Treml2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Treml2
Entrez Gene ID	328833
Full Name	triggering receptor expressed on myeloid cells-like 2
Synonyms	AW049306,Gm750,Tlt2
General protein information	Preferred Names triggering receptor expressed on myeloid cells-like 2 Names trem-like transcript 2 protein TLT-2 triggering receptor expressed on myeloid cells-like 2a dominant triggering receptor expressed on myeloid cells-like protein 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 17 Map Location: 17\|17 C

mRNA and Protein(s)

mRNA	Protein	Name
XM_006524440.2	XP_006524503.1	trem-like transcript 2 protein isoform X1
XM_006524441.3	XP_006524504.1	trem-like transcript 2 protein isoform X1
NM_001033405.2	NP_001028577.2	trem-like transcript 2 protein isoform 1 precursor
XM_006524442.2	XP_006524505.1	trem-like transcript 2 protein isoform X2
NM_001360121.1	NP_001347050.1	trem-like transcript 2 protein isoform 2 precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	LOC481791	XP_538912.4
Bos taurus (cattle)	TREML2	XP_005223586.1
Mus musculus (house mouse)	Treml2	NP_001028577.2
Pan troglodytes (chimpanzee)	TREML2	XP_001174125.1
	LOC719749	XP_001117312.1
Rattus norvegicus (Norway rat)	Treml2	XP_001059150.1
Homo sapiens (human)	TREML2	NP_079083.2

Gene Ontology
Bibliography

Related articles in PubMed

Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation.
Zheng H, Liu CC, Atagi Y, Chen XF, Jia L, Yang L, He W, Zhang X, Kang SS, Rosenberry TL, Fryer JD, Zhang YW, Xu H, Bu G
Neurobiology of aging42132-41(2016 06)

Identification of TLT2 as an engulfment receptor for apoptotic cells.
de Freitas A, Banerjee S, Xie N, Cui H, Davis KI, Friggeri A, Fu M, Abraham E, Liu G
Journal of immunology (Baltimore, Md. : 1950)188(12)6381-8(2012 Jun)

TLT2 potentiates neutrophil antibacterial activity and chemotaxis in response to G protein-coupled receptor-mediated signaling.
Halpert MM, Thomas KA, King RG, Justement LB
Journal of immunology (Baltimore, Md. : 1950)187(5)2346-55(2011 Sep)

Enhancement of effector CD8+ T-cell function by tumour-associated B7-H3 and modulation of its counter-receptor triggering receptor expressed on myeloid cell-like transcript 2 at tumour sites.
Kobori H, Hashiguchi M, Piao J, Kato M, Ritprajak P, Azuma M
Immunology130(3)363-73(2010 Jul)

A mouse knockout library for secreted and transmembrane proteins.
Tang T, Li L, Tang J, Li Y, Lin WY, Martin F, Grant D, Solloway M, Parker L, Ye W, Forrest W, Ghilardi N, Oravecz T, Platt KA, Rice DS, Hansen GM, Abuin A, Eberhart DE, Godowski P, Holt KH, Peterson A, Zambrowicz BP, de Sauvage FJ
Nature biotechnology28(7)749-55(2010 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TREM2 and TREML2 play opposite roles in microglia activation
Title: Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation.

Thus, our studies identified TLT2 as an engulfment receptor for apoptotic cells.
Title: Identification of TLT2 as an engulfment receptor for apoptotic cells.

TLT2 ligation enhances the neutrophil response to the formylated peptide FMLF, leading to increased reactive oxygen species production, degranulation, and chemotaxis
Title: TLT2 potentiates neutrophil antibacterial activity and chemotaxis in response to G protein-coupled receptor-mediated signaling.

(+) T-cell effector function, possibly by ligation of TLT-2 on tumour-infiltrating CD8(+) T cells at the local tumour site.
Title: Enhancement of effector CD8+ T-cell function by tumour-associated B7-H3 and modulation of its counter-receptor triggering receptor expressed on myeloid cell-like transcript 2 at tumour sites.

Data do not point to a role for TREML2 as a receptor for B7-H3.
Title: B7-H3 is a potent inhibitor of human T-cell activation: No evidence for B7-H3 and TREML2 interaction.

