Eloa cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Eloa
Entrez Gene ID	27224
Full Name	elongin A
Synonyms	110kDa,AA408125,Tceb3,Tceb3a
General protein information	Preferred Names elongin A Names elongin-A RNA polymerase II transcription factor SIII subunit A1 SIII p110 elongin 110 kDa subunit transcription elongation factor B polypeptide 3
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 4 Map Location: 4\|4 D3

mRNA and Protein(s)

mRNA	Protein	Name
NM_013736.4	NP_038764.2	elongin-A

Pathways from BioSystems

Homologies

Bos taurus (cattle)	LOC100851883	XP_005203441.1
Pan troglodytes (chimpanzee)	TCEB3	XP_513196.3
	TCEB3	XP_001103322.2
Canis lupus familiaris (dog)	TCEB3	XP_005617985.1
Mus musculus (house mouse)	Tceb3	NP_038764.2
Xenopus tropicalis (tropical clawed frog)	tceb3	XP_002933890.2
Homo sapiens (human)	TCEB3	NP_003189.2
Rattus norvegicus (Norway rat)	Tceb3	NP_058799.2
Gallus gallus (chicken)	TCEB3	NP_001026076.1
Danio rerio (zebrafish)	zgc:55573	NP_998620.1

Gene Ontology
Bibliography

Related articles in PubMed

Polycomb Repressive Complex 2 Methylates Elongin A to Regulate Transcription.
Ardehali MB, Anselmo A, Cochrane JC, Kundu S, Sadreyev RI, Kingston RE
Molecular cell68(5)872-884.e6(2017 Dec)

Transcriptional properties of mammalian elongin A and its role in stress response.
Kawauchi J, Inoue M, Fukuda M, Uchida Y, Yasukawa T, Conaway RC, Conaway JW, Aso T, Kitajima S
The Journal of biological chemistry288(34)24302-15(2013 Aug)

Transcriptional elongation factor elongin A regulates retinoic acid-induced gene expression during neuronal differentiation.
Yasukawa T, Bhatt S, Takeuchi T, Kawauchi J, Takahashi H, Tsutsui A, Muraoka T, Inoue M, Tsuda M, Kitajima S, Conaway RC, Conaway JW, Trainor PA, Aso T
Cell reports2(5)1129-36(2012 Nov)

A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H
Developmental cell17(6)836-48(2009 Dec)

Mammalian Elongin A complex mediates DNA-damage-induced ubiquitylation and degradation of Rpb1.
Yasukawa T, Kamura T, Kitajima S, Conaway RC, Conaway JW, Aso T
The EMBO journal27(24)3256-66(2008 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Polycomb repressive complex 2 modulates transcription of a subset of low expression target genes in part via methylation of EloA.
Title: Polycomb Repressive Complex 2 Methylates Elongin A to Regulate Transcription.

Elongin A transcription elongation activity, but not its ubiquitination activity, is most important for its function in induction of transcription of ATF3 and p21.
Title: Transcriptional properties of mammalian elongin A and its role in stress response.

Elongin A transcriptional elongation activity, but not its E3 ubiquitin ligase activity, is critical for these functions.
Title: Transcriptional elongation factor elongin A regulates retinoic acid-induced gene expression during neuronal differentiation.

The authors that both the ubiquitylation and proteasomal degradation of the largest subunit of pol II (Rpb1) following UV-irradiation are significantly suppressed in Elongin A-deficient cells.
Title: Mammalian Elongin A complex mediates DNA-damage-induced ubiquitylation and degradation of Rpb1.

a linkage between Elongin A function and cell cycle progression
Title: Mammalian elongin A is not essential for cell viability but is required for proper cell cycle progression with limited alteration of gene expression.

The following Eloa gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Eloa cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu15862	NM_013736.4 Latest version!	Mus musculus elongin A (Eloa), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$454.30 $649.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Eloa ( NM_013736.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_038764.2 Mus musculus elongin A (Eloa), mRNA.

Price & Availability↑

CloneID	OMu15862
Clone ID Related Accession (Same CDS sequence)	NM_013736.4
Accession Version	NM_013736.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2322bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-21
Organism	Mus musculus(house mouse)
Product	elongin-A
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AL672076.10. On May 1, 2007 this sequence version replaced NM_013736.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK036592.1, AK147088.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

