Tbpl1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tbpl1
Entrez Gene ID	237336
Full Name	TATA box binding protein-like 1
Synonyms	4732475G08,AW011832,AW491032,D18347,STD,TLF,TRF2,TRP,Tlp
General protein information	Preferred Names TATA box binding protein-like 1 Names TATA box-binding protein-like protein 1 21 kDa TBP-like protein TATA box binding protein-like protein TATA box-binding protein-related factor 2 TBP-like factor TBP-like protein 1 TBP-related factor 2 TBP-related protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 10 Map Location: 10\|10 A3

mRNA and Protein(s)

mRNA	Protein	Name
XM_006512730.4	XP_006512793.1	TATA box-binding protein-like protein 1 isoform X1
NM_011603.5	NP_035733.1	TATA box-binding protein-like protein 1
XM_006512730.3	XP_006512793.1	TATA box-binding protein-like protein 1 isoform X1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	TBPL1	NP_001092762.1
Bos taurus (cattle)	TBPL1	NP_001069758.1
Mus musculus (house mouse)	Tbpl1	NP_035733.1
Homo sapiens (human)	TBPL1	NP_001240605.1
Gallus gallus (chicken)	TBPL1	NP_990086.1
Danio rerio (zebrafish)	tbpl1	NP_991285.1
Canis lupus familiaris (dog)	TBPL1	NP_001239188.1
Rattus norvegicus (Norway rat)	Tbpl1	NP_001120673.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007517	XP_308361.4
Caenorhabditis elegans (roundworm)	tlf-1	NP_492356.1
Xenopus tropicalis (tropical clawed frog)	tbpl1	NP_001004932.1

Gene Ontology
Bibliography

Related articles in PubMed

Myocardial VHL-HIF Signaling Controls an Embryonic Metabolic Switch Essential for Cardiac Maturation.
Menendez-Montes I, Escobar B, Palacios B, G?mez MJ, Izquierdo-Garcia JL, Flores L, Jim?nez-Borreguero LJ, Aragones J, Ruiz-Cabello J, Torres M, Martin-Puig S
Developmental cell39(6)724-739(2016 12)

TBP-like protein (TLP) represses myogenesis via inhibition of the?myogenin promoter.
Nakazato A, Maeda R, Ishikawa K, Suzuki H, Tamura TA
Biochemical and biophysical research communications479(4)814-819(2016 Oct)

TRF2 is recruited to the pre-initiation complex as a testis-specific subunit of TFIIA/ALF to promote haploid cell gene expression.
Martianov I, Velt A, Davidson G, Choukrallah MA, Davidson I
Scientific reports632069(2016 Aug)

TDRD5 is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis in mice.
Yabuta Y, Ohta H, Abe T, Kurimoto K, Chuma S, Saitou M
The Journal of cell biology192(5)781-95(2011 Mar)

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.
Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P
Developmental cell18(4)675-85(2010 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Overexpression and knockdown of TLP revealed that the levels of muscle-specific myosin heavy chain and the myogenic transcription factor myogenin are downregulated by TLP. The proximal AT-rich sequence of the myogenin promoter is responsible for TLP-mediated transcriptional repression.
Title: TBP-like protein (TLP) represses myogenesis via inhibition of the?myogenin promoter.

Transplantation of TRF2 overexpressing bone marrow cells into the hematopoietic system of mice resulted in the the development of T-cell lymphomas, but overexpression of the TRF2 transgene was not detectable anymore in the tumors.
Title: Moderate expression of TRF2 in the hematopoietic system increases development of large cell blastic T-cell lymphomas.

Data report on the nucleosomal organization of telomeres that have become deprotected through the deletion of the shelterin components TRF2 or POT1a/b, and show no evidence of changes or nucleosome eviction near the telomere terminus.
Title: No overt nucleosome eviction at deprotected telomeres.

these results demonstrate that TRF2 increased expression is a potent oncogenic event that along with telomerase deficiency accelerates carcinogenesis, coincidental with a derepression of telomere recombination
Title: Telomerase abrogation dramatically accelerates TRF2-induced epithelial carcinogenesis.

reconfirmed cytoplasmic localization of TRF2; genotoxins caused it to migrate to the nucleus; TRF2 may be involved in genotoxin-induced transcriptional regulation
Title: TATA-binding protein-related factor 2 is localized in the cytoplasm of mammalian cells and much of it migrates to the nucleus in response to genotoxic agents.