The following Treml2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Treml2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu12656	NM_001033405.2 Latest version!	Mus musculus triggering receptor expressed on myeloid cells-like 2 (Treml2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu53708	NM_001360121.1 Latest version!	Mus musculus triggering receptor expressed on myeloid cells-like 2 (Treml2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu12656	XM_006524441.3 Latest version!	Mus musculus triggering receptor expressed on myeloid cells-like 2 (Treml2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu12656	XM_006524440.2 Latest version!	Mus musculus triggering receptor expressed on myeloid cells-like 2 (Treml2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu53708	XM_006524442.2 Latest version!	Mus musculus triggering receptor expressed on myeloid cells-like 2 (Treml2), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Treml2 ( NM_001033405.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001028577.2 Mus musculus triggering receptor expressed on myeloid cells-like 2 (Treml2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu12656
Clone ID Related Accession (Same CDS sequence)	XM_006524440.2 , XM_006524441.3 , NM_001033405.2
Accession Version	NM_001033405.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 990bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-06
Organism	Mus musculus(house mouse)
Product	trem-like transcript 2 protein isoform 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK132018.1, AC166164.2 and AK037593.1. On Mar 21, 2007 this sequence version replaced NM_001033405.1. Transcript Variant: This variant (1) encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by mRNA and EST alignments. ##Evidence-Data-START## Transcript exon combination :: DQ341272.1, DQ087184.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCCAT GGCCTCTTAC GTTCCTGCTG TTGCTGCTGC TGCTGCTGTG GCTACAGGGC 
TGTGTCTCAG GTCACTCCAA TGAGAACCTG TACAGGAAAG TGTGGCGGCG TGAAGGCGAG 
ACCCTGTCTG TGCAGTGCTC CTACAAGAAC CGCCGGAACT TAGTTGAGGC CAAGTCTTGG 
TGCAAAGTCA AGAAGAAGAA GTGCGACCAC AACTTCACCC GGAGCTGGGT GAGGGGTCCC 
AGCTACTCTC TGCGGGATGA TGCCAAGGTC AAGGTAGTCC GTATCACCAT GGAAGCTCTC 
AGAGTTCAGG ACTCCGGACG ATACTGGTGT ATGCGTAACA CGGCTGGGCA TTTCTACCCT 
TTGGTGGGTT TCCAACTGGA AGTGTATCCA GCCCTCACAA CTGAGAGAAA CGTTCCCCAC 
ACACATCTTA CCAACACCCC CATGGATGGA TTTGTCACGA CCGGCCAAGT CCATATTTCA 
GACCCTCACG CTCCTTTCAC ATCTGACGTG ACTATGTTCA CATCTGAAGT GACCATGTTC 
ACATCTGGAC TCCTCACCTT GGCTTCAGGG ACCACCACAC CAACCCCTGT GACAGGCTAC 
AGTTTCATCG ATACCAGTGG CACCGTTACA GAGCCTGAGA GGAACACAGA GTCCCAGCCC 
GCAACCCTGT CTCCTAGCAA TGCAAGATCC TTCTCTGCTG ATCCAGTGAC CACCTCCACC 
ATGTCCAGAC ACCAGAGTAG CAGCTTGTCC ACCACGGGGA CGTGCCACCC GTTAACTCCC 
AACAGGTCCC AGGAAACTTA CATCCCTGCG ATGGTGGTGG TGTTGACATT TCTTCCAGCA 
CCTGTGGTGT TGGTCGTAGC CTACGGGTTT TGGAAGAAGA GACATATGGG AAGATACAAC 
TTGGGCAGCA ACTATGCTAA ACCCTGGATA CACCTTCCTG AAGGACCAGA GACACCGTGG 
AAGCCTGCTT GGTCTAAGAT AACTCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001028577.2
CDS	490..1479
Translation	MEPWPLTFLLLLLLLLWLQGCVSGHSNENLYRKVWRREGETLSVQCSYKNRRNLVEAKSWCKVKKKKCDHNFTRSWVRGPSYSLRDDAKVKVVRITMEALRVQDSGRYWCMRNTAGHFYPLVGFQLEVYPALTTERNVPHTHLTNTPMDGFVTTGQVHISDPHAPFTSDVTMFTSEVTMFTSGLLTLASGTTTPTPVTGYSFIDTSGTVTEPERNTESQPATLSPSNARSFSADPVTTSTMSRHQSSSLSTTGTCHPLTPNRSQETYIPAMVVVLTFLPAPVVLVVAYGFWKKRHMGRYNLGSNYAKPWIHLPEGPETPWKPAWSKITQ

Target ORF information:

RefSeq Version	NM_001033405.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus triggering receptor expressed on myeloid cells-like 2 (Treml2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001033405.2

ORF Insert Sequence:

ATGGAGCCAT GGCCTCTTAC GTTCCTGCTG TTGCTGCTGC TGCTGCTGTG GCTACAGGGC 
TGTGTCTCAG GTCACTCCAA TGAGAACCTG TACAGGAAAG TGTGGCGGCG TGAAGGCGAG 
ACCCTGTCTG TGCAGTGCTC CTACAAGAAC CGCCGGAACT TAGTTGAGGC CAAGTCTTGG 
TGCAAAGTCA AGAAGAAGAA GTGCGACCAC AACTTCACCC GGAGCTGGGT GAGGGGTCCC 
AGCTACTCTC TGCGGGATGA TGCCAAGGTC AAGGTAGTCC GTATCACCAT GGAAGCTCTC 
AGAGTTCAGG ACTCCGGACG ATACTGGTGT ATGCGTAACA CGGCTGGGCA TTTCTACCCT 
TTGGTGGGTT TCCAACTGGA AGTGTATCCA GCCCTCACAA CTGAGAGAAA CGTTCCCCAC 
ACACATCTTA CCAACACCCC CATGGATGGA TTTGTCACGA CCGGCCAAGT CCATATTTCA 
GACCCTCACG CTCCTTTCAC ATCTGACGTG ACTATGTTCA CATCTGAAGT GACCATGTTC 
ACATCTGGAC TCCTCACCTT GGCTTCAGGG ACCACCACAC CAACCCCTGT GACAGGCTAC 
AGTTTCATCG ATACCAGTGG CACCGTTACA GAGCCTGAGA GGAACACAGA GTCCCAGCCC 
GCAACCCTGT CTCCTAGCAA TGCAAGATCC TTCTCTGCTG ATCCAGTGAC CACCTCCACC 
ATGTCCAGAC ACCAGAGTAG CAGCTTGTCC ACCACGGGGA CGTGCCACCC GTTAACTCCC 
AACAGGTCCC AGGAAACTTA CATCCCTGCG ATGGTGGTGG TGTTGACATT TCTTCCAGCA 
CCTGTGGTGT TGGTCGTAGC CTACGGGTTT TGGAAGAAGA GACATATGGG AAGATACAAC 
TTGGGCAGCA ACTATGCTAA ACCCTGGATA CACCTTCCTG AAGGACCAGA GACACCGTGG 
AAGCCTGCTT GGTCTAAGAT AACTCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Treml2 ( NM_001360121.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001347050.1 Mus musculus triggering receptor expressed on myeloid cells-like 2 (Treml2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu53708
Clone ID Related Accession (Same CDS sequence)	XM_006524442.2 , NM_001360121.1
Accession Version	NM_001360121.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 813bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-24
Organism	Mus musculus(house mouse)
Product	trem-like transcript 2 protein isoform 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC241601.3 and AC166164.2. On Jan 27, 2018 this sequence version replaced XM_006524442.2. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AK037593.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCCAT GGCCTCTTAC GTTCCTGCTG TTGCTGCTGC TGCTGCTGTG GCTACAGGGC 
TGTGTCTCAG GTCACTCCAA TGAGAACCTG TACAGGAAAG TGTGGCGGCG TGAAGGCGAG 
ACCCTGTCTG TGCAGTGCTC CTACAAGAAC CGCCGGAACT TAGTTGAGGC CAAGTCTTGG 
TGCAAAGTCA AGAAGAAGAA GTGCGACCAC AACTTCACCC GGAGCTGGGT GAGGGGTCCC 
AGCTACTCTC TGCGGGATGA TGCCAAGGTC AAGGTAGTCC GTATCACCAT GGAAGCTCTC 
AGAGTTCAGG ACTCCGGACG ATACTGGTGT ATGCGTAACA CGGCTGGGCA TTTCTACCCT 
TTGGTGGGTT TCCAACTGGA AGTGTATCCA GGGACCACCA CACCAACCCC TGTGACAGGC 
TACAGTTTCA TCGATACCAG TGGCACCGTT ACAGAGCCTG AGAGGAACAC AGAGTCCCAG 
CCCGCAACCC TGTCTCCTAG CAATGCAAGA TCCTTCTCTG CTGATCCAGT GACCACCTCC 
ACCATGTCCA GACACCAGAG TAGCAGCTTG TCCACCACGG GGACGTGCCA CCCGTTAACT 
CCCAACAGGT CCCAGGAAAC TTACATCCCT GCGATGGTGG TGGTGTTGAC ATTTCTTCCA 
GCACCTGTGG TGTTGGTCGT AGCCTACGGG TTTTGGAAGA AGAGACATAT GGGAAGATAC 
AACTTGGGCA GCAACTATGC TAAACCCTGG ATACACCTTC CTGAAGGACC AGAGACACCG 
TGGAAGCCTG CTTGGTCTAA GATAACTCAG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001347050.1
CDS	490..1302
Translation	MEPWPLTFLLLLLLLLWLQGCVSGHSNENLYRKVWRREGETLSVQCSYKNRRNLVEAKSWCKVKKKKCDHNFTRSWVRGPSYSLRDDAKVKVVRITMEALRVQDSGRYWCMRNTAGHFYPLVGFQLEVYPGTTTPTPVTGYSFIDTSGTVTEPERNTESQPATLSPSNARSFSADPVTTSTMSRHQSSSLSTTGTCHPLTPNRSQETYIPAMVVVLTFLPAPVVLVVAYGFWKKRHMGRYNLGSNYAKPWIHLPEGPETPWKPAWSKITQ

