ELOA cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ELOA
Entrez Gene ID	6924
Full Name	elongin A
Synonyms	SIII,SIII p110,TCEB3,TCEB3A
General protein information	Preferred Names elongin A Names elongin-A RNA polymerase II transcription factor SIII subunit A1 elongin 110 kDa subunit transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A) transcription elongation factor B alpha subunit transcription elongation factor B polypeptide 3 transcription elongation factor B subunit 3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p36.11
Summary	This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. [provided by RefSeq, Jul 2008].
Disorder MIM:	600786

mRNA and Protein(s)

mRNA	Protein	Name
NM_003198.2	NP_003189.2	elongin-A

Pathways from BioSystems

Homologies

Bos taurus (cattle)	LOC100851883	XP_005203441.1
Pan troglodytes (chimpanzee)	TCEB3	XP_513196.3
	TCEB3	XP_001103322.2
Canis lupus familiaris (dog)	TCEB3	XP_005617985.1
Mus musculus (house mouse)	Tceb3	NP_038764.2
Xenopus tropicalis (tropical clawed frog)	tceb3	XP_002933890.2
Homo sapiens (human)	TCEB3	NP_003189.2
Rattus norvegicus (Norway rat)	Tceb3	NP_058799.2
Gallus gallus (chicken)	TCEB3	NP_001026076.1
Danio rerio (zebrafish)	zgc:55573	NP_998620.1

Gene Ontology
Bibliography

Related articles in PubMed

Cockayne syndrome B protein regulates recruitment of the Elongin A ubiquitin ligase to sites of DNA damage.
Weems JC, Slaughter BD, Unruh JR, Boeing S, Hall SM, McLaird MB, Yasukawa T, Aso T, Svejstrup JQ, Conaway JW, Conaway RC
The Journal of biological chemistry292(16)6431-6437(2017 04)

TCEB3C a putative tumor suppressor gene of small intestinal neuroendocrine tumors.
Edfeldt K, Ahmad T, ?kerstr?m G, Janson ET, Hellman P, St?lberg P, Bj?rklund P, Westin G
Endocrine-related cancer21(2)275-84(2014 Apr)

Transcriptional properties of mammalian elongin A and its role in stress response.
Kawauchi J, Inoue M, Fukuda M, Uchida Y, Yasukawa T, Conaway RC, Conaway JW, Aso T, Kitajima S
The Journal of biological chemistry288(34)24302-15(2013 Aug)

Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach.
B?hm D, Keller K, Pieter J, Boehm N, Wolters D, Siggelkow W, Lebrecht A, Schmidt M, K?lbl H, Pfeiffer N, Grus FH
Oncology reports28(2)429-38(2012 Aug)

The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.
Landa I, Ruiz-Llorente S, Montero-Conde C, Inglada-P?rez L, Schiavi F, Leskel? S, Pita G, Milne R, Maravall J, Ramos I, And?a V, Rodr?guez-Poyo P, Jara-Albarr?n A, Meoro A, del Peso C, Arribas L, Iglesias P, Caballero J, Serrano J, Pic? A, Pomares F, Gim?nez G, L?pez-Mond?jar P, Castello R, Merante-Boschin I, Pelizzo MR, Mauricio D, Opocher G, Rodr?guez-Antona C, Gonz?lez-Neira A, Mat?as-Guiu X, Santisteban P, Robledo M
PLoS genetics5(9)e1000637(2009 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the Elongin A ubiquitin ligase and the CSB protein function together in a common pathway in response to Pol II stalling and DNA damage
Title: Cockayne syndrome B protein regulates recruitment of the Elongin A ubiquitin ligase to sites of DNA damage.

TCEB3C is a putative tumor suppressor gene of small intestinal neuroendocrine tumors
Title: TCEB3C a putative tumor suppressor gene of small intestinal neuroendocrine tumors.

Elongin A transcription elongation activity, but not its ubiquitination activity, is most important for its function in induction of transcription of ATF3 and p21.
Title: Transcriptional properties of mammalian elongin A and its role in stress response.

Observational study of gene-disease association. (HuGE Navigator)
Title: The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.