The following Tbpl1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tbpl1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu08452	NM_011603.5 Latest version!	Mus musculus TATA box binding protein-like 1 (Tbpl1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu08452	XM_006512730.4 Latest version!	Mus musculus TATA box binding protein-like 1 (Tbpl1), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OMu08452	XM_006512730.3	Mus musculus TATA box binding protein-like 1 (Tbpl1), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tbpl1 ( NM_011603.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035733.1 Mus musculus TATA box binding protein-like 1 (Tbpl1), mRNA.

Price & Availability↑

CloneID	OMu08452
Clone ID Related Accession (Same CDS sequence)	XM_006512730.4 , NM_011603.5 , XM_006512730.3
Accession Version	NM_011603.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 561bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-22
Organism	Mus musculus(house mouse)
Product	TATA box-binding protein-like protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY275848.1, AK049975.1, BE650743.1 and BE995552.1. On Apr 8, 2009 this sequence version replaced NM_011603.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK078547.1, SRR1660819.166027.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849384, SAMN01164131 [ECO:0000348] ##Evidence-Data-END##

ATGGATGCAG ACAGTGATGT TGCATTGGAC ATTTTAATTA CAAATGTAGT CTGTGTTTTT 
AGAACAAGAT GCCATTTGAA CTTAAGGAAG ATTGCTTTGG AGGGAGCAAA TGTAATTTAT 
AAGCGTGATG TTGGGAAAGT ATTAATGAAG CTTAGAAAAC CTAGAATTAC AGCTACAATT 
TGGTCCTCAG GAAAAATTAT TTGCACTGGA GCAACAAGTG AAGAAGAAGC TAAATTTGGT 
GCCAGACGTT TAGCCCGTAG TCTGCAGAAA CTAGGTTTTC AGGTCATCTT CACAGATTTT 
AAGGTGGTGA ATGTTTTGGC AGTGTGTAAC ATGCCCTTTG AGATCCGTTT GCCAGAATTT 
ACAAAGAACA ATAGACCTCA TGCCAGCTAT GAACCTGAAC TTCATCCTGC CGTGTGCTAT 
CGGATAAAGT CTCTAAGAGC TACATTACAG ATATTTTCAA CAGGAAGCAT CACAGTGACA 
GGGCCCAATG TAAAGGCTGT GGCGACTGCC GTGGAACAGA TCTACCCGTT CGTGTTTGAA 
AGCAGGAAGG AGATTTTATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035733.1
CDS	376..936
Translation	MDADSDVALDILITNVVCVFRTRCHLNLRKIALEGANVIYKRDVGKVLMKLRKPRITATIWSSGKIICTGATSEEEAKFGARRLARSLQKLGFQVIFTDFKVVNVLAVCNMPFEIRLPEFTKNNRPHASYEPELHPAVCYRIKSLRATLQIFSTGSITVTGPNVKAVATAVEQIYPFVFESRKEIL

Target ORF information:

RefSeq Version	NM_011603.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus TATA box binding protein-like 1 (Tbpl1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011603.5

ORF Insert Sequence:

ATGGATGCAG ACAGTGATGT TGCATTGGAC ATTTTAATTA CAAATGTAGT CTGTGTTTTT 
AGAACAAGAT GCCATTTGAA CTTAAGGAAG ATTGCTTTGG AGGGAGCAAA TGTAATTTAT 
AAGCGTGATG TTGGGAAAGT ATTAATGAAG CTTAGAAAAC CTAGAATTAC AGCTACAATT 
TGGTCCTCAG GAAAAATTAT TTGCACTGGA GCAACAAGTG AAGAAGAAGC TAAATTTGGT 
GCCAGACGTT TAGCCCGTAG TCTGCAGAAA CTAGGTTTTC AGGTCATCTT CACAGATTTT 
AAGGTGGTGA ATGTTTTGGC AGTGTGTAAC ATGCCCTTTG AGATCCGTTT GCCAGAATTT 
ACAAAGAACA ATAGACCTCA TGCCAGCTAT GAACCTGAAC TTCATCCTGC CGTGTGCTAT 
CGGATAAAGT CTCTAAGAGC TACATTACAG ATATTTTCAA CAGGAAGCAT CACAGTGACA 
GGGCCCAATG TAAAGGCTGT GGCGACTGCC GTGGAACAGA TCTACCCGTT CGTGTTTGAA 
AGCAGGAAGG AGATTTTATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Tbpl1 ( XM_006512730.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006512793.1 Mus musculus TATA box binding protein-like 1 (Tbpl1), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OMu08452
Clone ID Related Accession (Same CDS sequence)	XM_006512730.4 , NM_011603.5 , XM_006512730.3
Accession Version	XM_006512730.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 561bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	TATA box-binding protein-like protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000076.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006512730.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGATGCAG ACAGTGATGT TGCATTGGAC ATTTTAATTA CAAATGTAGT CTGTGTTTTT 
AGAACAAGAT GCCATTTGAA CTTAAGGAAG ATTGCTTTGG AGGGAGCAAA TGTAATTTAT 
AAGCGTGATG TTGGGAAAGT ATTAATGAAG CTTAGAAAAC CTAGAATTAC AGCTACAATT 
TGGTCCTCAG GAAAAATTAT TTGCACTGGA GCAACAAGTG AAGAAGAAGC TAAATTTGGT 
GCCAGACGTT TAGCCCGTAG TCTGCAGAAA CTAGGTTTTC AGGTCATCTT CACAGATTTT 
AAGGTGGTGA ATGTTTTGGC AGTGTGTAAC ATGCCCTTTG AGATCCGTTT GCCAGAATTT 
ACAAAGAACA ATAGACCTCA TGCCAGCTAT GAACCTGAAC TTCATCCTGC CGTGTGCTAT 
CGGATAAAGT CTCTAAGAGC TACATTACAG ATATTTTCAA CAGGAAGCAT CACAGTGACA 
GGGCCCAATG TAAAGGCTGT GGCGACTGCC GTGGAACAGA TCTACCCGTT CGTGTTTGAA 
AGCAGGAAGG AGATTTTATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006512793.1
CDS	506..1066
Translation	MDADSDVALDILITNVVCVFRTRCHLNLRKIALEGANVIYKRDVGKVLMKLRKPRITATIWSSGKIICTGATSEEEAKFGARRLARSLQKLGFQVIFTDFKVVNVLAVCNMPFEIRLPEFTKNNRPHASYEPELHPAVCYRIKSLRATLQIFSTGSITVTGPNVKAVATAVEQIYPFVFESRKEIL

Target ORF information:

RefSeq Version	XM_006512730.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus TATA box binding protein-like 1 (Tbpl1), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006512730.3

ORF Insert Sequence:

ATGGATGCAG ACAGTGATGT TGCATTGGAC ATTTTAATTA CAAATGTAGT CTGTGTTTTT 
AGAACAAGAT GCCATTTGAA CTTAAGGAAG ATTGCTTTGG AGGGAGCAAA TGTAATTTAT 
AAGCGTGATG TTGGGAAAGT ATTAATGAAG CTTAGAAAAC CTAGAATTAC AGCTACAATT 
TGGTCCTCAG GAAAAATTAT TTGCACTGGA GCAACAAGTG AAGAAGAAGC TAAATTTGGT 
GCCAGACGTT TAGCCCGTAG TCTGCAGAAA CTAGGTTTTC AGGTCATCTT CACAGATTTT 
AAGGTGGTGA ATGTTTTGGC AGTGTGTAAC ATGCCCTTTG AGATCCGTTT GCCAGAATTT 
ACAAAGAACA ATAGACCTCA TGCCAGCTAT GAACCTGAAC TTCATCCTGC CGTGTGCTAT 
CGGATAAAGT CTCTAAGAGC TACATTACAG ATATTTTCAA CAGGAAGCAT CACAGTGACA 
GGGCCCAATG TAAAGGCTGT GGCGACTGCC GTGGAACAGA TCTACCCGTT CGTGTTTGAA 
AGCAGGAAGG AGATTTTATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Tbpl1 ( XM_006512730.4 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006512793.1 Mus musculus TATA box binding protein-like 1 (Tbpl1), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OMu08452
Clone ID Related Accession (Same CDS sequence)	XM_006512730.4 , NM_011603.5 , XM_006512730.3
Accession Version	XM_006512730.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 561bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	TATA box-binding protein-like protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000076.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006512730.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGATGCAG ACAGTGATGT TGCATTGGAC ATTTTAATTA CAAATGTAGT CTGTGTTTTT 
AGAACAAGAT GCCATTTGAA CTTAAGGAAG ATTGCTTTGG AGGGAGCAAA TGTAATTTAT 
AAGCGTGATG TTGGGAAAGT ATTAATGAAG CTTAGAAAAC CTAGAATTAC AGCTACAATT 
TGGTCCTCAG GAAAAATTAT TTGCACTGGA GCAACAAGTG AAGAAGAAGC TAAATTTGGT 
GCCAGACGTT TAGCCCGTAG TCTGCAGAAA CTAGGTTTTC AGGTCATCTT CACAGATTTT 
AAGGTGGTGA ATGTTTTGGC AGTGTGTAAC ATGCCCTTTG AGATCCGTTT GCCAGAATTT 
ACAAAGAACA ATAGACCTCA TGCCAGCTAT GAACCTGAAC TTCATCCTGC CGTGTGCTAT 
CGGATAAAGT CTCTAAGAGC TACATTACAG ATATTTTCAA CAGGAAGCAT CACAGTGACA 
GGGCCCAATG TAAAGGCTGT GGCGACTGCC GTGGAACAGA TCTACCCGTT CGTGTTTGAA 
AGCAGGAAGG AGATTTTATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006512793.1
CDS	928..1488
Translation	MDADSDVALDILITNVVCVFRTRCHLNLRKIALEGANVIYKRDVGKVLMKLRKPRITATIWSSGKIICTGATSEEEAKFGARRLARSLQKLGFQVIFTDFKVVNVLAVCNMPFEIRLPEFTKNNRPHASYEPELHPAVCYRIKSLRATLQIFSTGSITVTGPNVKAVATAVEQIYPFVFESRKEIL

