H3c7 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	H3c7
Entrez Gene ID	260423
Full Name	histone cluster 1, H3f
Synonyms	H3.2-221,Hist1
General protein information	Preferred Names histone cluster 1, H3f Names histone H3.2 histone 1, H3f histone H3 histone gene complex 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 13 Map Location: 13 A3.1\|13 9.78 cM
Summary	Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Aug 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_013548.4	NP_038576.1	histone H3.2

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	LOC483172	XP_540290.2
Bos taurus (cattle)	LOC619141	XP_005204024.1
Gallus gallus (chicken)	LOC417953	XP_416193.2
Drosophila melanogaster (fruit fly)	His3:CG33815	NP_001027303.1
	LOC695573	XP_001083065.1
Rattus norvegicus (Norway rat)	LOC100359421	XP_002729690.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012573	XP_560604.5
Arabidopsis thaliana (thale cress)	AT1G13370	NP_172794.1
Homo sapiens (human)	HIST2H3A	NP_001005464.1
Mus musculus (house mouse)	Hist1h3f	NP_038576.1
Pan troglodytes (chimpanzee)	LOC100613592	XP_003314213.1
Danio rerio (zebrafish)	zgc:113983	NP_001020342.1
Xenopus tropicalis (tropical clawed frog)	LOC100487179	XP_004915673.1

Gene Ontology
Bibliography

Related articles in PubMed

BRACHYURY directs histone acetylation to target loci during mesoderm development.
Beisaw A, Tsaytler P, Koch F, Schmitz SU, Melissari MT, Senft AD, Wittler L, Pennimpede T, Macura K, Herrmann BG, Grote P
EMBO reports19(1)118-134(2018 Jan)

H3.3
Pathania M, De Jay N, Maestro N, Harutyunyan AS, Nitarska J, Pahlavan P, Henderson S, Mikael LG, Richard-Londt A, Zhang Y, Costa JR, H?bert S, Khazaei S, Ibrahim NS, Herrero J, Riccio A, Albrecht S, Ketteler R, Brandner S, Kleinman CL, Jabado N, Salomoni P
Cancer cell32(5)684-700.e9(2017 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Histone H3.3K27M and Trp53 loss and PDGFRA overexpression accelerates disease onset and increases tumor invasion.
Title: H3.3

Increased levels of decondensed chromatin in both normal progenitor cells and cancer cells are associated with global loss of H3K27me3, which is linked to MYC overexpression.
Title: Global levels of H3K27me3 track with differentiation in vivo and are deregulated by MYC in prostate cancer.

Histone H3 arginine 2 dimethylation lysine 4 trimethylation, not simply H3lysine 4 trimethylation alone, is the mark of active promoters
Title: Histone H3R2 symmetric dimethylation and histone H3K4 trimethylation are tightly correlated in eukaryotic genomes.

Hepatic lipid accumulation alters global histone h3 lysine 9 and 4 trimethylation in the peroxisome proliferator-activated receptor alpha network.
Title: Hepatic lipid accumulation alters global histone h3 lysine 9 and 4 trimethylation in the peroxisome proliferator-activated receptor alpha network.

Bmi1, which methylate H3K27, were present on the HSV-1 genome during latency.
Title: The polycomb group protein Bmi1 binds to the herpes simplex virus 1 latent genome and maintains repressive histone marks during latency.

The following H3c7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the H3c7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu16710	NM_013548.4 Latest version!	Mus musculus H3 clustered histone 7 (H3c7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

H3c7 ( NM_013548.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_038576.1 Mus musculus H3 clustered histone 7 (H3c7), mRNA.

Price & Availability↑

CloneID	OMu16710
Clone ID Related Accession (Same CDS sequence)	NM_013548.4
Accession Version	NM_013548.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 411bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	histone H3.2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC034285.6. On Feb 27, 2014 this sequence version replaced NM_013548.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTCGTA CTAAGCAGAC CGCTCGCAAG TCCACTGGCG GCAAGGCCCC GCGCAAGCAG 
CTGGCCACCA AGGCCGCCCG CAAGAGCGCC CCGGCCACCG GCGGCGTGAA GAAACCTCAC 
CGCTACCGTC CCGGCACCGT GGCGCTGCGC GAGATCCGGC GCTACCAGAA GTCGACCGAG 
CTGCTGATCC GCAAGCTGCC GTTCCAGCGC CTGGTGCGCG AGATCGCGCA GGACTTCAAG 
ACCGACCTGC GCTTCCAGAG CTCGGCCGTC ATGGCTCTGC AGGAGGCGAG CGAGGCCTAC 
CTTGTGGGTC TGTTTGAGGA CACCAACCTG TGCGCCATCC ACGCCAAGCG TGTCACCATC 
ATGCCCAAGG ACATCCAGCT GGCCCGCCGT ATCCGCGGCG AGCGGGCTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_038576.1
CDS	434..844
Translation	MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA

Target ORF information:

RefSeq Version	NM_013548.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus H3 clustered histone 7 (H3c7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013548.4

ORF Insert Sequence:

ATGGCTCGTA CTAAGCAGAC CGCTCGCAAG TCCACTGGCG GCAAGGCCCC GCGCAAGCAG 
CTGGCCACCA AGGCCGCCCG CAAGAGCGCC CCGGCCACCG GCGGCGTGAA GAAACCTCAC 
CGCTACCGTC CCGGCACCGT GGCGCTGCGC GAGATCCGGC GCTACCAGAA GTCGACCGAG 
CTGCTGATCC GCAAGCTGCC GTTCCAGCGC CTGGTGCGCG AGATCGCGCA GGACTTCAAG 
ACCGACCTGC GCTTCCAGAG CTCGGCCGTC ATGGCTCTGC AGGAGGCGAG CGAGGCCTAC 
CTTGTGGGTC TGTTTGAGGA CACCAACCTG TGCGCCATCC ACGCCAAGCG TGTCACCATC 
ATGCCCAAGG ACATCCAGCT GGCCCGCCGT ATCCGCGGCG AGCGGGCTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

BRACHYURY directs histone acetylation to target loci during mesoderm development.
EMBO reports19(1)118-134(2018 Jan)
Beisaw A,Tsaytler P,Koch F,Schmitz SU,Melissari MT,Senft AD,Wittler L,Pennimpede T,Macura K,Herrmann BG,Grote P

H3.3
Cancer cell32(5)684-700.e9(2017 Nov)
Pathania M,De Jay N,Maestro N,Harutyunyan AS,Nitarska J,Pahlavan P,Henderson S,Mikael LG,Richard-Londt A,Zhang Y,Costa JR,H?bert S,Khazaei S,Ibrahim NS,Herrero J,Riccio A,Albrecht S,Ketteler R,Brandner S,Kleinman CL,Jabado N,Salomoni P

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H3c7 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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