Ube2c cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ube2c
Entrez Gene ID	68612
Full Name	ubiquitin-conjugating enzyme E2C
Synonyms	1110015A16Rik,D2Ertd695e
General protein information	Preferred Names ubiquitin-conjugating enzyme E2C Names ubiquitin-conjugating enzyme E2 C (E3-independent) E2 ubiquitin-conjugating enzyme C E2 ubiquitin-conjugating enzyme C ubcH10 ubiquitin carrier protein C ubiquitin-protein ligase C
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 2 Map Location: 2 H3\|2 85.27 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_026785.2	NP_081061.1	ubiquitin-conjugating enzyme E2 C

Pathways from BioSystems

Homologies

Magnaporthe oryzae (rice blast fungus)	MGG_03728	XP_003716152.1
Bos taurus (cattle)	UBE2C	NP_001032526.1
Schizosaccharomyces pombe (fission yeast)	ubc11	NP_588069.1
Homo sapiens (human)	UBE2C	NP_008950.1
Canis lupus familiaris (dog)	UBE2C	XP_543022.2
Mus musculus (house mouse)	Ube2c	NP_081061.1
Danio rerio (zebrafish)	ube2c	NP_001032780.1
Drosophila melanogaster (fruit fly)	vih	NP_648582.1
Saccharomyces cerevisiae (baker's yeast)	UBC11	NP_014984.3
Arabidopsis thaliana (thale cress)	UBC20	NP_564572.1
Xenopus tropicalis (tropical clawed frog)	ube2c	NP_001095283.1
Pan troglodytes (chimpanzee)	UBE2C	XP_514682.2
	UBE2C	XP_001104061.1
Gallus gallus (chicken)	UBE2C	XP_003642518.2
Arabidopsis thaliana (thale cress)	UBC19	NP_566653.1
Oryza sativa (rice)	Os01g0273100	NP_001042713.1
Rattus norvegicus (Norway rat)	Ube2c	NP_001100012.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006238	XP_316306.3

Gene Ontology
Bibliography

Related articles in PubMed

Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program.
Sundberg JP, Dadras SS, Silva KA, Kennedy VE, Garland G, Murray SA, Sundberg BA, Schofield PN, Pratt CH
PloS one12(7)e0180682(2017)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Appropriate expression of Ube2C and Ube2S controls the progression of the first meiotic division.
Ben-Eliezer I, Pomerantz Y, Galiani D, Nevo N, Dekel N
FASEB journal : official publication of the Federation of American Societies for Experimental Biology29(11)4670-81(2015 Nov)

The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells.
Ray JP, Staron MM, Shyer JA, Ho PC, Marshall HD, Gray SM, Laidlaw BJ, Araki K, Ahmed R, Kaech SM, Craft J
Immunity43(4)690-702(2015 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

alongside their canonical function in protein degradation, Ube2C and -S also control the extrusion of the first polar body.
Title: Appropriate expression of Ube2C and Ube2S controls the progression of the first meiotic division.

UbcH10 overexpression increases carcinogenesis and blocks ALLN susceptibility in colorectal cancer.
Title: UbcH10 overexpression increases carcinogenesis and blocks ALLN susceptibility in colorectal cancer.

results identify UbcH10 as a prominent protooncogene that causes whole chromosome instability and tumor formation over a wide gradient of overexpression levels
Title: Overexpression of the E2 ubiquitin-conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation.

The following Ube2c gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ube2c cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu03009	NM_026785.2 Latest version!	Mus musculus ubiquitin-conjugating enzyme E2C (Ube2c), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ube2c ( NM_026785.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_081061.1 Mus musculus ubiquitin-conjugating enzyme E2C (Ube2c), mRNA.

