Cib1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cib1
Entrez Gene ID	23991
Full Name	calcium and integrin binding 1 (calmyrin)
Synonyms	Cibkip,Kip,Prkdcip
General protein information	Preferred Names calcium and integrin binding 1 (calmyrin) Names calcium and integrin-binding protein 1 CIB DNA-PKcs-interacting protein calcium and integrin binding, protein kinase interacting protein calmyrin kinase-interacting protein protein kinase, DNA activated, catalytic polypeptide interacting protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7\|7 D2

mRNA and Protein(s)

mRNA	Protein	Name
XM_011250861.2	XP_011249163.1	calcium and integrin-binding protein 1 isoform X1
XM_030242553.1	XP_030098413.1	calcium and integrin-binding protein 1 isoform X1
XM_011250861.3	XP_011249163.1	calcium and integrin-binding protein 1 isoform X1
NM_001291276.1	NP_001278205.1	calcium and integrin-binding protein 1 isoform 3
NM_001291275.1	NP_001278204.1	calcium and integrin-binding protein 1 isoform 2
NM_011870.5	NP_036000.1	calcium and integrin-binding protein 1 isoform 1

Pathways from BioSystems

Homologies

	CIB1	XP_001096008.1
Mus musculus (house mouse)	Cib1	NP_036000.1
Gallus gallus (chicken)	CIB1	NP_001264577.1
Danio rerio (zebrafish)	cib1	NP_001017681.1
Homo sapiens (human)	CIB1	NP_006375.2
Canis lupus familiaris (dog)	CIB1	XP_849876.1
Pan troglodytes (chimpanzee)	CIB1	XP_510591.2
Rattus norvegicus (Norway rat)	Cib1	NP_112407.1
Bos taurus (cattle)	CIB1	NP_001068901.1
Danio rerio (zebrafish)	LOC100536377	XP_003201427.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008474	XP_316971.2
Xenopus tropicalis (tropical clawed frog)	cib1	NP_001011480.1

Gene Ontology
Bibliography

Related articles in PubMed

CIB1 protects against MPTP-induced neurotoxicity through inhibiting ASK1.
Yoon KW, Yang HS, Kim YM, Kim Y, Kang S, Sun W, Naik UP, Parise LV, Choi EJ
Scientific reports7(1)12178(2017 Sep)

CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells.
Giese APJ, Tang YQ, Sinha GP, Bowl MR, Goldring AC, Parker A, Freeman MJ, Brown SDM, Riazuddin S, Fettiplace R, Schafer WR, Frolenkov GI, Ahmed ZM
Nature communications8(1)43(2017 06)

Binding of CIB1 to the ?IIb tail of ?IIb?3 is required for FAK recruitment and activation in platelets.
Naik MU, Naik TU, Summer R, Naik UP
PloS one12(5)e0176602(2017)

Biophysical and structural studies of the human calcium- and integrin-binding protein family: understanding their functional similarities and differences.
Huang H, Bogstie JN, Vogel HJ
Biochemistry and cell biology = Biochimie et biologie cellulaire90(5)646-56(2012 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

results suggest that interaction of CIB1 with alphaIIb is one of the early events occurring during outside-in signaling. Furthermore, CIB1 recruits FAK to the alphaIIbbeta3 complex at the filopodia where FAK is activated, which in turn activates c-Src, resulting in propagation of outside-in signaling leading to platelet spreading.
Title: Binding of CIB1 to the ?IIb tail of ?IIb?3 is required for FAK recruitment and activation in platelets.

CIB1 is involved in regulating endomitosis, perhaps through its interaction with Polo-like kinase 3
Title: Calcium- and integrin-binding protein 1 regulates endomitosis and its interaction with Polo-like kinase 3 is enhanced in endomitotic Dami cells.

CIB1 functions as a previously undescribed regulator of cardiac hypertrophy through its ability to regulate the association of calcineurin with the sarcolemma and its activation.
Title: CIB1 is a regulator of pathological cardiac hypertrophy.