Target ORF information:

RefSeq Version	NM_001360121.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus triggering receptor expressed on myeloid cells-like 2 (Treml2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001360121.1

ORF Insert Sequence:

ATGGAGCCAT GGCCTCTTAC GTTCCTGCTG TTGCTGCTGC TGCTGCTGTG GCTACAGGGC 
TGTGTCTCAG GTCACTCCAA TGAGAACCTG TACAGGAAAG TGTGGCGGCG TGAAGGCGAG 
ACCCTGTCTG TGCAGTGCTC CTACAAGAAC CGCCGGAACT TAGTTGAGGC CAAGTCTTGG 
TGCAAAGTCA AGAAGAAGAA GTGCGACCAC AACTTCACCC GGAGCTGGGT GAGGGGTCCC 
AGCTACTCTC TGCGGGATGA TGCCAAGGTC AAGGTAGTCC GTATCACCAT GGAAGCTCTC 
AGAGTTCAGG ACTCCGGACG ATACTGGTGT ATGCGTAACA CGGCTGGGCA TTTCTACCCT 
TTGGTGGGTT TCCAACTGGA AGTGTATCCA GGGACCACCA CACCAACCCC TGTGACAGGC 
TACAGTTTCA TCGATACCAG TGGCACCGTT ACAGAGCCTG AGAGGAACAC AGAGTCCCAG 
CCCGCAACCC TGTCTCCTAG CAATGCAAGA TCCTTCTCTG CTGATCCAGT GACCACCTCC 
ACCATGTCCA GACACCAGAG TAGCAGCTTG TCCACCACGG GGACGTGCCA CCCGTTAACT 
CCCAACAGGT CCCAGGAAAC TTACATCCCT GCGATGGTGG TGGTGTTGAC ATTTCTTCCA 
GCACCTGTGG TGTTGGTCGT AGCCTACGGG TTTTGGAAGA AGAGACATAT GGGAAGATAC 
AACTTGGGCA GCAACTATGC TAAACCCTGG ATACACCTTC CTGAAGGACC AGAGACACCG 
TGGAAGCCTG CTTGGTCTAA GATAACTCAG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Treml2 ( XM_006524440.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006524503.1 Mus musculus triggering receptor expressed on myeloid cells-like 2 (Treml2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu12656
Clone ID Related Accession (Same CDS sequence)	XM_006524440.2 , XM_006524441.3 , NM_001033405.2
Accession Version	XM_006524440.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 990bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	trem-like transcript 2 protein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000083.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 9, 2015 this sequence version replaced XM_006524440.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGCCAT GGCCTCTTAC GTTCCTGCTG TTGCTGCTGC TGCTGCTGTG GCTACAGGGC 
TGTGTCTCAG GTCACTCCAA TGAGAACCTG TACAGGAAAG TGTGGCGGCG TGAAGGCGAG 
ACCCTGTCTG TGCAGTGCTC CTACAAGAAC CGCCGGAACT TAGTTGAGGC CAAGTCTTGG 
TGCAAAGTCA AGAAGAAGAA GTGCGACCAC AACTTCACCC GGAGCTGGGT GAGGGGTCCC 
AGCTACTCTC TGCGGGATGA TGCCAAGGTC AAGGTAGTCC GTATCACCAT GGAAGCTCTC 
AGAGTTCAGG ACTCCGGACG ATACTGGTGT ATGCGTAACA CGGCTGGGCA TTTCTACCCT 
TTGGTGGGTT TCCAACTGGA AGTGTATCCA GCCCTCACAA CTGAGAGAAA CGTTCCCCAC 
ACACATCTTA CCAACACCCC CATGGATGGA TTTGTCACGA CCGGCCAAGT CCATATTTCA 
GACCCTCACG CTCCTTTCAC ATCTGACGTG ACTATGTTCA CATCTGAAGT GACCATGTTC 
ACATCTGGAC TCCTCACCTT GGCTTCAGGG ACCACCACAC CAACCCCTGT GACAGGCTAC 
AGTTTCATCG ATACCAGTGG CACCGTTACA GAGCCTGAGA GGAACACAGA GTCCCAGCCC 
GCAACCCTGT CTCCTAGCAA TGCAAGATCC TTCTCTGCTG ATCCAGTGAC CACCTCCACC 
ATGTCCAGAC ACCAGAGTAG CAGCTTGTCC ACCACGGGGA CGTGCCACCC GTTAACTCCC 
AACAGGTCCC AGGAAACTTA CATCCCTGCG ATGGTGGTGG TGTTGACATT TCTTCCAGCA 
CCTGTGGTGT TGGTCGTAGC CTACGGGTTT TGGAAGAAGA GACATATGGG AAGATACAAC 
TTGGGCAGCA ACTATGCTAA ACCCTGGATA CACCTTCCTG AAGGACCAGA GACACCGTGG 
AAGCCTGCTT GGTCTAAGAT AACTCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006524503.1
CDS	696..1685
Translation	MEPWPLTFLLLLLLLLWLQGCVSGHSNENLYRKVWRREGETLSVQCSYKNRRNLVEAKSWCKVKKKKCDHNFTRSWVRGPSYSLRDDAKVKVVRITMEALRVQDSGRYWCMRNTAGHFYPLVGFQLEVYPALTTERNVPHTHLTNTPMDGFVTTGQVHISDPHAPFTSDVTMFTSEVTMFTSGLLTLASGTTTPTPVTGYSFIDTSGTVTEPERNTESQPATLSPSNARSFSADPVTTSTMSRHQSSSLSTTGTCHPLTPNRSQETYIPAMVVVLTFLPAPVVLVVAYGFWKKRHMGRYNLGSNYAKPWIHLPEGPETPWKPAWSKITQ

