Gatm cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gatm
Entrez Gene ID	67092
Full Name	glycine amidinotransferase (L-arginine:glycine amidinotransferase)
Synonyms	1810003P21Rik,AI314789,AT
General protein information	Preferred Names glycine amidinotransferase (L-arginine:glycine amidinotransferase) Names glycine amidinotransferase, mitochondrial L-arginine:glycine amidinotransferase transamidinase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 2 Map Location: 2 E5\|2 60.63 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_025961.5	NP_080237.1	glycine amidinotransferase, mitochondrial precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	GATM	XP_001163621.2
Rattus norvegicus (Norway rat)	Gatm	NP_112293.1
	GATM	XP_001111604.1
Danio rerio (zebrafish)	gatm	NP_955825.1
Xenopus tropicalis (tropical clawed frog)	gatm	NP_988971.1
Neurospora crassa	NCU07176	XP_957401.1
Homo sapiens (human)	GATM	NP_001473.1
Bos taurus (cattle)	GATM	NP_001039343.1
Mus musculus (house mouse)	Gatm	NP_080237.1
Canis lupus familiaris (dog)	GATM	XP_544663.2
Gallus gallus (chicken)	GATM	NP_990076.1

Gene Ontology
Bibliography

Related articles in PubMed

Impaired cardiac contractile function in AGAT knockout mice devoid of creatine is rescued by homoarginine but not creatine.
Faller KME, Atzler D, McAndrew DJ, Zervou S, Whittington HJ, Simon JN, Aksentijevic D, Hove MT, Choe CU, Isbrandt D, Casadei B, Schneider JE, Neubauer S, Lygate CA
Cardiovascular research(2017 Dec)

Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity.
Kazak L, Chouchani ET, Lu GZ, Jedrychowski MP, Bare CJ, Mina AI, Kumari M, Zhang S, Vuckovic I, Laznik-Bogoslavski D, Dzeja P, Banks AS, Rosen ED, Spiegelman BM
Cell metabolism26(4)660-671.e3(2017 Oct)

Disruption of the ATXN1-CIC complex causes a spectrum of neurobehavioral phenotypes in mice and humans.
Lu HC, Tan Q, Rousseaux MW, Wang W, Kim JY, Richman R, Wan YW, Yeh SY, Patel JM, Liu X, Lin T, Lee Y, Fryer JD, Han J, Chahrour M, Finnell RH, Lei Y, Zurita-Jimenez ME, Ahimaz P, Anyane-Yeboa K, Van Maldergem L, Lehalle D, Jean-Marcais N, Mosca-Boidron AL, Thevenon J, Cousin MA, Bro DE, Lanpher BC, Klee EW, Alexander N, Bainbridge MN, Orr HT, Sillitoe RV, Ljungberg MC, Liu Z, Schaaf CP, Zoghbi HY
Nature genetics49(4)527-536(2017 Apr)

Creatine maintains intestinal homeostasis and protects against colitis.
Turer E, McAlpine W, Wang KW, Lu T, Li X, Tang M, Zhan X, Wang T, Zhan X, Bu CH, Murray AR, Beutler B
Proceedings of the National Academy of Sciences of the United States of America114(7)E1273-E1281(2017 Feb)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

results show marked metabolic effects of creatine deficiency via the chronic activation of AMPK in a first animal model of AGAT deficiency
Title: L-arginine:glycine amidinotransferase deficiency protects from metabolic syndrome.

The following Gatm gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gatm cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu13085	NM_025961.5 Latest version!	Mus musculus glycine amidinotransferase (L-arginine:glycine amidinotransferase) (Gatm), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gatm ( NM_025961.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_080237.1 Mus musculus glycine amidinotransferase (L-arginine:glycine amidinotransferase) (Gatm), mRNA.

