Hspb6 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hspb6
Entrez Gene ID	243912
Full Name	heat shock protein, alpha-crystallin-related, B6
Synonyms	AA387366,Gm479,Hsp20
General protein information	Preferred Names heat shock protein, alpha-crystallin-related, B6 Names heat shock protein beta-6 cardiac heat shock protein p20 cardiac p20
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7\|7 B1

mRNA and Protein(s)

mRNA	Protein	Name
XM_006539957.4	XP_006540020.1	heat shock protein beta-6 isoform X1
NM_001012401.2	NP_001012401.1	heat shock protein beta-6
NM_001364179.1	NP_001351108.1	heat shock protein beta-6 isoform 2
XM_006539957.3	XP_006540020.1	heat shock protein beta-6 isoform X1
NM_001012401.3	NP_001012401.1	heat shock protein beta-6 isoform 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	HSPB6	XP_003316346.1
Canis lupus familiaris (dog)	HSPB6	XP_541688.1
Bos taurus (cattle)	HSPB6	NP_001069495.1
Homo sapiens (human)	HSPB6	NP_653218.1
	HSPB6	XP_001098599.1
Mus musculus (house mouse)	Hspb6	NP_001012401.1
Rattus norvegicus (Norway rat)	Hspb6	NP_620242.1

Gene Ontology
Bibliography

Related articles in PubMed

Blockade of Ser16-Hsp20 phosphorylation attenuates neuroprotection dependent upon Bcl-2 and Bax.
Zeng L, Tan J, Lu W, Hu Z
Current neurovascular research10(3)208-15(2013 Aug)

Type 2 diabetic obese db/db mice are refractory to myocardial ischaemic post-conditioning in vivo: potential role for Hsp20, F1-ATPase ? and Echs1.
Zhu SG, Xi L, Kukreja RC
Journal of cellular and molecular medicine16(4)950-8(2012 Apr)

Small heat shock protein 20 interacts with protein phosphatase-1 and enhances sarcoplasmic reticulum calcium cycling.
Qian J, Vafiadaki E, Florea SM, Singh VP, Song W, Lam CK, Wang Y, Yuan Q, Pritchard TJ, Cai W, Haghighi K, Rodriguez P, Wang HS, Sanoudou D, Fan GC, Kranias EG
Circulation research108(12)1429-38(2011 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Increased expression of Hsp20 in neuroblastoma cells protected against ischemia-reperfusion injury.
Title: Blockade of Ser16-Hsp20 phosphorylation attenuates neuroprotection dependent upon Bcl-2 and Bax.

potential protein targets for the loss of PostC may include F(1)-ATPase gamma, Echs1 and Hsp20 that could regulate cellular ATP consumption/production and defense response to ischaemic stress
Title: Type 2 diabetic obese db/db mice are refractory to myocardial ischaemic post-conditioning in vivo: potential role for Hsp20, F1-ATPase ? and Echs1.

the activity of type 1 protein phosphatase (PP1), a known regulator of PLN signaling, was significantly reduced by Hsp20 overexpression, suggesting that the Hsp20 stimulatory effects are partially mediated through the PP1-PLN axis.
Title: Small heat shock protein 20 interacts with protein phosphatase-1 and enhances sarcoplasmic reticulum calcium cycling.

Blockade of Hsp20 phosphorylation exacerbates cardiac ischemia/reperfusion injury by suppressed autophagy and increased cell death.
Title: Blockade of Hsp20 phosphorylation exacerbates cardiac ischemia/reperfusion injury by suppressed autophagy and increased cell death.

Hsp20 expression prevents endotoxin-induced myocardial dysfunction and apoptosis via inhibition of NF-kappaB activation
Title: Overexpression of Hsp20 prevents endotoxin-induced myocardial dysfunction and apoptosis via inhibition of NF-kappaB activation.