Data demonstrate that CIB1 is not required for AID to mediate antibody gene diversification processes. It remains possible that CIB1 has an alternative, a redundant or a subtle non-limiting regulatory role in AID biology.
Title: The interaction between AID and CIB1 is nonessential for antibody gene diversification by gene conversion or class switch recombination.

CIB1 is a key regulator of thrombosis, by affecting platelet spreading, but not platelet filopodia formation.
Title: CIB1 deficiency results in impaired thrombosis: the potential role of CIB1 in outside-in signaling through integrin alpha IIb beta 3.

The following Cib1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cib1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu16476	NM_001291275.1 Latest version!	Mus musculus calcium and integrin binding 1 (calmyrin) (Cib1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu16479	NM_001291276.1 Latest version!	Mus musculus calcium and integrin binding 1 (calmyrin) (Cib1), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu16478	NM_011870.5 Latest version!	Mus musculus calcium and integrin binding 1 (calmyrin) (Cib1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu69159	XM_011250861.3 Latest version!	Mus musculus calcium and integrin binding 1 (calmyrin) (Cib1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OMu69159	XM_030242553.1 Latest version!	Mus musculus calcium and integrin binding 1 (calmyrin) (Cib1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OMu69159	XM_011250861.2	Mus musculus calcium and integrin binding 1 (calmyrin) (Cib1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cib1 ( XM_011250861.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_011249163.1 Mus musculus calcium and integrin binding 1 (calmyrin) (Cib1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu69159
Clone ID Related Accession (Same CDS sequence)	XM_011250861.2 , XM_030242553.1 , XM_011250861.3
Accession Version	XM_011250861.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 354bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	calcium and integrin-binding protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_011250861.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTCTTCT CCACATCACC TACCAGAGAC AGCCTGAGCT TTGAGGACTT CCTGGACCTC 
CTGAGTGTCT TCAGTGACAC AGCAACCCCA GACATCAAGT CACACTATGC CTTCCGCATC 
TTTGACTTTG ATGACGATGG AACCCTGGAC AGAGAAGACC TGAGCCAGCT TGTGAATTGC 
CTCACGGGAG AGGGCGAGGA CACTCGGCTC AGTGCTTCTG AGATGAAGCA GCTGATTGAC 
AATATCCTGG AAGAGTCAGA CATTGACAGG GATGGGACCA TCAATCTTTC CGAGTTCCAG 
CATGTCATCT CGCGCTCACC AGACTTTGCC AGCTCCTTTA AGATTGTCCT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011249163.1
CDS	391..744
Translation	MVFSTSPTRDSLSFEDFLDLLSVFSDTATPDIKSHYAFRIFDFDDDGTLDREDLSQLVNCLTGEGEDTRLSASEMKQLIDNILEESDIDRDGTINLSEFQHVISRSPDFASSFKIVL

Target ORF information:

RefSeq Version	XM_011250861.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus calcium and integrin binding 1 (calmyrin) (Cib1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011250861.2

ORF Insert Sequence:

ATGGTCTTCT CCACATCACC TACCAGAGAC AGCCTGAGCT TTGAGGACTT CCTGGACCTC 
CTGAGTGTCT TCAGTGACAC AGCAACCCCA GACATCAAGT CACACTATGC CTTCCGCATC 
TTTGACTTTG ATGACGATGG AACCCTGGAC AGAGAAGACC TGAGCCAGCT TGTGAATTGC 
CTCACGGGAG AGGGCGAGGA CACTCGGCTC AGTGCTTCTG AGATGAAGCA GCTGATTGAC 
AATATCCTGG AAGAGTCAGA CATTGACAGG GATGGGACCA TCAATCTTTC CGAGTTCCAG 
CATGTCATCT CGCGCTCACC AGACTTTGCC AGCTCCTTTA AGATTGTCCT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cib1 ( NM_001291275.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001278204.1 Mus musculus calcium and integrin binding 1 (calmyrin) (Cib1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu16476
Clone ID Related Accession (Same CDS sequence)	NM_001291275.1
Accession Version	NM_001291275.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 561bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Mus musculus(house mouse)
Product	calcium and integrin-binding protein 1 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CF104297.1, AK152805.1 and BP770454.1. Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CK031089.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386, SAMN00849389 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGAGGTT CGGGCAGTCG CCTGTCTAAG GAGCTGCTGG CCGAGTACCA GGACCTGACG 
TTCCTGACCA AGCAGGAGAT CCTCCTAGCC CACAGACGCT TTTGTGAGCT GCTTCCCCCA 
GAGCAGCGGA CCGTGGAGGA GTCACTGCAC ACCCGAGTAT CGTTTGAGCA GATCCTCAGC 
CTCCCAGAGC TCAAGGAGCG AATCTGCATG GTCTTCTCCA CATCACCTAC CAGAGACAGC 
CTGAGCTTTG AGGACTTCCT GGACCTCCTG AGTGTCTTCA GTGACACAGC AACCCCAGAC 
ATCAAGTCAC ACTATGCCTT CCGCATCTTT GACTTTGATG ACGATGGAAC CCTGGACAGA 
GAAGACCTGA GCCAGCTTGT GAATTGCCTC ACGGGAGAGG GCGAGGACAC TCGGCTCAGT 
GCTTCTGAGA TGAAGCAGCT GATTGACAAT ATCCTGGAAG AGTCAGACAT TGACAGGGAT 
GGGACCATCA ATCTTTCCGA GTTCCAGCAT GTCATCTCGC GCTCACCAGA CTTTGCCAGC 
TCCTTTAAGA TTGTCCTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001278204.1
CDS	246..806
Translation	MGGSGSRLSKELLAEYQDLTFLTKQEILLAHRRFCELLPPEQRTVEESLHTRVSFEQILSLPELKERICMVFSTSPTRDSLSFEDFLDLLSVFSDTATPDIKSHYAFRIFDFDDDGTLDREDLSQLVNCLTGEGEDTRLSASEMKQLIDNILEESDIDRDGTINLSEFQHVISRSPDFASSFKIVL

Target ORF information:

RefSeq Version	NM_001291275.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus calcium and integrin binding 1 (calmyrin) (Cib1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001291275.1

ORF Insert Sequence:

ATGGGAGGTT CGGGCAGTCG CCTGTCTAAG GAGCTGCTGG CCGAGTACCA GGACCTGACG 
TTCCTGACCA AGCAGGAGAT CCTCCTAGCC CACAGACGCT TTTGTGAGCT GCTTCCCCCA 
GAGCAGCGGA CCGTGGAGGA GTCACTGCAC ACCCGAGTAT CGTTTGAGCA GATCCTCAGC 
CTCCCAGAGC TCAAGGAGCG AATCTGCATG GTCTTCTCCA CATCACCTAC CAGAGACAGC 
CTGAGCTTTG AGGACTTCCT GGACCTCCTG AGTGTCTTCA GTGACACAGC AACCCCAGAC 
ATCAAGTCAC ACTATGCCTT CCGCATCTTT GACTTTGATG ACGATGGAAC CCTGGACAGA 
GAAGACCTGA GCCAGCTTGT GAATTGCCTC ACGGGAGAGG GCGAGGACAC TCGGCTCAGT 
GCTTCTGAGA TGAAGCAGCT GATTGACAAT ATCCTGGAAG AGTCAGACAT TGACAGGGAT 
GGGACCATCA ATCTTTCCGA GTTCCAGCAT GTCATCTCGC GCTCACCAGA CTTTGCCAGC 
TCCTTTAAGA TTGTCCTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cib1 ( NM_001291276.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001278205.1 Mus musculus calcium and integrin binding 1 (calmyrin) (Cib1), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OMu16479
Clone ID Related Accession (Same CDS sequence)	NM_001291276.1
Accession Version	NM_001291276.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 432bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Mus musculus(house mouse)
Product	calcium and integrin-binding protein 1 isoform 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CF104297.1, BB843350.1, AK152805.1 and BP770454.1. On Apr 1, 2014 this sequence version replaced XM_006540859.1. Transcript Variant: This variant (3) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CK021021.1, AK088450.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGAGGTT CGGGCAGTCG CCTGTCTAAG GAGCTGCTGG CCGAGTACCA GGCTAACCCT 
TTCAAGGAGC GAATCTGCAT GGTCTTCTCC ACATCACCTA CCAGAGACAG CCTGAGCTTT 
GAGGACTTCC TGGACCTCCT GAGTGTCTTC AGTGACACAG CAACCCCAGA CATCAAGTCA 
CACTATGCCT TCCGCATCTT TGACTTTGAT GACGATGGAA CCCTGGACAG AGAAGACCTG 
AGCCAGCTTG TGAATTGCCT CACGGGAGAG GGCGAGGACA CTCGGCTCAG TGCTTCTGAG 
ATGAAGCAGC TGATTGACAA TATCCTGGAA GAGTCAGACA TTGACAGGGA TGGGACCATC 
AATCTTTCCG AGTTCCAGCA TGTCATCTCG CGCTCACCAG ACTTTGCCAG CTCCTTTAAG 
ATTGTCCTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001278205.1
CDS	246..677
Translation	MGGSGSRLSKELLAEYQANPFKERICMVFSTSPTRDSLSFEDFLDLLSVFSDTATPDIKSHYAFRIFDFDDDGTLDREDLSQLVNCLTGEGEDTRLSASEMKQLIDNILEESDIDRDGTINLSEFQHVISRSPDFASSFKIVL