Price & Availability↑

CloneID	OMu03009
Clone ID Related Accession (Same CDS sequence)	NM_026785.2
Accession Version	NM_026785.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 540bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-20
Organism	Mus musculus(house mouse)
Product	ubiquitin-conjugating enzyme E2 C
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AK003722.1. On Apr 6, 2007 this sequence version replaced NM_026785.1. ##Evidence-Data-START## Transcript exon combination :: AK003722.1, BU514529.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGCCTCAC AAAACCGCGA CCCAGCTGCT GCCAGCGTTG CCGCGGTTCG AAAAGGAGCC 
GAGCCCTGCG GGGGCGCCGC CCGAGGCCCT GTGGGCAAGC GGCTACAGCA GGAACTGATG 
ATCCTCATGA CATCTGGTGA CAAAGGAATC TCCGCCTTCC CTGAGTCAGA CAACCTGTTC 
AAGTGGGTGG GGACCATCCA CGGAGCAGCC GGCACCGTAT ATGAAGACCT GAGGTACAAA 
CTCTCCCTAG AGTTCCCCAG CGGCTACCCT TACAACGCAC CCACAGTGAA GTTCCTCACA 
CCCTGCTACC ACCCCAACGT GGACACCCAG GGCAACATCT GCCTGGACAT CCTCAAGGAT 
AAGTGGTCTG CACTATATGA TGTCAGGACT ATCTTGCTCT CTATCCAGAG CCTGCTAGGA 
GAACCCAACA TCGATAGCCC TTTGAACACA CACGCTGCGG AACTCTGGAA AAACCCCACA 
GCATTTAAGA AATACCTGCA AGAAACCTAT TCAAAGCAGG TCTCCAGCCA AGATCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_081061.1
CDS	52..591
Translation	MASQNRDPAAASVAAVRKGAEPCGGAARGPVGKRLQQELMILMTSGDKGISAFPESDNLFKWVGTIHGAAGTVYEDLRYKLSLEFPSGYPYNAPTVKFLTPCYHPNVDTQGNICLDILKDKWSALYDVRTILLSIQSLLGEPNIDSPLNTHAAELWKNPTAFKKYLQETYSKQVSSQDP

Target ORF information:

RefSeq Version	NM_026785.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus ubiquitin-conjugating enzyme E2C (Ube2c), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_026785.2

ORF Insert Sequence:

ATGGCCTCAC AAAACCGCGA CCCAGCTGCT GCCAGCGTTG CCGCGGTTCG AAAAGGAGCC 
GAGCCCTGCG GGGGCGCCGC CCGAGGCCCT GTGGGCAAGC GGCTACAGCA GGAACTGATG 
ATCCTCATGA CATCTGGTGA CAAAGGAATC TCCGCCTTCC CTGAGTCAGA CAACCTGTTC 
AAGTGGGTGG GGACCATCCA CGGAGCAGCC GGCACCGTAT ATGAAGACCT GAGGTACAAA 
CTCTCCCTAG AGTTCCCCAG CGGCTACCCT TACAACGCAC CCACAGTGAA GTTCCTCACA 
CCCTGCTACC ACCCCAACGT GGACACCCAG GGCAACATCT GCCTGGACAT CCTCAAGGAT 
AAGTGGTCTG CACTATATGA TGTCAGGACT ATCTTGCTCT CTATCCAGAG CCTGCTAGGA 
GAACCCAACA TCGATAGCCC TTTGAACACA CACGCTGCGG AACTCTGGAA AAACCCCACA 
GCATTTAAGA AATACCTGCA AGAAACCTAT TCAAAGCAGG TCTCCAGCCA AGATCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program.
PloS one12(7)e0180682(2017)
Sundberg JP,Dadras SS,Silva KA,Kennedy VE,Garland G,Murray SA,Sundberg BA,Schofield PN,Pratt CH

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Appropriate expression of Ube2C and Ube2S controls the progression of the first meiotic division.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology29(11)4670-81(2015 Nov)
Ben-Eliezer I,Pomerantz Y,Galiani D,Nevo N,Dekel N

The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells.
Immunity43(4)690-702(2015 Oct)
Ray JP,Staron MM,Shyer JA,Ho PC,Marshall HD,Gray SM,Laidlaw BJ,Araki K,Ahmed R,Kaech SM,Craft J