Target ORF information:

RefSeq Version	XM_006524440.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus triggering receptor expressed on myeloid cells-like 2 (Treml2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006524440.2

ORF Insert Sequence:

ATGGAGCCAT GGCCTCTTAC GTTCCTGCTG TTGCTGCTGC TGCTGCTGTG GCTACAGGGC 
TGTGTCTCAG GTCACTCCAA TGAGAACCTG TACAGGAAAG TGTGGCGGCG TGAAGGCGAG 
ACCCTGTCTG TGCAGTGCTC CTACAAGAAC CGCCGGAACT TAGTTGAGGC CAAGTCTTGG 
TGCAAAGTCA AGAAGAAGAA GTGCGACCAC AACTTCACCC GGAGCTGGGT GAGGGGTCCC 
AGCTACTCTC TGCGGGATGA TGCCAAGGTC AAGGTAGTCC GTATCACCAT GGAAGCTCTC 
AGAGTTCAGG ACTCCGGACG ATACTGGTGT ATGCGTAACA CGGCTGGGCA TTTCTACCCT 
TTGGTGGGTT TCCAACTGGA AGTGTATCCA GCCCTCACAA CTGAGAGAAA CGTTCCCCAC 
ACACATCTTA CCAACACCCC CATGGATGGA TTTGTCACGA CCGGCCAAGT CCATATTTCA 
GACCCTCACG CTCCTTTCAC ATCTGACGTG ACTATGTTCA CATCTGAAGT GACCATGTTC 
ACATCTGGAC TCCTCACCTT GGCTTCAGGG ACCACCACAC CAACCCCTGT GACAGGCTAC 
AGTTTCATCG ATACCAGTGG CACCGTTACA GAGCCTGAGA GGAACACAGA GTCCCAGCCC 
GCAACCCTGT CTCCTAGCAA TGCAAGATCC TTCTCTGCTG ATCCAGTGAC CACCTCCACC 
ATGTCCAGAC ACCAGAGTAG CAGCTTGTCC ACCACGGGGA CGTGCCACCC GTTAACTCCC 
AACAGGTCCC AGGAAACTTA CATCCCTGCG ATGGTGGTGG TGTTGACATT TCTTCCAGCA 
CCTGTGGTGT TGGTCGTAGC CTACGGGTTT TGGAAGAAGA GACATATGGG AAGATACAAC 
TTGGGCAGCA ACTATGCTAA ACCCTGGATA CACCTTCCTG AAGGACCAGA GACACCGTGG 
AAGCCTGCTT GGTCTAAGAT AACTCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Treml2 ( XM_006524441.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006524504.1 Mus musculus triggering receptor expressed on myeloid cells-like 2 (Treml2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OMu12656
Clone ID Related Accession (Same CDS sequence)	XM_006524440.2 , XM_006524441.3 , NM_001033405.2
