H1f2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	H1f2
Entrez Gene ID	50708
Full Name	histone cluster 1, H1c
Synonyms	0610008C09Rik,H1.2,H1c,H1f2,H1var1,His1a
General protein information	Preferred Names histone cluster 1, H1c Names histone H1.2 H1 VAR.1 H1 histone family, member 2 histone 1, H1c histone H1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 13 Map Location: 13\|13 A3.1
Summary	Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Feb 2014].

mRNA and Protein(s)

mRNA	Protein	Name
NM_015786.3	NP_056601.1	histone H1.2

Pathways from BioSystems

Homologies

	LOC696005	XP_001084417.1
Mus musculus (house mouse)	Hist1h1c	NP_056601.1
Pan troglodytes (chimpanzee)	HIST1H1C	XP_001172525.1
Homo sapiens (human)	HIST1H1C	NP_005310.1

Gene Ontology
Bibliography

Related articles in PubMed

Zbtb7b engages the long noncoding RNA Blnc1 to drive brown and beige fat development and thermogenesis.
Li S, Mi L, Yu L, Yu Q, Liu T, Wang GX, Zhao XY, Wu J, Lin JD
Proceedings of the National Academy of Sciences of the United States of America114(34)E7111-E7120(2017 Aug)

Dynamic changes in H1 subtype composition during epigenetic reprogramming.
Izzo A, Ziegler-Birling C, Hill PWS, Brondani L, Hajkova P, Torres-Padilla ME, Schneider R
The Journal of cell biology(2017 Aug)

Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss.
Scekic-Zahirovic J, Sendscheid O, El Oussini H, Jambeau M, Sun Y, Mersmann S, Wagner M, Dieterl? S, Sinniger J, Dirrig-Grosch S, Drenner K, Birling MC, Qiu J, Zhou Y, Li H, Fu XD, Rouaux C, Shelkovnikova T, Witting A, Ludolph AC, Kiefer F, Storkebaum E, Lagier-Tourenne C, Dupuis L
The EMBO journal35(10)1077-97(2016 05)

Role of H1 linker histones in mammalian development and stem cell differentiation.
Pan C, Fan Y
Biochimica et biophysica acta1859(3)496-509(2016 Mar)

Identification of Viral and Host Proteins That Interact with Murine Gammaherpesvirus 68 Latency-Associated Nuclear Antigen during Lytic Replication: a Role for Hsc70 in Viral Replication.
Salinas E, Byrum SD, Moreland LE, Mackintosh SG, Tackett AJ, Forrest JC
Journal of virology90(3)1397-413(2015 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Histone H1c gene expression is developmentally up-regulated to promote facultative heterochromatin in mature rod photoreceptors.
Title: Developmentally regulated linker histone H1c promotes heterochromatin condensation and mediates structural integrity of rod photoreceptors in mouse retina.

These results integrate the localization of an understudied type of chromatin proteins, namely the H1 variants, into the epigenome map of mouse ESCs.
Title: High-resolution mapping of h1 linker histone variants in embryonic stem cells.

The N-terminal domain contributes toward the differential chromatin binding affinity, whereas the C-terminal domain contributes toward distinct nucleosomal interface of isotypes H10 and H1c.
Title: N- and C-terminal domains determine differential nucleosomal binding geometry and affinity of linker histone isotypes H1(0) and H1c.

The amount of the linker histone H1c is strongly reduced in nuclear extracts of SCA7 retinas and that the cellular distribution of H1c is particularly altered in the facultative heterochromatin compartment.
Title: The linker histone H1C contributes to the SCA7 nuclear phenotype.

These observations reveal a mode of p53 regulation mediated by CHD8, which may set a threshold for induction of apoptosis during early embryogenesis by counteracting p53 function through recruitment of histone H1.
Title: CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis.

The following H1f2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the H1f2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu16774	NM_015786.3 Latest version!	Mus musculus H1.2 linker histone, cluster member (H1f2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

H1f2 ( NM_015786.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_056601.1 Mus musculus H1.2 linker histone, cluster member (H1f2), mRNA.

