Rnf41 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Rnf41
Entrez Gene ID	67588
Full Name	ring finger protein 41
Synonyms	2210404G21Rik,4930511A05Rik,4933415P08Rik,D10Ertd722e,FLRF,Nrdp1
General protein information	Preferred Names ring finger protein 41 Names E3 ubiquitin-protein ligase NRDP1 RING-type E3 ubiquitin transferase NRDP1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 10 Map Location: 10 D3\|10 76.55 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_001164237.1	NP_001157709.1	E3 ubiquitin-protein ligase NRDP1
XM_011243540.1	XP_011241842.1	E3 ubiquitin-protein ligase NRDP1 isoform X1
NM_026259.3	NP_080535.2	E3 ubiquitin-protein ligase NRDP1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Rnf41	NP_001157709.1
Rattus norvegicus (Norway rat)	Rnf41	NP_001012195.1
Gallus gallus (chicken)	RNF41	XP_424113.3
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001882	XP_321185.3
Bos taurus (cattle)	RNF41	NP_001039990.1
Drosophila melanogaster (fruit fly)	elgi	NP_001261904.1
Pan troglodytes (chimpanzee)	RNF41	XP_001169244.1
	RNF41	XP_001114651.1
Xenopus tropicalis (tropical clawed frog)	rnf41	XP_004911929.1
Homo sapiens (human)	RNF41	NP_001229755.1
Canis lupus familiaris (dog)	RNF41	XP_848722.1
Danio rerio (zebrafish)	rnf41	NP_998681.1

Gene Ontology
Bibliography

Related articles in PubMed

K33-linked polyubiquitination of Zap70 by Nrdp1 controls CD8(+) T cell activation.
Yang M, Chen T, Li X, Yu Z, Tang S, Wang C, Gu Y, Liu Y, Xu S, Li W, Zhang X, Wang J, Cao X
Nature immunology16(12)1253-62(2015 Dec)

Diabetes Susceptibility Genes Pdx1 and Clec16a Function in a Pathway Regulating Mitophagy in ?-Cells.
Soleimanpour SA, Ferrari AM, Raum JC, Groff DN, Yang J, Kaufman BA, Stoffers DA
Diabetes64(10)3475-84(2015 Oct)

The diabetes susceptibility gene Clec16a regulates mitophagy.
Soleimanpour SA, Gupta A, Bakay M, Ferrari AM, Groff DN, Fadista J, Spruce LA, Kushner JA, Groop L, Seeholzer SH, Kaufman BA, Hakonarson H, Stoffers DA
Cell157(7)1577-90(2014 Jun)

The E3 ubiquitin ligase neuregulin receptor degradation protein 1 (Nrdp1) promotes M2 macrophage polarization by ubiquitinating and activating transcription factor CCAAT/enhancer-binding Protein ? (C/EBP?).
Ye S, Xu H, Jin J, Yang M, Wang C, Yu Y, Cao X
The Journal of biological chemistry287(32)26740-8(2012 Aug)

Overexpression of Nrdp1 in the heart exacerbates doxorubicin-induced cardiac dysfunction in mice.
Zhang Y, Kang YM, Tian C, Zeng Y, Jia LX, Ma X, Du J, Li HH
PloS one6(6)e21104(2011)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that ring finger protein 41 Nrdp1 terminates T cell antigen receptors (TCRs) signaling by inactivating Zap70 kinase.
Title: K33-linked polyubiquitination of Zap70 by Nrdp1 controls CD8(+) T cell activation.

The novel Pdx1-Clec16a-Nrdp1 pathway this study describes provides a genetic basis for the pathogenesis of mitochondrial dysfunction in multiple forms of diabetes.
Title: Diabetes Susceptibility Genes Pdx1 and Clec16a Function in a Pathway Regulating Mitophagy in ?-Cells.

demonstrate that Nrdp1-mediated ubiquitination and activation of C/EBPbeta contributes to a ubiquitin-dependent nonproteolytic pathway that up-regulates Arg1 expression and promotes M2 macrophage polarization
Title: The E3 ubiquitin ligase neuregulin receptor degradation protein 1 (Nrdp1) promotes M2 macrophage polarization by ubiquitinating and activating transcription factor CCAAT/enhancer-binding Protein ? (C/EBP?).

these results provide evidence for an important role for Nrdp1 in regulating ischemia/reperfusioninduced cardiac injury
Title: Cardiac-specific overexpression of E3 ligase Nrdp1 increases ischemia and reperfusion-induced cardiac injury.

