 
ACAGGCAAGG GAACAGAGCA AAATCCAAGA CAGCAGAACG AATTGAAGAC AGAAAGCAAA 
ACTGAGGCTC CTTTGCTAAC CCAGACTCGA ATCATCACCC AGAATGCTCT ACACAGAGCT 
CCCCACTATA ACAGTTGCTG CCGGAGGAAG CACAGACCAG AAGCCCCTGC TCCCTCTGTC 
TCCAGTCCTC CTTTGCCAAC TGCAGAGGTC CAACTCCAGA GTGCAGAGAT CAGTAAGGAA 
CCTGAGCCTA GGGAGAGATC AGATGCCAAA GAGTCAGCAG CTCTCTTGGC CTCTGCACCC 
ATGAGCCCCA CCAAACGATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Scnm1 ( NM_001163573.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001157045.1 Mus musculus sodium channel modifier 1 (Scnm1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu09211
Clone ID Related Accession (Same CDS sequence)	NM_001163573.1
Accession Version	NM_001163573.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 495bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Mus musculus(house mouse)
Product	sodium channel modifier 1 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK013948.1, BQ032998.1 and BU756175.1. Transcript Variant: This variant (2) lacks the exon containing the stop codon compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: BQ747001.1, SRR1660813.400843.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164139 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCTTTTA AGAGGGAAGG GGACGACTGG AGTCAACTCA ATGTGCTCAA AAAACGGAGA 
GTTGGGGACC TGCTGGCTAG TTACATCCCT GAGGACGAGG CACTGATGCT GCGGGATGGA 
CGCTTTGCTT GTGCCATCTG CCCCCATCGA CCAGTACTAG ACACGCTGGC CATGTTGACA 
GCCCACCGTG CAGGCAAGAA GCATTTGTCC AGTCTGAAGC TTTTCTATGG CAAAAAGCAA 
ACAGGCAAGG GAACAGAGCA AAATCCAAGA CAGCAGAACG AATTGAAGAC AGAAAGCAAA 
ACTGAGGCTC CTTTGCTAAC CCAGACTCGA ATCATCACCC AGAATGCTCT ACACAGAGCT 
CCCCACTATA ACAGTTGCTG CCGGAGGAAG CACAGCTCTG GATGGGTCCC AGATGGACGA 
GGTCGATGGA TAAAGGATGA AAATGTTGAG TTTGACTCTG ATGAGGAAGA GCCCCCCGAT 
CTCCCCTTGG ACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001157045.1
CDS	118..612
Translation	MSFKREGDDWSQLNVLKKRRVGDLLASYIPEDEALMLRDGRFACAICPHRPVLDTLAMLTAHRAGKKHLSSLKLFYGKKQTGKGTEQNPRQQNELKTESKTEAPLLTQTRIITQNALHRAPHYNSCCRRKHSSGWVPDGRGRWIKDENVEFDSDEEEPPDLPLD

Target ORF information:

RefSeq Version	NM_001163573.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus sodium channel modifier 1 (Scnm1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001163573.1

ORF Insert Sequence:

ATGTCTTTTA AGAGGGAAGG GGACGACTGG AGTCAACTCA ATGTGCTCAA AAAACGGAGA 
GTTGGGGACC TGCTGGCTAG TTACATCCCT GAGGACGAGG CACTGATGCT GCGGGATGGA 
CGCTTTGCTT GTGCCATCTG CCCCCATCGA CCAGTACTAG ACACGCTGGC CATGTTGACA 
GCCCACCGTG CAGGCAAGAA GCATTTGTCC AGTCTGAAGC TTTTCTATGG CAAAAAGCAA 
ACAGGCAAGG GAACAGAGCA AAATCCAAGA CAGCAGAACG AATTGAAGAC AGAAAGCAAA 
ACTGAGGCTC CTTTGCTAAC CCAGACTCGA ATCATCACCC AGAATGCTCT ACACAGAGCT 
CCCCACTATA ACAGTTGCTG CCGGAGGAAG CACAGCTCTG GATGGGTCCC AGATGGACGA 
GGTCGATGGA TAAAGGATGA AAATGTTGAG TTTGACTCTG ATGAGGAAGA GCCCCCCGAT 
CTCCCCTTGG ACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Scnm1 ( XM_017319715.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_017175204.1 Mus musculus sodium channel modifier 1 (Scnm1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu80697
Clone ID Related Accession (Same CDS sequence)	XM_017319715.2 , XM_017319715.1
Accession Version	XM_017319715.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 435bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	sodium channel modifier 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000069.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_017319715.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCTTTTA AGAGGGAAGG GGACGACTGG AGTCAACTCA ATGTGCTCAA AAAACGGAGA 
GTTGGGGACC TGCTGGCTAG TTACATCCCT GAGGACGAGG CACTGATGCT GCGGGATGGA 
CGCTTTGCTT GTGCCATCTG CCCCCATCGA CCAGTACTAG ACACGCTGGC CATGTTGACA 
GCCCACCGTG CAGGCAAGAA GCATTTGTCC AGTCTGAAGC TTTTCTATGG CAAAAAGCAA 
ACAGGCAAGG GAACAGAGCA AAATCCAAGA CAGCAGAACG AATTGAAGAC AGAAAGCAAA 
ACTGAGGCTC CTTTGCTAAC CCAGACTCGA ATCATCACCC AGAATGCTCT ACACAGAGCT 
CCCCACTATA ACAGTTGCTG CCGGAGGAAG CACAGCCCTG GCTGTCCTGA AACCCTGCTA 
TTTAGACCAA GGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017175204.1
CDS	156..590
Translation	MSFKREGDDWSQLNVLKKRRVGDLLASYIPEDEALMLRDGRFACAICPHRPVLDTLAMLTAHRAGKKHLSSLKLFYGKKQTGKGTEQNPRQQNELKTESKTEAPLLTQTRIITQNALHRAPHYNSCCRRKHSPGCPETLLFRPR

Target ORF information:

RefSeq Version	XM_017319715.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus sodium channel modifier 1 (Scnm1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017319715.2

ORF Insert Sequence:

ATGTCTTTTA AGAGGGAAGG GGACGACTGG AGTCAACTCA ATGTGCTCAA AAAACGGAGA 
GTTGGGGACC TGCTGGCTAG TTACATCCCT GAGGACGAGG CACTGATGCT GCGGGATGGA 
CGCTTTGCTT GTGCCATCTG CCCCCATCGA CCAGTACTAG ACACGCTGGC CATGTTGACA 
GCCCACCGTG CAGGCAAGAA GCATTTGTCC AGTCTGAAGC TTTTCTATGG CAAAAAGCAA 
ACAGGCAAGG GAACAGAGCA AAATCCAAGA CAGCAGAACG AATTGAAGAC AGAAAGCAAA 
ACTGAGGCTC CTTTGCTAAC CCAGACTCGA ATCATCACCC AGAATGCTCT ACACAGAGCT 
CCCCACTATA ACAGTTGCTG CCGGAGGAAG CACAGCCCTG GCTGTCCTGA AACCCTGCTA 
TTTAGACCAA GGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Scnm1 ( XM_017319715.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_017175204.1 Mus musculus sodium channel modifier 1 (Scnm1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu80697
Clone ID Related Accession (Same CDS sequence)	XM_017319715.2 , XM_017319715.1
Accession Version	XM_017319715.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 435bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	sodium channel modifier 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000069.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCTTTTA AGAGGGAAGG GGACGACTGG AGTCAACTCA ATGTGCTCAA AAAACGGAGA 
GTTGGGGACC TGCTGGCTAG TTACATCCCT GAGGACGAGG CACTGATGCT GCGGGATGGA 
CGCTTTGCTT GTGCCATCTG CCCCCATCGA CCAGTACTAG ACACGCTGGC CATGTTGACA 
GCCCACCGTG CAGGCAAGAA GCATTTGTCC AGTCTGAAGC TTTTCTATGG CAAAAAGCAA 
ACAGGCAAGG GAACAGAGCA AAATCCAAGA CAGCAGAACG AATTGAAGAC AGAAAGCAAA 
ACTGAGGCTC CTTTGCTAAC CCAGACTCGA ATCATCACCC AGAATGCTCT ACACAGAGCT 
CCCCACTATA ACAGTTGCTG CCGGAGGAAG CACAGCCCTG GCTGTCCTGA AACCCTGCTA 
TTTAGACCAA GGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017175204.1
CDS	151..585
Translation	MSFKREGDDWSQLNVLKKRRVGDLLASYIPEDEALMLRDGRFACAICPHRPVLDTLAMLTAHRAGKKHLSSLKLFYGKKQTGKGTEQNPRQQNELKTESKTEAPLLTQTRIITQNALHRAPHYNSCCRRKHSPGCPETLLFRPR