The following ELOA gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ELOA cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu30702	NM_003198.2 Latest version!	Homo sapiens elongin A (ELOA), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$404.50-$566.30 $809.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ELOA ( NM_003198.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_003189.2 Homo sapiens elongin A (ELOA), mRNA.

Price & Availability↑

CloneID	OHu30702
Clone ID Related Accession (Same CDS sequence)	NM_003198.2
Accession Version	NM_003198.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2397bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-17
Organism	Homo sapiens(human)
Product	elongin-A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB461774.1, AK310229.1, AL031295.1 and AW451236.1. On Oct 2, 2008 this sequence version replaced NM_003198.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.126573.1, SRR1803614.158340.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCACGGAG GGCGGAGCTG CGGCCCGAGG ACGCGACGCG AGCCCAGTTC CGGCGAGGAG 
GCCGCGCCAG TGACAGCGAT GGCGGCGGAG TCGGCGCTCC AAGTTGTGGA GAAGCTGCAG 
GCGCGCCTGG CCGCGAACCC GGACCCTAAG AAGCTATTGA AATATTTGAA GAAACTCTCC 
ACCCTGCCTA TTACAGTAGA CATTCTTGCG GAGACTGGGG TTGGGAAAAC AGTAAATAGC 
TTGCGAAAAC ACGAGCATGT TGGAAGCTTT GCCAGGGACC TAGTGGCCCA GTGGAAGAAG 
CTGGTTCCTG TGGAACGAAA TGCTGAGCCT GATGAACAGG ACTTTGAGAA GAGCAATTCC 
CGAAAGCGCC CTCGGGATGC CCTGCAGAAG GAGGAGGAGA TGGAGGGGGA CTACCAAGAA 
ACCTGGAAAG CCACGGGGAG CCGATCCTAT AGCCCTGACC ACAGGCAGAA GAAACATAGG 
AAACTCTCGG AGCTCGAGAG ACCTCACAAA GTGTCTCACG GTCATGAGAG GAGAGATGAG 
AGAAAGAGGT GTCACAGAAT GTCACCAACT TACTCTTCAG ACCCTGAGTC TTCTGATTAT 
GGCCATGTTC AATCCCCTCC ATCTTGTACC AGTCCTCATC AGATGTACGT CGACCACTAC 
AGATCCCTGG AGGAGGACCA GGAGCCCATT GTTTCACACC AGAAGCCTGG GAAAGGCCAC 
AGCAATGCCT TTCAGGACAG ACTCGGGGCC AGCCAAGAAC GACACCTGGG TGAACCCCAT 
GGGAAAGGGG TTGTGAGTCA AAACAAGGAG CACAAATCTT CCCACAAGGA CAAACGCCCC 
GTGGATGCCA AGAGTGATGA GAAGGCCTCT GTGGTGAGCA GAGAGAAATC ACACAAGGCC 
CTCTCCAAAG AGGAGAACCG AAGGCCACCC TCAGGGGACA ATGCAAGGGA GAAACCGCCC 
TCTAGTGGCG TAAAGAAAGA GAAGGACAGA GAGGGCAGCA GCCTGAAGAA GAAGTGTTTG 
CCTCCCTCAG AGGCCGCTTC AGACAACCAC CTGAAAAAGC CAAAGCACAG AGACCCAGAG 
AAAGCCAAAT TGGACAAAAG CAAGCAAGGT CTGGACAGCT TTGACACAGG AAAAGGAGCA 