Nrdp1 may be a key mediator in the development of cardiac dysfunction after DOX treatment and associated with inhibition of Akt, ERK1/2 and STAT3.
Title: Overexpression of Nrdp1 in the heart exacerbates doxorubicin-induced cardiac dysfunction in mice.

The following Rnf41 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rnf41 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu01886	NM_001164237.1 Latest version!	Mus musculus ring finger protein 41 (Rnf41), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OMu01886	NM_026259.3 Latest version!	Mus musculus ring finger protein 41 (Rnf41), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OMu01886	XM_011243540.1 Latest version!	Mus musculus ring finger protein 41 (Rnf41), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rnf41 ( NM_001164237.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001157709.1 Mus musculus ring finger protein 41 (Rnf41), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu01886
Clone ID Related Accession (Same CDS sequence)	NM_001164237.1 , XM_011243540.1 , NM_026259.3
Accession Version	NM_001164237.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 954bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-21
Organism	Mus musculus(house mouse)
Product	E3 ubiquitin-protein ligase NRDP1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK045760.1, AK028551.1 and BC049078.1. Transcript Variant: This variant (1) represents the longest transcript which encodes a functional protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660821.105364.1, SRR1660821.132955.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGTATG ATGTGACCCG TTTCCAGGGG GACGTTGACG AGGACCTTAT CTGCCCTATT 
TGCAGTGGAG TCTTGGAGGA GCCAGTGCAG GCGCCTCATT GTGAGCATGC CTTCTGCAAC 
GCCTGCATCA CCCAATGGTT CTCTCAGCAG CAGACGTGTC CGGTAGACCG TAGCGTTGTC 
ACGGTTGCCC ACCTGCGCCC AGTACCTCGG ATCATGCGGA ACATGTTGTC AAAGCTACAG 
ATTGCCTGTG ACAACGCTGT GTTTGGCTGC AGTGCTGTTG TCAGGCTTGA CAACCTCATG 
TCCCACCTCA GTGACTGTGA GCACAACCCG AAGCGGCCTG TGACCTGTGA GCAGGGCTGT 
GGCCTGGAGA TGCCCAAAGA TGAACTGCCA AACCACAATT GCATTAAGCA CCTGCGCTCC 
GTGGTCCAGC AGCAGCAGTC GCGCATTGCA GAGCTGGAGA AGACCTCGGC TGAACACAAG 
CACCAGCTGG CAGAGCAGAA GCGAGACATT CAGCTGCTGA AGGCGTATAT GCGAGCCATC 
CGCAGTGTCA ACCCCAACCT TCAGAACCTG GAGGAGACAA TCGAATACAA TGAGATCCTC 
GAGTGGGTGA ACTCCCTGCA GCCGGCAAGG GTGACCCGCT GGGGGGGCAT GATCTCCACT 
CCTGATGCTG TGCTCCAGGC TGTCATCAAG CGCTCCCTCG TGGAAAGTGG CTGCCCGGCC 
TCCATCGTCA ACGAGCTGAT TGAAAATGCC CATGAACGCA GCTGGCCCCA GGGTCTGGCC 
ACACTAGAGA CAAGACAGAT GAACCGGCGC TACTATGAGA ACTACGTGGC CAAGCGCATC 
CCTGGCAAGC AGGCTGTAGT GGTGATGGCC TGTGAGAACC AGCACATGGG GGACGACATG 
GTGCAGGAGC CAGGGCTCGT CATGATATTT GCGCATGGTG TGGAGGAGAT ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001157709.1
CDS	417..1370
Translation	MGYDVTRFQGDVDEDLICPICSGVLEEPVQAPHCEHAFCNACITQWFSQQQTCPVDRSVVTVAHLRPVPRIMRNMLSKLQIACDNAVFGCSAVVRLDNLMSHLSDCEHNPKRPVTCEQGCGLEMPKDELPNHNCIKHLRSVVQQQQSRIAELEKTSAEHKHQLAEQKRDIQLLKAYMRAIRSVNPNLQNLEETIEYNEILEWVNSLQPARVTRWGGMISTPDAVLQAVIKRSLVESGCPASIVNELIENAHERSWPQGLATLETRQMNRRYYENYVAKRIPGKQAVVVMACENQHMGDDMVQEPGLVMIFAHGVEEI

