Gja6 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gja6
Entrez Gene ID	414089
Full Name	gap junction protein, alpha 6
Synonyms	A530015O12Rik,Cnx33,Cx33,Gja-6
General protein information	Preferred Names gap junction protein, alpha 6 Names gap junction alpha-6 protein connexin-33 gap junction membrane channel protein alpha 6
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: X Map Location: X F4\|X 73.95 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_001001496.2	NP_001001496.1	gap junction alpha-6 protein

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Gja6	NP_001001496.1
Rattus norvegicus (Norway rat)	Gja6	NP_062181.1

Gene Ontology
Bibliography

Related articles in PubMed

Heteromeric connexin 43/connexin 33 complex endocytosis: a connexin phosphorylation independent mechanism.
Carette D, Gilleron J, Segretain D, Pointis G
Biochimie92(5)555-9(2010 May)

The novel mouse connexin39 gene is expressed in developing striated muscle fibers.
von Maltzahn J, Euwens C, Willecke K, S?hl G
Journal of cell science117(Pt 22)5381-92(2004 Oct)

An update on connexin genes and their nomenclature in mouse and man.
S?hl G, Willecke K
Cell communication & adhesion10(4-6)173-80(2003 Jul-Dec)

Loss of alpha 1 connexin does not alter the prenatal differentiation of pancreatic beta cells and leads to the identification of another islet cell connexin.
Charollais A, Serre V, Mock C, Cogne F, Bosco D, Meda P
Developmental genetics24(1-2)13-26(1999)

Connexin45 (alpha 6) expression delineates an extended conduction system in the embryonic and mature rodent heart.
Coppen SR, Severs NJ, Gourdie RG
Developmental genetics24(1-2)82-90(1999)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

findings demonstrate that the interaction of Cx33 with Cx43 within a same heteromeric complex may conduce to channel instability through alteration of the phosphorylation status of Cx43 independently of the control of the c-Src kinase
Title: Heteromeric connexin 43/connexin 33 complex endocytosis: a connexin phosphorylation independent mechanism.

The following Gja6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gja6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu10384	NM_001001496.2 Latest version!	Mus musculus gap junction protein, alpha 6 (Gja6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gja6 ( NM_001001496.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001001496.1 Mus musculus gap junction protein, alpha 6 (Gja6), mRNA.

Price & Availability↑

CloneID	OMu10384
Clone ID Related Accession (Same CDS sequence)	NM_001001496.2
Accession Version	NM_001001496.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 852bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	gap junction alpha-6 protein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK146838.1 and AK040693.1. On Dec 12, 2009 this sequence version replaced NM_001001496.1. ##Evidence-Data-START## Transcript exon combination :: AK146838.1, BC117760.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849379, SAMN00849384 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGTGATT GGAGTGCCTT ACACCAGCTC CTAGAAAAGG TTCAACCCTA CTCCACAGCT 
GGAGGAAAGG TATGGATCAA GGTTCTTTTC ATTTTCCGCA TCCTGCTCCT GGGCACTGCT 
ATCGAGTCGG CTTGGAGTGA CGAGCAGTTT GAGTTCCATT GCAACACTCA GCAGCCTGGT 
TGTGAAAATG TCTGCTATGA CCATGCCTTC CCAATCTCTC ACGTGCGCCT CTGGGTCCTC 
CAGGTCATTT TCGTATCTGT GCCTATTCTC TTATACCTGG CACATGTGTA CTATGTGGTT 
CGACAGAATA AGAAGTTGAA CAAGCAAGAG GAAGAACTGG AAGCTGCTCA TTTTAATGAG 
GCCAGCGTGG AAAGGCACTT GGAGACAATT GCAGGAGAGC AGTTCAAGTG TGGCAGTGAA 
GAACAGAGTA AGGTGAAAAT GAGAGGCAGA TTGCTGCTAA CCTACATGGC CAGCATCTTC 
TTCAAGTCTG TCTTCGAGAT GGCCTTCCTC CTGATCCAGT GGTACATTTA TGGATTTACT 
CTGAGTGCCC TTTACATCTG TGAGCAGTCT CCTTGCCCAC GTCGGGTGGA CTGCTTCCTC 
TCTCGCCCCA CCGAGAAAAC CATCTTCATC CTCTTCATGT TTGTGGTGTC AGTGGTGTCT 
TTTGTCTTGG ATATCATTGA GCTGTTCTAT GTCTTATTTA AGGCTATTAA GAATCGTATG 
AGAAAAGCGG AGGATGAGGT TTACTGTGAT GAGCTACCAT GCCCTTCCCA TGTCTCTTCA 
TCAACTGTTC TCACCACCAT AGATTCTAGT GAGCAGGCGG TTCCAGTGGA ACTTTCTTCA 
GTTTGTATTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001001496.1
CDS	199..1050
Translation	MSDWSALHQLLEKVQPYSTAGGKVWIKVLFIFRILLLGTAIESAWSDEQFEFHCNTQQPGCENVCYDHAFPISHVRLWVLQVIFVSVPILLYLAHVYYVVRQNKKLNKQEEELEAAHFNEASVERHLETIAGEQFKCGSEEQSKVKMRGRLLLTYMASIFFKSVFEMAFLLIQWYIYGFTLSALYICEQSPCPRRVDCFLSRPTEKTIFILFMFVVSVVSFVLDIIELFYVLFKAIKNRMRKAEDEVYCDELPCPSHVSSSTVLTTIDSSEQAVPVELSSVCI