GGAGACCTGT TGCCCAAGGT AAAAGAGAAG GGTTCTAACA ACCTAAAGAC TCCAGAAGGG 
AAAGTCAAAA CTAATTTGGA TAGAAAGTCA CTGGGCTCCC TCCCTAAAGT TGAGGAGACA 
GATATGGAGG ATGAATTCGA GCAGCCAACC ATGTCTTTTG AATCCTACCT CAGCTATGAC 
CAGCCCCGGA AGAAAAAGAA AAAGATTGTG AAAACTTCAG CCACGGCACT TGGAGATAAA 
GGACTTAAAA AAAATGACTC TAAAAGCACT GGTAAAAACT TGGACTCAGT TCAGAAATTA 
CCCAAGGTGA ACAAAACCAA GTCAGAGAAG CCGGCTGGAG CTGATTTAGC CAAGCTGAGA 
AAGGTGCCTG ATGTGTTGCC AGTGTTGCCA GACCTCCCGT TACCCGCGAT ACAGGCCAAT 
TACCGTCCAC TGCCTTCCCT CGAGCTGATA TCCTCCTTCC AGCCAAAGCG AAAAGCGTTC 
TCTTCACCCC AGGAAGAAGA AGAAGCTGGA TTTACTGGGC GCAGAATGAA TTCCAAGATG 
CAGGTGTATT CTGGTTCCAA GTGTGCCTAT CTCCCTAAAA TGATGACCTT GCACCAGCAA 
TGCATCCGAG TACTTAAAAA CAACATCGAT TCAATCTTTG AAGTGGGAGG AGTCCCATAC 
TCTGTTCTTG AACCCGTTTT GGAGAGGTGT ACACCTGATC AGCTGTATCG CATAGAGGAA 
TACAATCATG TATTAATTGA AGAAACAGAT CAATTATGGA AAGTTCATTG TCACCGAGAC 
TTTAAGGAAG AAAGACCCGA AGAGTATGAG TCGTGGCGAG AGATGTACCT GCGGCTTCAG 
GACGCCCGAG AGCAGCGGCT ACGAGTACTA ACAAAGAATA TCCAGTTCGC ACATGCCAAT 
AAGCCCAAAG GCCGACAAGC AAAGATGGCC TTTGTCAACT CTGTGGCCAA GCCACCTCGT 
GACGTCCGGA GGAGGCAGGA AAAGTTTGGA ACGGGAGGAG CAGCTGTCCC TGAGAAAATC 
AAGATCAAGC CAGCCCCGTA CCCCATGGGA AGCAGCCATG CTTCCGCCAG TAGCATCAGC 
TTTAACCCCA GCCCTGAGGA GCCGGCCTAT GATGGCCCAA GCACCAGCAG TGCCCACTTG 
GCACCAGTGG TCAGCAGCAC TGTTTCCTAT GATCCTAGGA AACCCACTGT GAAGAAAATT 
GCCCCAATGA TGGCCAAGAC AATTAAAGCT TTCAAGAACA GATTCTCCCG ACGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003189.2
CDS	61..2457
Translation	MHGGRSCGPRTRREPSSGEEAAPVTAMAAESALQVVEKLQARLAANPDPKKLLKYLKKLSTLPITVDILAETGVGKTVNSLRKHEHVGSFARDLVAQWKKLVPVERNAEPDEQDFEKSNSRKRPRDALQKEEEMEGDYQETWKATGSRSYSPDHRQKKHRKLSELERPHKVSHGHERRDERKRCHRMSPTYSSDPESSDYGHVQSPPSCTSPHQMYVDHYRSLEEDQEPIVSHQKPGKGHSNAFQDRLGASQERHLGEPHGKGVVSQNKEHKSSHKDKRPVDAKSDEKASVVSREKSHKALSKEENRRPPSGDNAREKPPSSGVKKEKDREGSSLKKKCLPPSEAASDNHLKKPKHRDPEKAKLDKSKQGLDSFDTGKGAGDLLPKVKEKGSNNLKTPEGKVKTNLDRKSLGSLPKVEETDMEDEFEQPTMSFESYLSYDQPRKKKKKIVKTSATALGDKGLKKNDSKSTGKNLDSVQKLPKVNKTKSEKPAGADLAKLRKVPDVLPVLPDLPLPAIQANYRPLPSLELISSFQPKRKAFSSPQEEEEAGFTGRRMNSKMQVYSGSKCAYLPKMMTLHQQCIRVLKNNIDSIFEVGGVPYSVLEPVLERCTPDQLYRIEEYNHVLIEETDQLWKVHCHRDFKEERPEEYESWREMYLRLQDAREQRLRVLTKNIQFAHANKPKGRQAKMAFVNSVAKPPRDVRRRQEKFGTGGAAVPEKIKIKPAPYPMGSSHASASSISFNPSPEEPAYDGPSTSSAHLAPVVSSTVSYDPRKPTVKKIAPMMAKTIKAFKNRFSRR

