Dstn cDNA ORF clone, Mus musculus(house mouse)

The role of actin depolymerizing factor in advanced glycation endproducts-induced impairment in mouse brain microvascular endothelial cells.
Liu X, Zhang R, Di H, Zhao D, Wang J
Molecular and cellular biochemistry433(1-2)103-112(2017 Sep)

Identification of functional pathways associated with the conditional ablation of serum response factor in Dstncorn1 mice.
Huo Y, Xie X, Jiang B
Molecular medicine reports15(1)139-145(2017 Jan)

Planar cell polarity genes Celsr1 and Vangl2 are necessary for kidney growth, differentiation, and rostrocaudal patterning.
Brz?ska H?, d'Esposito AM, Kolatsi-Joannou M, Patel V, Igarashi P, Lei Y, Finnell RH, Lythgoe MF, Woolf AS, Papakrivopoulou E, Long DA
Kidney international90(6)1274-1284(2016 Dec)

Actin-Depolymerizing Factor and Cofilin-1 Have Unique and Overlapping Functions in Regulating Intestinal Epithelial Junctions and Mucosal Inflammation.
Wang D, Naydenov NG, Feygin A, Baranwal S, Kuemmerle JF, Ivanov AI
The American journal of pathology186(4)844-58(2016 Apr)

ADF and Cofilin1 Control Actin Stress Fibers, Nuclear Integrity, and Cell Survival.
Kanellos G, Zhou J, Patel H, Ridgway RA, Huels D, Gurniak CB, Sandilands E, Carragher NO, Sansom OJ, Witke W, Brunton VG, Frame MC
Cell reports13(9)1949-64(2015 Dec)

Dstncorn1 mice are homozygous for a spontaneous null actin depolymerizing factor destrin (DSTN) allele, which results in an increase in serum response factor (Srf) expression.This study performs identification of functional pathways associated with the conditional ablation of serum response factor in Dstn corn1 mice.
Title: Identification of functional pathways associated with the conditional ablation of serum response factor in Dstncorn1 mice.

Actin depolymerizing factor/cofilin double mutant mice exhibited hyperlocomotion, impulsivity, and impaired working memory. Hyperlocomotion and impulsive behavior were reversed by methylphenidate.
Title: Attention-Deficit/Hyperactivity Disorder-like Phenotype in a Mouse Model with Impaired Actin Dynamics.

SRF binding is significantly decreased in the destrin (corn1) mutant cornea.
Title: Serum response factor: positive and negative regulation of an epithelial gene expression network in the destrin mutant cornea.

A single QTL is responsible for modification of neovascularization in the Dstn null mutation mouse.
Title: Genetic modification of corneal neovascularization in Dstn (corn1) mice.

findings identify actin-depolymerizing factor (ADF) as a key signaling molecule in the regulation of BBB integrity and suggest that ADF might be used as a target to modulate diseases accompanied by ox-LDL-induced BBB compromise.
Title: Overexpression of actin-depolymerizing factor blocks oxidized low-density lipoprotein-induced mouse brain microvascular endothelial cell barrier dysfunction.