The following Hspb6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hspb6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu14184	NM_001012401.3 Latest version!	Mus musculus heat shock protein, alpha-crystallin-related, B6 (Hspb6), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu83963	NM_001364179.1 Latest version!	Mus musculus heat shock protein, alpha-crystallin-related, B6 (Hspb6), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OMu38243	XM_006539957.4 Latest version!	Mus musculus heat shock protein, alpha-crystallin-related, B6 (Hspb6), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OMu38243	XM_006539957.3	Mus musculus heat shock protein, alpha-crystallin-related, B6 (Hspb6), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu14184	NM_001012401.2	Mus musculus heat shock protein, alpha-crystallin-related, B6 (Hspb6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hspb6 ( XM_006539957.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006540020.1 Mus musculus heat shock protein, alpha-crystallin-related, B6 (Hspb6), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu38243
Clone ID Related Accession (Same CDS sequence)	XM_006539957.4 , XM_006539957.3
Accession Version	XM_006539957.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 432bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	heat shock protein beta-6 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006539957.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTCACCT TAACCACTTT CCTCTTGAGC AGCTGGCCGT ACTCCTTGCC AGGCCCGGGC 
TCCTGGCCCA GAGAGTGCTG GGTCCCAGAA GCCAAGACCC CTATCCGATC GACGCCCCAC 
CCCTACCCGC CATGTGTGCA GGTGTCCACG GACTCTGGGT ATTTTTCCGT GCTGCTGGAT 
GTGAAGCACT TCTTGCCAGA GGAAATCTCT GTCAAGGTGG TTGACGACCA TGTGGAGGTC 
CATGCTCGGC ACGAGGAGCG CCCGGATGAA CACGGATTCA TTGCTCGAGA GTTCCACCGC 
CGATACCGCC TGCCTCCTGG TGTGGACCCT GCTGCTGTGA CCTCAGCACT GTCTCCTGAG 
GGTGTCCTGT CCATCCAGGC CACACCAGCG TCGGCCCAGG CCCAACTTCC GTCACCACCT 
GCTGCCAAGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006540020.1
CDS	102..533
Translation	MVTLTTFLLSSWPYSLPGPGSWPRECWVPEAKTPIRSTPHPYPPCVQVSTDSGYFSVLLDVKHFLPEEISVKVVDDHVEVHARHEERPDEHGFIAREFHRRYRLPPGVDPAAVTSALSPEGVLSIQATPASAQAQLPSPPAAK

Target ORF information:

RefSeq Version	XM_006539957.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus heat shock protein, alpha-crystallin-related, B6 (Hspb6), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006539957.3

ORF Insert Sequence:

ATGGTCACCT TAACCACTTT CCTCTTGAGC AGCTGGCCGT ACTCCTTGCC AGGCCCGGGC 
TCCTGGCCCA GAGAGTGCTG GGTCCCAGAA GCCAAGACCC CTATCCGATC GACGCCCCAC 
CCCTACCCGC CATGTGTGCA GGTGTCCACG GACTCTGGGT ATTTTTCCGT GCTGCTGGAT 
GTGAAGCACT TCTTGCCAGA GGAAATCTCT GTCAAGGTGG TTGACGACCA TGTGGAGGTC 
CATGCTCGGC ACGAGGAGCG CCCGGATGAA CACGGATTCA TTGCTCGAGA GTTCCACCGC 
CGATACCGCC TGCCTCCTGG TGTGGACCCT GCTGCTGTGA CCTCAGCACT GTCTCCTGAG 
GGTGTCCTGT CCATCCAGGC CACACCAGCG TCGGCCCAGG CCCAACTTCC GTCACCACCT 
GCTGCCAAGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Hspb6 ( NM_001012401.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001012401.1 Mus musculus heat shock protein, alpha-crystallin-related, B6 (Hspb6), mRNA.

