Padi6 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Padi6
Entrez Gene ID	242726
Full Name	peptidyl arginine deiminase, type VI
Synonyms	Pad6,Padi5,ePAD
General protein information	Preferred Names peptidyl arginine deiminase, type VI Names protein-arginine deiminase type-6 arginine deiminase-like protein egg and embryo abundant PAD peptidyl arginine deiminase, egg and embryo abundant peptidylarginine deiminase VI protein-arginine deiminase type VI
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 4 Map Location: 4 D3\|4 72.26 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_153106.2	NP_694746.2	protein-arginine deiminase type-6

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PADI6	XP_524564.2
Canis lupus familiaris (dog)	PADI6	NP_001091016.1
Mus musculus (house mouse)	Padi6	NP_694746.2
Rattus norvegicus (Norway rat)	Padi6	NP_001178695.1
	PADI6	XP_001089244.1
Homo sapiens (human)	PADI6	NP_997304.3
Bos taurus (cattle)	PADI6	XP_002685843.1

Gene Ontology
Bibliography

Related articles in PubMed

Role for PADI6 in securing the mRNA-MSY2 complex to the oocyte cytoplasmic lattices.
Liu X, Morency E, Li T, Qin H, Zhang X, Zhang X, Coonrod S
Cell cycle (Georgetown, Tex.)16(4)360-366(2017 Feb)

Mutations in PADI6 Cause Female Infertility Characterized by Early Embryonic Arrest.
Xu Y, Shi Y, Fu J, Yu M, Feng R, Sang Q, Liang B, Chen B, Qu R, Li B, Yan Z, Mao X, Kuang Y, Jin L, He L, Sun X, Wang L
American journal of human genetics99(3)744-752(2016 Sep)

BTG4 is a meiotic cell cycle-coupled maternal-zygotic-transition licensing factor in oocytes.
Yu C, Ji SY, Sha QQ, Dang Y, Zhou JJ, Zhang YL, Liu Y, Wang ZW, Hu B, Sun QY, Sun SC, Tang F, Fan HY
Nature structural & molecular biology23(5)387-94(2016 05)

NOD-like receptors interfacing the immune and reproductive systems.
Van Gorp H, Kuchmiy A, Van Hauwermeiren F, Lamkanfi M
The FEBS journal281(20)4568-82(2014 Oct)

Regulation of mouse oocyte microtubule and organelle dynamics by PADI6 and the cytoplasmic lattices.
Kan R, Yurttas P, Kim B, Jin M, Wo L, Lee B, Gosden R, Coonrod SA
Developmental biology350(2)311-22(2011 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

mRNAs, possibly in a complex with MSY2 and PADI6, are bound in the cytoplasmic lattices (CPLs) and may play a role in securing the mRNA-MSY2 complex to the CPLs.
Title: Role for PADI6 in securing the mRNA-MSY2 complex to the oocyte cytoplasmic lattices.

Mutations in PADI6 Cause Female Infertility Characterized by Early Embryonic Arrest
Title: Mutations in PADI6 Cause Female Infertility Characterized by Early Embryonic Arrest.

PADI6/cytoplasmic lattice superstructure plays a key role in regulating microtubule-mediated organelle positioning and movement.
Title: Regulation of mouse oocyte microtubule and organelle dynamics by PADI6 and the cytoplasmic lattices.

embryonic genome activation (EGA) is defective in Padi6-/- two-cell embryos
Title: Role for PADI6 and the cytoplasmic lattices in ribosomal storage in oocytes and translational control in the early mouse embryo.

Phosphorylation and/or YWHA binding may serve as a means of intracellular PADI6 regulation.
Title: Phosphorylation-dependent interaction of tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein (YWHA) with PADI6 following oocyte maturation in mice.

The following Padi6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Padi6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu20766	NM_153106.2 Latest version!	Mus musculus peptidyl arginine deiminase, type VI (Padi6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Padi6 ( NM_153106.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_694746.2 Mus musculus peptidyl arginine deiminase, type VI (Padi6), mRNA.

