Cbx6 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cbx6
Entrez Gene ID	494448
Full Name	chromobox 6
General protein information	Preferred Names chromobox 6 Names chromobox protein homolog 6 chromobox homolog 6
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 15 Map Location: 15\|15 E1

mRNA and Protein(s)

mRNA	Protein	Name
NM_028763.3	NP_083039.2	chromobox protein homolog 6

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CBX6	XP_003317298.1
Mus musculus (house mouse)	Cbx6	NP_083039.2
Xenopus tropicalis (tropical clawed frog)	cbx6	NP_001016617.1
Bos taurus (cattle)	CBX6	NP_001096564.1
Rattus norvegicus (Norway rat)	Cbx6	NP_001012119.1
Homo sapiens (human)	CBX6	NP_055107.3
Canis lupus familiaris (dog)	CBX6	XP_849882.2
Danio rerio (zebrafish)	LOC556231	XP_005171671.1

Gene Ontology
Bibliography

Related articles in PubMed

The Polycomb group protein CBX6 is an essential regulator of embryonic stem cell identity.
Santanach A, Blanco E, Jiang H, Molloy KR, Sans? M, LaCava J, Morey L, Di Croce L
Nature communications8(1)1235(2017 Nov)

Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun.
Gurdziel K, Vogt KR, Walton KD, Schneider GK, Gumucio DL
Developmental dynamics : an official publication of the American Association of Anatomists245(5)614-26(2016 May)

Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen.
Liakath-Ali K, Vancollie VE, Heath E, Smedley DP, Estabel J, Sunter D, Ditommaso T, White JK, Ramirez-Solis R, Smyth I, Steel KP, Watt FM
Nature communications53540(2014 Apr)

Different polycomb group CBX family proteins associate with distinct regions of chromatin using nonhomologous protein sequences.
Vincenz C, Kerppola TK
Proceedings of the National Academy of Sciences of the United States of America105(43)16572-7(2008 Oct)

Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin.
Bernstein E, Duncan EM, Masui O, Gil J, Heard E, Allis CD
Molecular and cellular biology26(7)2560-9(2006 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

different CBX proteins are recruited to distinct chromatin regions through nonconserved interactions. Metaphase spreads revealed reciprocal patterns of chromosome association by CBX2 and CBX6
Title: Different polycomb group CBX family proteins associate with distinct regions of chromatin using nonhomologous protein sequences.

The following Cbx6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cbx6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu06084	NM_028763.3 Latest version!	Mus musculus chromobox 6 (Cbx6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cbx6 ( NM_028763.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_083039.2 Mus musculus chromobox 6 (Cbx6), mRNA.

Price & Availability↑

CloneID	OMu06084
Clone ID Related Accession (Same CDS sequence)	NM_028763.3
Accession Version	NM_028763.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1245bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	chromobox protein homolog 6
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY237361.1, AK035250.1, AK004679.2 and AC113595.11. On Mar 21, 2005 this sequence version replaced NM_028763.2. ##Evidence-Data-START## Transcript exon combination :: AK004679.2, BC011199.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGAGCTGT CTGCAGTAGG CGAGCGGGTC TTCGCGGCCG AATCCATCAT TAAACGCCGG 
ATCCGCAAGG GACGCATCGA GTACCTGGTG AAATGGAAAG GGTGGGCGAT CAAGTACAGC 
ACTTGGGAGC CAGAGGAGAA CATTCTGGAT TCGAGGCTCA TCGCAGCCTT CGAGCAGAAG 
GAAAGGGAAC GTGAGCTGTA TGGGCCCAAG AAGAGGGGAC CTAAACCCAA AACTTTCCTC 
CTAAAGGCCC GGGCCCAGGC GGAGGCCCTC CGCATCAGTG ATGTGCATTT CTCTGTCAAG 
CCGAGCGCCA GCGCCTCCTC GCCCAAGCTG CACTCCAGCG CTGCGGTGCA CCGGCTCAAG 
AAAGACATCC GCCGCTGCCA CCGTATGTCT CGCCGTCCCC TGCCACGACC AGACCCACAA 
GGGGGTAGCC CTGGCCTACG CCCACCCATC TCGCCCTTTT CTGAGACCGT GCGCATCATC 
AACCGTAAGG TGAAGCCCCG GGAGCCCAAG CGGAACCGCA TCATCCTGAA CCTGAAGGTG 
ATTGACAAGG GTCCGGGAGG TGGCAGCACT GCGCAGGGCA CCGGGGCACT GGCCCGCCCG 
AAAGTCCCCT CGCGGAACCG GGTCATTGGG AAGAGCAAGA AGTTCAGCGA GAGCATGCTC 
CGTACCCAGA TCCGCCACAT GAAGTTTGGC ACATTTGCGC TCTACAAGCC CCCTCCTGCC 
CCTCTGGCGC CCTCTACTGC GGGCAAAGCC GATGTGGCCT CCTCGGGGCC TGGGCTGCTC 
CTGGCCACCC CAGCTGCTGC CCCCTTTGAC GCACACAGCT CCAGCTCTTC CGGCTGCCCC 
TCACCCACAC TGCAGTCCTC TGACCCAGAC GATGCACCAC CCAAGCTACT CCCGGAGACC 
CTGAGCCGAT CTGTGCCCAA CTGGCGAGAG TCAGAGGTGC TCGATCTGTC CATCCCTCCT 
GAGGCGGCTG CCACCGGCCA GCGGGTGCCT CCTGATGTCA CTGGTGCTGC GGACCAGGCG 
CTACATACAG CTCTGGAGCC CACAGGTGCT GGCTCCTCCG AGCCTGAGGC TGGGGACTGG 
CGCCCCGAGA TGTCGCCATG CTCCAATGTA GTTGTCACAG ATGTCACCAG CAACCTCCTG 
ACCGTGACCA TCAAGGAATT CTGCAGCCCG GAGGATTTTG AGAAGGTGGC CGCTGGGGTG 
GCAGGTGCTA CAGGGGGCGG GGGTGGCACT GGGCCAAGTA AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_083039.2
CDS	123..1367
Translation	MELSAVGERVFAAESIIKRRIRKGRIEYLVKWKGWAIKYSTWEPEENILDSRLIAAFEQKERERELYGPKKRGPKPKTFLLKARAQAEALRISDVHFSVKPSASASSPKLHSSAAVHRLKKDIRRCHRMSRRPLPRPDPQGGSPGLRPPISPFSETVRIINRKVKPREPKRNRIILNLKVIDKGPGGGSTAQGTGALARPKVPSRNRVIGKSKKFSESMLRTQIRHMKFGTFALYKPPPAPLAPSTAGKADVASSGPGLLLATPAAAPFDAHSSSSSGCPSPTLQSSDPDDAPPKLLPETLSRSVPNWRESEVLDLSIPPEAAATGQRVPPDVTGAADQALHTALEPTGAGSSEPEAGDWRPEMSPCSNVVVTDVTSNLLTVTIKEFCSPEDFEKVAAGVAGATGGGGGTGPSK