Target ORF information:

RefSeq Version	NM_001164237.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus ring finger protein 41 (Rnf41), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001164237.1

ORF Insert Sequence:

ATGGGGTATG ATGTGACCCG TTTCCAGGGG GACGTTGACG AGGACCTTAT CTGCCCTATT 
TGCAGTGGAG TCTTGGAGGA GCCAGTGCAG GCGCCTCATT GTGAGCATGC CTTCTGCAAC 
GCCTGCATCA CCCAATGGTT CTCTCAGCAG CAGACGTGTC CGGTAGACCG TAGCGTTGTC 
ACGGTTGCCC ACCTGCGCCC AGTACCTCGG ATCATGCGGA ACATGTTGTC AAAGCTACAG 
ATTGCCTGTG ACAACGCTGT GTTTGGCTGC AGTGCTGTTG TCAGGCTTGA CAACCTCATG 
TCCCACCTCA GTGACTGTGA GCACAACCCG AAGCGGCCTG TGACCTGTGA GCAGGGCTGT 
GGCCTGGAGA TGCCCAAAGA TGAACTGCCA AACCACAATT GCATTAAGCA CCTGCGCTCC 
GTGGTCCAGC AGCAGCAGTC GCGCATTGCA GAGCTGGAGA AGACCTCGGC TGAACACAAG 
CACCAGCTGG CAGAGCAGAA GCGAGACATT CAGCTGCTGA AGGCGTATAT GCGAGCCATC 
CGCAGTGTCA ACCCCAACCT TCAGAACCTG GAGGAGACAA TCGAATACAA TGAGATCCTC 
GAGTGGGTGA ACTCCCTGCA GCCGGCAAGG GTGACCCGCT GGGGGGGCAT GATCTCCACT 
CCTGATGCTG TGCTCCAGGC TGTCATCAAG CGCTCCCTCG TGGAAAGTGG CTGCCCGGCC 
TCCATCGTCA ACGAGCTGAT TGAAAATGCC CATGAACGCA GCTGGCCCCA GGGTCTGGCC 
ACACTAGAGA CAAGACAGAT GAACCGGCGC TACTATGAGA ACTACGTGGC CAAGCGCATC 
CCTGGCAAGC AGGCTGTAGT GGTGATGGCC TGTGAGAACC AGCACATGGG GGACGACATG 
GTGCAGGAGC CAGGGCTCGT CATGATATTT GCGCATGGTG TGGAGGAGAT ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Rnf41 ( NM_026259.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_080535.2 Mus musculus ring finger protein 41 (Rnf41), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu01886
Clone ID Related Accession (Same CDS sequence)	NM_001164237.1 , XM_011243540.1 , NM_026259.3
Accession Version	NM_026259.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 954bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-21
Organism	Mus musculus(house mouse)
Product	E3 ubiquitin-protein ligase NRDP1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK045760.1 and BC049078.1. On Aug 15, 2009 this sequence version replaced NM_026259.2. Transcript Variant: This variant (2) lacks an internal segment in the 3' UTR, compared to variant 1. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC049078.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849376, SAMN00849382 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGTATG ATGTGACCCG TTTCCAGGGG GACGTTGACG AGGACCTTAT CTGCCCTATT 
TGCAGTGGAG TCTTGGAGGA GCCAGTGCAG GCGCCTCATT GTGAGCATGC CTTCTGCAAC 
GCCTGCATCA CCCAATGGTT CTCTCAGCAG CAGACGTGTC CGGTAGACCG TAGCGTTGTC 
ACGGTTGCCC ACCTGCGCCC AGTACCTCGG ATCATGCGGA ACATGTTGTC AAAGCTACAG 
ATTGCCTGTG ACAACGCTGT GTTTGGCTGC AGTGCTGTTG TCAGGCTTGA CAACCTCATG 
TCCCACCTCA GTGACTGTGA GCACAACCCG AAGCGGCCTG TGACCTGTGA GCAGGGCTGT 
GGCCTGGAGA TGCCCAAAGA TGAACTGCCA AACCACAATT GCATTAAGCA CCTGCGCTCC 
GTGGTCCAGC AGCAGCAGTC GCGCATTGCA GAGCTGGAGA AGACCTCGGC TGAACACAAG 
CACCAGCTGG CAGAGCAGAA GCGAGACATT CAGCTGCTGA AGGCGTATAT GCGAGCCATC 
CGCAGTGTCA ACCCCAACCT TCAGAACCTG GAGGAGACAA TCGAATACAA TGAGATCCTC 
GAGTGGGTGA ACTCCCTGCA GCCGGCAAGG GTGACCCGCT GGGGGGGCAT GATCTCCACT 
CCTGATGCTG TGCTCCAGGC TGTCATCAAG CGCTCCCTCG TGGAAAGTGG CTGCCCGGCC 
TCCATCGTCA ACGAGCTGAT TGAAAATGCC CATGAACGCA GCTGGCCCCA GGGTCTGGCC 
ACACTAGAGA CAAGACAGAT GAACCGGCGC TACTATGAGA ACTACGTGGC CAAGCGCATC 
CCTGGCAAGC AGGCTGTAGT GGTGATGGCC TGTGAGAACC AGCACATGGG GGACGACATG 
GTGCAGGAGC CAGGGCTCGT CATGATATTT GCGCATGGTG TGGAGGAGAT ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_080535.2
CDS	417..1370
Translation	MGYDVTRFQGDVDEDLICPICSGVLEEPVQAPHCEHAFCNACITQWFSQQQTCPVDRSVVTVAHLRPVPRIMRNMLSKLQIACDNAVFGCSAVVRLDNLMSHLSDCEHNPKRPVTCEQGCGLEMPKDELPNHNCIKHLRSVVQQQQSRIAELEKTSAEHKHQLAEQKRDIQLLKAYMRAIRSVNPNLQNLEETIEYNEILEWVNSLQPARVTRWGGMISTPDAVLQAVIKRSLVESGCPASIVNELIENAHERSWPQGLATLETRQMNRRYYENYVAKRIPGKQAVVVMACENQHMGDDMVQEPGLVMIFAHGVEEI