Accession Version	XM_006524441.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 990bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	trem-like transcript 2 protein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000083.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006524441.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGCCAT GGCCTCTTAC GTTCCTGCTG TTGCTGCTGC TGCTGCTGTG GCTACAGGGC 
TGTGTCTCAG GTCACTCCAA TGAGAACCTG TACAGGAAAG TGTGGCGGCG TGAAGGCGAG 
ACCCTGTCTG TGCAGTGCTC CTACAAGAAC CGCCGGAACT TAGTTGAGGC CAAGTCTTGG 
TGCAAAGTCA AGAAGAAGAA GTGCGACCAC AACTTCACCC GGAGCTGGGT GAGGGGTCCC 
AGCTACTCTC TGCGGGATGA TGCCAAGGTC AAGGTAGTCC GTATCACCAT GGAAGCTCTC 
AGAGTTCAGG ACTCCGGACG ATACTGGTGT ATGCGTAACA CGGCTGGGCA TTTCTACCCT 
TTGGTGGGTT TCCAACTGGA AGTGTATCCA GCCCTCACAA CTGAGAGAAA CGTTCCCCAC 
ACACATCTTA CCAACACCCC CATGGATGGA TTTGTCACGA CCGGCCAAGT CCATATTTCA 
GACCCTCACG CTCCTTTCAC ATCTGACGTG ACTATGTTCA CATCTGAAGT GACCATGTTC 
ACATCTGGAC TCCTCACCTT GGCTTCAGGG ACCACCACAC CAACCCCTGT GACAGGCTAC 
AGTTTCATCG ATACCAGTGG CACCGTTACA GAGCCTGAGA GGAACACAGA GTCCCAGCCC 
GCAACCCTGT CTCCTAGCAA TGCAAGATCC TTCTCTGCTG ATCCAGTGAC CACCTCCACC 
ATGTCCAGAC ACCAGAGTAG CAGCTTGTCC ACCACGGGGA CGTGCCACCC GTTAACTCCC 
AACAGGTCCC AGGAAACTTA CATCCCTGCG ATGGTGGTGG TGTTGACATT TCTTCCAGCA 
CCTGTGGTGT TGGTCGTAGC CTACGGGTTT TGGAAGAAGA GACATATGGG AAGATACAAC 
TTGGGCAGCA ACTATGCTAA ACCCTGGATA CACCTTCCTG AAGGACCAGA GACACCGTGG 
AAGCCTGCTT GGTCTAAGAT AACTCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006524504.1
CDS	637..1626
Translation	MEPWPLTFLLLLLLLLWLQGCVSGHSNENLYRKVWRREGETLSVQCSYKNRRNLVEAKSWCKVKKKKCDHNFTRSWVRGPSYSLRDDAKVKVVRITMEALRVQDSGRYWCMRNTAGHFYPLVGFQLEVYPALTTERNVPHTHLTNTPMDGFVTTGQVHISDPHAPFTSDVTMFTSEVTMFTSGLLTLASGTTTPTPVTGYSFIDTSGTVTEPERNTESQPATLSPSNARSFSADPVTTSTMSRHQSSSLSTTGTCHPLTPNRSQETYIPAMVVVLTFLPAPVVLVVAYGFWKKRHMGRYNLGSNYAKPWIHLPEGPETPWKPAWSKITQ

Target ORF information:

RefSeq Version	XM_006524441.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus triggering receptor expressed on myeloid cells-like 2 (Treml2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006524441.3

ORF Insert Sequence:

ATGGAGCCAT GGCCTCTTAC GTTCCTGCTG TTGCTGCTGC TGCTGCTGTG GCTACAGGGC 
TGTGTCTCAG GTCACTCCAA TGAGAACCTG TACAGGAAAG TGTGGCGGCG TGAAGGCGAG 
ACCCTGTCTG TGCAGTGCTC CTACAAGAAC CGCCGGAACT TAGTTGAGGC CAAGTCTTGG 
TGCAAAGTCA AGAAGAAGAA GTGCGACCAC AACTTCACCC GGAGCTGGGT GAGGGGTCCC 
AGCTACTCTC TGCGGGATGA TGCCAAGGTC AAGGTAGTCC GTATCACCAT GGAAGCTCTC 
AGAGTTCAGG ACTCCGGACG ATACTGGTGT ATGCGTAACA CGGCTGGGCA TTTCTACCCT 
TTGGTGGGTT TCCAACTGGA AGTGTATCCA GCCCTCACAA CTGAGAGAAA CGTTCCCCAC 
ACACATCTTA CCAACACCCC CATGGATGGA TTTGTCACGA CCGGCCAAGT CCATATTTCA 
GACCCTCACG CTCCTTTCAC ATCTGACGTG ACTATGTTCA CATCTGAAGT GACCATGTTC 
ACATCTGGAC TCCTCACCTT GGCTTCAGGG ACCACCACAC CAACCCCTGT GACAGGCTAC 
AGTTTCATCG ATACCAGTGG CACCGTTACA GAGCCTGAGA GGAACACAGA GTCCCAGCCC 
GCAACCCTGT CTCCTAGCAA TGCAAGATCC TTCTCTGCTG ATCCAGTGAC CACCTCCACC 
ATGTCCAGAC ACCAGAGTAG CAGCTTGTCC ACCACGGGGA CGTGCCACCC GTTAACTCCC 
AACAGGTCCC AGGAAACTTA CATCCCTGCG ATGGTGGTGG TGTTGACATT TCTTCCAGCA 
CCTGTGGTGT TGGTCGTAGC CTACGGGTTT TGGAAGAAGA GACATATGGG AAGATACAAC 
TTGGGCAGCA ACTATGCTAA ACCCTGGATA CACCTTCCTG AAGGACCAGA GACACCGTGG 
AAGCCTGCTT GGTCTAAGAT AACTCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Treml2 ( XM_006524442.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006524505.1 Mus musculus triggering receptor expressed on myeloid cells-like 2 (Treml2), transcript variant X3, mRNA.

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CloneID	OMu53708
Clone ID Related Accession (Same CDS sequence)	XM_006524442.2 , NM_001360121.1
Accession Version	XM_006524442.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 813bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	trem-like transcript 2 protein isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000083.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 9, 2015 this sequence version replaced XM_006524442.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGCCAT GGCCTCTTAC GTTCCTGCTG TTGCTGCTGC TGCTGCTGTG GCTACAGGGC 
TGTGTCTCAG GTCACTCCAA TGAGAACCTG TACAGGAAAG TGTGGCGGCG TGAAGGCGAG 
ACCCTGTCTG TGCAGTGCTC CTACAAGAAC CGCCGGAACT TAGTTGAGGC CAAGTCTTGG 
TGCAAAGTCA AGAAGAAGAA GTGCGACCAC AACTTCACCC GGAGCTGGGT GAGGGGTCCC 
AGCTACTCTC TGCGGGATGA TGCCAAGGTC AAGGTAGTCC GTATCACCAT GGAAGCTCTC 
AGAGTTCAGG ACTCCGGACG ATACTGGTGT ATGCGTAACA CGGCTGGGCA TTTCTACCCT 
TTGGTGGGTT TCCAACTGGA AGTGTATCCA GGGACCACCA CACCAACCCC TGTGACAGGC 
TACAGTTTCA TCGATACCAG TGGCACCGTT ACAGAGCCTG AGAGGAACAC AGAGTCCCAG 
CCCGCAACCC TGTCTCCTAG CAATGCAAGA TCCTTCTCTG CTGATCCAGT GACCACCTCC 
ACCATGTCCA GACACCAGAG TAGCAGCTTG TCCACCACGG GGACGTGCCA CCCGTTAACT 
CCCAACAGGT CCCAGGAAAC TTACATCCCT GCGATGGTGG TGGTGTTGAC ATTTCTTCCA 
GCACCTGTGG TGTTGGTCGT AGCCTACGGG TTTTGGAAGA AGAGACATAT GGGAAGATAC 
AACTTGGGCA GCAACTATGC TAAACCCTGG ATACACCTTC CTGAAGGACC AGAGACACCG 
TGGAAGCCTG CTTGGTCTAA GATAACTCAG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006524505.1
CDS	727..1539
Translation	MEPWPLTFLLLLLLLLWLQGCVSGHSNENLYRKVWRREGETLSVQCSYKNRRNLVEAKSWCKVKKKKCDHNFTRSWVRGPSYSLRDDAKVKVVRITMEALRVQDSGRYWCMRNTAGHFYPLVGFQLEVYPGTTTPTPVTGYSFIDTSGTVTEPERNTESQPATLSPSNARSFSADPVTTSTMSRHQSSSLSTTGTCHPLTPNRSQETYIPAMVVVLTFLPAPVVLVVAYGFWKKRHMGRYNLGSNYAKPWIHLPEGPETPWKPAWSKITQ