Price & Availability↑

CloneID	OMu20766
Clone ID Related Accession (Same CDS sequence)	NM_153106.2
Accession Version	NM_153106.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2049bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	protein-arginine deiminase type-6
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK139616.1, BC053724.1 and CJ202890.1. On Dec 13, 2006 this sequence version replaced NM_153106.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC053724.1, AF529423.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849381 [ECO:0000350] ##Evidence-Data-END##

ATGTCTTTTC AGAACTCACT CAGCCTGTCT CTGGTCAATC CCACCCATGC CCTCTGCATG 
GTAGGCATGG AAATCACCTT GGACATCAGC AAGTGTGCAC CAGACAAGTG CAAGTCTTTC 
ACCATCCGTG GTTCCCCCAG GATCTTGATC CACATCTCTA GCTCCGTCAT CGCTGGCAAA 
GAGGACACTG TGGTCTGGAG GTCAATGAAC CATCCCACAG TGGCATTGGT GAGGATGGTG 
GCGCCCAGCC CCACTGTGGA TGAAGACAAG GTGCTGGTCT CCTACTTCTG TCCTGACCAA 
GAAGTCCCCA CGGCCACAGC TGTGCTGTTT CTCACCGGCA TCGAGATCTC CCTGGAGGCA 
GACATCTATC GAGATGGACA ACTGGACATG CCAAGTGATA AGCAAGCTAA GAAAAAATGG 
ATGTGGGGTA TGAACGGCTG GGGAGCCATC CTGCTTGTGA ATTGTAGCCC TAATGCTGTG 
GGCCAGCCTG ATGAACAGTC CTTTCAGGAG GGCCCCAGAG AAATACAGAA CCTGTCTCAG 
ATGAATGTAA CTGTGGAGGG CCCCACCAGC ATCCTACAGA ATTACCAGTT GATCCTACAT 
ACCTCCGAAG AAGAGGCGAA GAAGACAAGA GTCTACTGGT CTCAGAGAGG CTCCTCTGCG 
TATGAACTGG TGGTGGGACC CAACAAGCCT GTCTATCTCC TGCCTACCTT TGAGAACCGT 
AGGAAAGAGG CTTTCTACGT AGAAGCCACG GAATTCCCAT CTCCCAGCTT CTCGGGCCTG 
ATCTCCTTGT CACTCTCCCT AGTAGAAAAG GCTCACGACG AGTGCATCCC AGAGATTCCG 
CTCTATAAGG ATACAGTGAT GTTCCGGGTG GCACCTTATA TCTTCATGCC CAGCACCCAG 
ATGCCTCTAG AGGTTTACCT GTGCAGGGAG CTACAGCTGC AAGGCTTTGT GGACTCAGTG 
ACCAAGCTGA GCGAGAAGAG CAAAGTGCAG GTGGTAAAGG TCTATGAGGA CCCCAACCGC 
CAGAGCAAGT GGCTCCAGGA CGAGATGGCT TTCTGCTATA CTCAGGCTCC TCACAAGACG 
