Uchl5 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Uchl5
Entrez Gene ID	56207
Full Name	ubiquitin carboxyl-terminal esterase L5
Synonyms	5830413B11Rik,Uch37
General protein information	Preferred Names ubiquitin carboxyl-terminal esterase L5 Names ubiquitin carboxyl-terminal hydrolase isozyme L5 UCH-L5 ubiquitin C-terminal hydrolase 37 ubiquitin C-terminal hydrolase UCH37 ubiquitin thioesterase L5
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1 F\|1 62.54 cM

mRNA and Protein(s)

mRNA	Protein	Name
XM_006529760.4	XP_006529823.1	ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X1
NM_019562.2	NP_062508.2	ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 1
NM_001159866.1	NP_001153338.1	ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 2
XM_006529760.3	XP_006529823.1	ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X1

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	uchl5	NP_998249.1
Oryza sativa (rice)	Os02g0822200	NP_001048557.1
Canis lupus familiaris (dog)	UCHL5	XP_536116.2
Arabidopsis thaliana (thale cress)	UCH2	NP_564858.1
Homo sapiens (human)	UCHL5	NP_057068.1
Pan troglodytes (chimpanzee)	UCHL5	XP_514069.4
Rattus norvegicus (Norway rat)	Uchl5	NP_001012149.1
Xenopus tropicalis (tropical clawed frog)	uchl5	XP_002939132.1
Drosophila melanogaster (fruit fly)	Uch-L3	NP_524003.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005540	XP_315540.2
Caenorhabditis elegans (roundworm)	ubh-4	NP_495684.2
	LOC712473	XP_001112706.2
Bos taurus (cattle)	UCHL5	NP_776906.2
Mus musculus (house mouse)	Uchl5	NP_062508.2
Gallus gallus (chicken)	UCHL5	NP_001006530.1

Gene Ontology
Bibliography

Related articles in PubMed

Strain survey and genetic analysis of vasoreactivity in mouse aorta.
Kim SK, Avila JJ, Massett MP
Physiological genomics48(11)861-873(2016 Nov)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Usp12 stabilizes the T-cell receptor complex at the cell surface during signaling.
Jahan AS, Lestra M, Swee LK, Fan Y, Lamers MM, Tafesse FG, Theile CS, Spooner E, Bruzzone R, Ploegh HL, Sanyal S
Proceedings of the National Academy of Sciences of the United States of America113(6)E705-14(2016 Feb)

Redundant Roles of Rpn10 and Rpn13 in Recognition of Ubiquitinated Proteins and Cellular Homeostasis.
Hamazaki J, Hirayama S, Murata S
PLoS genetics11(7)e1005401(2015 Jul)

Ubiquitin C-terminal hydrolase-L5 is required for high glucose-induced transforming growth factor-? receptor I expression and hypertrophy in mesangial cells.
Ko YM, Chang CY, Chiou SJ, Hsu FJ, Huang JS, Yang YL, Guh JY, Chuang LY
Archives of biochemistry and biophysics535(2)177-86(2013 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PI3K-dependent UCHL5 is required for high glucose-induced TGF-betaR1 protein expression in mesangial cells. UCHL5 is also required for high glucose-induced TGF-betaR1 protein deubiquitination, p21(WAF1) and fibronectin protein expression and cell hypertrophy.
Title: Ubiquitin C-terminal hydrolase-L5 is required for high glucose-induced transforming growth factor-? receptor I expression and hypertrophy in mesangial cells.

ubiquitinated loosely folded proteins, after becoming bound to the 26 S, interact with Ubp6/Usp14 or Uch37 to activate ATP hydrolysis and enhance their own destruction
Title: Ubiquitinated proteins activate the proteasomal ATPases by binding to Usp14 or Uch37 homologs.

this is the first report characterizing the physiological roles of Uch37 and Rpn13 in murine development and implicating a non-ATPase proteasomal protein, Rpn13, in the process of gametogenesis
Title: Regulators of the proteasome pathway, Uch37 and Rpn13, play distinct roles in mouse development.