ATGGCGGCGG AGTCGGCGCT CCAAGTTGTG GAGAAGCTCC AGGCGCGCCT GGCTGCGAAC 
CCGGACCCCA AGAAGCTATT GAAATATTTG AAGAAACTTT CCATCTTACC TATCACAGTA 
GACATTCTTG TGGAGACTGG GGTAGGGAAA ACAGTGAACA GCTTTCGGAA GCATGAGCAA 
GTAGGAAACT TTGCCAGAGA CCTGGTGGCC CAGTGGAAGA AGCTGGTTCC AGTAGAGCGA 
AATAGTGAGG CCGAGGATCA GGATTTTGAG AAGAACAATT CCCGTAAGCG TCCCAGAGAT 
GCTCTTCAGA GGGAGGAGGA GTTGGAGGGG AACTACCAGG AAAGCTGGAA ACCCTCTGGT 
AGCCGGTCCT ACAGCCCTGA GCACAGACAG AAAAAACACA AAAAACTTTC TGAGCCTGAA 
AGGCCTCACA AAGTGGCTCA CAGTCACGAG AAGAGAGATG AAAGGAAGAG GTGTCACAAA 
GTGTCACCAC CATATTCTTC AGACCCCGAG TCATCTGACT ATGGCCATGT TCAATCCCCT 
CCACCTTCAA GTCCTCATCA AATGTATACA GACCTCTCCA GGTCCCCAGA GGAGGACCAG 
GAGCCCATCA TCTCACACCA GAAGCCAGGA AAAGTCCACA GTAATACCTT TCAGGACAGA 
CTAGGGGTTA GTCACCTGGG TGAACAAGGA AAAGGGGCTG TTAGCCACCA CAAGCAGCAC 
AGATCTTCAC ACAAGGAGAA GCACCCTGCA GATGCCAGAG AGGATGAGAA GATCTCTGCT 
GTGAGCAGAG AGAAGTCACA CAAAGCCTCT TCCAAAGAGG AAAGCCGAAG ACTACTGTCA 
GGGGACAGTG CCAAGGAGAA GCTGCCCTCT AGTGTTGTTA AGAAAGACAA GGACAGAGAA 
GGCAGCAGTC TCAAGAAGAA GTTTTCACCT GCCTTAGATG TTGCTTCAGA CAACCACTTT 
AAAAAGCCCA AACACAAGGA CTCCGAGAAA GCCAAATCTG ACAAAAACAA GCAGAGTGTA 
GATGGCGTGG ACTCAGGACG AGGGACAGGA GACCCATTGC CCAAAGCCAA GGAGAAAGTT 
CCCAACCACC TGAAGGCTCA GGAGGGGAAA GTAAGAACTA ACGCAGATGG AAAGTCAGCA 
GGCCCGCTCC ACCCTAAAGC GGAGGAGACA GATGTGGACG ATGAGTTTGA GCGGCCCACG 
ATGTCCTTCG AGTCCTACCT CAGCTATGAC CAGCCCCGGA AGAAAAAGAA GAAGGTTGTG 
AAAACGTCCA GTACAGCACT TGGAGAAAAA GGACTTAAAA AAAAGGACTC TAAAAGCACT 
AGTAAAAACT TGAACTCAGC TCAGAAATTG CCCAAAGTCA ACGAAAACAA GTCAGAGAAG 
TTGCAGCCAG CTGGAGCCGA ACCCACCAGG CCTCGAAAGG TCCCTACTGA TGTGCTGCCA 
GCATTGCCAG ACATCCCCTT ACCTGCCATT CATGCCAACT ACCGGCCCCT TCCTTCCCTT 
GAGTTGATTC CCTCCTTTCA GCCAAAGCGA AAAGCTTTCT CTTCACCCCA GGAAGAAGAA 