Target ORF information:

RefSeq Version	NM_028763.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus chromobox 6 (Cbx6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_028763.3

ORF Insert Sequence:

ATGGAGCTGT CTGCAGTAGG CGAGCGGGTC TTCGCGGCCG AATCCATCAT TAAACGCCGG 
ATCCGCAAGG GACGCATCGA GTACCTGGTG AAATGGAAAG GGTGGGCGAT CAAGTACAGC 
ACTTGGGAGC CAGAGGAGAA CATTCTGGAT TCGAGGCTCA TCGCAGCCTT CGAGCAGAAG 
GAAAGGGAAC GTGAGCTGTA TGGGCCCAAG AAGAGGGGAC CTAAACCCAA AACTTTCCTC 
CTAAAGGCCC GGGCCCAGGC GGAGGCCCTC CGCATCAGTG ATGTGCATTT CTCTGTCAAG 
CCGAGCGCCA GCGCCTCCTC GCCCAAGCTG CACTCCAGCG CTGCGGTGCA CCGGCTCAAG 
AAAGACATCC GCCGCTGCCA CCGTATGTCT CGCCGTCCCC TGCCACGACC AGACCCACAA 
GGGGGTAGCC CTGGCCTACG CCCACCCATC TCGCCCTTTT CTGAGACCGT GCGCATCATC 
AACCGTAAGG TGAAGCCCCG GGAGCCCAAG CGGAACCGCA TCATCCTGAA CCTGAAGGTG 
ATTGACAAGG GTCCGGGAGG TGGCAGCACT GCGCAGGGCA CCGGGGCACT GGCCCGCCCG 
AAAGTCCCCT CGCGGAACCG GGTCATTGGG AAGAGCAAGA AGTTCAGCGA GAGCATGCTC 
CGTACCCAGA TCCGCCACAT GAAGTTTGGC ACATTTGCGC TCTACAAGCC CCCTCCTGCC 
CCTCTGGCGC CCTCTACTGC GGGCAAAGCC GATGTGGCCT CCTCGGGGCC TGGGCTGCTC 
CTGGCCACCC CAGCTGCTGC CCCCTTTGAC GCACACAGCT CCAGCTCTTC CGGCTGCCCC 
TCACCCACAC TGCAGTCCTC TGACCCAGAC GATGCACCAC CCAAGCTACT CCCGGAGACC 
CTGAGCCGAT CTGTGCCCAA CTGGCGAGAG TCAGAGGTGC TCGATCTGTC CATCCCTCCT 
GAGGCGGCTG CCACCGGCCA GCGGGTGCCT CCTGATGTCA CTGGTGCTGC GGACCAGGCG 
CTACATACAG CTCTGGAGCC CACAGGTGCT GGCTCCTCCG AGCCTGAGGC TGGGGACTGG 
CGCCCCGAGA TGTCGCCATG CTCCAATGTA GTTGTCACAG ATGTCACCAG CAACCTCCTG 
ACCGTGACCA TCAAGGAATT CTGCAGCCCG GAGGATTTTG AGAAGGTGGC CGCTGGGGTG 
GCAGGTGCTA CAGGGGGCGG GGGTGGCACT GGGCCAAGTA AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The Polycomb group protein CBX6 is an essential regulator of embryonic stem cell identity.
Nature communications8(1)1235(2017 Nov)
Santanach A,Blanco E,Jiang H,Molloy KR,Sans? M,LaCava J,Morey L,Di Croce L

Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun.
Developmental dynamics : an official publication of the American Association of Anatomists245(5)614-26(2016 May)
Gurdziel K,Vogt KR,Walton KD,Schneider GK,Gumucio DL

Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen.
Nature communications53540(2014 Apr)
Liakath-Ali K,Vancollie VE,Heath E,Smedley DP,Estabel J,Sunter D,Ditommaso T,White JK,Ramirez-Solis R,Smyth I,Steel KP,Watt FM

Different polycomb group CBX family proteins associate with distinct regions of chromatin using nonhomologous protein sequences.
Proceedings of the National Academy of Sciences of the United States of America105(43)16572-7(2008 Oct)
Vincenz C,Kerppola TK

Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin.
Molecular and cellular biology26(7)2560-9(2006 Apr)
Bernstein E,Duncan EM,Masui O,Gil J,Heard E,Allis CD