Target ORF information:

RefSeq Version	NM_026259.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus ring finger protein 41 (Rnf41), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_026259.3

ORF Insert Sequence:

ATGGGGTATG ATGTGACCCG TTTCCAGGGG GACGTTGACG AGGACCTTAT CTGCCCTATT 
TGCAGTGGAG TCTTGGAGGA GCCAGTGCAG GCGCCTCATT GTGAGCATGC CTTCTGCAAC 
GCCTGCATCA CCCAATGGTT CTCTCAGCAG CAGACGTGTC CGGTAGACCG TAGCGTTGTC 
ACGGTTGCCC ACCTGCGCCC AGTACCTCGG ATCATGCGGA ACATGTTGTC AAAGCTACAG 
ATTGCCTGTG ACAACGCTGT GTTTGGCTGC AGTGCTGTTG TCAGGCTTGA CAACCTCATG 
TCCCACCTCA GTGACTGTGA GCACAACCCG AAGCGGCCTG TGACCTGTGA GCAGGGCTGT 
GGCCTGGAGA TGCCCAAAGA TGAACTGCCA AACCACAATT GCATTAAGCA CCTGCGCTCC 
GTGGTCCAGC AGCAGCAGTC GCGCATTGCA GAGCTGGAGA AGACCTCGGC TGAACACAAG 
CACCAGCTGG CAGAGCAGAA GCGAGACATT CAGCTGCTGA AGGCGTATAT GCGAGCCATC 
CGCAGTGTCA ACCCCAACCT TCAGAACCTG GAGGAGACAA TCGAATACAA TGAGATCCTC 
GAGTGGGTGA ACTCCCTGCA GCCGGCAAGG GTGACCCGCT GGGGGGGCAT GATCTCCACT 
CCTGATGCTG TGCTCCAGGC TGTCATCAAG CGCTCCCTCG TGGAAAGTGG CTGCCCGGCC 
TCCATCGTCA ACGAGCTGAT TGAAAATGCC CATGAACGCA GCTGGCCCCA GGGTCTGGCC 
ACACTAGAGA CAAGACAGAT GAACCGGCGC TACTATGAGA ACTACGTGGC CAAGCGCATC 
CCTGGCAAGC AGGCTGTAGT GGTGATGGCC TGTGAGAACC AGCACATGGG GGACGACATG 
GTGCAGGAGC CAGGGCTCGT CATGATATTT GCGCATGGTG TGGAGGAGAT ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Rnf41 ( XM_011243540.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_011241842.1 Mus musculus ring finger protein 41 (Rnf41), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu01886
Clone ID Related Accession (Same CDS sequence)	NM_001164237.1 , XM_011243540.1 , NM_026259.3
Accession Version	XM_011243540.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 954bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-02-08
Organism	Mus musculus(House mouse)
Product	E3 ubiquitin-protein ligase NRDP1 isoform X1
Comment