The following Uchl5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Uchl5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu15748	NM_001159866.1 Latest version!	Mus musculus ubiquitin carboxyl-terminal esterase L5 (Uchl5), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu16074	NM_019562.2 Latest version!	Mus musculus ubiquitin carboxyl-terminal esterase L5 (Uchl5), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
OMu28353	XM_006529760.4 Latest version!	Mus musculus ubiquitin carboxyl-terminal esterase L5 (Uchl5), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OMu28353	XM_006529760.3	Mus musculus ubiquitin carboxyl-terminal esterase L5 (Uchl5), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Uchl5 ( NM_001159866.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001153338.1 Mus musculus ubiquitin carboxyl-terminal esterase L5 (Uchl5), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu15748
Clone ID Related Accession (Same CDS sequence)	NM_001159866.1
Accession Version	NM_001159866.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 987bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-20
Organism	Mus musculus(house mouse)
Product	ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY279731.1 and AK017925.1. Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: AK017925.1, SRR1660821.280576.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCGAGCA ATGCCGGGGA GTGGTGTCTC ATGGAAAGCG ACCCCGGGGT CTTCACCGAG 
CTCATTAAAG GATTCGGTTG CCGAGGGGCC CAAGTAGAAG AAATATGGAG CTTAGAACCT 
GAGAGTTTTG AAAAGCTAAA GCCAGTTCAT GGGTTAATTT TTCTTTTCAA GTGGCAGCCA 
GGAGAAGAAC CTGCTGGCTC TGTGGTCCAG GACTCCAGAC TTGAAACAAT ATTTTTTGCC 
AAGCAGGTAA TTAATAATGC TTGTGCCACT CAGGCTATCG TAAGTGTACT ACTGAACTGT 
ACGCATCAAG ATGTGCATTT AGGAGAGACA TTATCAGAAT TTAAAGAATT TTCTCAAAGT 
TTTGATGCAG CTATGAAGGG GCTGGCATTG AGTAACTCAG ATGTGATTCG ACAAGTGCAC 
AACAGTTTTG CCAGGCAGCA GATGTTTGAA TTTGATACAA AGACACCAGC CAAAGAGGAG 
GATGCTTTTC ACTTTGTCAG TTACGTTCCA GTCAATGGGA GGCTGTATGA ACTAGACGGG 
TTAAGAGAGG GCCCAATTGA TTTAGGTGCA TGCAATCAAG ATGACTGGAT TACTGCAGTG 
AGGCCAGTAA TAGAGAAAAG GATTCAAAAG TATAGTGAAG GAGAAATTCG ATTTAATTTA 
ATGGCCATTG TATCTGACAG AAAAATGATA TATGAACAGA AGATAGCAGA GTTACAAAGA 
CAACTTGCAG AGGAACCCAT GGATACAGAT CAAGGTAGTA CCGTGTTAAG TGCTATTCAG 
TCAGAAGTTG CCAGAAACCA GATGCTTATT GAAGAAGAGG TACAAAAGTT AAAGAGATAT 
AAGATTGAAA ATATCAGAAG GAAGCATAAT TACTTGCCTT TCATTATGGA ATTGTTAAAG 
ACCTTAGCTG AGCACCAGCA GTTAATTCCA CTTGTGGAAA AGGCAAAAGA AAAACAGAAT 
GCAAAGAAAG CTCAGGAAAC TAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001153338.1
CDS	124..1110
Translation	MSSNAGEWCLMESDPGVFTELIKGFGCRGAQVEEIWSLEPESFEKLKPVHGLIFLFKWQPGEEPAGSVVQDSRLETIFFAKQVINNACATQAIVSVLLNCTHQDVHLGETLSEFKEFSQSFDAAMKGLALSNSDVIRQVHNSFARQQMFEFDTKTPAKEEDAFHFVSYVPVNGRLYELDGLREGPIDLGACNQDDWITAVRPVIEKRIQKYSEGEIRFNLMAIVSDRKMIYEQKIAELQRQLAEEPMDTDQGSTVLSAIQSEVARNQMLIEEEVQKLKRYKIENIRRKHNYLPFIMELLKTLAEHQQLIPLVEKAKEKQNAKKAQETK

Target ORF information:

RefSeq Version	NM_001159866.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus ubiquitin carboxyl-terminal esterase L5 (Uchl5), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001159866.1

ORF Insert Sequence:

ATGTCGAGCA ATGCCGGGGA GTGGTGTCTC ATGGAAAGCG ACCCCGGGGT CTTCACCGAG 
CTCATTAAAG GATTCGGTTG CCGAGGGGCC CAAGTAGAAG AAATATGGAG CTTAGAACCT 
GAGAGTTTTG AAAAGCTAAA GCCAGTTCAT GGGTTAATTT TTCTTTTCAA GTGGCAGCCA 
GGAGAAGAAC CTGCTGGCTC TGTGGTCCAG GACTCCAGAC TTGAAACAAT ATTTTTTGCC 
AAGCAGGTAA TTAATAATGC TTGTGCCACT CAGGCTATCG TAAGTGTACT ACTGAACTGT 
ACGCATCAAG ATGTGCATTT AGGAGAGACA TTATCAGAAT TTAAAGAATT TTCTCAAAGT 
TTTGATGCAG CTATGAAGGG GCTGGCATTG AGTAACTCAG ATGTGATTCG ACAAGTGCAC 
AACAGTTTTG CCAGGCAGCA GATGTTTGAA TTTGATACAA AGACACCAGC CAAAGAGGAG 
GATGCTTTTC ACTTTGTCAG TTACGTTCCA GTCAATGGGA GGCTGTATGA ACTAGACGGG 
TTAAGAGAGG GCCCAATTGA TTTAGGTGCA TGCAATCAAG ATGACTGGAT TACTGCAGTG 
AGGCCAGTAA TAGAGAAAAG GATTCAAAAG TATAGTGAAG GAGAAATTCG ATTTAATTTA 
ATGGCCATTG TATCTGACAG AAAAATGATA TATGAACAGA AGATAGCAGA GTTACAAAGA 
CAACTTGCAG AGGAACCCAT GGATACAGAT CAAGGTAGTA CCGTGTTAAG TGCTATTCAG 
TCAGAAGTTG CCAGAAACCA GATGCTTATT GAAGAAGAGG TACAAAAGTT AAAGAGATAT 
AAGATTGAAA ATATCAGAAG GAAGCATAAT TACTTGCCTT TCATTATGGA ATTGTTAAAG 
ACCTTAGCTG AGCACCAGCA GTTAATTCCA CTTGTGGAAA AGGCAAAAGA AAAACAGAAT 
GCAAAGAAAG CTCAGGAAAC TAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Uchl5 ( NM_019562.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_062508.2 Mus musculus ubiquitin carboxyl-terminal esterase L5 (Uchl5), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu16074
Clone ID Related Accession (Same CDS sequence)	NM_019562.2
Accession Version	NM_019562.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 990bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-20
Organism	Mus musculus(house mouse)
Product	ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY279731.1, AF148447.1 and AL592403.6. On May 7, 2009 this sequence version replaced NM_019562.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660821.250437.1, AK011117.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849383 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCGAGCA ATGCCGGGGA GTGGTGTCTC ATGGAAAGCG ACCCCGGGGT CTTCACCGAG 
CTCATTAAAG GATTCGGTTG CCGAGGGGCC CAAGTAGAAG AAATATGGAG CTTAGAACCT 
GAGAGTTTTG AAAAGCTAAA GCCAGTTCAT GGGTTAATTT TTCTTTTCAA GTGGCAGCCA 
GGAGAAGAAC CTGCTGGCTC TGTGGTCCAG GACTCCAGAC TTGAAACAAT ATTTTTTGCC 
AAGCAGGTAA TTAATAATGC TTGTGCCACT CAGGCTATCG TAAGTGTACT ACTGAACTGT 
ACGCATCAAG ATGTGCATTT AGGAGAGACA TTATCAGAAT TTAAAGAATT TTCTCAAAGT 
TTTGATGCAG CTATGAAGGG GCTGGCATTG AGTAACTCAG ATGTGATTCG ACAAGTGCAC 
AACAGTTTTG CCAGGCAGCA GATGTTTGAA TTTGATACAA AGACACCAGC CAAAGAGGAG 
GATGCTTTTC ACTTTGTCAG TTACGTTCCA GTCAATGGGA GGCTGTATGA ACTAGACGGG 
TTAAGAGAGG GCCCAATTGA TTTAGGTGCA TGCAATCAAG ATGACTGGAT TACTGCAGTG 
AGGCCAGTAA TAGAGAAAAG GATTCAAAAG TATAGTGAAG GAGAAATTCG ATTTAATTTA 
ATGGCCATTG TATCTGACAG AAAAATGATA TATGAACAGA AGATAGCAGA GTTACAAAGA 
CAACTTGCAG AGGAGGAACC CATGGATACA GATCAAGGTA GTACCGTGTT AAGTGCTATT 
CAGTCAGAAG TTGCCAGAAA CCAGATGCTT ATTGAAGAAG AGGTACAAAA GTTAAAGAGA 
TATAAGATTG AAAATATCAG AAGGAAGCAT AATTACTTGC CTTTCATTAT GGAATTGTTA 
AAGACCTTAG CTGAGCACCA GCAGTTAATT CCACTTGTGG AAAAGGCAAA AGAAAAACAG 
AATGCAAAGA AAGCTCAGGA AACTAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062508.2
CDS	124..1113
Translation	MSSNAGEWCLMESDPGVFTELIKGFGCRGAQVEEIWSLEPESFEKLKPVHGLIFLFKWQPGEEPAGSVVQDSRLETIFFAKQVINNACATQAIVSVLLNCTHQDVHLGETLSEFKEFSQSFDAAMKGLALSNSDVIRQVHNSFARQQMFEFDTKTPAKEEDAFHFVSYVPVNGRLYELDGLREGPIDLGACNQDDWITAVRPVIEKRIQKYSEGEIRFNLMAIVSDRKMIYEQKIAELQRQLAEEEPMDTDQGSTVLSAIQSEVARNQMLIEEEVQKLKRYKIENIRRKHNYLPFIMELLKTLAEHQQLIPLVEKAKEKQNAKKAQETK