GAAGCTGGGT TCACAGGACG CAGAATGAAT TCTAAGATGC AGGTGTATTC TGGTTCCAAG 
TGTGCCTATC TCCCCAAAAT GATGACATTG CACCAGCAGT GTATCCGGGT GCTTAAGAAT 
AATATTGACT CTATCTTTGA AGTAGGAGGA GTCCCCTATT CTGTTCTTGA ACCTGTCTTG 
GAGAGGTGCA CACCTGATCA GCTCTACCGG ATAGAGGAAT GCAATCATGT ATTAATTGAA 
GAAACAGATC AGTTGTGGAA AGTTCACTGT CACCGAGACT TTAAGGAAGA AAGGCCAGAA 
GAGTATGAGT CCTGGAGGGA GATGTACCTG AGGCTTCAGG ACGCCAGAGA GCAGCGGCTG 
CGCCTGCTCA CAAACAACAT CCGCTCTGCT CATGCCAATA AGCCAAAGGG ACGACAAGCA 
AAGATGGCTT TTGTCAACTC TGTGGCCAAG CCACCAAGAG ATGTCCGAAG AAGGCAGGAG 
AAGTTTGGAA CCGGGGGAGC AGCTGTTCCT GAGAAAGTCA GGATAAAGCC AGCGCCATAT 
ACAACAGGAA GCAGCCATGT TCCTGCCAGC AACAGCAGCA GCAACTTCCA CTCCAGTCCT 
GAGGAGCTGG CCTATGATGG GCCCAGTACT AGCAGTGCCC ACTTAGCTCC TGTGGCCAGC 
AGTTCTGTTT CCTATGATCC CAGGAAACCA GCTGTGAAGA AAATTGCTCC GATGATGGCC 
AAGACCATTA AAGCATTCAA GAACAGATTC TCCCGGCGAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_038764.2
CDS	25..2346
Translation	MAAESALQVVEKLQARLAANPDPKKLLKYLKKLSILPITVDILVETGVGKTVNSFRKHEQVGNFARDLVAQWKKLVPVERNSEAEDQDFEKNNSRKRPRDALQREEELEGNYQESWKPSGSRSYSPEHRQKKHKKLSEPERPHKVAHSHEKRDERKRCHKVSPPYSSDPESSDYGHVQSPPPSSPHQMYTDLSRSPEEDQEPIISHQKPGKVHSNTFQDRLGVSHLGEQGKGAVSHHKQHRSSHKEKHPADAREDEKISAVSREKSHKASSKEESRRLLSGDSAKEKLPSSVVKKDKDREGSSLKKKFSPALDVASDNHFKKPKHKDSEKAKSDKNKQSVDGVDSGRGTGDPLPKAKEKVPNHLKAQEGKVRTNADGKSAGPLHPKAEETDVDDEFERPTMSFESYLSYDQPRKKKKKVVKTSSTALGEKGLKKKDSKSTSKNLNSAQKLPKVNENKSEKLQPAGAEPTRPRKVPTDVLPALPDIPLPAIHANYRPLPSLELIPSFQPKRKAFSSPQEEEEAGFTGRRMNSKMQVYSGSKCAYLPKMMTLHQQCIRVLKNNIDSIFEVGGVPYSVLEPVLERCTPDQLYRIEECNHVLIEETDQLWKVHCHRDFKEERPEEYESWREMYLRLQDAREQRLRLLTNNIRSAHANKPKGRQAKMAFVNSVAKPPRDVRRRQEKFGTGGAAVPEKVRIKPAPYTTGSSHVPASNSSSNFHSSPEELAYDGPSTSSAHLAPVASSSVSYDPRKPAVKKIAPMMAKTIKAFKNRFSRR