Price & Availability↑

CloneID	OMu14184
Clone ID Related Accession (Same CDS sequence)	NM_001012401.2 , NM_001012401.3
Accession Version	NM_001012401.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 489bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-28
Organism	Mus musculus(house mouse)
Product	heat shock protein beta-6
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC089621.1. On Apr 5, 2007 this sequence version replaced NM_001012401.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC089621.1, DV049563.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGAGATCC CCGTGCCTGT GCAGCCTTCT TGGCTGCGCC GTGCTTCAGC TCCTTTACCA 
GGTTTCTCTG CTCCGGGACG CCTCTTTGAC CAGCGTTTCG GCGAAGGGCT GCTTGAGGCA 
GAGCTGGCTT CACTGTGCCC TGCTGCGATC GCCCCCTACT ATCTGCGCGC CCCCAGTGTG 
GCGTTACCCA CAGCCCAGGT GTCCACGGAC TCTGGGTATT TTTCCGTGCT GCTGGATGTG 
AAGCACTTCT TGCCAGAGGA AATCTCTGTC AAGGTGGTTG ACGACCATGT GGAGGTCCAT 
GCTCGGCACG AGGAGCGCCC GGATGAACAC GGATTCATTG CTCGAGAGTT CCACCGCCGA 
TACCGCCTGC CTCCTGGTGT GGACCCTGCT GCTGTGACCT CAGCACTGTC TCCTGAGGGT 
GTCCTGTCCA TCCAGGCCAC ACCAGCGTCG GCCCAGGCCC AACTTCCGTC ACCACCTGCT 
GCCAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001012401.1
CDS	34..522
Translation	MEIPVPVQPSWLRRASAPLPGFSAPGRLFDQRFGEGLLEAELASLCPAAIAPYYLRAPSVALPTAQVSTDSGYFSVLLDVKHFLPEEISVKVVDDHVEVHARHEERPDEHGFIAREFHRRYRLPPGVDPAAVTSALSPEGVLSIQATPASAQAQLPSPPAAK

Target ORF information:

RefSeq Version	NM_001012401.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus heat shock protein, alpha-crystallin-related, B6 (Hspb6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001012401.2

ORF Insert Sequence:

ATGGAGATCC CCGTGCCTGT GCAGCCTTCT TGGCTGCGCC GTGCTTCAGC TCCTTTACCA 
GGTTTCTCTG CTCCGGGACG CCTCTTTGAC CAGCGTTTCG GCGAAGGGCT GCTTGAGGCA 
GAGCTGGCTT CACTGTGCCC TGCTGCGATC GCCCCCTACT ATCTGCGCGC CCCCAGTGTG 
GCGTTACCCA CAGCCCAGGT GTCCACGGAC TCTGGGTATT TTTCCGTGCT GCTGGATGTG 
AAGCACTTCT TGCCAGAGGA AATCTCTGTC AAGGTGGTTG ACGACCATGT GGAGGTCCAT 
GCTCGGCACG AGGAGCGCCC GGATGAACAC GGATTCATTG CTCGAGAGTT CCACCGCCGA 
TACCGCCTGC CTCCTGGTGT GGACCCTGCT GCTGTGACCT CAGCACTGTC TCCTGAGGGT 
GTCCTGTCCA TCCAGGCCAC ACCAGCGTCG GCCCAGGCCC AACTTCCGTC ACCACCTGCT 
GCCAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Hspb6 ( NM_001012401.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001012401.1 Mus musculus heat shock protein, alpha-crystallin-related, B6 (Hspb6), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu14184
Clone ID Related Accession (Same CDS sequence)	NM_001012401.2 , NM_001012401.3
Accession Version	NM_001012401.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 489bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Mus musculus(house mouse)
Product	heat shock protein beta-6 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CK627709.1, BC089621.1 and BQ176401.1. On Jun 9, 2018 this sequence version replaced NM_001012401.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC089621.1, DV049563.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGATCC CCGTGCCTGT GCAGCCTTCT TGGCTGCGCC GTGCTTCAGC TCCTTTACCA 
GGTTTCTCTG CTCCGGGACG CCTCTTTGAC CAGCGTTTCG GCGAAGGGCT GCTTGAGGCA 
GAGCTGGCTT CACTGTGCCC TGCTGCGATC GCCCCCTACT ATCTGCGCGC CCCCAGTGTG 
GCGTTACCCA CAGCCCAGGT GTCCACGGAC TCTGGGTATT TTTCCGTGCT GCTGGATGTG 
AAGCACTTCT TGCCAGAGGA AATCTCTGTC AAGGTGGTTG ACGACCATGT GGAGGTCCAT 
GCTCGGCACG AGGAGCGCCC GGATGAACAC GGATTCATTG CTCGAGAGTT CCACCGCCGA 
TACCGCCTGC CTCCTGGTGT GGACCCTGCT GCTGTGACCT CAGCACTGTC TCCTGAGGGT 
GTCCTGTCCA TCCAGGCCAC ACCAGCGTCG GCCCAGGCCC AACTTCCGTC ACCACCTGCT 
GCCAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001012401.1
CDS	35..523
Translation	MEIPVPVQPSWLRRASAPLPGFSAPGRLFDQRFGEGLLEAELASLCPAAIAPYYLRAPSVALPTAQVSTDSGYFSVLLDVKHFLPEEISVKVVDDHVEVHARHEERPDEHGFIAREFHRRYRLPPGVDPAAVTSALSPEGVLSIQATPASAQAQLPSPPAAK