Target ORF information:

RefSeq Version	NM_019562.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus ubiquitin carboxyl-terminal esterase L5 (Uchl5), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019562.2

ORF Insert Sequence:

ATGTCGAGCA ATGCCGGGGA GTGGTGTCTC ATGGAAAGCG ACCCCGGGGT CTTCACCGAG 
CTCATTAAAG GATTCGGTTG CCGAGGGGCC CAAGTAGAAG AAATATGGAG CTTAGAACCT 
GAGAGTTTTG AAAAGCTAAA GCCAGTTCAT GGGTTAATTT TTCTTTTCAA GTGGCAGCCA 
GGAGAAGAAC CTGCTGGCTC TGTGGTCCAG GACTCCAGAC TTGAAACAAT ATTTTTTGCC 
AAGCAGGTAA TTAATAATGC TTGTGCCACT CAGGCTATCG TAAGTGTACT ACTGAACTGT 
ACGCATCAAG ATGTGCATTT AGGAGAGACA TTATCAGAAT TTAAAGAATT TTCTCAAAGT 
TTTGATGCAG CTATGAAGGG GCTGGCATTG AGTAACTCAG ATGTGATTCG ACAAGTGCAC 
AACAGTTTTG CCAGGCAGCA GATGTTTGAA TTTGATACAA AGACACCAGC CAAAGAGGAG 
GATGCTTTTC ACTTTGTCAG TTACGTTCCA GTCAATGGGA GGCTGTATGA ACTAGACGGG 
TTAAGAGAGG GCCCAATTGA TTTAGGTGCA TGCAATCAAG ATGACTGGAT TACTGCAGTG 
AGGCCAGTAA TAGAGAAAAG GATTCAAAAG TATAGTGAAG GAGAAATTCG ATTTAATTTA 
ATGGCCATTG TATCTGACAG AAAAATGATA TATGAACAGA AGATAGCAGA GTTACAAAGA 
CAACTTGCAG AGGAGGAACC CATGGATACA GATCAAGGTA GTACCGTGTT AAGTGCTATT 
CAGTCAGAAG TTGCCAGAAA CCAGATGCTT ATTGAAGAAG AGGTACAAAA GTTAAAGAGA 
TATAAGATTG AAAATATCAG AAGGAAGCAT AATTACTTGC CTTTCATTAT GGAATTGTTA 
AAGACCTTAG CTGAGCACCA GCAGTTAATT CCACTTGTGG AAAAGGCAAA AGAAAAACAG 
AATGCAAAGA AAGCTCAGGA AACTAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Uchl5 ( XM_006529760.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006529823.1 Mus musculus ubiquitin carboxyl-terminal esterase L5 (Uchl5), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OMu28353
Clone ID Related Accession (Same CDS sequence)	XM_006529760.4 , XM_006529760.3
Accession Version	XM_006529760.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 975bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006529760.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCGAGCA ATGCCGGGGA GTGGTGTCTC ATGGAAAGCG ACCCCGGGGT CTTCACCGAG 
