Rsad2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Rsad2
Entrez Gene ID	58185
Full Name	radical S-adenosyl methionine domain containing 2
Synonyms	2510004L01Rik,Vig1,cig5
General protein information	Preferred Names radical S-adenosyl methionine domain containing 2 Names radical S-adenosyl methionine domain-containing protein 2 VHSV-induced-like protein rsad2 viperin viral hemorrhagic septicemia virus (VHSV)-induced gene 1 virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 12 Map Location: 12\|12 A2

mRNA and Protein(s)

mRNA	Protein	Name
NM_021384.4	NP_067359.2	radical S-adenosyl methionine domain-containing protein 2

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	RSAD2	XP_851276.1
Danio rerio (zebrafish)	rsad2	NP_001020727.1
Pan troglodytes (chimpanzee)	RSAD2	XP_515283.2
	RSAD2	XP_001099610.1
Bos taurus (cattle)	RSAD2	NP_001039406.1
Mus musculus (house mouse)	Rsad2	NP_067359.2
Xenopus tropicalis (tropical clawed frog)	rsad2	XP_002935073.1
Rattus norvegicus (Norway rat)	Rsad2	NP_620236.1
Gallus gallus (chicken)	RSAD2	XP_426208.2
Homo sapiens (human)	RSAD2	NP_542388.2

Gene Ontology
Bibliography

Related articles in PubMed

Viperin is an important host restriction factor in control of Zika virus infection.
Van der Hoek KH, Eyre NS, Shue B, Khantisitthiporn O, Glab-Ampi K, Carr JM, Gartner MJ, Jolly LA, Thomas PQ, Adikusuma F, Jankovic-Karasoulos T, Roberts CT, Helbig KJ, Beard MR
Scientific reports7(1)4475(2017 Jun)

Structural studies of viperin, an antiviral radical SAM enzyme.
Fenwick MK, Li Y, Cresswell P, Modis Y, Ealick SE
Proceedings of the National Academy of Sciences of the United States of America114(26)6806-6811(2017 Jun)

Viperin interaction with mitochondrial antiviral signaling protein (MAVS) limits viperin-mediated inhibition of the interferon response in macrophages.
Hee JS, Cresswell P
PloS one12(2)e0172236(2017)

Viperin inhibits rabies virus replication via reduced cholesterol and sphingomyelin and is regulated upstream by TLR4.
Tang HB, Lu ZL, Wei XK, Zhong TZ, Zhong YZ, Ouyang LX, Luo Y, Xing XW, Liao F, Peng KK, Deng CQ, Minamoto N, Luo TR
Scientific reports630529(2016 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A relatively high level of viperin protein expression was detected in infected RAW 264.7 cells, and it was extensively localized throughout the cytoplasm of infected cells
Title: Viperin protein expression inhibits the late stage of respiratory syncytial virus morphogenesis.

The data indicate that viperin is the major effector underlying the ability of HCMV to regulate cellular lipid metabolism.
Title: Viperin regulates cellular lipid metabolism during human cytomegalovirus infection.

The viperin-deficient mouse model indicated that absence of viperin enhanced neither the viral load nor pulmonary damage in the lungs.
Title: In vivo and in vitro studies on the antiviral activities of viperin against influenza H1N1 virus infection.

Viperin(-/-) adult mice infected with West Nile virus via the subcutaneous or intracranial route showed increased lethality and/or enhanced viral replication in central nervous system (CNS) tissues.
Title: The interferon-inducible gene viperin restricts West Nile virus pathogenesis.

study shows human cytomegalovirus (HCMV)-induced viperin disrupts cellular metabolism to enhance infectious process; viperin interaction with vMIA resulted in viperin relocalization from endoplasmic reticulum to mitochondria
Title: Human cytomegalovirus directly induces the antiviral protein viperin to enhance infectivity.

The following Rsad2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rsad2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu15238	NM_021384.4 Latest version!	Mus musculus radical S-adenosyl methionine domain containing 2 (Rsad2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rsad2 ( NM_021384.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_067359.2 Mus musculus radical S-adenosyl methionine domain containing 2 (Rsad2), mRNA.