GTGTCATTGA TCCTTGACAC CCCAAGGGTT TCCAAGCTGG AAGACTTCCC CATGAAATAC 
ACACTGACCC CTGGCTCTGG CTACCTGATC CGACAAACTG AGGACCACCG GGTGGCTAGC 
CTGGATTCCA TCGGGAACCT GATGGTATCT CCGCCTGTCA AGGCTCAGGG CAAAGACTAC 
CCTCTAGGGA GGGTCCTCAT TGGTGGCAGC TTTTACCCCA GCTCTGAGGG CCGGGACATG 
AACAAGGGCC TGCGAGAATT CGTGTATGCC CAGCAGGTGC AGGCCCCTGT GGAACTCTTC 
TCGGACTGGC TGATGACCGG TCACATGGAT CAATTCATGT GCTTTGTCCC TACCAATGAT 
AAAAACAACG ACCAGAAGGA CTTCCGCCTG CTGCTGGCCA GCCCCAGTGC CTGCTTTGAG 
CTGTTCGAAC AGAAGCAGAA GGAAGGCTAT GGGAACGTGA CCCTGTTTGA AGACATTGGA 
GCAGAACAGC TCCTTTCTAA TGGGAGGGAG AGCAAAACTA TTTCCCAAAT CCTGGCTGAC 
AAGAGTTTTC GAGAGCAGAA CACCTATGTT GAGAAGTGTA TCAGCCTGAA CCGCACCCTC 
CTGAAGACAG AACTGGGATT GGAGGACAAG GACATCATCC TGATCCCGCA GCTCTTCTGC 
CTGGAGCAGC TGACGAATGT CCCCTCCAAC CAGCAGAGCA CCAAACTCTT CGCGAGGCCG 
TACTTCCCCG ACATGCTGCA GATAATCGTG TTGGGCAAGA ACCTTGGAAT CCCCAAGCCC 
TTTGGGCCCA AAATCAATGG CACCTGCTGC CTAGAAGAGA AAGTGTGTGG ATTACTGGAG 
CCCCTGGGTC TCAAGTGCAC CTTCATTGAT GATTTTGACT GCTACCTGGC CAACATAGGG 
GACGTCTGTG CCAGTGCCAT CATAAACAGG GTGCCATTTG CATTCAAGTG GTGGAAGATG 
ACCCCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_694746.2
CDS	64..2112
Translation	MSFQNSLSLSLVNPTHALCMVGMEITLDISKCAPDKCKSFTIRGSPRILIHISSSVIAGKEDTVVWRSMNHPTVALVRMVAPSPTVDEDKVLVSYFCPDQEVPTATAVLFLTGIEISLEADIYRDGQLDMPSDKQAKKKWMWGMNGWGAILLVNCSPNAVGQPDEQSFQEGPREIQNLSQMNVTVEGPTSILQNYQLILHTSEEEAKKTRVYWSQRGSSAYELVVGPNKPVYLLPTFENRRKEAFYVEATEFPSPSFSGLISLSLSLVEKAHDECIPEIPLYKDTVMFRVAPYIFMPSTQMPLEVYLCRELQLQGFVDSVTKLSEKSKVQVVKVYEDPNRQSKWLQDEMAFCYTQAPHKTVSLILDTPRVSKLEDFPMKYTLTPGSGYLIRQTEDHRVASLDSIGNLMVSPPVKAQGKDYPLGRVLIGGSFYPSSEGRDMNKGLREFVYAQQVQAPVELFSDWLMTGHMDQFMCFVPTNDKNNDQKDFRLLLASPSACFELFEQKQKEGYGNVTLFEDIGAEQLLSNGRESKTISQILADKSFREQNTYVEKCISLNRTLLKTELGLEDKDIILIPQLFCLEQLTNVPSNQQSTKLFARPYFPDMLQIIVLGKNLGIPKPFGPKINGTCCLEEKVCGLLEPLGLKCTFIDDFDCYLANIGDVCASAIINRVPFAFKWWKMTP