CTCATTAAAG GATTCGGTTG CCGAGGGGCC CAAGTAGAAG AAATATGGAG CTTAGAACCT 
GAGAGTTTTG AAAAGCTAAA GCCAGTTCAT GGGTTAATTT TTCTTTTCAA GTGGCAGCCA 
GGAGAAGAAC CTGCTGGCTC TGTGGTCCAG GACTCCAGAC TTGAAACAAT ATTTTTTGCC 
AAGCAGGTAA TTAATAATGC TTGTGCCACT CAGGCTATCG TAAGTGTACT ACTGAACTGT 
ACGCATCAAG ATGTGCATTT AGGAGAGACA TTATCAGAAT TTAAAGAATT TTCTCAAAGT 
TTTGATGCAG CTATGAAGGG GCTGGCATTG AGTAACTCAG ATGTGATTCG ACAAGTGCAC 
AACAGTTTTG CCAGGCAGCA GATGTTTGAA TTTGATACAA AGACACCAGC CAAAGAGGAG 
GATGCTTTTC ACTTTGTCAG TTACGTTCCA GTCAATGGGA GGCTGTATGA ACTAGACGGG 
TTAAGAGAGG GCCCAATTGA TTTAGGTGCA TGCAATCAAG ATGACTGGAT TACTGCAGTG 
AGGCCAGTAA TAGAGAAAAG GATTCAAAAG TATAGTGAAG GAGAAATTCG ATTTAATTTA 
ATGGCCATTG TATCTGACAG AAAAATGATA TATGAACAGA AGATAGCAGA GTTACAAAGA 
CAACTTGCAG AGGAGGAACC CATGGATACA GATCAAGGTA GTACCGTGTT AAGTGCTATT 
CAGTCAGAAG TTGCCAGAAA CCAGATGCTT ATTGAAGAAG AGGTACAAAA GTTAAAGAGA 
TATAAGATTG AAAATATCAG AAGGAAGCAT AATTACTTGC CTTTCATTAT GGAATTGTTA 
AAGACCTTAG CTGAGCACCA GCAGTTAATT CCACTTGTGG AAAAGATATT CTCATGTAGG 
GGAAAGAATC TTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006529823.1
CDS	184..1158
Translation	MSSNAGEWCLMESDPGVFTELIKGFGCRGAQVEEIWSLEPESFEKLKPVHGLIFLFKWQPGEEPAGSVVQDSRLETIFFAKQVINNACATQAIVSVLLNCTHQDVHLGETLSEFKEFSQSFDAAMKGLALSNSDVIRQVHNSFARQQMFEFDTKTPAKEEDAFHFVSYVPVNGRLYELDGLREGPIDLGACNQDDWITAVRPVIEKRIQKYSEGEIRFNLMAIVSDRKMIYEQKIAELQRQLAEEEPMDTDQGSTVLSAIQSEVARNQMLIEEEVQKLKRYKIENIRRKHNYLPFIMELLKTLAEHQQLIPLVEKIFSCRGKNL

Target ORF information:

RefSeq Version	XM_006529760.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus ubiquitin carboxyl-terminal esterase L5 (Uchl5), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006529760.3

ORF Insert Sequence:

ATGTCGAGCA ATGCCGGGGA GTGGTGTCTC ATGGAAAGCG ACCCCGGGGT CTTCACCGAG 
CTCATTAAAG GATTCGGTTG CCGAGGGGCC CAAGTAGAAG AAATATGGAG CTTAGAACCT 
GAGAGTTTTG AAAAGCTAAA GCCAGTTCAT GGGTTAATTT TTCTTTTCAA GTGGCAGCCA 
GGAGAAGAAC CTGCTGGCTC TGTGGTCCAG GACTCCAGAC TTGAAACAAT ATTTTTTGCC 
AAGCAGGTAA TTAATAATGC TTGTGCCACT CAGGCTATCG TAAGTGTACT ACTGAACTGT 
ACGCATCAAG ATGTGCATTT AGGAGAGACA TTATCAGAAT TTAAAGAATT TTCTCAAAGT 
TTTGATGCAG CTATGAAGGG GCTGGCATTG AGTAACTCAG ATGTGATTCG ACAAGTGCAC 
AACAGTTTTG CCAGGCAGCA GATGTTTGAA TTTGATACAA AGACACCAGC CAAAGAGGAG 
GATGCTTTTC ACTTTGTCAG TTACGTTCCA GTCAATGGGA GGCTGTATGA ACTAGACGGG 
TTAAGAGAGG GCCCAATTGA TTTAGGTGCA TGCAATCAAG ATGACTGGAT TACTGCAGTG 
AGGCCAGTAA TAGAGAAAAG GATTCAAAAG TATAGTGAAG GAGAAATTCG ATTTAATTTA 
ATGGCCATTG TATCTGACAG AAAAATGATA TATGAACAGA AGATAGCAGA GTTACAAAGA 
CAACTTGCAG AGGAGGAACC CATGGATACA GATCAAGGTA GTACCGTGTT AAGTGCTATT 
CAGTCAGAAG TTGCCAGAAA CCAGATGCTT ATTGAAGAAG AGGTACAAAA GTTAAAGAGA 
TATAAGATTG AAAATATCAG AAGGAAGCAT AATTACTTGC CTTTCATTAT GGAATTGTTA 
AAGACCTTAG CTGAGCACCA GCAGTTAATT CCACTTGTGG AAAAGATATT CTCATGTAGG 
GGAAAGAATC TTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Uchl5 ( XM_006529760.4 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006529823.1 Mus musculus ubiquitin carboxyl-terminal esterase L5 (Uchl5), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OMu28353
Clone ID Related Accession (Same CDS sequence)	XM_006529760.4 , XM_006529760.3
Accession Version	XM_006529760.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 975bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006529760.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCGAGCA ATGCCGGGGA GTGGTGTCTC ATGGAAAGCG ACCCCGGGGT CTTCACCGAG 
CTCATTAAAG GATTCGGTTG CCGAGGGGCC CAAGTAGAAG AAATATGGAG CTTAGAACCT 
GAGAGTTTTG AAAAGCTAAA GCCAGTTCAT GGGTTAATTT TTCTTTTCAA GTGGCAGCCA 
GGAGAAGAAC CTGCTGGCTC TGTGGTCCAG GACTCCAGAC TTGAAACAAT ATTTTTTGCC 
AAGCAGGTAA TTAATAATGC TTGTGCCACT CAGGCTATCG TAAGTGTACT ACTGAACTGT 
ACGCATCAAG ATGTGCATTT AGGAGAGACA TTATCAGAAT TTAAAGAATT TTCTCAAAGT 
TTTGATGCAG CTATGAAGGG GCTGGCATTG AGTAACTCAG ATGTGATTCG ACAAGTGCAC 
AACAGTTTTG CCAGGCAGCA GATGTTTGAA TTTGATACAA AGACACCAGC CAAAGAGGAG 
GATGCTTTTC ACTTTGTCAG TTACGTTCCA GTCAATGGGA GGCTGTATGA ACTAGACGGG 
TTAAGAGAGG GCCCAATTGA TTTAGGTGCA TGCAATCAAG ATGACTGGAT TACTGCAGTG 
AGGCCAGTAA TAGAGAAAAG GATTCAAAAG TATAGTGAAG GAGAAATTCG ATTTAATTTA 
ATGGCCATTG TATCTGACAG AAAAATGATA TATGAACAGA AGATAGCAGA GTTACAAAGA 
CAACTTGCAG AGGAGGAACC CATGGATACA GATCAAGGTA GTACCGTGTT AAGTGCTATT 
CAGTCAGAAG TTGCCAGAAA CCAGATGCTT ATTGAAGAAG AGGTACAAAA GTTAAAGAGA 
TATAAGATTG AAAATATCAG AAGGAAGCAT AATTACTTGC CTTTCATTAT GGAATTGTTA 
AAGACCTTAG CTGAGCACCA GCAGTTAATT CCACTTGTGG AAAAGATATT CTCATGTAGG 
GGAAAGAATC TTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006529823.1
CDS	168..1142
Translation	MSSNAGEWCLMESDPGVFTELIKGFGCRGAQVEEIWSLEPESFEKLKPVHGLIFLFKWQPGEEPAGSVVQDSRLETIFFAKQVINNACATQAIVSVLLNCTHQDVHLGETLSEFKEFSQSFDAAMKGLALSNSDVIRQVHNSFARQQMFEFDTKTPAKEEDAFHFVSYVPVNGRLYELDGLREGPIDLGACNQDDWITAVRPVIEKRIQKYSEGEIRFNLMAIVSDRKMIYEQKIAELQRQLAEEEPMDTDQGSTVLSAIQSEVARNQMLIEEEVQKLKRYKIENIRRKHNYLPFIMELLKTLAEHQQLIPLVEKIFSCRGKNL