ATGGGGTATG ATGTGACCCG TTTCCAGGGG GACGTTGACG AGGACCTTAT CTGCCCTATT 
TGCAGTGGAG TCTTGGAGGA GCCAGTGCAG GCGCCTCATT GTGAGCATGC CTTCTGCAAC 
GCCTGCATCA CCCAATGGTT CTCTCAGCAG CAGACGTGTC CGGTAGACCG TAGCGTTGTC 
ACGGTTGCCC ACCTGCGCCC AGTACCTCGG ATCATGCGGA ACATGTTGTC AAAGCTACAG 
ATTGCCTGTG ACAACGCTGT GTTTGGCTGC AGTGCTGTTG TCAGGCTTGA CAACCTCATG 
TCCCACCTCA GTGACTGTGA GCACAACCCG AAGCGGCCTG TGACCTGTGA GCAGGGCTGT 
GGCCTGGAGA TGCCCAAAGA TGAACTGCCA AACCACAATT GCATTAAGCA CCTGCGCTCC 
GTGGTCCAGC AGCAGCAGTC GCGCATTGCA GAGCTGGAGA AGACCTCGGC TGAACACAAG 
CACCAGCTGG CAGAGCAGAA GCGAGACATT CAGCTGCTGA AGGCGTATAT GCGAGCCATC 
CGCAGTGTCA ACCCCAACCT TCAGAACCTG GAGGAGACAA TCGAATACAA TGAGATCCTC 
GAGTGGGTGA ACTCCCTGCA GCCGGCAAGG GTGACCCGCT GGGGGGGCAT GATCTCCACT 
CCTGATGCTG TGCTCCAGGC TGTCATCAAG CGCTCCCTCG TGGAAAGTGG CTGCCCGGCC 
TCCATCGTCA ACGAGCTGAT TGAAAATGCC CATGAACGCA GCTGGCCCCA GGGTCTGGCC 
ACACTAGAGA CAAGACAGAT GAACCGGCGC TACTATGAGA ACTACGTGGC CAAGCGCATC 
CCTGGCAAGC AGGCTGTAGT GGTGATGGCC TGTGAGAACC AGCACATGGG GGACGACATG 
GTGCAGGAGC CAGGGCTCGT CATGATATTT GCGCATGGTG TGGAGGAGAT ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011241842.1
Translation	MGYDVTRFQGDVDEDLICPICSGVLEEPVQAPHCEHAFCNACITQWFSQQQTCPVDRSVVTVAHLRPVPRIMRNMLSKLQIACDNAVFGCSAVVRLDNLMSHLSDCEHNPKRPVTCEQGCGLEMPKDELPNHNCIKHLRSVVQQQQSRIAELEKTSAEHKHQLAEQKRDIQLLKAYMRAIRSVNPNLQNLEETIEYNEILEWVNSLQPARVTRWGGMISTPDAVLQAVIKRSLVESGCPASIVNELIENAHERSWPQGLATLETRQMNRRYYENYVAKRIPGKQAVVVMACENQHMGDDMVQEPGLVMIFAHGVEEI

Target ORF information:

RefSeq Version	XM_011243540.1
Organism	Mus musculus(House mouse)
Definition	Mus musculus ring finger protein 41 (Rnf41), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011243540.1

ORF Insert Sequence:

ATGGGGTATG ATGTGACCCG TTTCCAGGGG GACGTTGACG AGGACCTTAT CTGCCCTATT 
TGCAGTGGAG TCTTGGAGGA GCCAGTGCAG GCGCCTCATT GTGAGCATGC CTTCTGCAAC 
GCCTGCATCA CCCAATGGTT CTCTCAGCAG CAGACGTGTC CGGTAGACCG TAGCGTTGTC 
ACGGTTGCCC ACCTGCGCCC AGTACCTCGG ATCATGCGGA ACATGTTGTC AAAGCTACAG 
ATTGCCTGTG ACAACGCTGT GTTTGGCTGC AGTGCTGTTG TCAGGCTTGA CAACCTCATG 
TCCCACCTCA GTGACTGTGA GCACAACCCG AAGCGGCCTG TGACCTGTGA GCAGGGCTGT 
GGCCTGGAGA TGCCCAAAGA TGAACTGCCA AACCACAATT GCATTAAGCA CCTGCGCTCC 
GTGGTCCAGC AGCAGCAGTC GCGCATTGCA GAGCTGGAGA AGACCTCGGC TGAACACAAG 
CACCAGCTGG CAGAGCAGAA GCGAGACATT CAGCTGCTGA AGGCGTATAT GCGAGCCATC 
CGCAGTGTCA ACCCCAACCT TCAGAACCTG GAGGAGACAA TCGAATACAA TGAGATCCTC 
GAGTGGGTGA ACTCCCTGCA GCCGGCAAGG GTGACCCGCT GGGGGGGCAT GATCTCCACT 
CCTGATGCTG TGCTCCAGGC TGTCATCAAG CGCTCCCTCG TGGAAAGTGG CTGCCCGGCC 
TCCATCGTCA ACGAGCTGAT TGAAAATGCC CATGAACGCA GCTGGCCCCA GGGTCTGGCC 
ACACTAGAGA CAAGACAGAT GAACCGGCGC TACTATGAGA ACTACGTGGC CAAGCGCATC 
CCTGGCAAGC AGGCTGTAGT GGTGATGGCC TGTGAGAACC AGCACATGGG GGACGACATG 
GTGCAGGAGC CAGGGCTCGT CATGATATTT GCGCATGGTG TGGAGGAGAT ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

K33-linked polyubiquitination of Zap70 by Nrdp1 controls CD8(+) T cell activation.
Nature immunology16(12)1253-62(2015 Dec)
Yang M,Chen T,Li X,Yu Z,Tang S,Wang C,Gu Y,Liu Y,Xu S,Li W,Zhang X,Wang J,Cao X

Diabetes Susceptibility Genes Pdx1 and Clec16a Function in a Pathway Regulating Mitophagy in ?-Cells.
Diabetes64(10)3475-84(2015 Oct)
Soleimanpour SA,Ferrari AM,Raum JC,Groff DN,Yang J,Kaufman BA,Stoffers DA

The diabetes susceptibility gene Clec16a regulates mitophagy.
Cell157(7)1577-90(2014 Jun)
Soleimanpour SA,Gupta A,Bakay M,Ferrari AM,Groff DN,Fadista J,Spruce LA,Kushner JA,Groop L,Seeholzer SH,Kaufman BA,Hakonarson H,Stoffers DA

The E3 ubiquitin ligase neuregulin receptor degradation protein 1 (Nrdp1) promotes M2 macrophage polarization by ubiquitinating and activating transcription factor CCAAT/enhancer-binding Protein ? (C/EBP?).
The Journal of biological chemistry287(32)26740-8(2012 Aug)
Ye S,Xu H,Jin J,Yang M,Wang C,Yu Y,Cao X

Overexpression of Nrdp1 in the heart exacerbates doxorubicin-induced cardiac dysfunction in mice.
PloS one6(6)e21104(2011)
Zhang Y,Kang YM,Tian C,Zeng Y,Jia LX,Ma X,Du J,Li HH

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Rnf41 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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