Target ORF information:

RefSeq Version	NM_013736.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus elongin A (Eloa), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013736.4

ORF Insert Sequence:

ATGGCGGCGG AGTCGGCGCT CCAAGTTGTG GAGAAGCTCC AGGCGCGCCT GGCTGCGAAC 
CCGGACCCCA AGAAGCTATT GAAATATTTG AAGAAACTTT CCATCTTACC TATCACAGTA 
GACATTCTTG TGGAGACTGG GGTAGGGAAA ACAGTGAACA GCTTTCGGAA GCATGAGCAA 
GTAGGAAACT TTGCCAGAGA CCTGGTGGCC CAGTGGAAGA AGCTGGTTCC AGTAGAGCGA 
AATAGTGAGG CCGAGGATCA GGATTTTGAG AAGAACAATT CCCGTAAGCG TCCCAGAGAT 
GCTCTTCAGA GGGAGGAGGA GTTGGAGGGG AACTACCAGG AAAGCTGGAA ACCCTCTGGT 
AGCCGGTCCT ACAGCCCTGA GCACAGACAG AAAAAACACA AAAAACTTTC TGAGCCTGAA 
AGGCCTCACA AAGTGGCTCA CAGTCACGAG AAGAGAGATG AAAGGAAGAG GTGTCACAAA 
GTGTCACCAC CATATTCTTC AGACCCCGAG TCATCTGACT ATGGCCATGT TCAATCCCCT 
CCACCTTCAA GTCCTCATCA AATGTATACA GACCTCTCCA GGTCCCCAGA GGAGGACCAG 
GAGCCCATCA TCTCACACCA GAAGCCAGGA AAAGTCCACA GTAATACCTT TCAGGACAGA 
CTAGGGGTTA GTCACCTGGG TGAACAAGGA AAAGGGGCTG TTAGCCACCA CAAGCAGCAC 
AGATCTTCAC ACAAGGAGAA GCACCCTGCA GATGCCAGAG AGGATGAGAA GATCTCTGCT 
GTGAGCAGAG AGAAGTCACA CAAAGCCTCT TCCAAAGAGG AAAGCCGAAG ACTACTGTCA 
GGGGACAGTG CCAAGGAGAA GCTGCCCTCT AGTGTTGTTA AGAAAGACAA GGACAGAGAA 
GGCAGCAGTC TCAAGAAGAA GTTTTCACCT GCCTTAGATG TTGCTTCAGA CAACCACTTT 
AAAAAGCCCA AACACAAGGA CTCCGAGAAA GCCAAATCTG ACAAAAACAA GCAGAGTGTA 
GATGGCGTGG ACTCAGGACG AGGGACAGGA GACCCATTGC CCAAAGCCAA GGAGAAAGTT 
CCCAACCACC TGAAGGCTCA GGAGGGGAAA GTAAGAACTA ACGCAGATGG AAAGTCAGCA 
GGCCCGCTCC ACCCTAAAGC GGAGGAGACA GATGTGGACG ATGAGTTTGA GCGGCCCACG 
ATGTCCTTCG AGTCCTACCT CAGCTATGAC CAGCCCCGGA AGAAAAAGAA GAAGGTTGTG 
AAAACGTCCA GTACAGCACT TGGAGAAAAA GGACTTAAAA AAAAGGACTC TAAAAGCACT 
AGTAAAAACT TGAACTCAGC TCAGAAATTG CCCAAAGTCA ACGAAAACAA GTCAGAGAAG 
TTGCAGCCAG CTGGAGCCGA ACCCACCAGG CCTCGAAAGG TCCCTACTGA TGTGCTGCCA 
GCATTGCCAG ACATCCCCTT ACCTGCCATT CATGCCAACT ACCGGCCCCT TCCTTCCCTT 
GAGTTGATTC CCTCCTTTCA GCCAAAGCGA AAAGCTTTCT CTTCACCCCA GGAAGAAGAA 
GAAGCTGGGT TCACAGGACG CAGAATGAAT TCTAAGATGC AGGTGTATTC TGGTTCCAAG 
TGTGCCTATC TCCCCAAAAT GATGACATTG CACCAGCAGT GTATCCGGGT GCTTAAGAAT 
AATATTGACT CTATCTTTGA AGTAGGAGGA GTCCCCTATT CTGTTCTTGA ACCTGTCTTG 
GAGAGGTGCA CACCTGATCA GCTCTACCGG ATAGAGGAAT GCAATCATGT ATTAATTGAA 
GAAACAGATC AGTTGTGGAA AGTTCACTGT CACCGAGACT TTAAGGAAGA AAGGCCAGAA 
GAGTATGAGT CCTGGAGGGA GATGTACCTG AGGCTTCAGG ACGCCAGAGA GCAGCGGCTG 
CGCCTGCTCA CAAACAACAT CCGCTCTGCT CATGCCAATA AGCCAAAGGG ACGACAAGCA 
AAGATGGCTT TTGTCAACTC TGTGGCCAAG CCACCAAGAG ATGTCCGAAG AAGGCAGGAG 
AAGTTTGGAA CCGGGGGAGC AGCTGTTCCT GAGAAAGTCA GGATAAAGCC AGCGCCATAT 
ACAACAGGAA GCAGCCATGT TCCTGCCAGC AACAGCAGCA GCAACTTCCA CTCCAGTCCT 
GAGGAGCTGG CCTATGATGG GCCCAGTACT AGCAGTGCCC ACTTAGCTCC TGTGGCCAGC 
AGTTCTGTTT CCTATGATCC CAGGAAACCA GCTGTGAAGA AAATTGCTCC GATGATGGCC 
AAGACCATTA AAGCATTCAA GAACAGATTC TCCCGGCGAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Polycomb Repressive Complex 2 Methylates Elongin A to Regulate Transcription.
Molecular cell68(5)872-884.e6(2017 Dec)
Ardehali MB,Anselmo A,Cochrane JC,Kundu S,Sadreyev RI,Kingston RE

Transcriptional properties of mammalian elongin A and its role in stress response.
The Journal of biological chemistry288(34)24302-15(2013 Aug)
Kawauchi J,Inoue M,Fukuda M,Uchida Y,Yasukawa T,Conaway RC,Conaway JW,Aso T,Kitajima S

Transcriptional elongation factor elongin A regulates retinoic acid-induced gene expression during neuronal differentiation.
Cell reports2(5)1129-36(2012 Nov)
Yasukawa T,Bhatt S,Takeuchi T,Kawauchi J,Takahashi H,Tsutsui A,Muraoka T,Inoue M,Tsuda M,Kitajima S,Conaway RC,Conaway JW,Trainor PA,Aso T

A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Developmental cell17(6)836-48(2009 Dec)
Yokoyama S,Ito Y,Ueno-Kudoh H,Shimizu H,Uchibe K,Albini S,Mitsuoka K,Miyaki S,Kiso M,Nagai A,Hikata T,Osada T,Fukuda N,Yamashita S,Harada D,Mezzano V,Kasai M,Puri PL,Hayashizaki Y,Okado H,Hashimoto M,Asahara H

Mammalian Elongin A complex mediates DNA-damage-induced ubiquitylation and degradation of Rpb1.
The EMBO journal27(24)3256-66(2008 Dec)
Yasukawa T,Kamura T,Kitajima S,Conaway RC,Conaway JW,Aso T

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Eloa cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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