Target ORF information:

RefSeq Version	XM_017319715.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus sodium channel modifier 1 (Scnm1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017319715.1

ORF Insert Sequence:

ATGTCTTTTA AGAGGGAAGG GGACGACTGG AGTCAACTCA ATGTGCTCAA AAAACGGAGA 
GTTGGGGACC TGCTGGCTAG TTACATCCCT GAGGACGAGG CACTGATGCT GCGGGATGGA 
CGCTTTGCTT GTGCCATCTG CCCCCATCGA CCAGTACTAG ACACGCTGGC CATGTTGACA 
GCCCACCGTG CAGGCAAGAA GCATTTGTCC AGTCTGAAGC TTTTCTATGG CAAAAAGCAA 
ACAGGCAAGG GAACAGAGCA AAATCCAAGA CAGCAGAACG AATTGAAGAC AGAAAGCAAA 
ACTGAGGCTC CTTTGCTAAC CCAGACTCGA ATCATCACCC AGAATGCTCT ACACAGAGCT 
CCCCACTATA ACAGTTGCTG CCGGAGGAAG CACAGCCCTG GCTGTCCTGA AACCCTGCTA 
TTTAGACCAA GGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Scnm1 ( XM_017319716.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_017175205.1 Mus musculus sodium channel modifier 1 (Scnm1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OMu80698
Clone ID Related Accession (Same CDS sequence)	XM_017319716.1 , XM_017319716.2
Accession Version	XM_017319716.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 351bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	sodium channel modifier 1 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000069.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCTTTTA AGAGGGAAGG GGACGACTGG AGTCAACTCA ATGTGCTCAA AAAACGGAGA 
GTTGGGGACC TGCTGGCTAG TTACATCCCT GAGGACGAGG CACTGATGCT GCGGGATGGA 
CGCTTTGCTT GTGCCATCTG CCCCCATCGA CCAGTACTAG ACACGCTGGC CATGTTGACA 
GCCCACCGTG CAGGCAAGAA GCATTTGTCC AGTCTGAAGC TTTTCTATGG CAAAAAGCAA 
ACAGGCAAGG GAACAGAGCA AAATCCAAGA CAGCAGAACG AATTGAAGAC AGAAAGCAAA 
ACTGAGCTCT GGATGGGTCC CAGATGGACG AGGTCGATGG ATAAAGGATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017175205.1
CDS	151..501
Translation	MSFKREGDDWSQLNVLKKRRVGDLLASYIPEDEALMLRDGRFACAICPHRPVLDTLAMLTAHRAGKKHLSSLKLFYGKKQTGKGTEQNPRQQNELKTESKTELWMGPRWTRSMDKG

Target ORF information:

RefSeq Version	XM_017319716.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus sodium channel modifier 1 (Scnm1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017319716.1

ORF Insert Sequence:

ATGTCTTTTA AGAGGGAAGG GGACGACTGG AGTCAACTCA ATGTGCTCAA AAAACGGAGA 
GTTGGGGACC TGCTGGCTAG TTACATCCCT GAGGACGAGG CACTGATGCT GCGGGATGGA 
CGCTTTGCTT GTGCCATCTG CCCCCATCGA CCAGTACTAG ACACGCTGGC CATGTTGACA 
GCCCACCGTG CAGGCAAGAA GCATTTGTCC AGTCTGAAGC TTTTCTATGG CAAAAAGCAA 
ACAGGCAAGG GAACAGAGCA AAATCCAAGA CAGCAGAACG AATTGAAGAC AGAAAGCAAA 
ACTGAGCTCT GGATGGGTCC CAGATGGACG AGGTCGATGG ATAAAGGATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Scnm1 ( XM_017319716.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_017175205.1 Mus musculus sodium channel modifier 1 (Scnm1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OMu80698
Clone ID Related Accession (Same CDS sequence)	XM_017319716.1 , XM_017319716.2
Accession Version	XM_017319716.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 351bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	sodium channel modifier 1 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000069.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_017319716.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCTTTTA AGAGGGAAGG GGACGACTGG AGTCAACTCA ATGTGCTCAA AAAACGGAGA 
GTTGGGGACC TGCTGGCTAG TTACATCCCT GAGGACGAGG CACTGATGCT GCGGGATGGA 
CGCTTTGCTT GTGCCATCTG CCCCCATCGA CCAGTACTAG ACACGCTGGC CATGTTGACA 
GCCCACCGTG CAGGCAAGAA GCATTTGTCC AGTCTGAAGC TTTTCTATGG CAAAAAGCAA 
ACAGGCAAGG GAACAGAGCA AAATCCAAGA CAGCAGAACG AATTGAAGAC AGAAAGCAAA 
ACTGAGCTCT GGATGGGTCC CAGATGGACG AGGTCGATGG ATAAAGGATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017175205.1
CDS	156..506
Translation	MSFKREGDDWSQLNVLKKRRVGDLLASYIPEDEALMLRDGRFACAICPHRPVLDTLAMLTAHRAGKKHLSSLKLFYGKKQTGKGTEQNPRQQNELKTESKTELWMGPRWTRSMDKG

Target ORF information:

RefSeq Version	XM_017319716.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus sodium channel modifier 1 (Scnm1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017319716.2

ORF Insert Sequence:

ATGTCTTTTA AGAGGGAAGG GGACGACTGG AGTCAACTCA ATGTGCTCAA AAAACGGAGA 
GTTGGGGACC TGCTGGCTAG TTACATCCCT GAGGACGAGG CACTGATGCT GCGGGATGGA 
CGCTTTGCTT GTGCCATCTG CCCCCATCGA CCAGTACTAG ACACGCTGGC CATGTTGACA 
GCCCACCGTG CAGGCAAGAA GCATTTGTCC AGTCTGAAGC TTTTCTATGG CAAAAAGCAA 
ACAGGCAAGG GAACAGAGCA AAATCCAAGA CAGCAGAACG AATTGAAGAC AGAAAGCAAA 
ACTGAGCTCT GGATGGGTCC CAGATGGACG AGGTCGATGG ATAAAGGATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Widespread and dynamic translational control of red blood cell development.
Blood129(5)619-629(2017 02)
Alvarez-Dominguez JR,Zhang X,Hu W

A targeted deleterious allele of the splicing factor SCNM1 in the mouse.
Genetics180(3)1419-27(2008 Nov)
Howell VM,de Haan G,Bergren S,Jones JM,Culiat CT,Michaud EJ,Frankel WN,Meisler MH

Evidence for a direct role of the disease modifier SCNM1 in splicing.
Human molecular genetics16(20)2506-16(2007 Oct)
Howell VM,Jones JM,Bergren SK,Li L,Billi AC,Avenarius MR,Meisler MH

Efficient gene-driven germ-line point mutagenesis of C57BL/6J mice.
BMC genomics6164(2005 Nov)
Michaud EJ,Culiat CT,Klebig ML,Barker PE,Cain KT,Carpenter DJ,Easter LL,Foster CM,Gardner AW,Guo ZY,Houser KJ,Hughes LA,Kerley MK,Liu Z,Olszewski RE,Pinn I,Shaw GD,Shinpock SG,Wymore AM,Rinchik EM,Johnson DK

High-resolution mapping of the sodium channel modifier Scnm1 on mouse chromosome 3 and identification of a 1.3-kb recombination hot spot.
Genomics82(4)452-9(2003 Oct)
Buchner DA,Trudeau M,George AL Jr,Sprunger LK,Meisler MH

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Scnm1 cDNA ORF clone, Mus musculus(house mouse)

Gene

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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