Price & Availability↑

CloneID	OMu15238
Clone ID Related Accession (Same CDS sequence)	NM_021384.4
Accession Version	NM_021384.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1089bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-20
Organism	Mus musculus(house mouse)
Product	radical S-adenosyl methionine domain-containing protein 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CK623585.1, AK151476.1 and AK153234.1. On May 14, 2009 this sequence version replaced NM_021384.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK153234.1, AK151971.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386, SAMN01164134 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGATGC TGGTGCCCAC TGCTCTAGCT GCTCGGCTGC TGAGCCTGTT CCAGCAGCAG 
CTGGGTTCCC TCTGGAGTGG CCTGGCCATC CTGTTCTGCT GGCTGAGAAT AGCATTAGGG 
TGGCTAGATC CCGGGAAGGA ACAGCCACAG GTCCGGGGTG AGCCGGAGGA CACCCAGGAG 
ACCCAGGAAG ATGGGAACAG CACTCAGCCC ACAACCCCCG TGAGTGTCAA CTACCACTTC 
ACTCGTCAGT GCAACTACAA ATGTGGCTTC TGCTTCCACA CAGCCAAGAC ATCCTTCGTG 
CTGCCCCTGG AGGAGGCCAA GCGAGGACTG CTTCTGCTCA AACAGGCTGG TTTGGAGAAG 
ATCAACTTTT CTGGAGGAGA ACCCTTCCTT CAGGACAGGG GTGAATACTT GGGCAAGCTT 
GTGAGATTCT GCAAGGAGGA GCTAGCCCTG CCCTCTGTGA GCATAGTGAG CAATGGCAGC 
CTTATCCGGG AGAGATGGTT CAAGGACTAT GGGGAGTATT TGGACATTCT TGCTATCTCC 
TGCGACAGCT TCGATGAGCA GGTTAATGCT CTGATTGGCC GTGGTCAAGG AAAAAAGAAC 
CATGTGGAAA ACCTTCAAAA GCTGAGGAGG TGGTGCAGGG ATTACAAGGT GGCTTTCAAG 
ATCAACTCTG TCATTAATCG CTTCAACGTG GACGAAGACA TGAATGAACA CATCAAGGCC 
CTGAGCCCTG TGCGCTGGAA GGTTTTCCAG TGCCTCCTAA TTGAGGGTGA GAACTCAGGA 
GAAGATGCCC TGAGGGAAGC AGAAAGATTT CTTATAAGCA ATGAAGAATT TGAAACATTC 
TTGGAGCGTC ACAAAGAGGT GTCCTGTTTG GTGCCTGAAT CTAACCAGAA GATGAAAGAC 
TCCTACCTTA TCCTAGATGA ATATATGCGC TTTCTGAACT GTACCGGTGG CCGGAAGGAC 
CCTTCCAAGT CTATTCTGGA TGTTGGCGTG GAAGAAGCAA TAAAGTTCAG TGGATTTGAT 
GAGAAGATGT TTCTGAAGCG TGGCGGAAAG TATGTGTGGA GTAAAGCTGA CCTGAAGCTG 
GACTGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_067359.2
CDS	34..1122
Translation	MGMLVPTALAARLLSLFQQQLGSLWSGLAILFCWLRIALGWLDPGKEQPQVRGEPEDTQETQEDGNSTQPTTPVSVNYHFTRQCNYKCGFCFHTAKTSFVLPLEEAKRGLLLLKQAGLEKINFSGGEPFLQDRGEYLGKLVRFCKEELALPSVSIVSNGSLIRERWFKDYGEYLDILAISCDSFDEQVNALIGRGQGKKNHVENLQKLRRWCRDYKVAFKINSVINRFNVDEDMNEHIKALSPVRWKVFQCLLIEGENSGEDALREAERFLISNEEFETFLERHKEVSCLVPESNQKMKDSYLILDEYMRFLNCTGGRKDPSKSILDVGVEEAIKFSGFDEKMFLKRGGKYVWSKADLKLDW

Target ORF information:

RefSeq Version	NM_021384.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus radical S-adenosyl methionine domain containing 2 (Rsad2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021384.4

ORF Insert Sequence:

ATGGGGATGC TGGTGCCCAC TGCTCTAGCT GCTCGGCTGC TGAGCCTGTT CCAGCAGCAG 
CTGGGTTCCC TCTGGAGTGG CCTGGCCATC CTGTTCTGCT GGCTGAGAAT AGCATTAGGG 
TGGCTAGATC CCGGGAAGGA ACAGCCACAG GTCCGGGGTG AGCCGGAGGA CACCCAGGAG 
ACCCAGGAAG ATGGGAACAG CACTCAGCCC ACAACCCCCG TGAGTGTCAA CTACCACTTC 
ACTCGTCAGT GCAACTACAA ATGTGGCTTC TGCTTCCACA CAGCCAAGAC ATCCTTCGTG 
CTGCCCCTGG AGGAGGCCAA GCGAGGACTG CTTCTGCTCA AACAGGCTGG TTTGGAGAAG 
ATCAACTTTT CTGGAGGAGA ACCCTTCCTT CAGGACAGGG GTGAATACTT GGGCAAGCTT 
GTGAGATTCT GCAAGGAGGA GCTAGCCCTG CCCTCTGTGA GCATAGTGAG CAATGGCAGC 
CTTATCCGGG AGAGATGGTT CAAGGACTAT GGGGAGTATT TGGACATTCT TGCTATCTCC 
TGCGACAGCT TCGATGAGCA GGTTAATGCT CTGATTGGCC GTGGTCAAGG AAAAAAGAAC 
CATGTGGAAA ACCTTCAAAA GCTGAGGAGG TGGTGCAGGG ATTACAAGGT GGCTTTCAAG 
ATCAACTCTG TCATTAATCG CTTCAACGTG GACGAAGACA TGAATGAACA CATCAAGGCC 
CTGAGCCCTG TGCGCTGGAA GGTTTTCCAG TGCCTCCTAA TTGAGGGTGA GAACTCAGGA 
GAAGATGCCC TGAGGGAAGC AGAAAGATTT CTTATAAGCA ATGAAGAATT TGAAACATTC 
TTGGAGCGTC ACAAAGAGGT GTCCTGTTTG GTGCCTGAAT CTAACCAGAA GATGAAAGAC 
TCCTACCTTA TCCTAGATGA ATATATGCGC TTTCTGAACT GTACCGGTGG CCGGAAGGAC 
CCTTCCAAGT CTATTCTGGA TGTTGGCGTG GAAGAAGCAA TAAAGTTCAG TGGATTTGAT 
GAGAAGATGT TTCTGAAGCG TGGCGGAAAG TATGTGTGGA GTAAAGCTGA CCTGAAGCTG 
GACTGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Viperin is an important host restriction factor in control of Zika virus infection.
Scientific reports7(1)4475(2017 Jun)
Van der Hoek KH,Eyre NS,Shue B,Khantisitthiporn O,Glab-Ampi K,Carr JM,Gartner MJ,Jolly LA,Thomas PQ,Adikusuma F,Jankovic-Karasoulos T,Roberts CT,Helbig KJ,Beard MR

Structural studies of viperin, an antiviral radical SAM enzyme.
Proceedings of the National Academy of Sciences of the United States of America114(26)6806-6811(2017 Jun)
Fenwick MK,Li Y,Cresswell P,Modis Y,Ealick SE

Viperin interaction with mitochondrial antiviral signaling protein (MAVS) limits viperin-mediated inhibition of the interferon response in macrophages.
PloS one12(2)e0172236(2017)
Hee JS,Cresswell P

Viperin inhibits rabies virus replication via reduced cholesterol and sphingomyelin and is regulated upstream by TLR4.
Scientific reports630529(2016 Jul)
Tang HB,Lu ZL,Wei XK,Zhong TZ,Zhong YZ,Ouyang LX,Luo Y,Xing XW,Liao F,Peng KK,Deng CQ,Minamoto N,Luo TR

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Rsad2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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