Target ORF information:

RefSeq Version	NM_001012401.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus heat shock protein, alpha-crystallin-related, B6 (Hspb6), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001012401.3

ORF Insert Sequence:

ATGGAGATCC CCGTGCCTGT GCAGCCTTCT TGGCTGCGCC GTGCTTCAGC TCCTTTACCA 
GGTTTCTCTG CTCCGGGACG CCTCTTTGAC CAGCGTTTCG GCGAAGGGCT GCTTGAGGCA 
GAGCTGGCTT CACTGTGCCC TGCTGCGATC GCCCCCTACT ATCTGCGCGC CCCCAGTGTG 
GCGTTACCCA CAGCCCAGGT GTCCACGGAC TCTGGGTATT TTTCCGTGCT GCTGGATGTG 
AAGCACTTCT TGCCAGAGGA AATCTCTGTC AAGGTGGTTG ACGACCATGT GGAGGTCCAT 
GCTCGGCACG AGGAGCGCCC GGATGAACAC GGATTCATTG CTCGAGAGTT CCACCGCCGA 
TACCGCCTGC CTCCTGGTGT GGACCCTGCT GCTGTGACCT CAGCACTGTC TCCTGAGGGT 
GTCCTGTCCA TCCAGGCCAC ACCAGCGTCG GCCCAGGCCC AACTTCCGTC ACCACCTGCT 
GCCAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Hspb6 ( NM_001364179.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001351108.1 Mus musculus heat shock protein, alpha-crystallin-related, B6 (Hspb6), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OMu83963
Clone ID Related Accession (Same CDS sequence)	NM_001364179.1
Accession Version	NM_001364179.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 312bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Mus musculus(house mouse)
Product	heat shock protein beta-6 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK144390.1 and BQ176401.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK144390.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATTGCCA CACCTATAAG GGTGTCCACG GACTCTGGGT ATTTTTCCGT GCTGCTGGAT 
GTGAAGCACT TCTTGCCAGA GGAAATCTCT GTCAAGGTGG TTGACGACCA TGTGGAGGTC 
CATGCTCGGC ACGAGGAGCG CCCGGATGAA CACGGATTCA TTGCTCGAGA GTTCCACCGC 
CGATACCGCC TGCCTCCTGG TGTGGACCCT GCTGCTGTGA CCTCAGCACT GTCTCCTGAG 
GGTGTCCTGT CCATCCAGGC CACACCAGCG TCGGCCCAGG CCCAACTTCC GTCACCACCT 
GCTGCCAAGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001351108.1
CDS	503..814
Translation	MIATPIRVSTDSGYFSVLLDVKHFLPEEISVKVVDDHVEVHARHEERPDEHGFIAREFHRRYRLPPGVDPAAVTSALSPEGVLSIQATPASAQAQLPSPPAAK

Target ORF information:

RefSeq Version	NM_001364179.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus heat shock protein, alpha-crystallin-related, B6 (Hspb6), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001364179.1

ORF Insert Sequence:

ATGATTGCCA CACCTATAAG GGTGTCCACG GACTCTGGGT ATTTTTCCGT GCTGCTGGAT 
GTGAAGCACT TCTTGCCAGA GGAAATCTCT GTCAAGGTGG TTGACGACCA TGTGGAGGTC 
CATGCTCGGC ACGAGGAGCG CCCGGATGAA CACGGATTCA TTGCTCGAGA GTTCCACCGC 
CGATACCGCC TGCCTCCTGG TGTGGACCCT GCTGCTGTGA CCTCAGCACT GTCTCCTGAG 
GGTGTCCTGT CCATCCAGGC CACACCAGCG TCGGCCCAGG CCCAACTTCC GTCACCACCT 
GCTGCCAAGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Hspb6 ( XM_006539957.4 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006540020.1 Mus musculus heat shock protein, alpha-crystallin-related, B6 (Hspb6), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu38243
Clone ID Related Accession (Same CDS sequence)	XM_006539957.4 , XM_006539957.3
Accession Version	XM_006539957.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 432bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	heat shock protein beta-6 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006539957.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTCACCT TAACCACTTT CCTCTTGAGC AGCTGGCCGT ACTCCTTGCC AGGCCCGGGC 
TCCTGGCCCA GAGAGTGCTG GGTCCCAGAA GCCAAGACCC CTATCCGATC GACGCCCCAC 
CCCTACCCGC CATGTGTGCA GGTGTCCACG GACTCTGGGT ATTTTTCCGT GCTGCTGGAT 
GTGAAGCACT TCTTGCCAGA GGAAATCTCT GTCAAGGTGG TTGACGACCA TGTGGAGGTC 
CATGCTCGGC ACGAGGAGCG CCCGGATGAA CACGGATTCA TTGCTCGAGA GTTCCACCGC 
CGATACCGCC TGCCTCCTGG TGTGGACCCT GCTGCTGTGA CCTCAGCACT GTCTCCTGAG 
GGTGTCCTGT CCATCCAGGC CACACCAGCG TCGGCCCAGG CCCAACTTCC GTCACCACCT 
GCTGCCAAGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006540020.1
CDS	123..554
Translation	MVTLTTFLLSSWPYSLPGPGSWPRECWVPEAKTPIRSTPHPYPPCVQVSTDSGYFSVLLDVKHFLPEEISVKVVDDHVEVHARHEERPDEHGFIAREFHRRYRLPPGVDPAAVTSALSPEGVLSIQATPASAQAQLPSPPAAK

Target ORF information:

RefSeq Version	XM_006539957.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus heat shock protein, alpha-crystallin-related, B6 (Hspb6), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006539957.4

ORF Insert Sequence:

ATGGTCACCT TAACCACTTT CCTCTTGAGC AGCTGGCCGT ACTCCTTGCC AGGCCCGGGC 
TCCTGGCCCA GAGAGTGCTG GGTCCCAGAA GCCAAGACCC CTATCCGATC GACGCCCCAC 
CCCTACCCGC CATGTGTGCA GGTGTCCACG GACTCTGGGT ATTTTTCCGT GCTGCTGGAT 
GTGAAGCACT TCTTGCCAGA GGAAATCTCT GTCAAGGTGG TTGACGACCA TGTGGAGGTC 
CATGCTCGGC ACGAGGAGCG CCCGGATGAA CACGGATTCA TTGCTCGAGA GTTCCACCGC 
CGATACCGCC TGCCTCCTGG TGTGGACCCT GCTGCTGTGA CCTCAGCACT GTCTCCTGAG 
GGTGTCCTGT CCATCCAGGC CACACCAGCG TCGGCCCAGG CCCAACTTCC GTCACCACCT 
GCTGCCAAGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Blockade of Ser16-Hsp20 phosphorylation attenuates neuroprotection dependent upon Bcl-2 and Bax.
Current neurovascular research10(3)208-15(2013 Aug)
Zeng L,Tan J,Lu W,Hu Z

Type 2 diabetic obese db/db mice are refractory to myocardial ischaemic post-conditioning in vivo: potential role for Hsp20, F1-ATPase ? and Echs1.
Journal of cellular and molecular medicine16(4)950-8(2012 Apr)
Zhu SG,Xi L,Kukreja RC

Small heat shock protein 20 interacts with protein phosphatase-1 and enhances sarcoplasmic reticulum calcium cycling.
Circulation research108(12)1429-38(2011 Jun)
Qian J,Vafiadaki E,Florea SM,Singh VP,Song W,Lam CK,Wang Y,Yuan Q,Pritchard TJ,Cai W,Haghighi K,Rodriguez P,Wang HS,Sanoudou D,Fan GC,Kranias EG

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Hspb6 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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