Target ORF information:

RefSeq Version	NM_003198.2
Organism	Homo sapiens(human)
Definition	Homo sapiens elongin A (ELOA), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003198.2

ORF Insert Sequence:

ATGCACGGAG GGCGGAGCTG CGGCCCGAGG ACGCGACGCG AGCCCAGTTC CGGCGAGGAG 
GCCGCGCCAG TGACAGCGAT GGCGGCGGAG TCGGCGCTCC AAGTTGTGGA GAAGCTGCAG 
GCGCGCCTGG CCGCGAACCC GGACCCTAAG AAGCTATTGA AATATTTGAA GAAACTCTCC 
ACCCTGCCTA TTACAGTAGA CATTCTTGCG GAGACTGGGG TTGGGAAAAC AGTAAATAGC 
TTGCGAAAAC ACGAGCATGT TGGAAGCTTT GCCAGGGACC TAGTGGCCCA GTGGAAGAAG 
CTGGTTCCTG TGGAACGAAA TGCTGAGCCT GATGAACAGG ACTTTGAGAA GAGCAATTCC 
CGAAAGCGCC CTCGGGATGC CCTGCAGAAG GAGGAGGAGA TGGAGGGGGA CTACCAAGAA 
ACCTGGAAAG CCACGGGGAG CCGATCCTAT AGCCCTGACC ACAGGCAGAA GAAACATAGG 
AAACTCTCGG AGCTCGAGAG ACCTCACAAA GTGTCTCACG GTCATGAGAG GAGAGATGAG 
AGAAAGAGGT GTCACAGAAT GTCACCAACT TACTCTTCAG ACCCTGAGTC TTCTGATTAT 
GGCCATGTTC AATCCCCTCC ATCTTGTACC AGTCCTCATC AGATGTACGT CGACCACTAC 
AGATCCCTGG AGGAGGACCA GGAGCCCATT GTTTCACACC AGAAGCCTGG GAAAGGCCAC 
AGCAATGCCT TTCAGGACAG ACTCGGGGCC AGCCAAGAAC GACACCTGGG TGAACCCCAT 
GGGAAAGGGG TTGTGAGTCA AAACAAGGAG CACAAATCTT CCCACAAGGA CAAACGCCCC 
GTGGATGCCA AGAGTGATGA GAAGGCCTCT GTGGTGAGCA GAGAGAAATC ACACAAGGCC 
CTCTCCAAAG AGGAGAACCG AAGGCCACCC TCAGGGGACA ATGCAAGGGA GAAACCGCCC 
TCTAGTGGCG TAAAGAAAGA GAAGGACAGA GAGGGCAGCA GCCTGAAGAA GAAGTGTTTG 
CCTCCCTCAG AGGCCGCTTC AGACAACCAC CTGAAAAAGC CAAAGCACAG AGACCCAGAG 
AAAGCCAAAT TGGACAAAAG CAAGCAAGGT CTGGACAGCT TTGACACAGG AAAAGGAGCA 
GGAGACCTGT TGCCCAAGGT AAAAGAGAAG GGTTCTAACA ACCTAAAGAC TCCAGAAGGG 
AAAGTCAAAA CTAATTTGGA TAGAAAGTCA CTGGGCTCCC TCCCTAAAGT TGAGGAGACA 
GATATGGAGG ATGAATTCGA GCAGCCAACC ATGTCTTTTG AATCCTACCT CAGCTATGAC 
CAGCCCCGGA AGAAAAAGAA AAAGATTGTG AAAACTTCAG CCACGGCACT TGGAGATAAA 
GGACTTAAAA AAAATGACTC TAAAAGCACT GGTAAAAACT TGGACTCAGT TCAGAAATTA 
CCCAAGGTGA ACAAAACCAA GTCAGAGAAG CCGGCTGGAG CTGATTTAGC CAAGCTGAGA 
AAGGTGCCTG ATGTGTTGCC AGTGTTGCCA GACCTCCCGT TACCCGCGAT ACAGGCCAAT 
TACCGTCCAC TGCCTTCCCT CGAGCTGATA TCCTCCTTCC AGCCAAAGCG AAAAGCGTTC 
TCTTCACCCC AGGAAGAAGA AGAAGCTGGA TTTACTGGGC GCAGAATGAA TTCCAAGATG 
CAGGTGTATT CTGGTTCCAA GTGTGCCTAT CTCCCTAAAA TGATGACCTT GCACCAGCAA 
TGCATCCGAG TACTTAAAAA CAACATCGAT TCAATCTTTG AAGTGGGAGG AGTCCCATAC 
TCTGTTCTTG AACCCGTTTT GGAGAGGTGT ACACCTGATC AGCTGTATCG CATAGAGGAA 
TACAATCATG TATTAATTGA AGAAACAGAT CAATTATGGA AAGTTCATTG TCACCGAGAC 
TTTAAGGAAG AAAGACCCGA AGAGTATGAG TCGTGGCGAG AGATGTACCT GCGGCTTCAG 
GACGCCCGAG AGCAGCGGCT ACGAGTACTA ACAAAGAATA TCCAGTTCGC ACATGCCAAT 
AAGCCCAAAG GCCGACAAGC AAAGATGGCC TTTGTCAACT CTGTGGCCAA GCCACCTCGT 
GACGTCCGGA GGAGGCAGGA AAAGTTTGGA ACGGGAGGAG CAGCTGTCCC TGAGAAAATC 
AAGATCAAGC CAGCCCCGTA CCCCATGGGA AGCAGCCATG CTTCCGCCAG TAGCATCAGC 
TTTAACCCCA GCCCTGAGGA GCCGGCCTAT GATGGCCCAA GCACCAGCAG TGCCCACTTG 
GCACCAGTGG TCAGCAGCAC TGTTTCCTAT GATCCTAGGA AACCCACTGT GAAGAAAATT 
GCCCCAATGA TGGCCAAGAC AATTAAAGCT TTCAAGAACA GATTCTCCCG ACGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cockayne syndrome B protein regulates recruitment of the Elongin A ubiquitin ligase to sites of DNA damage.
The Journal of biological chemistry292(16)6431-6437(2017 04)
Weems JC,Slaughter BD,Unruh JR,Boeing S,Hall SM,McLaird MB,Yasukawa T,Aso T,Svejstrup JQ,Conaway JW,Conaway RC