Target ORF information:

RefSeq Version	NM_153106.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus peptidyl arginine deiminase, type VI (Padi6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_153106.2

ORF Insert Sequence:

ATGTCTTTTC AGAACTCACT CAGCCTGTCT CTGGTCAATC CCACCCATGC CCTCTGCATG 
GTAGGCATGG AAATCACCTT GGACATCAGC AAGTGTGCAC CAGACAAGTG CAAGTCTTTC 
ACCATCCGTG GTTCCCCCAG GATCTTGATC CACATCTCTA GCTCCGTCAT CGCTGGCAAA 
GAGGACACTG TGGTCTGGAG GTCAATGAAC CATCCCACAG TGGCATTGGT GAGGATGGTG 
GCGCCCAGCC CCACTGTGGA TGAAGACAAG GTGCTGGTCT CCTACTTCTG TCCTGACCAA 
GAAGTCCCCA CGGCCACAGC TGTGCTGTTT CTCACCGGCA TCGAGATCTC CCTGGAGGCA 
GACATCTATC GAGATGGACA ACTGGACATG CCAAGTGATA AGCAAGCTAA GAAAAAATGG 
ATGTGGGGTA TGAACGGCTG GGGAGCCATC CTGCTTGTGA ATTGTAGCCC TAATGCTGTG 
GGCCAGCCTG ATGAACAGTC CTTTCAGGAG GGCCCCAGAG AAATACAGAA CCTGTCTCAG 
ATGAATGTAA CTGTGGAGGG CCCCACCAGC ATCCTACAGA ATTACCAGTT GATCCTACAT 
ACCTCCGAAG AAGAGGCGAA GAAGACAAGA GTCTACTGGT CTCAGAGAGG CTCCTCTGCG 
TATGAACTGG TGGTGGGACC CAACAAGCCT GTCTATCTCC TGCCTACCTT TGAGAACCGT 
AGGAAAGAGG CTTTCTACGT AGAAGCCACG GAATTCCCAT CTCCCAGCTT CTCGGGCCTG 
ATCTCCTTGT CACTCTCCCT AGTAGAAAAG GCTCACGACG AGTGCATCCC AGAGATTCCG 
CTCTATAAGG ATACAGTGAT GTTCCGGGTG GCACCTTATA TCTTCATGCC CAGCACCCAG 
ATGCCTCTAG AGGTTTACCT GTGCAGGGAG CTACAGCTGC AAGGCTTTGT GGACTCAGTG 
ACCAAGCTGA GCGAGAAGAG CAAAGTGCAG GTGGTAAAGG TCTATGAGGA CCCCAACCGC 
CAGAGCAAGT GGCTCCAGGA CGAGATGGCT TTCTGCTATA CTCAGGCTCC TCACAAGACG 
GTGTCATTGA TCCTTGACAC CCCAAGGGTT TCCAAGCTGG AAGACTTCCC CATGAAATAC 
ACACTGACCC CTGGCTCTGG CTACCTGATC CGACAAACTG AGGACCACCG GGTGGCTAGC 
CTGGATTCCA TCGGGAACCT GATGGTATCT CCGCCTGTCA AGGCTCAGGG CAAAGACTAC 
CCTCTAGGGA GGGTCCTCAT TGGTGGCAGC TTTTACCCCA GCTCTGAGGG CCGGGACATG 
AACAAGGGCC TGCGAGAATT CGTGTATGCC CAGCAGGTGC AGGCCCCTGT GGAACTCTTC 
TCGGACTGGC TGATGACCGG TCACATGGAT CAATTCATGT GCTTTGTCCC TACCAATGAT 
AAAAACAACG ACCAGAAGGA CTTCCGCCTG CTGCTGGCCA GCCCCAGTGC CTGCTTTGAG 
CTGTTCGAAC AGAAGCAGAA GGAAGGCTAT GGGAACGTGA CCCTGTTTGA AGACATTGGA 
GCAGAACAGC TCCTTTCTAA TGGGAGGGAG AGCAAAACTA TTTCCCAAAT CCTGGCTGAC 
AAGAGTTTTC GAGAGCAGAA CACCTATGTT GAGAAGTGTA TCAGCCTGAA CCGCACCCTC 
CTGAAGACAG AACTGGGATT GGAGGACAAG GACATCATCC TGATCCCGCA GCTCTTCTGC 
CTGGAGCAGC TGACGAATGT CCCCTCCAAC CAGCAGAGCA CCAAACTCTT CGCGAGGCCG 
TACTTCCCCG ACATGCTGCA GATAATCGTG TTGGGCAAGA ACCTTGGAAT CCCCAAGCCC 
TTTGGGCCCA AAATCAATGG CACCTGCTGC CTAGAAGAGA AAGTGTGTGG ATTACTGGAG 
CCCCTGGGTC TCAAGTGCAC CTTCATTGAT GATTTTGACT GCTACCTGGC CAACATAGGG 
GACGTCTGTG CCAGTGCCAT CATAAACAGG GTGCCATTTG CATTCAAGTG GTGGAAGATG 
ACCCCATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Role for PADI6 in securing the mRNA-MSY2 complex to the oocyte cytoplasmic lattices.
Cell cycle (Georgetown, Tex.)16(4)360-366(2017 Feb)
Liu X,Morency E,Li T,Qin H,Zhang X,Zhang X,Coonrod S

Mutations in PADI6 Cause Female Infertility Characterized by Early Embryonic Arrest.
American journal of human genetics99(3)744-752(2016 Sep)
Xu Y,Shi Y,Fu J,Yu M,Feng R,Sang Q,Liang B,Chen B,Qu R,Li B,Yan Z,Mao X,Kuang Y,Jin L,He L,Sun X,Wang L

BTG4 is a meiotic cell cycle-coupled maternal-zygotic-transition licensing factor in oocytes.
Nature structural & molecular biology23(5)387-94(2016 05)
Yu C,Ji SY,Sha QQ,Dang Y,Zhou JJ,Zhang YL,Liu Y,Wang ZW,Hu B,Sun QY,Sun SC,Tang F,Fan HY

NOD-like receptors interfacing the immune and reproductive systems.
The FEBS journal281(20)4568-82(2014 Oct)
Van Gorp H,Kuchmiy A,Van Hauwermeiren F,Lamkanfi M

Regulation of mouse oocyte microtubule and organelle dynamics by PADI6 and the cytoplasmic lattices.
Developmental biology350(2)311-22(2011 Feb)
Kan R,Yurttas P,Kim B,Jin M,Wo L,Lee B,Gosden R,Coonrod SA

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Padi6 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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