gRNAs
The following Dock5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dock5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OMu78845 | |
| Clone ID Related Accession (Same CDS sequence) | XM_017316175.1 | |
| Accession Version | XM_017316175.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 3945bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-08-07 | |
| Organism | Mus musculus(house mouse) | |
| Product | dedicator of cytokinesis protein 5 isoform X2 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000080.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGAACGCAG ATGGTACCAC GCTGCAGGAT GGGAGGCACG ACCTGGTGGT GTACAAGGGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_017171664.1 |
| CDS | 117..4061 |
| Translation |
Target ORF information:
Target ORF information:
|
 XM_017316175.1 |
1 | ATGAACGCAG ATGGTACCAC GCTGCAGGAT GGGAGGCACG ACCTGGTGGT GTACAAGGGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OMu20827 | |
| Clone ID Related Accession (Same CDS sequence) | NM_177780.3 | |
| Accession Version | NM_177780.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 5607bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-08-03 | |
| Organism | Mus musculus(house mouse) | |
| Product | dedicator of cytokinesis protein 5 | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC090431.9, AK147975.1, CF746784.1, BC050992.1, AC093020.6 and AK004325.1. On or before Jun 12, 2008 this sequence version replaced NM_172811.1, XM_001003634.1, XM_001003643.1, XM_001003628.1, XM_001003638.1, XM_990099.1, XM_619261.3, XM_619262.3, XM_990127.1, XM_001001616.1, XM_001001588.1, NM_177780.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC158046.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGGCCCGTT GGATCCCTAC CAAGAGGCAG AAGTATGGGG TTGCCATCTA CAACTACAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_808448.2 |
| CDS | 239..5845 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_177780.3 |
1 | ATGGCCCGTT GGATCCCTAC CAAGAGGCAG AAGTATGGGG TTGCCATCTA CAACTACAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OMu70338 | |
| Clone ID Related Accession (Same CDS sequence) | XM_011245170.2 | |
| Accession Version | XM_011245170.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 5580bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-08-07 | |
| Organism | Mus musculus(house mouse) | |
| Product | dedicator of cytokinesis protein 5 isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000080.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_011245170.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGTTCAATG AACTGGCCAT CTACAACTAC AATGCATCTC AAGATGTGGA GCTCTCCTTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_011243472.1 |
| CDS | 46..5625 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_011245170.2 |
1 | ATGTTCAATG AACTGGCCAT CTACAACTAC AATGCATCTC AAGATGTGGA GCTCTCCTTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Tensins are versatile regulators of Rho GTPase signalling and cell adhesion. |
Tensin 3 is a new partner of Dock5 that controls osteoclast podosome organization and activity. |
Pharmacological inhibition of Dock5 prevents osteolysis by affecting osteoclast podosome organization while preserving bone formation. |
DOCK2 and DOCK5 act additively in neutrophils to regulate chemotaxis, superoxide production, and extracellular trap formation. |
The mineral dissolution function of osteoclasts is dispensable for hypertrophic cartilage degradation during long bone development and growth. |