Target ORF information:

RefSeq Version	XM_006512730.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus TATA box binding protein-like 1 (Tbpl1), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006512730.4

ORF Insert Sequence:

ATGGATGCAG ACAGTGATGT TGCATTGGAC ATTTTAATTA CAAATGTAGT CTGTGTTTTT 
AGAACAAGAT GCCATTTGAA CTTAAGGAAG ATTGCTTTGG AGGGAGCAAA TGTAATTTAT 
AAGCGTGATG TTGGGAAAGT ATTAATGAAG CTTAGAAAAC CTAGAATTAC AGCTACAATT 
TGGTCCTCAG GAAAAATTAT TTGCACTGGA GCAACAAGTG AAGAAGAAGC TAAATTTGGT 
GCCAGACGTT TAGCCCGTAG TCTGCAGAAA CTAGGTTTTC AGGTCATCTT CACAGATTTT 
AAGGTGGTGA ATGTTTTGGC AGTGTGTAAC ATGCCCTTTG AGATCCGTTT GCCAGAATTT 
ACAAAGAACA ATAGACCTCA TGCCAGCTAT GAACCTGAAC TTCATCCTGC CGTGTGCTAT 
CGGATAAAGT CTCTAAGAGC TACATTACAG ATATTTTCAA CAGGAAGCAT CACAGTGACA 
GGGCCCAATG TAAAGGCTGT GGCGACTGCC GTGGAACAGA TCTACCCGTT CGTGTTTGAA 
AGCAGGAAGG AGATTTTATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Myocardial VHL-HIF Signaling Controls an Embryonic Metabolic Switch Essential for Cardiac Maturation.
Developmental cell39(6)724-739(2016 12)
Menendez-Montes I,Escobar B,Palacios B,G?mez MJ,Izquierdo-Garcia JL,Flores L,Jim?nez-Borreguero LJ,Aragones J,Ruiz-Cabello J,Torres M,Martin-Puig S

TBP-like protein (TLP) represses myogenesis via inhibition of the?myogenin promoter.
Biochemical and biophysical research communications479(4)814-819(2016 Oct)
Nakazato A,Maeda R,Ishikawa K,Suzuki H,Tamura TA

TRF2 is recruited to the pre-initiation complex as a testis-specific subunit of TFIIA/ALF to promote haploid cell gene expression.
Scientific reports632069(2016 Aug)
Martianov I,Velt A,Davidson G,Choukrallah MA,Davidson I

TDRD5 is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis in mice.
The Journal of cell biology192(5)781-95(2011 Mar)
Yabuta Y,Ohta H,Abe T,Kurimoto K,Chuma S,Saitou M

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.
Developmental cell18(4)675-85(2010 Apr)
Guo G,Huss M,Tong GQ,Wang C,Li Sun L,Clarke ND,Robson P

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Tbpl1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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