Price & Availability↑

CloneID	OMu13085
Clone ID Related Accession (Same CDS sequence)	NM_025961.5
Accession Version	NM_025961.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1272bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-11
Organism	Mus musculus(house mouse)
Product	glycine amidinotransferase, mitochondrial precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK146111.1. On Oct 24, 2007 this sequence version replaced NM_025961.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK145914.1, AK146111.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849385, SAMN01164131 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTACGGG TGCGGTGTCT GCGCGGAGGC AGCCGAGGTG CCGAGGCGGT GCACTACATC 
GGCTCTCGGC TTGGAGGATC CTTAACAGGA TGGGTGCAGC GAACTTTCCA GAGCACCCAG 
GCAGCTACAG CTTCCTCCCG AAATTCCTGT GCAGCTGAAG ACAAGGCCAC CCATCCTCTG 
CCCAAGGACT GCCCTGTCTC CTCTTACAAC GAATGGGACC CTTTAGAGGA AGTGATAGTG 
GGCAGAGCTG AAAATGCCTG TGTGCCACCA TTCACAGTGG AGGTGAAGGC CAATACATAT 
GAAAAGTACT GGCCATTTTA CCAAAAAAAT GGAGGTCTTT ATTTTCCCAA AGATCATCTG 
AAGAAGGCTG TTGCTGAGGT CGAAGAGATG TGCAATATTT TATCAATGGA AGGAGTGACC 
GTGAGGCGGC CTGACCCCAT CGACTGGTCA CTCAAGTATA AGACTCCTGA TTTTGAGTCT 
ACAGGTTTGT ACAGCGCAAT GCCTCGAGAC ATCCTGATGG TTGTGGGAAA CGAGATTATA 
GAAGCACCCA TGGCATGGCG CTCACGCTTC TTTGAGTACC GAGCGTACAG GTCAATTATC 
AAAGACTACT TCCATCGTGG TGCCAAGTGG ACAACAGCAC CCAAGCCCAC AATGGCTGAC 
GAACTGTATG ACCAGAATTA TCCCATCCAT TCCGTGGAAG ACAGACACAA ATTGGCCGCT 
CAGGGAAAGT TCGTGACGAC TGAGTTTGAG CCTTGCTTTG ATGCTGCTGA CTTCATTCGA 
GCTGGAAGAG ATATTTTTGC ACAGAGAAGC CAGGTTACAA ACTACCTGGG CATCGAGTGG 
ATGCGTAGGC ATCTTGCTCC AGACTACAGA GTACATATCA TCTCTTTTAA AGACCCCAAT 
CCAATGCACA TCGATGCCAC CTTCAACATC ATTGGACCTG GTCTTGTGCT CTCCAACCCC 
GACCGTCCCT GTCATCAGAT TGATCTTTTC AAGAAAGCAG GATGGACCAT AGTTACTCCT 
CCAACACCAG TCATCCCCGA TGATCATCCC CTCTGGATGT CATCCAAATG GCTTTCCATG 
AACGTCTTAA TGCTAGATGA GAAGCGCGTG ATGGTAGATG CCAATGAAGT TCCAATTCAA 
AAGATGTTTG AGAAGCTGGG TATCAGTACC ATTAAGGTTA ACATTCGAAA TGCCAATTCC 
CTGGGAGGAG GCTTCCACTG CTGGACCTGC GACGTCCGGC GCCGAGGCAC CCTTCAGTCC 
TACTTTGACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_080237.1
CDS	62..1333
Translation	MLRVRCLRGGSRGAEAVHYIGSRLGGSLTGWVQRTFQSTQAATASSRNSCAAEDKATHPLPKDCPVSSYNEWDPLEEVIVGRAENACVPPFTVEVKANTYEKYWPFYQKNGGLYFPKDHLKKAVAEVEEMCNILSMEGVTVRRPDPIDWSLKYKTPDFESTGLYSAMPRDILMVVGNEIIEAPMAWRSRFFEYRAYRSIIKDYFHRGAKWTTAPKPTMADELYDQNYPIHSVEDRHKLAAQGKFVTTEFEPCFDAADFIRAGRDIFAQRSQVTNYLGIEWMRRHLAPDYRVHIISFKDPNPMHIDATFNIIGPGLVLSNPDRPCHQIDLFKKAGWTIVTPPTPVIPDDHPLWMSSKWLSMNVLMLDEKRVMVDANEVPIQKMFEKLGISTIKVNIRNANSLGGGFHCWTCDVRRRGTLQSYFD

Target ORF information:

RefSeq Version	NM_025961.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus glycine amidinotransferase (L-arginine:glycine amidinotransferase) (Gatm), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_025961.5

ORF Insert Sequence:

ATGCTACGGG TGCGGTGTCT GCGCGGAGGC AGCCGAGGTG CCGAGGCGGT GCACTACATC 
GGCTCTCGGC TTGGAGGATC CTTAACAGGA TGGGTGCAGC GAACTTTCCA GAGCACCCAG 
GCAGCTACAG CTTCCTCCCG AAATTCCTGT GCAGCTGAAG ACAAGGCCAC CCATCCTCTG 
CCCAAGGACT GCCCTGTCTC CTCTTACAAC GAATGGGACC CTTTAGAGGA AGTGATAGTG 
GGCAGAGCTG AAAATGCCTG TGTGCCACCA TTCACAGTGG AGGTGAAGGC CAATACATAT 
GAAAAGTACT GGCCATTTTA CCAAAAAAAT GGAGGTCTTT ATTTTCCCAA AGATCATCTG 
AAGAAGGCTG TTGCTGAGGT CGAAGAGATG TGCAATATTT TATCAATGGA AGGAGTGACC 
GTGAGGCGGC CTGACCCCAT CGACTGGTCA CTCAAGTATA AGACTCCTGA TTTTGAGTCT 
ACAGGTTTGT ACAGCGCAAT GCCTCGAGAC ATCCTGATGG TTGTGGGAAA CGAGATTATA 
GAAGCACCCA TGGCATGGCG CTCACGCTTC TTTGAGTACC GAGCGTACAG GTCAATTATC 
AAAGACTACT TCCATCGTGG TGCCAAGTGG ACAACAGCAC CCAAGCCCAC AATGGCTGAC 
GAACTGTATG ACCAGAATTA TCCCATCCAT TCCGTGGAAG ACAGACACAA ATTGGCCGCT 
CAGGGAAAGT TCGTGACGAC TGAGTTTGAG CCTTGCTTTG ATGCTGCTGA CTTCATTCGA 
GCTGGAAGAG ATATTTTTGC ACAGAGAAGC CAGGTTACAA ACTACCTGGG CATCGAGTGG 
ATGCGTAGGC ATCTTGCTCC AGACTACAGA GTACATATCA TCTCTTTTAA AGACCCCAAT 
CCAATGCACA TCGATGCCAC CTTCAACATC ATTGGACCTG GTCTTGTGCT CTCCAACCCC 
GACCGTCCCT GTCATCAGAT TGATCTTTTC AAGAAAGCAG GATGGACCAT AGTTACTCCT 
CCAACACCAG TCATCCCCGA TGATCATCCC CTCTGGATGT CATCCAAATG GCTTTCCATG 
AACGTCTTAA TGCTAGATGA GAAGCGCGTG ATGGTAGATG CCAATGAAGT TCCAATTCAA 
AAGATGTTTG AGAAGCTGGG TATCAGTACC ATTAAGGTTA ACATTCGAAA TGCCAATTCC 
CTGGGAGGAG GCTTCCACTG CTGGACCTGC GACGTCCGGC GCCGAGGCAC CCTTCAGTCC 
TACTTTGACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Impaired cardiac contractile function in AGAT knockout mice devoid of creatine is rescued by homoarginine but not creatine.
Cardiovascular research(2017 Dec)
Faller KME,Atzler D,McAndrew DJ,Zervou S,Whittington HJ,Simon JN,Aksentijevic D,Hove MT,Choe CU,Isbrandt D,Casadei B,Schneider JE,Neubauer S,Lygate CA

Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity.
Cell metabolism26(4)660-671.e3(2017 Oct)
Kazak L,Chouchani ET,Lu GZ,Jedrychowski MP,Bare CJ,Mina AI,Kumari M,Zhang S,Vuckovic I,Laznik-Bogoslavski D,Dzeja P,Banks AS,Rosen ED,Spiegelman BM

Disruption of the ATXN1-CIC complex causes a spectrum of neurobehavioral phenotypes in mice and humans.
Nature genetics49(4)527-536(2017 Apr)
Lu HC,Tan Q,Rousseaux MW,Wang W,Kim JY,Richman R,Wan YW,Yeh SY,Patel JM,Liu X,Lin T,Lee Y,Fryer JD,Han J,Chahrour M,Finnell RH,Lei Y,Zurita-Jimenez ME,Ahimaz P,Anyane-Yeboa K,Van Maldergem L,Lehalle D,Jean-Marcais N,Mosca-Boidron AL,Thevenon J,Cousin MA,Bro DE,Lanpher BC,Klee EW,Alexander N,Bainbridge MN,Orr HT,Sillitoe RV,Ljungberg MC,Liu Z,Schaaf CP,Zoghbi HY

Creatine maintains intestinal homeostasis and protects against colitis.
Proceedings of the National Academy of Sciences of the United States of America114(7)E1273-E1281(2017 Feb)
Turer E,McAlpine W,Wang KW,Lu T,Li X,Tang M,Zhan X,Wang T,Zhan X,Bu CH,Murray AR,Beutler B

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

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Gatm cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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