Target ORF information:

RefSeq Version	XM_006529760.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus ubiquitin carboxyl-terminal esterase L5 (Uchl5), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006529760.4

ORF Insert Sequence:

ATGTCGAGCA ATGCCGGGGA GTGGTGTCTC ATGGAAAGCG ACCCCGGGGT CTTCACCGAG 
CTCATTAAAG GATTCGGTTG CCGAGGGGCC CAAGTAGAAG AAATATGGAG CTTAGAACCT 
GAGAGTTTTG AAAAGCTAAA GCCAGTTCAT GGGTTAATTT TTCTTTTCAA GTGGCAGCCA 
GGAGAAGAAC CTGCTGGCTC TGTGGTCCAG GACTCCAGAC TTGAAACAAT ATTTTTTGCC 
AAGCAGGTAA TTAATAATGC TTGTGCCACT CAGGCTATCG TAAGTGTACT ACTGAACTGT 
ACGCATCAAG ATGTGCATTT AGGAGAGACA TTATCAGAAT TTAAAGAATT TTCTCAAAGT 
TTTGATGCAG CTATGAAGGG GCTGGCATTG AGTAACTCAG ATGTGATTCG ACAAGTGCAC 
AACAGTTTTG CCAGGCAGCA GATGTTTGAA TTTGATACAA AGACACCAGC CAAAGAGGAG 
GATGCTTTTC ACTTTGTCAG TTACGTTCCA GTCAATGGGA GGCTGTATGA ACTAGACGGG 
TTAAGAGAGG GCCCAATTGA TTTAGGTGCA TGCAATCAAG ATGACTGGAT TACTGCAGTG 
AGGCCAGTAA TAGAGAAAAG GATTCAAAAG TATAGTGAAG GAGAAATTCG ATTTAATTTA 
ATGGCCATTG TATCTGACAG AAAAATGATA TATGAACAGA AGATAGCAGA GTTACAAAGA 
CAACTTGCAG AGGAGGAACC CATGGATACA GATCAAGGTA GTACCGTGTT AAGTGCTATT 
CAGTCAGAAG TTGCCAGAAA CCAGATGCTT ATTGAAGAAG AGGTACAAAA GTTAAAGAGA 
TATAAGATTG AAAATATCAG AAGGAAGCAT AATTACTTGC CTTTCATTAT GGAATTGTTA 
AAGACCTTAG CTGAGCACCA GCAGTTAATT CCACTTGTGG AAAAGATATT CTCATGTAGG 
GGAAAGAATC TTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Strain survey and genetic analysis of vasoreactivity in mouse aorta.
Physiological genomics48(11)861-873(2016 Nov)
Kim SK,Avila JJ,Massett MP

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Usp12 stabilizes the T-cell receptor complex at the cell surface during signaling.
Proceedings of the National Academy of Sciences of the United States of America113(6)E705-14(2016 Feb)
Jahan AS,Lestra M,Swee LK,Fan Y,Lamers MM,Tafesse FG,Theile CS,Spooner E,Bruzzone R,Ploegh HL,Sanyal S

Redundant Roles of Rpn10 and Rpn13 in Recognition of Ubiquitinated Proteins and Cellular Homeostasis.
PLoS genetics11(7)e1005401(2015 Jul)
Hamazaki J,Hirayama S,Murata S

Ubiquitin C-terminal hydrolase-L5 is required for high glucose-induced transforming growth factor-? receptor I expression and hypertrophy in mesangial cells.
Archives of biochemistry and biophysics535(2)177-86(2013 Jul)
Ko YM,Chang CY,Chiou SJ,Hsu FJ,Huang JS,Yang YL,Guh JY,Chuang LY

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Uchl5 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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