Angptl8 cDNA ORF clone, Mus musculus(house mouse)

ANGPTL8 promotes the ability of ANGPTL3 to bind and inhibit lipoprotein lipase.
Chi X, Britt EC, Shows HW, Hjelmaas AJ, Shetty SK, Cushing EM, Li W, Dou A, Zhang R, Davies BSJ
Molecular metabolism6(10)1137-1149(2017 Oct)

Angiopoietin-like 8 (Angptl8) controls adipocyte lipolysis and phospholipid composition.
Mysore R, Liebisch G, Zhou Y, Olkkonen VM, Nidhina Haridas PA
Chemistry and physics of lipids207(Pt B)246-252(2017 Oct)

ANGPTL8 requires ANGPTL3 to inhibit lipoprotein lipase and plasma triglyceride clearance.
Haller JF, Mintah IJ, Shihanian LM, Stevis P, Buckler D, Alexa-Braun CA, Kleiner S, Banfi S, Cohen JC, Hobbs HH, Yancopoulos GD, Murphy AJ, Gusarova V, Gromada J
Journal of lipid research58(6)1166-1173(2017 Jun)

ANGPTL8 Blockade With a Monoclonal Antibody Promotes Triglyceride Clearance, Energy Expenditure, and Weight Loss in Mice.
Gusarova V, Banfi S, Alexa-Braun CA, Shihanian LM, Mintah IJ, Lee JS, Xin Y, Su Q, Kamat V, Cohen JC, Hobbs HH, Zambrowicz B, Yancopoulos GD, Murphy AJ, Gromada J
Endocrinology158(5)1252-1259(2017 May)

knock-down of Angptl8 in adipocytes suggests that the protein acts to inhibit intracellular lipolysis, analogous to its activity in the circulation. Depletion of Angptl8 results in an altered cellular phospholipid composition. The findings identify Angptl8 as a central insulin-regulated controller of adipocyte lipid metabolism.
Title: Angiopoietin-like 8 (Angptl8) controls adipocyte lipolysis and phospholipid composition.

ANGPTL8 has a functional LPL inhibitory motif, but only inhibits LPL and increases plasma TG levels in mice in the presence of ANGPTL3
Title: ANGPTL8 requires ANGPTL3 to inhibit lipoprotein lipase and plasma triglyceride clearance.

The high levels of ANGPTL8 found in fetal life together with its relationship with newborn adiposity and brown adipose tissue point to ANGPTL8 as a potential new player in the modulation of the thermogenic machinery during the fetal-neonatal transition.
Title: Angiopoietin-like protein 8 (ANGPTL8) in pregnancy: a brown adipose tissue-derived endocrine factor with a potential role in fetal growth.

Obesity is associated with increased betatrophin suppression after an oral glucose load; this response appears to be driven by hyperglycemia. Data suggest that insulin or low glucose (as in hypoglycemia) increases betatrophin expression/secretion in adipocytes (3T3-L1 cells here); elevation of glucose levels blunts this effect.
Title: Weight Loss Partially Restores Glucose-Driven Betatrophin Response in Humans.

The expression of betatrophin is upregulated in the liver, white adipose tissue (WAT) and brown adipose tissue in obese hyperinsulinemic type 2 diabetes but decreased in WAT in hypoinsulinemic type 1 diabetes, suggesting its positive correlation with body weight and plasma insulin but not blood glucose.
Title: Betatrophin expression is promoted in obese hyperinsulinemic type 2 but not type 1 diabetic mice.