Price & Availability↑

CloneID	OMu16774
Clone ID Related Accession (Same CDS sequence)	NM_015786.3
Accession Version	NM_015786.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 639bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Mus musculus(house mouse)
Product	histone H1.2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL590388.4. On Feb 25, 2014 this sequence version replaced NM_015786.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: CA468737.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCTGAGG CTGCTCCTGC TGCCCCCGCT GCCGCGCCCC CTGCGGAGAA GGCGCCTGCC 
AAAAAGAAGG CCGCCAAGAA GCCCGCCGGG GTGCGCCGTA AGGCGTCCGG ACCCCCGGTG 
TCCGAGCTCA TCACCAAGGC TGTGGCCGCC TCCAAGGAGC GCAGCGGCGT GTCCCTGGCT 
GCGCTCAAGA AGGCGCTGGC GGCCGCGGGG TACGATGTGG AGAAGAACAA CAGCCGCATC 
AAGCTCGGCC TGAAGAGCCT GGTGAGCAAG GGCATCCTGG TGCAAACCAA GGGCACCGGT 
GCCTCCGGCT CCTTCAAACT CAACAAGAAG GCGGCTTCTG GCGAGGCCAA ACCCCAGGCT 
AAGAAGGCAG GCGCGGCCAA GGCGAAGAAG CCCGCGGGAG CAGCCAAGAA GCCTAAGAAG 
GCGACTGGTG CTGCCACACC CAAAAAGGCG GCCAAGAAGA CCCCGAAGAA GGCGAAGAAG 
CCCGCGGCGG CGGCTGTGAC CAAGAAAGTG GCCAAGAGCC CAAAGAAGGC GAAGGTCACC 
AAGCCCAAGA AGGTCAAGAG CGCGTCTAAA GCCGTAAAGC CAAAGGCTGC CAAGCCCAAG 
GTTGCCAAGG CCAAGAAGGT TGCAGCCAAG AAAAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_056601.1
CDS	43..681
Translation	MSEAAPAAPAAAPPAEKAPAKKKAAKKPAGVRRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGYDVEKNNSRIKLGLKSLVSKGILVQTKGTGASGSFKLNKKAASGEAKPQAKKAGAAKAKKPAGAAKKPKKATGAATPKKAAKKTPKKAKKPAAAAVTKKVAKSPKKAKVTKPKKVKSASKAVKPKAAKPKVAKAKKVAAKKK

Target ORF information:

RefSeq Version	NM_015786.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus H1.2 linker histone, cluster member (H1f2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015786.3

ORF Insert Sequence:

ATGTCTGAGG CTGCTCCTGC TGCCCCCGCT GCCGCGCCCC CTGCGGAGAA GGCGCCTGCC 
AAAAAGAAGG CCGCCAAGAA GCCCGCCGGG GTGCGCCGTA AGGCGTCCGG ACCCCCGGTG 
TCCGAGCTCA TCACCAAGGC TGTGGCCGCC TCCAAGGAGC GCAGCGGCGT GTCCCTGGCT 
GCGCTCAAGA AGGCGCTGGC GGCCGCGGGG TACGATGTGG AGAAGAACAA CAGCCGCATC 
AAGCTCGGCC TGAAGAGCCT GGTGAGCAAG GGCATCCTGG TGCAAACCAA GGGCACCGGT 
GCCTCCGGCT CCTTCAAACT CAACAAGAAG GCGGCTTCTG GCGAGGCCAA ACCCCAGGCT 
AAGAAGGCAG GCGCGGCCAA GGCGAAGAAG CCCGCGGGAG CAGCCAAGAA GCCTAAGAAG 
GCGACTGGTG CTGCCACACC CAAAAAGGCG GCCAAGAAGA CCCCGAAGAA GGCGAAGAAG 
CCCGCGGCGG CGGCTGTGAC CAAGAAAGTG GCCAAGAGCC CAAAGAAGGC GAAGGTCACC 
AAGCCCAAGA AGGTCAAGAG CGCGTCTAAA GCCGTAAAGC CAAAGGCTGC CAAGCCCAAG 
GTTGCCAAGG CCAAGAAGGT TGCAGCCAAG AAAAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Zbtb7b engages the long noncoding RNA Blnc1 to drive brown and beige fat development and thermogenesis.
Proceedings of the National Academy of Sciences of the United States of America114(34)E7111-E7120(2017 Aug)
Li S,Mi L,Yu L,Yu Q,Liu T,Wang GX,Zhao XY,Wu J,Lin JD

Dynamic changes in H1 subtype composition during epigenetic reprogramming.
The Journal of cell biology(2017 Aug)
Izzo A,Ziegler-Birling C,Hill PWS,Brondani L,Hajkova P,Torres-Padilla ME,Schneider R

Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss.
The EMBO journal35(10)1077-97(2016 05)
Scekic-Zahirovic J,Sendscheid O,El Oussini H,Jambeau M,Sun Y,Mersmann S,Wagner M,Dieterl? S,Sinniger J,Dirrig-Grosch S,Drenner K,Birling MC,Qiu J,Zhou Y,Li H,Fu XD,Rouaux C,Shelkovnikova T,Witting A,Ludolph AC,Kiefer F,Storkebaum E,Lagier-Tourenne C,Dupuis L

Role of H1 linker histones in mammalian development and stem cell differentiation.
Biochimica et biophysica acta1859(3)496-509(2016 Mar)
Pan C,Fan Y

Identification of Viral and Host Proteins That Interact with Murine Gammaherpesvirus 68 Latency-Associated Nuclear Antigen during Lytic Replication: a Role for Hsc70 in Viral Replication.
Journal of virology90(3)1397-413(2015 Nov)
Salinas E,Byrum SD,Moreland LE,Mackintosh SG,Tackett AJ,Forrest JC

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H1f2 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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