Target ORF information:

RefSeq Version	NM_001291276.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus calcium and integrin binding 1 (calmyrin) (Cib1), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001291276.1

ORF Insert Sequence:

ATGGGAGGTT CGGGCAGTCG CCTGTCTAAG GAGCTGCTGG CCGAGTACCA GGCTAACCCT 
TTCAAGGAGC GAATCTGCAT GGTCTTCTCC ACATCACCTA CCAGAGACAG CCTGAGCTTT 
GAGGACTTCC TGGACCTCCT GAGTGTCTTC AGTGACACAG CAACCCCAGA CATCAAGTCA 
CACTATGCCT TCCGCATCTT TGACTTTGAT GACGATGGAA CCCTGGACAG AGAAGACCTG 
AGCCAGCTTG TGAATTGCCT CACGGGAGAG GGCGAGGACA CTCGGCTCAG TGCTTCTGAG 
ATGAAGCAGC TGATTGACAA TATCCTGGAA GAGTCAGACA TTGACAGGGA TGGGACCATC 
AATCTTTCCG AGTTCCAGCA TGTCATCTCG CGCTCACCAG ACTTTGCCAG CTCCTTTAAG 
ATTGTCCTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cib1 ( NM_011870.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_036000.1 Mus musculus calcium and integrin binding 1 (calmyrin) (Cib1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu16478
Clone ID Related Accession (Same CDS sequence)	NM_011870.5
Accession Version	NM_011870.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 576bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Mus musculus(house mouse)
Product	calcium and integrin-binding protein 1 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CF104297.1, AK152805.1 and BP770454.1. On Apr 1, 2014 this sequence version replaced NM_011870.4. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DV055722.1, CK020088.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386, SAMN00849389 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGAGGTT CGGGCAGTCG CCTGTCTAAG GAGCTGCTGG CCGAGTACCA GGACCTGACG 
TTCCTGACCA AGCAGGAGAT CCTCCTAGCC CACAGACGCT TTTGTGAGCT GCTTCCCCCA 
GAGCAGCGGA CCGTGGAGGA GTCACTGCAC ACCCGAGTAT CGTTTGAGCA GATCCTCAGC 
CTCCCAGAGC TCAAGGCTAA CCCTTTCAAG GAGCGAATCT GCATGGTCTT CTCCACATCA 
CCTACCAGAG ACAGCCTGAG CTTTGAGGAC TTCCTGGACC TCCTGAGTGT CTTCAGTGAC 
ACAGCAACCC CAGACATCAA GTCACACTAT GCCTTCCGCA TCTTTGACTT TGATGACGAT 
GGAACCCTGG ACAGAGAAGA CCTGAGCCAG CTTGTGAATT GCCTCACGGG AGAGGGCGAG 
GACACTCGGC TCAGTGCTTC TGAGATGAAG CAGCTGATTG ACAATATCCT GGAAGAGTCA 
GACATTGACA GGGATGGGAC CATCAATCTT TCCGAGTTCC AGCATGTCAT CTCGCGCTCA 
CCAGACTTTG CCAGCTCCTT TAAGATTGTC CTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036000.1
CDS	246..821
Translation	MGGSGSRLSKELLAEYQDLTFLTKQEILLAHRRFCELLPPEQRTVEESLHTRVSFEQILSLPELKANPFKERICMVFSTSPTRDSLSFEDFLDLLSVFSDTATPDIKSHYAFRIFDFDDDGTLDREDLSQLVNCLTGEGEDTRLSASEMKQLIDNILEESDIDRDGTINLSEFQHVISRSPDFASSFKIVL