Target ORF information:

RefSeq Version	XM_006524442.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus triggering receptor expressed on myeloid cells-like 2 (Treml2), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006524442.2

ORF Insert Sequence:

ATGGAGCCAT GGCCTCTTAC GTTCCTGCTG TTGCTGCTGC TGCTGCTGTG GCTACAGGGC 
TGTGTCTCAG GTCACTCCAA TGAGAACCTG TACAGGAAAG TGTGGCGGCG TGAAGGCGAG 
ACCCTGTCTG TGCAGTGCTC CTACAAGAAC CGCCGGAACT TAGTTGAGGC CAAGTCTTGG 
TGCAAAGTCA AGAAGAAGAA GTGCGACCAC AACTTCACCC GGAGCTGGGT GAGGGGTCCC 
AGCTACTCTC TGCGGGATGA TGCCAAGGTC AAGGTAGTCC GTATCACCAT GGAAGCTCTC 
AGAGTTCAGG ACTCCGGACG ATACTGGTGT ATGCGTAACA CGGCTGGGCA TTTCTACCCT 
TTGGTGGGTT TCCAACTGGA AGTGTATCCA GGGACCACCA CACCAACCCC TGTGACAGGC 
TACAGTTTCA TCGATACCAG TGGCACCGTT ACAGAGCCTG AGAGGAACAC AGAGTCCCAG 
CCCGCAACCC TGTCTCCTAG CAATGCAAGA TCCTTCTCTG CTGATCCAGT GACCACCTCC 
ACCATGTCCA GACACCAGAG TAGCAGCTTG TCCACCACGG GGACGTGCCA CCCGTTAACT 
CCCAACAGGT CCCAGGAAAC TTACATCCCT GCGATGGTGG TGGTGTTGAC ATTTCTTCCA 
GCACCTGTGG TGTTGGTCGT AGCCTACGGG TTTTGGAAGA AGAGACATAT GGGAAGATAC 
AACTTGGGCA GCAACTATGC TAAACCCTGG ATACACCTTC CTGAAGGACC AGAGACACCG 
TGGAAGCCTG CTTGGTCTAA GATAACTCAG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation.
Neurobiology of aging42132-41(2016 06)
Zheng H,Liu CC,Atagi Y,Chen XF,Jia L,Yang L,He W,Zhang X,Kang SS,Rosenberry TL,Fryer JD,Zhang YW,Xu H,Bu G

Identification of TLT2 as an engulfment receptor for apoptotic cells.
Journal of immunology (Baltimore, Md. : 1950)188(12)6381-8(2012 Jun)
de Freitas A,Banerjee S,Xie N,Cui H,Davis KI,Friggeri A,Fu M,Abraham E,Liu G

TLT2 potentiates neutrophil antibacterial activity and chemotaxis in response to G protein-coupled receptor-mediated signaling.
Journal of immunology (Baltimore, Md. : 1950)187(5)2346-55(2011 Sep)
Halpert MM,Thomas KA,King RG,Justement LB

Enhancement of effector CD8+ T-cell function by tumour-associated B7-H3 and modulation of its counter-receptor triggering receptor expressed on myeloid cell-like transcript 2 at tumour sites.
Immunology130(3)363-73(2010 Jul)
Kobori H,Hashiguchi M,Piao J,Kato M,Ritprajak P,Azuma M

A mouse knockout library for secreted and transmembrane proteins.
Nature biotechnology28(7)749-55(2010 Jul)
Tang T,Li L,Tang J,Li Y,Lin WY,Martin F,Grant D,Solloway M,Parker L,Ye W,Forrest W,Ghilardi N,Oravecz T,Platt KA,Rice DS,Hansen GM,Abuin A,Eberhart DE,Godowski P,Holt KH,Peterson A,Zambrowicz BP,de Sauvage FJ

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Treml2 cDNA ORF clone, Mus musculus(house mouse)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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