TCEB3C a putative tumor suppressor gene of small intestinal neuroendocrine tumors.
Endocrine-related cancer21(2)275-84(2014 Apr)
Edfeldt K,Ahmad T,?kerstr?m G,Janson ET,Hellman P,St?lberg P,Bj?rklund P,Westin G

Transcriptional properties of mammalian elongin A and its role in stress response.
The Journal of biological chemistry288(34)24302-15(2013 Aug)
Kawauchi J,Inoue M,Fukuda M,Uchida Y,Yasukawa T,Conaway RC,Conaway JW,Aso T,Kitajima S

Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach.
Oncology reports28(2)429-38(2012 Aug)
B?hm D,Keller K,Pieter J,Boehm N,Wolters D,Siggelkow W,Lebrecht A,Schmidt M,K?lbl H,Pfeiffer N,Grus FH

The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.
PLoS genetics5(9)e1000637(2009 Sep)
Landa I,Ruiz-Llorente S,Montero-Conde C,Inglada-P?rez L,Schiavi F,Leskel? S,Pita G,Milne R,Maravall J,Ramos I,And?a V,Rodr?guez-Poyo P,Jara-Albarr?n A,Meoro A,del Peso C,Arribas L,Iglesias P,Caballero J,Serrano J,Pic? A,Pomares F,Gim?nez G,L?pez-Mond?jar P,Castello R,Merante-Boschin I,Pelizzo MR,Mauricio D,Opocher G,Rodr?guez-Antona C,Gonz?lez-Neira A,Mat?as-Guiu X,Santisteban P,Robledo M

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ELOA cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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