Target ORF information:

RefSeq Version	NM_011870.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus calcium and integrin binding 1 (calmyrin) (Cib1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011870.5

ORF Insert Sequence:

ATGGGAGGTT CGGGCAGTCG CCTGTCTAAG GAGCTGCTGG CCGAGTACCA GGACCTGACG 
TTCCTGACCA AGCAGGAGAT CCTCCTAGCC CACAGACGCT TTTGTGAGCT GCTTCCCCCA 
GAGCAGCGGA CCGTGGAGGA GTCACTGCAC ACCCGAGTAT CGTTTGAGCA GATCCTCAGC 
CTCCCAGAGC TCAAGGCTAA CCCTTTCAAG GAGCGAATCT GCATGGTCTT CTCCACATCA 
CCTACCAGAG ACAGCCTGAG CTTTGAGGAC TTCCTGGACC TCCTGAGTGT CTTCAGTGAC 
ACAGCAACCC CAGACATCAA GTCACACTAT GCCTTCCGCA TCTTTGACTT TGATGACGAT 
GGAACCCTGG ACAGAGAAGA CCTGAGCCAG CTTGTGAATT GCCTCACGGG AGAGGGCGAG 
GACACTCGGC TCAGTGCTTC TGAGATGAAG CAGCTGATTG ACAATATCCT GGAAGAGTCA 
GACATTGACA GGGATGGGAC CATCAATCTT TCCGAGTTCC AGCATGTCAT CTCGCGCTCA 
CCAGACTTTG CCAGCTCCTT TAAGATTGTC CTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cib1 ( XM_030242553.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_030098413.1 Mus musculus calcium and integrin binding 1 (calmyrin) (Cib1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu69159
Clone ID Related Accession (Same CDS sequence)	XM_011250861.2 , XM_030242553.1 , XM_011250861.3
Accession Version	XM_030242553.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 354bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	calcium and integrin-binding protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTCTTCT CCACATCACC TACCAGAGAC AGCCTGAGCT TTGAGGACTT CCTGGACCTC 
CTGAGTGTCT TCAGTGACAC AGCAACCCCA GACATCAAGT CACACTATGC CTTCCGCATC 
TTTGACTTTG ATGACGATGG AACCCTGGAC AGAGAAGACC TGAGCCAGCT TGTGAATTGC 
CTCACGGGAG AGGGCGAGGA CACTCGGCTC AGTGCTTCTG AGATGAAGCA GCTGATTGAC 
AATATCCTGG AAGAGTCAGA CATTGACAGG GATGGGACCA TCAATCTTTC CGAGTTCCAG 
CATGTCATCT CGCGCTCACC AGACTTTGCC AGCTCCTTTA AGATTGTCCT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_030098413.1
CDS	778..1131
Translation	MVFSTSPTRDSLSFEDFLDLLSVFSDTATPDIKSHYAFRIFDFDDDGTLDREDLSQLVNCLTGEGEDTRLSASEMKQLIDNILEESDIDRDGTINLSEFQHVISRSPDFASSFKIVL

Target ORF information:

RefSeq Version	XM_030242553.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus calcium and integrin binding 1 (calmyrin) (Cib1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_030242553.1

ORF Insert Sequence:

ATGGTCTTCT CCACATCACC TACCAGAGAC AGCCTGAGCT TTGAGGACTT CCTGGACCTC 
CTGAGTGTCT TCAGTGACAC AGCAACCCCA GACATCAAGT CACACTATGC CTTCCGCATC 
TTTGACTTTG ATGACGATGG AACCCTGGAC AGAGAAGACC TGAGCCAGCT TGTGAATTGC 
CTCACGGGAG AGGGCGAGGA CACTCGGCTC AGTGCTTCTG AGATGAAGCA GCTGATTGAC 
AATATCCTGG AAGAGTCAGA CATTGACAGG GATGGGACCA TCAATCTTTC CGAGTTCCAG 
CATGTCATCT CGCGCTCACC AGACTTTGCC AGCTCCTTTA AGATTGTCCT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cib1 ( XM_011250861.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_011249163.1 Mus musculus calcium and integrin binding 1 (calmyrin) (Cib1), transcript variant X2, mRNA.

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CloneID	OMu69159
Clone ID Related Accession (Same CDS sequence)	XM_011250861.2 , XM_030242553.1 , XM_011250861.3
Accession Version	XM_011250861.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 354bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	calcium and integrin-binding protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_011250861.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTCTTCT CCACATCACC TACCAGAGAC AGCCTGAGCT TTGAGGACTT CCTGGACCTC 
CTGAGTGTCT TCAGTGACAC AGCAACCCCA GACATCAAGT CACACTATGC CTTCCGCATC 
TTTGACTTTG ATGACGATGG AACCCTGGAC AGAGAAGACC TGAGCCAGCT TGTGAATTGC 
CTCACGGGAG AGGGCGAGGA CACTCGGCTC AGTGCTTCTG AGATGAAGCA GCTGATTGAC 
AATATCCTGG AAGAGTCAGA CATTGACAGG GATGGGACCA TCAATCTTTC CGAGTTCCAG 
CATGTCATCT CGCGCTCACC AGACTTTGCC AGCTCCTTTA AGATTGTCCT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011249163.1
CDS	407..760
Translation	MVFSTSPTRDSLSFEDFLDLLSVFSDTATPDIKSHYAFRIFDFDDDGTLDREDLSQLVNCLTGEGEDTRLSASEMKQLIDNILEESDIDRDGTINLSEFQHVISRSPDFASSFKIVL

Target ORF information:

RefSeq Version	XM_011250861.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus calcium and integrin binding 1 (calmyrin) (Cib1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011250861.3

ORF Insert Sequence:

ATGGTCTTCT CCACATCACC TACCAGAGAC AGCCTGAGCT TTGAGGACTT CCTGGACCTC 
CTGAGTGTCT TCAGTGACAC AGCAACCCCA GACATCAAGT CACACTATGC CTTCCGCATC 
TTTGACTTTG ATGACGATGG AACCCTGGAC AGAGAAGACC TGAGCCAGCT TGTGAATTGC 
CTCACGGGAG AGGGCGAGGA CACTCGGCTC AGTGCTTCTG AGATGAAGCA GCTGATTGAC 
AATATCCTGG AAGAGTCAGA CATTGACAGG GATGGGACCA TCAATCTTTC CGAGTTCCAG 
CATGTCATCT CGCGCTCACC AGACTTTGCC AGCTCCTTTA AGATTGTCCT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CIB1 protects against MPTP-induced neurotoxicity through inhibiting ASK1.
Scientific reports7(1)12178(2017 Sep)
Yoon KW,Yang HS,Kim YM,Kim Y,Kang S,Sun W,Naik UP,Parise LV,Choi EJ

CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells.
Nature communications8(1)43(2017 06)
Giese APJ,Tang YQ,Sinha GP,Bowl MR,Goldring AC,Parker A,Freeman MJ,Brown SDM,Riazuddin S,Fettiplace R,Schafer WR,Frolenkov GI,Ahmed ZM

Binding of CIB1 to the ?IIb tail of ?IIb?3 is required for FAK recruitment and activation in platelets.
PloS one12(5)e0176602(2017)
Naik MU,Naik TU,Summer R,Naik UP

Biophysical and structural studies of the human calcium- and integrin-binding protein family: understanding their functional similarities and differences.
Biochemistry and cell biology = Biochimie et biologie cellulaire90(5)646-56(2012 Oct)
Huang H,Bogstie JN,Vogel HJ

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Cib1 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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