Target ORF information:

RefSeq Version	NM_001001496.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus gap junction protein, alpha 6 (Gja6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001001496.2

ORF Insert Sequence:

ATGAGTGATT GGAGTGCCTT ACACCAGCTC CTAGAAAAGG TTCAACCCTA CTCCACAGCT 
GGAGGAAAGG TATGGATCAA GGTTCTTTTC ATTTTCCGCA TCCTGCTCCT GGGCACTGCT 
ATCGAGTCGG CTTGGAGTGA CGAGCAGTTT GAGTTCCATT GCAACACTCA GCAGCCTGGT 
TGTGAAAATG TCTGCTATGA CCATGCCTTC CCAATCTCTC ACGTGCGCCT CTGGGTCCTC 
CAGGTCATTT TCGTATCTGT GCCTATTCTC TTATACCTGG CACATGTGTA CTATGTGGTT 
CGACAGAATA AGAAGTTGAA CAAGCAAGAG GAAGAACTGG AAGCTGCTCA TTTTAATGAG 
GCCAGCGTGG AAAGGCACTT GGAGACAATT GCAGGAGAGC AGTTCAAGTG TGGCAGTGAA 
GAACAGAGTA AGGTGAAAAT GAGAGGCAGA TTGCTGCTAA CCTACATGGC CAGCATCTTC 
TTCAAGTCTG TCTTCGAGAT GGCCTTCCTC CTGATCCAGT GGTACATTTA TGGATTTACT 
CTGAGTGCCC TTTACATCTG TGAGCAGTCT CCTTGCCCAC GTCGGGTGGA CTGCTTCCTC 
TCTCGCCCCA CCGAGAAAAC CATCTTCATC CTCTTCATGT TTGTGGTGTC AGTGGTGTCT 
TTTGTCTTGG ATATCATTGA GCTGTTCTAT GTCTTATTTA AGGCTATTAA GAATCGTATG 
AGAAAAGCGG AGGATGAGGT TTACTGTGAT GAGCTACCAT GCCCTTCCCA TGTCTCTTCA 
TCAACTGTTC TCACCACCAT AGATTCTAGT GAGCAGGCGG TTCCAGTGGA ACTTTCTTCA 
GTTTGTATTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Heteromeric connexin 43/connexin 33 complex endocytosis: a connexin phosphorylation independent mechanism.
Biochimie92(5)555-9(2010 May)
Carette D,Gilleron J,Segretain D,Pointis G

The novel mouse connexin39 gene is expressed in developing striated muscle fibers.
Journal of cell science117(Pt 22)5381-92(2004 Oct)
von Maltzahn J,Euwens C,Willecke K,S?hl G

An update on connexin genes and their nomenclature in mouse and man.
Cell communication & adhesion10(4-6)173-80(2003 Jul-Dec)
S?hl G,Willecke K

Loss of alpha 1 connexin does not alter the prenatal differentiation of pancreatic beta cells and leads to the identification of another islet cell connexin.
Developmental genetics24(1-2)13-26(1999)
Charollais A,Serre V,Mock C,Cogne F,Bosco D,Meda P

Connexin45 (alpha 6) expression delineates an extended conduction system in the embryonic and mature rodent heart.
Developmental genetics24(1-2)82-90(1999)
Coppen SR,Severs NJ,Gourdie RG